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Entry version 153 (26 Feb 2020)
Sequence version 1 (01 Jun 2001)
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Protein

39S ribosomal protein L4, mitochondrial

Gene

MRPL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
39S ribosomal protein L4, mitochondrial
Short name:
L4mt
Short name:
MRP-L4
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL4m1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRPL4
ORF Names:CDABP0091, CGI-28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14276 MRPL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611823 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYD3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51073

Open Targets

More...
OpenTargetsi
ENSG00000105364

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30971

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BYD3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRPL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733471

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002389491 – 31139S ribosomal protein L4, mitochondrialAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei147Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BYD3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BYD3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BYD3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYD3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYD3

PeptideAtlas

More...
PeptideAtlasi
Q9BYD3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYD3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79617 [Q9BYD3-1]
79618 [Q9BYD3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYD3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105364 Expressed in apex of heart and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BYD3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BYD3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051261

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Interacts with MIEF1 upstream open reading frame protein (PubMed:30215512).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119264, 150 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BYD3

Protein interaction database and analysis system

More...
IntActi
Q9BYD3, 100 interactors

Molecular INTeraction database

More...
MINTi
Q9BYD3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253099

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BYD3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1311
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYD3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1624 Eukaryota
COG0088 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014512

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYD3

KEGG Orthology (KO)

More...
KOi
K02926

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSMLKHE

Database of Orthologous Groups

More...
OrthoDBi
1592747at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYD3

TreeFam database of animal gene trees

More...
TreeFami
TF313913

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1370.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01328_B Ribosomal_L4_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002136 Ribosomal_L4/L1e
IPR023574 Ribosomal_L4_dom_sf
IPR013005 Ribosomal_uL4/L1e

The PANTHER Classification System

More...
PANTHERi
PTHR10746 PTHR10746, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00573 Ribosomal_L4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52166 SSF52166, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03953 rplD_bact, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYD3-1) [UniParc]FASTAAdd to basket
Also known as: isoform a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK
60 70 80 90 100
VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA
110 120 130 140 150
MWQKNFKRIS YAKTKTRAEV RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG
160 170 180 190 200
VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLAQDDLHIM DSLELPTGDP
210 220 230 240 250
QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF NLIPAVGLNV
260 270 280 290 300
HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA
310
TQGPAATPYH C
Length:311
Mass (Da):34,919
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8267C61C42BFCF07
GO
Isoform 2 (identifier: Q9BYD3-2) [UniParc]FASTAAdd to basket
Also known as: isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     248-263: LNVHSMLKHQTLVLTL → EQRAQAPRVRMCRLRC
     264-311: Missing.

Show »
Length:263
Mass (Da):29,502
Checksum:i698CAA74688002FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RAY8X6RAY8_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
357Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES61K7ES61_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELQ0K7ELQ0_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ73K7EJ73_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELF1K7ELF1_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKI4K7EKI4_HUMAN
39S ribosomal protein L4, mitochond...
MRPL4
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27737 differs from that shown. Reason: Frameshift.Curated
The sequence AAG02005 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019027248 – 263LNVHS…LVLTL → EQRAQAPRVRMCRLRC in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019028264 – 311Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB049635 mRNA Translation: BAB40840.1
AF132962 mRNA Translation: AAD27737.1 Frameshift.
AC011511 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84083.1
BC000756 mRNA Translation: AAH00756.1
BC009858 mRNA Translation: AAH09858.1
AY007152 mRNA Translation: AAG02005.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12230.1 [Q9BYD3-1]
CCDS42499.1 [Q9BYD3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_057040.2, NM_015956.2 [Q9BYD3-1]
NP_666499.1, NM_146387.1 [Q9BYD3-1]
NP_666500.1, NM_146388.1 [Q9BYD3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253099; ENSP00000253099; ENSG00000105364 [Q9BYD3-1]
ENST00000307422; ENSP00000306902; ENSG00000105364 [Q9BYD3-1]
ENST00000590669; ENSP00000465143; ENSG00000105364 [Q9BYD3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51073

