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Protein

39S ribosomal protein L9, mitochondrial

Gene

MRPL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L9, mitochondrial
Short name:
L9mt
Short name:
MRP-L9
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL9m1 Publication
Gene namesi
Name:MRPL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143436.10
HGNCiHGNC:14277 MRPL9
MIMi611824 gene
neXtProtiNX_Q9BYD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65005
OpenTargetsiENSG00000143436
PharmGKBiPA30991

Polymorphism and mutation databases

BioMutaiMRPL9
DMDMi209572671

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionBy similarityAdd BLAST52
ChainiPRO_000003055053 – 26739S ribosomal protein L9, mitochondrialAdd BLAST215

Proteomic databases

EPDiQ9BYD2
MaxQBiQ9BYD2
PaxDbiQ9BYD2
PeptideAtlasiQ9BYD2
PRIDEiQ9BYD2
ProteomicsDBi79616

PTM databases

iPTMnetiQ9BYD2
PhosphoSitePlusiQ9BYD2

Expressioni

Gene expression databases

BgeeiENSG00000143436 Expressed in 234 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_MRPL9
ExpressionAtlasiQ9BYD2 baseline and differential
GenevisibleiQ9BYD2 HS

Organism-specific databases

HPAiHPA008579

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-726059,EBI-10175124

Protein-protein interaction databases

BioGridi122370, 93 interactors
CORUMiQ9BYD2
IntActiQ9BYD2, 75 interactors
MINTiQ9BYD2
STRINGi9606.ENSP00000357823

Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYD2
SMRiQ9BYD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4607 Eukaryota
ENOG4111HFB LUCA
GeneTreeiENSGT00390000008281
HOGENOMiHOG000247066
HOVERGENiHBG002704
InParanoidiQ9BYD2
KOiK02939
OMAiKAGFHCK
OrthoDBiEOG091G0F05
PhylomeDBiQ9BYD2
TreeFamiTF300170

Family and domain databases

Gene3Di3.40.5.10, 1 hit
InterProiView protein in InterPro
IPR000244 Ribosomal_L9
IPR009027 Ribosomal_L9/RNase_H1_N
IPR020070 Ribosomal_L9_N
IPR036935 Ribosomal_L9_N_sf
PANTHERiPTHR21368 PTHR21368, 1 hit
PfamiView protein in Pfam
PF01281 Ribosomal_L9_N, 1 hit
SUPFAMiSSF55658 SSF55658, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9BYD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN
60 70 80 90 100
RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHRP KENLELILTQ
110 120 130 140 150
SVENVGVRGD LVSVKKSLGR NRLLPQGLAV YASPENKKLF EEEKLLRQEG
160 170 180 190 200
KLEKIQTKAG EATVKFLKSC RLEVGMKNNV KWELNPEIVA RHFFKNLGVV
210 220 230 240 250
VAPHTLKLPE EPITRWGEYW CEVTVNGLDT VRVPMSVVNF EKPKTKRYKY
260
WLAQQAAKAM APTSPQI
Length:267
Mass (Da):30,243
Last modified:October 14, 2008 - v2
Checksum:i3468214224FBD1B4
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SZR1Q5SZR1_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
233Annotation score:
A0A1W2PQB6A0A1W2PQB6_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
130Annotation score:
A0A1W2PPE5A0A1W2PPE5_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
87Annotation score:
A0A1W2PS92A0A1W2PS92_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
153Annotation score:
A0A1W2PRK9A0A1W2PRK9_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
122Annotation score:
A0A1W2PPK1A0A1W2PPK1_HUMAN
39S ribosomal protein L9, mitochond...
MRPL9
77Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02813667E → G. Corresponds to variant dbSNP:rs7007Ensembl.1
Natural variantiVAR_028137210E → A1 PublicationCorresponds to variant dbSNP:rs8480Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049636 mRNA Translation: BAB40841.1
AK315459 mRNA Translation: BAG37846.1
AL589765 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53415.1
BC004517 mRNA Translation: AAH04517.1
CCDSiCCDS1003.1
RefSeqiNP_001287662.1, NM_001300733.1
NP_113608.1, NM_031420.3
UniGeneiHs.288936

Genome annotation databases

EnsembliENST00000368830; ENSP00000357823; ENSG00000143436
GeneIDi65005
KEGGihsa:65005
UCSCiuc001eyv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049636 mRNA Translation: BAB40841.1
AK315459 mRNA Translation: BAG37846.1
AL589765 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53415.1
BC004517 mRNA Translation: AAH04517.1
CCDSiCCDS1003.1
RefSeqiNP_001287662.1, NM_001300733.1
NP_113608.1, NM_031420.3
UniGeneiHs.288936

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40H1-267[»]
3J9Melectron microscopy3.50H1-267[»]
5OOLelectron microscopy3.06H1-267[»]
5OOMelectron microscopy3.03H1-267[»]
ProteinModelPortaliQ9BYD2
SMRiQ9BYD2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122370, 93 interactors
CORUMiQ9BYD2
IntActiQ9BYD2, 75 interactors
MINTiQ9BYD2
STRINGi9606.ENSP00000357823

PTM databases

iPTMnetiQ9BYD2
PhosphoSitePlusiQ9BYD2

Polymorphism and mutation databases

BioMutaiMRPL9
DMDMi209572671

Proteomic databases

EPDiQ9BYD2
MaxQBiQ9BYD2
PaxDbiQ9BYD2
PeptideAtlasiQ9BYD2
PRIDEiQ9BYD2
ProteomicsDBi79616

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368830; ENSP00000357823; ENSG00000143436
GeneIDi65005
KEGGihsa:65005
UCSCiuc001eyv.4 human

Organism-specific databases

CTDi65005
DisGeNETi65005
EuPathDBiHostDB:ENSG00000143436.10
GeneCardsiMRPL9
HGNCiHGNC:14277 MRPL9
HPAiHPA008579
MIMi611824 gene
neXtProtiNX_Q9BYD2
OpenTargetsiENSG00000143436
PharmGKBiPA30991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4607 Eukaryota
ENOG4111HFB LUCA
GeneTreeiENSGT00390000008281
HOGENOMiHOG000247066
HOVERGENiHBG002704
InParanoidiQ9BYD2
KOiK02939
OMAiKAGFHCK
OrthoDBiEOG091G0F05
PhylomeDBiQ9BYD2
TreeFamiTF300170

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL9 human
GenomeRNAii65005
PROiPR:Q9BYD2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143436 Expressed in 234 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_MRPL9
ExpressionAtlasiQ9BYD2 baseline and differential
GenevisibleiQ9BYD2 HS

Family and domain databases

Gene3Di3.40.5.10, 1 hit
InterProiView protein in InterPro
IPR000244 Ribosomal_L9
IPR009027 Ribosomal_L9/RNase_H1_N
IPR020070 Ribosomal_L9_N
IPR036935 Ribosomal_L9_N_sf
PANTHERiPTHR21368 PTHR21368, 1 hit
PfamiView protein in Pfam
PF01281 Ribosomal_L9_N, 1 hit
SUPFAMiSSF55658 SSF55658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM09_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD2
Secondary accession number(s): B2RD99, Q5SZR2, Q9BSW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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