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Protein

39S ribosomal protein L32, mitochondrial

Gene

MRPL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL32m1 Publication
Gene namesi
Name:MRPL32
ORF Names:HSPC283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106591.3
HGNCiHGNC:14035 MRPL32
MIMi611839 gene
neXtProtiNX_Q9BYC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106591
PharmGKBiPA30963

Polymorphism and mutation databases

BioMutaiMRPL32
DMDMi22001923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030513? – 18839S ribosomal protein L32, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9BYC8
MaxQBiQ9BYC8
PaxDbiQ9BYC8
PeptideAtlasiQ9BYC8
PRIDEiQ9BYC8
ProteomicsDBi79613

PTM databases

iPTMnetiQ9BYC8
PhosphoSitePlusiQ9BYC8

Expressioni

Gene expression databases

BgeeiENSG00000106591 Expressed in 207 organ(s), highest expression level in oocyte
CleanExiHS_MRPL32
ExpressionAtlasiQ9BYC8 baseline and differential
GenevisibleiQ9BYC8 HS

Organism-specific databases

HPAiHPA048965

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bL32m has a zinc binding site.3 Publications

Protein-protein interaction databases

BioGridi122368, 63 interactors
CORUMiQ9BYC8
IntActiQ9BYC8, 10 interactors
MINTiQ9BYC8
STRINGi9606.ENSP00000223324

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BYC8
SMRiQ9BYC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4080 Eukaryota
COG0333 LUCA
GeneTreeiENSGT00390000014996
HOGENOMiHOG000252980
HOVERGENiHBG036112
InParanoidiQ9BYC8
KOiK02911
OMAiWFTKNLL
OrthoDBiEOG091G0PVT
PhylomeDBiQ9BYC8
TreeFamiTF106139

Family and domain databases

InterProiView protein in InterPro
IPR002677 Ribosomal_L32p
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF01783 Ribosomal_L32p, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BYC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ
60 70 80 90 100
GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEVN RCRRRNPQKL
110 120 130 140 150
IKVKNNIDVC PECGHLKQKH VLCAYCYEKV CKETAEIRRQ IGKQEGGPFK
160 170 180
APTIETVVLY TGETPSEQDQ GKRIIERDRK RPSWFTQN
Length:188
Mass (Da):21,405
Last modified:June 1, 2001 - v1
Checksum:i60164AD910AE3EFD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KQX1B3KQX1_HUMAN
Mitochondrial ribosomal protein L32...
MRPL32 hCG_19886
107Annotation score:
H7BZU9H7BZU9_HUMAN
39S ribosomal protein L32, mitochon...
MRPL32
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 43SPWSA…PSPPW → RRGLRPGECFETTGSDCYGS FRRAGRAFPVLRGV (Ref. 3) CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049649 mRNA Translation: BAB40854.1
BC013147 mRNA Translation: AAH13147.1
AF161401 mRNA Translation: AAF28961.1
AB051343 Genomic DNA Translation: BAB54933.1
CCDSiCCDS5468.1
RefSeqiNP_114109.1, NM_031903.2
UniGeneiHs.50252

Genome annotation databases

EnsembliENST00000223324; ENSP00000223324; ENSG00000106591
GeneIDi64983
KEGGihsa:64983
UCSCiuc003tia.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049649 mRNA Translation: BAB40854.1
BC013147 mRNA Translation: AAH13147.1
AF161401 mRNA Translation: AAF28961.1
AB051343 Genomic DNA Translation: BAB54933.1
CCDSiCCDS5468.1
RefSeqiNP_114109.1, NM_031903.2
UniGeneiHs.50252

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4001-188[»]
3J9Melectron microscopy3.5001-188[»]
5OOLelectron microscopy3.0601-188[»]
5OOMelectron microscopy3.0301-188[»]
ProteinModelPortaliQ9BYC8
SMRiQ9BYC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122368, 63 interactors
CORUMiQ9BYC8
IntActiQ9BYC8, 10 interactors
MINTiQ9BYC8
STRINGi9606.ENSP00000223324

PTM databases

iPTMnetiQ9BYC8
PhosphoSitePlusiQ9BYC8

Polymorphism and mutation databases

BioMutaiMRPL32
DMDMi22001923

Proteomic databases

EPDiQ9BYC8
MaxQBiQ9BYC8
PaxDbiQ9BYC8
PeptideAtlasiQ9BYC8
PRIDEiQ9BYC8
ProteomicsDBi79613

Protocols and materials databases

DNASUi64983
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223324; ENSP00000223324; ENSG00000106591
GeneIDi64983
KEGGihsa:64983
UCSCiuc003tia.4 human

Organism-specific databases

CTDi64983
EuPathDBiHostDB:ENSG00000106591.3
GeneCardsiMRPL32
HGNCiHGNC:14035 MRPL32
HPAiHPA048965
MIMi611839 gene
neXtProtiNX_Q9BYC8
OpenTargetsiENSG00000106591
PharmGKBiPA30963
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4080 Eukaryota
COG0333 LUCA
GeneTreeiENSGT00390000014996
HOGENOMiHOG000252980
HOVERGENiHBG036112
InParanoidiQ9BYC8
KOiK02911
OMAiWFTKNLL
OrthoDBiEOG091G0PVT
PhylomeDBiQ9BYC8
TreeFamiTF106139

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL32 human
GeneWikiiMRPL32
GenomeRNAii64983
PROiPR:Q9BYC8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106591 Expressed in 207 organ(s), highest expression level in oocyte
CleanExiHS_MRPL32
ExpressionAtlasiQ9BYC8 baseline and differential
GenevisibleiQ9BYC8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002677 Ribosomal_L32p
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF01783 Ribosomal_L32p, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM32_HUMAN
AccessioniPrimary (citable) accession number: Q9BYC8
Secondary accession number(s): Q96Q68, Q9P098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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