Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L1, mitochondrial

Gene

MRPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L1, mitochondrial
Short name:
L1mt
Short name:
MRP-L1
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL1m1 Publication
Gene namesi
Name:MRPL1
ORF Names:BM-022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169288.17
HGNCiHGNC:14275 MRPL1
MIMi611821 gene
neXtProtiNX_Q9BYD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65008
OpenTargetsiENSG00000169288
PharmGKBiPA30938

Polymorphism and mutation databases

BioMutaiMRPL1
DMDMi239938694

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 50MitochondrionSequence analysisAdd BLAST50
ChainiPRO_000025244051 – 32539S ribosomal protein L1, mitochondrialAdd BLAST275

Proteomic databases

EPDiQ9BYD6
MaxQBiQ9BYD6
PaxDbiQ9BYD6
PeptideAtlasiQ9BYD6
PRIDEiQ9BYD6
ProteomicsDBi79621

PTM databases

iPTMnetiQ9BYD6
PhosphoSitePlusiQ9BYD6
SwissPalmiQ9BYD6

Expressioni

Gene expression databases

BgeeiENSG00000169288 Expressed in 197 organ(s), highest expression level in biceps brachii
CleanExiHS_MRPL1
ExpressionAtlasiQ9BYD6 baseline and differential
GenevisibleiQ9BYD6 HS

Organism-specific databases

HPAiHPA043656

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:11279069). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-5325394,EBI-349832

Protein-protein interaction databases

BioGridi122371, 87 interactors
CORUMiQ9BYD6
IntActiQ9BYD6, 68 interactors
MINTiQ9BYD6
STRINGi9606.ENSP00000315017

Structurei

3D structure databases

ProteinModelPortaliQ9BYD6
SMRiQ9BYD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1569 Eukaryota
COG0081 LUCA
GeneTreeiENSGT00390000003587
HOVERGENiHBG061212
InParanoidiQ9BYD6
KOiK02863
OMAiVDNFQRM
OrthoDBiEOG091G0CV1
PhylomeDBiQ9BYD6
TreeFamiTF314989

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR005879 Ribosomal_L1_mit
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
TIGRFAMsiTIGR01170 rplA_mito, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BYD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVRCMGR ALIHHQRHSL SKMVYQTSLC SCSVNIRVPN RHFAAATKSA
60 70 80 90 100
KKTKKGAKEK TPDEKKDEIE KIKAYPYMEG EPEDDVYLKR LYPRQIYEVE
110 120 130 140 150
KAVHLLKKFQ ILDFTSPKQS VYLDLTLDMA LGKKKNVEPF TSVLSLPYPF
160 170 180 190 200
ASEINKVAVF TENASEVKIA EENGAAFAGG TSLIQKIWDD EIVADFYVAV
210 220 230 240 250
PEIMPELNRL RKKLNKKYPK LSRNSIGRDI PKMLELFKNG HEIKVDEERE
260 270 280 290 300
NFLQTKIATL DMSSDQIAAN LQAVINEVCR HRPLNLGPFV VRAFLRSSTS
310 320
EGLLLKIDPL LPKEVKNEES EKEDA
Length:325
Mass (Da):36,909
Last modified:June 16, 2009 - v2
Checksum:iEB53BEE59065B682
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8N7H0Y8N7_HUMAN
39S ribosomal protein L1, mitochond...
MRPL1
231Annotation score:

