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Protein

39S ribosomal protein L20, mitochondrial

Gene

MRPL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA binding Source: InterPro
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L20, mitochondrial
Short name:
L20mt
Short name:
MRP-L20
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL20m1 Publication
Gene namesi
Name:MRPL20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000242485.5
HGNCiHGNC:14478 MRPL20
MIMi611833 gene
neXtProtiNX_Q9BYC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000242485
PharmGKBiPA30950

Polymorphism and mutation databases

BioMutaiMRPL20
DMDMi74752447

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 9MitochondrionBy similarity9
ChainiPRO_000024827910 – 14939S ribosomal protein L20, mitochondrialAdd BLAST140

Proteomic databases

EPDiQ9BYC9
MaxQBiQ9BYC9
PaxDbiQ9BYC9
PeptideAtlasiQ9BYC9
PRIDEiQ9BYC9
ProteomicsDBi79614

PTM databases

iPTMnetiQ9BYC9
PhosphoSitePlusiQ9BYC9
SwissPalmiQ9BYC9

Expressioni

Gene expression databases

BgeeiENSG00000242485 Expressed in 235 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_MRPL20
ExpressionAtlasiQ9BYC9 baseline and differential
GenevisibleiQ9BYC9 HS

Organism-specific databases

HPAiHPA047074

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi120374, 51 interactors
CORUMiQ9BYC9
IntActiQ9BYC9, 22 interactors
MINTiQ9BYC9
STRINGi9606.ENSP00000341082

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYC9
SMRiQ9BYC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4707 Eukaryota
COG0292 LUCA
GeneTreeiENSGT00390000015823
HOGENOMiHOG000035046
HOVERGENiHBG058971
InParanoidiQ9BYC9
KOiK02887
OMAiDLAMNHP
OrthoDBiEOG091G0Q0P
PhylomeDBiQ9BYC9
TreeFamiTF324702

Family and domain databases

CDDicd07026 Ribosomal_L20, 1 hit
Gene3Di1.10.1900.20, 1 hit
InterProiView protein in InterPro
IPR005813 Ribosomal_L20
IPR035566 Ribosomal_protein_L20_C
PANTHERiPTHR10986 PTHR10986, 1 hit
PfamiView protein in Pfam
PF00453 Ribosomal_L20, 1 hit
PRINTSiPR00062 RIBOSOMALL20
SUPFAMiSSF74731 SSF74731, 1 hit
TIGRFAMsiTIGR01032 rplT_bact, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF
60 70 80 90 100
VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGNL VKCQVELNRK
110 120 130 140
VLADLAIYEP KTFKSLAALA SRRRHEGFAA ALGDGKEPEG IFSRVVQYH
Length:149
Mass (Da):17,443
Last modified:June 1, 2001 - v1
Checksum:i53AD05B3BBD9AE6B
GO
Isoform 2 (identifier: Q9BYC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-149: CQVELNRKVL...GIFSRVVQYH → VWVSMWVPLK...VSMLSVVSIW

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):18,099
Checksum:iDCB0C378CF4DF3B1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2X1I3L2X1_HUMAN
39S ribosomal protein L20, mitochon...
MRPL20
66Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05608493 – 149CQVEL…VVQYH → VWVSMWVPLKFWTSAETIMR GVVVLPVVPANQEAEARGSL ETDFWAVVCYADGVSMLSVV SIW in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049644 mRNA Translation: BAB40849.1
AK301440 mRNA Translation: BAH13482.1
AK315794 mRNA Translation: BAG38138.1
AL391244 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56207.1
BC009515 mRNA Translation: AAH09515.1
BC014316 mRNA Translation: AAH14316.1
BC059945 mRNA Translation: AAH59945.1
CCDSiCCDS26.1 [Q9BYC9-1]
RefSeqiNP_060441.2, NM_017971.3 [Q9BYC9-1]
UniGeneiHs.182698

Genome annotation databases

EnsembliENST00000344843; ENSP00000341082; ENSG00000242485 [Q9BYC9-1]
ENST00000482352; ENSP00000460924; ENSG00000242485 [Q9BYC9-2]
GeneIDi55052
KEGGihsa:55052
UCSCiuc001afo.5 human [Q9BYC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049644 mRNA Translation: BAB40849.1
AK301440 mRNA Translation: BAH13482.1
AK315794 mRNA Translation: BAG38138.1
AL391244 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56207.1
BC009515 mRNA Translation: AAH09515.1
BC014316 mRNA Translation: AAH14316.1
BC059945 mRNA Translation: AAH59945.1
CCDSiCCDS26.1 [Q9BYC9-1]
RefSeqiNP_060441.2, NM_017971.3 [Q9BYC9-1]
UniGeneiHs.182698

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40R1-149[»]
3J9Melectron microscopy3.50R1-149[»]
5OOLelectron microscopy3.06R1-149[»]
5OOMelectron microscopy3.03R1-149[»]
ProteinModelPortaliQ9BYC9
SMRiQ9BYC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120374, 51 interactors
CORUMiQ9BYC9
IntActiQ9BYC9, 22 interactors
MINTiQ9BYC9
STRINGi9606.ENSP00000341082

PTM databases

iPTMnetiQ9BYC9
PhosphoSitePlusiQ9BYC9
SwissPalmiQ9BYC9

Polymorphism and mutation databases

BioMutaiMRPL20
DMDMi74752447

Proteomic databases

EPDiQ9BYC9
MaxQBiQ9BYC9
PaxDbiQ9BYC9
PeptideAtlasiQ9BYC9
PRIDEiQ9BYC9
ProteomicsDBi79614

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344843; ENSP00000341082; ENSG00000242485 [Q9BYC9-1]
ENST00000482352; ENSP00000460924; ENSG00000242485 [Q9BYC9-2]
GeneIDi55052
KEGGihsa:55052
UCSCiuc001afo.5 human [Q9BYC9-1]

Organism-specific databases

CTDi55052
EuPathDBiHostDB:ENSG00000242485.5
GeneCardsiMRPL20
H-InvDBiHIX0000027
HGNCiHGNC:14478 MRPL20
HPAiHPA047074
MIMi611833 gene
neXtProtiNX_Q9BYC9
OpenTargetsiENSG00000242485
PharmGKBiPA30950
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4707 Eukaryota
COG0292 LUCA
GeneTreeiENSGT00390000015823
HOGENOMiHOG000035046
HOVERGENiHBG058971
InParanoidiQ9BYC9
KOiK02887
OMAiDLAMNHP
OrthoDBiEOG091G0Q0P
PhylomeDBiQ9BYC9
TreeFamiTF324702

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GeneWikiiMRPL20
GenomeRNAii55052
PROiPR:Q9BYC9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242485 Expressed in 235 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_MRPL20
ExpressionAtlasiQ9BYC9 baseline and differential
GenevisibleiQ9BYC9 HS

Family and domain databases

CDDicd07026 Ribosomal_L20, 1 hit
Gene3Di1.10.1900.20, 1 hit
InterProiView protein in InterPro
IPR005813 Ribosomal_L20
IPR035566 Ribosomal_protein_L20_C
PANTHERiPTHR10986 PTHR10986, 1 hit
PfamiView protein in Pfam
PF00453 Ribosomal_L20, 1 hit
PRINTSiPR00062 RIBOSOMALL20
SUPFAMiSSF74731 SSF74731, 1 hit
TIGRFAMsiTIGR01032 rplT_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM20_HUMAN
AccessioniPrimary (citable) accession number: Q9BYC9
Secondary accession number(s): B2RE41, B7Z746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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