UCSC genome browser

More...
UCSCi
uc002mnm.4 human [Q9BYD3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049635 mRNA Translation: BAB40840.1
AF132962 mRNA Translation: AAD27737.1 Frameshift.
AC011511 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84083.1
BC000756 mRNA Translation: AAH00756.1
BC009858 mRNA Translation: AAH09858.1
AY007152 mRNA Translation: AAG02005.1 Different initiation.
CCDSiCCDS12230.1 [Q9BYD3-1]
CCDS42499.1 [Q9BYD3-2]
RefSeqiNP_057040.2, NM_015956.2 [Q9BYD3-1]
NP_666499.1, NM_146387.1 [Q9BYD3-1]
NP_666500.1, NM_146388.1 [Q9BYD3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40F1-311[»]
3J9Melectron microscopy3.50F1-311[»]
5OOLelectron microscopy3.06F1-311[»]
5OOMelectron microscopy3.03F1-311[»]
6NU2electron microscopy3.90F45-294[»]
6NU3electron microscopy4.40F1-311[»]
SMRiQ9BYD3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119264, 150 interactors
CORUMiQ9BYD3
IntActiQ9BYD3, 100 interactors
MINTiQ9BYD3
STRINGi9606.ENSP00000253099

PTM databases

iPTMnetiQ9BYD3
PhosphoSitePlusiQ9BYD3

Polymorphism and mutation databases

BioMutaiMRPL4
DMDMi74733471

Proteomic databases

EPDiQ9BYD3
jPOSTiQ9BYD3
MassIVEiQ9BYD3
MaxQBiQ9BYD3
PaxDbiQ9BYD3
PeptideAtlasiQ9BYD3
PRIDEiQ9BYD3
ProteomicsDBi79617 [Q9BYD3-1]
79618 [Q9BYD3-2]

Genome annotation databases

EnsembliENST00000253099; ENSP00000253099; ENSG00000105364 [Q9BYD3-1]
ENST00000307422; ENSP00000306902; ENSG00000105364 [Q9BYD3-1]
ENST00000590669; ENSP00000465143; ENSG00000105364 [Q9BYD3-2]
GeneIDi51073
KEGGihsa:51073
UCSCiuc002mnm.4 human [Q9BYD3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51073
DisGeNETi51073

GeneCards: human genes, protein and diseases

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GeneCardsi
MRPL4
HGNCiHGNC:14276 MRPL4
HPAiHPA051261
MIMi611823 gene
neXtProtiNX_Q9BYD3
OpenTargetsiENSG00000105364
PharmGKBiPA30971

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1624 Eukaryota
COG0088 LUCA
GeneTreeiENSGT00390000014512
InParanoidiQ9BYD3
KOiK02926
OMAiHSMLKHE
OrthoDBi1592747at2759
PhylomeDBiQ9BYD3
TreeFamiTF313913

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MRPL4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MRPL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51073
PharosiQ9BYD3 Tdark

Protein Ontology

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PROi
PR:Q9BYD3
RNActiQ9BYD3 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105364 Expressed in apex of heart and 204 other tissues
ExpressionAtlasiQ9BYD3 baseline and differential
GenevisibleiQ9BYD3 HS

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
HAMAPiMF_01328_B Ribosomal_L4_B, 1 hit
InterProiView protein in InterPro
IPR002136 Ribosomal_L4/L1e
IPR023574 Ribosomal_L4_dom_sf
IPR013005 Ribosomal_uL4/L1e
PANTHERiPTHR10746 PTHR10746, 1 hit
PfamiView protein in Pfam
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
TIGRFAMsiTIGR03953 rplD_bact, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRM04_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYD3
Secondary accession number(s): A6NNV7
, Q9BW07, Q9H4N2, Q9Y317
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: February 26, 2020
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
UniProt is an ELIXIR core data resource
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