Sequence cautioni

The sequence AAF87327 differs from that shown. Reason: Frameshift at positions 4, 6, 19, 123, 139 and 147.Curated
The sequence AAF87327 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH14356 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15109 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH32595 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAY41057 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB15005 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB40180 differs from that shown. Reason: Frameshift at position 20.Curated
The sequence BAB40180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85D → N in BAB15005 (PubMed:14702039).Curated1
Sequence conflicti229D → H in CAG33472 (PubMed:15489334).Curated1
Sequence conflicti265D → G in BAB15005 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02786547T → K1 PublicationCorresponds to variant dbSNP:rs17851275Ensembl.1
Natural variantiVAR_027866177F → S1 PublicationCorresponds to variant dbSNP:rs17855456Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212225 mRNA Translation: AAF87327.1 Sequence problems.
AC112225 Genomic DNA Translation: AAY41057.1 Sequence problems.
AC114801 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05820.1
BC014356 mRNA Translation: AAH14356.1 Different initiation.
BC015109 mRNA Translation: AAH15109.1 Different initiation.
BC032595 mRNA Translation: AAH32595.1 Different initiation.
AB049474 mRNA Translation: BAB40180.1 Sequence problems.
CR457191 mRNA Translation: CAG33472.1
AK024791 mRNA Translation: BAB15005.1 Different initiation.
CCDSiCCDS3583.2
RefSeqiNP_064621.3, NM_020236.3
XP_011530500.1, XM_011532198.2
XP_011530501.1, XM_011532199.1
UniGeneiHs.532019

Genome annotation databases

EnsembliENST00000315567; ENSP00000315017; ENSG00000169288
GeneIDi65008
KEGGihsa:65008
UCSCiuc003hku.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212225 mRNA Translation: AAF87327.1 Sequence problems.
AC112225 Genomic DNA Translation: AAY41057.1 Sequence problems.
AC114801 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05820.1
BC014356 mRNA Translation: AAH14356.1 Different initiation.
BC015109 mRNA Translation: AAH15109.1 Different initiation.
BC032595 mRNA Translation: AAH32595.1 Different initiation.
AB049474 mRNA Translation: BAB40180.1 Sequence problems.
CR457191 mRNA Translation: CAG33472.1
AK024791 mRNA Translation: BAB15005.1 Different initiation.
CCDSiCCDS3583.2
RefSeqiNP_064621.3, NM_020236.3
XP_011530500.1, XM_011532198.2
XP_011530501.1, XM_011532199.1
UniGeneiHs.532019

3D structure databases

ProteinModelPortaliQ9BYD6
SMRiQ9BYD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122371, 87 interactors
CORUMiQ9BYD6
IntActiQ9BYD6, 68 interactors
MINTiQ9BYD6
STRINGi9606.ENSP00000315017

PTM databases

iPTMnetiQ9BYD6
PhosphoSitePlusiQ9BYD6
SwissPalmiQ9BYD6

Polymorphism and mutation databases

BioMutaiMRPL1
DMDMi239938694

Proteomic databases

EPDiQ9BYD6
MaxQBiQ9BYD6
PaxDbiQ9BYD6
PeptideAtlasiQ9BYD6
PRIDEiQ9BYD6
ProteomicsDBi79621

Protocols and materials databases

DNASUi65008
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315567; ENSP00000315017; ENSG00000169288
GeneIDi65008
KEGGihsa:65008
UCSCiuc003hku.3 human

Organism-specific databases

CTDi65008
DisGeNETi65008
EuPathDBiHostDB:ENSG00000169288.17
GeneCardsiMRPL1
HGNCiHGNC:14275 MRPL1
HPAiHPA043656
MIMi611821 gene
neXtProtiNX_Q9BYD6
OpenTargetsiENSG00000169288
PharmGKBiPA30938
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1569 Eukaryota
COG0081 LUCA
GeneTreeiENSGT00390000003587
HOVERGENiHBG061212
InParanoidiQ9BYD6
KOiK02863
OMAiVDNFQRM
OrthoDBiEOG091G0CV1
PhylomeDBiQ9BYD6
TreeFamiTF314989

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMRPL1
GenomeRNAii65008
PROiPR:Q9BYD6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169288 Expressed in 197 organ(s), highest expression level in biceps brachii
CleanExiHS_MRPL1
ExpressionAtlasiQ9BYD6 baseline and differential
GenevisibleiQ9BYD6 HS

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR005879 Ribosomal_L1_mit
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
TIGRFAMsiTIGR01170 rplA_mito, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM01_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD6
Secondary accession number(s): A6NG03
, Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again