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Protein

39S ribosomal protein L13, mitochondrial

Gene

MRPL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L13, mitochondrial
Short name:
L13mt
Short name:
MRP-L13
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL13m1 Publication
Gene namesi
Name:MRPL13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000172172.7
HGNCiHGNC:14278 MRPL13
MIMi610200 gene
neXtProtiNX_Q9BYD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28998
OpenTargetsiENSG00000172172
PharmGKBiPA30942

Polymorphism and mutation databases

BioMutaiMRPL13
DMDMi22257023

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001337932 – 17839S ribosomal protein L13, mitochondrialAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BYD1
MaxQBiQ9BYD1
PaxDbiQ9BYD1
PeptideAtlasiQ9BYD1
PRIDEiQ9BYD1
ProteomicsDBi79615
TopDownProteomicsiQ9BYD1

PTM databases

iPTMnetiQ9BYD1
PhosphoSitePlusiQ9BYD1

Expressioni

Gene expression databases

BgeeiENSG00000172172 Expressed in 219 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPL13
ExpressionAtlasiQ9BYD1 baseline and differential
GenevisibleiQ9BYD1 HS

Organism-specific databases

HPAiHPA060899

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi118817, 108 interactors
CORUMiQ9BYD1
IntActiQ9BYD1, 26 interactors
MINTiQ9BYD1
STRINGi9606.ENSP00000306548

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYD1
SMRiQ9BYD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3203 Eukaryota
COG0102 LUCA
GeneTreeiENSGT00390000001515
HOGENOMiHOG000225288
HOVERGENiHBG036111
InParanoidiQ9BYD1
KOiK02871
OMAiVLMGKHK
OrthoDBiEOG091G0QCX
PhylomeDBiQ9BYD1
TreeFamiTF312914

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR005823 Ribosomal_L13_bac-type
IPR023563 Ribosomal_L13_CS
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01066 rplM_bact, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BYD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL
60 70 80 90 100
SDCGDHVVIM NTRHIAFSGN KWEQKVYSSH TGYPGGFRQV TAAQLHLRDP
110 120 130 140 150
VAIVKLAIYG MLPKNLHRRT MMERLHLFPD EYIPEDILKN LVEELPQPRK
160 170
IPKRLDEYTQ EEIDAFPRLW TPPEDYRL
Length:178
Mass (Da):20,692
Last modified:June 1, 2001 - v1
Checksum:iAF4FD524CC234D52
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJI7E5RJI7_HUMAN
39S ribosomal protein L13, mitochon...
MRPL13
147Annotation score:
E5RFI2E5RFI2_HUMAN
39S ribosomal protein L13, mitochon...
MRPL13
58Annotation score:
H0YAX3H0YAX3_HUMAN
39S ribosomal protein L13, mitochon...
MRPL13
47Annotation score:

Sequence cautioni

The sequence AAF17202 differs from that shown. Reason: Frameshift at position 160.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049640 mRNA Translation: BAB40845.1
AF112214 mRNA Translation: AAF17202.1 Frameshift.
AK311924 mRNA Translation: BAG34865.1
CH471060 Genomic DNA Translation: EAW92004.1
BC009190 mRNA Translation: AAH09190.1
BC021744 mRNA Translation: AAH21744.1
CCDSiCCDS6332.1
RefSeqiNP_054797.2, NM_014078.5
UniGeneiHs.333823

Genome annotation databases

EnsembliENST00000306185; ENSP00000306548; ENSG00000172172
GeneIDi28998
KEGGihsa:28998
UCSCiuc003ypa.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049640 mRNA Translation: BAB40845.1
AF112214 mRNA Translation: AAF17202.1 Frameshift.
AK311924 mRNA Translation: BAG34865.1
CH471060 Genomic DNA Translation: EAW92004.1
BC009190 mRNA Translation: AAH09190.1
BC021744 mRNA Translation: AAH21744.1
CCDSiCCDS6332.1
RefSeqiNP_054797.2, NM_014078.5
UniGeneiHs.333823

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40K1-178[»]
3J9Melectron microscopy3.50K1-178[»]
5OOLelectron microscopy3.06K1-178[»]
5OOMelectron microscopy3.03K1-178[»]
ProteinModelPortaliQ9BYD1
SMRiQ9BYD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118817, 108 interactors
CORUMiQ9BYD1
IntActiQ9BYD1, 26 interactors
MINTiQ9BYD1
STRINGi9606.ENSP00000306548

PTM databases

iPTMnetiQ9BYD1
PhosphoSitePlusiQ9BYD1

Polymorphism and mutation databases

BioMutaiMRPL13
DMDMi22257023

Proteomic databases

EPDiQ9BYD1
MaxQBiQ9BYD1
PaxDbiQ9BYD1
PeptideAtlasiQ9BYD1
PRIDEiQ9BYD1
ProteomicsDBi79615
TopDownProteomicsiQ9BYD1

Protocols and materials databases

DNASUi28998
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306185; ENSP00000306548; ENSG00000172172
GeneIDi28998
KEGGihsa:28998
UCSCiuc003ypa.4 human

Organism-specific databases

CTDi28998
DisGeNETi28998
EuPathDBiHostDB:ENSG00000172172.7
GeneCardsiMRPL13
HGNCiHGNC:14278 MRPL13
HPAiHPA060899
MIMi610200 gene
neXtProtiNX_Q9BYD1
OpenTargetsiENSG00000172172
PharmGKBiPA30942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3203 Eukaryota
COG0102 LUCA
GeneTreeiENSGT00390000001515
HOGENOMiHOG000225288
HOVERGENiHBG036111
InParanoidiQ9BYD1
KOiK02871
OMAiVLMGKHK
OrthoDBiEOG091G0QCX
PhylomeDBiQ9BYD1
TreeFamiTF312914

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL13 human
GenomeRNAii28998
PROiPR:Q9BYD1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172172 Expressed in 219 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPL13
ExpressionAtlasiQ9BYD1 baseline and differential
GenevisibleiQ9BYD1 HS

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR005823 Ribosomal_L13_bac-type
IPR023563 Ribosomal_L13_CS
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01066 rplM_bact, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM13_HUMAN
AccessioniPrimary (citable) accession number: Q9BYD1
Secondary accession number(s): B2R4R8, Q9UI04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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