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Entry version 175 (13 Feb 2019)
Sequence version 2 (05 Mar 2002)
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Protein

Alpha-(1,6)-fucosyltransferase

Gene

FUT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-(1->6)-fucosyltransferase activity Source: GO_Central
  • glycoprotein 6-alpha-L-fucosyltransferase activity Source: UniProtKB
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00491-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.68 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT23 Glycosyltransferase Family 23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferase (EC:2.4.1.68)
Short name:
Alpha1-6FucT
Alternative name(s):
Fucosyltransferase 8
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
Glycoprotein 6-alpha-L-fucosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000033170.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4019 FUT8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602589 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYC5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 575LumenalSequence analysisAdd BLAST545

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation with defective fucosylation (CDGF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a genetically heterogeneous group of multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDGF is an autosomal recessive disorder, apparent from birth, characterized by poor growth, failure to thrive, hypotonia, skeletal anomalies, and delayed psychomotor development with intellectual disability.
See also OMIM:618005
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080978239 – 575Missing in CDGF; drastic decrease of protein level in patient's fibroblasts and complete loss of total core fucosylated N-glycans in serum and fibroblasts compared to controls. 1 PublicationAdd BLAST337
Natural variantiVAR_080979315 – 557Missing in CDGF; complete loss of total core fucosylated N-glycans in patient's serum and fibroblasts compared to controls. 1 PublicationAdd BLAST243
Natural variantiVAR_080980337R → G in CDGF; drastic decrease of protein level in patient's fibroblasts and complete loss of total core fucosylated N-glycans in serum and fibroblasts compared to controls. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi365R → A or K: Complete loss of activity. 2 Publications1
Mutagenesisi366R → A or K: Decreases activity to 3%. 1 Publication1
Mutagenesisi368D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi369K → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi373E → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi382Y → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi409D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi410D → A: No effect on enzyme activity. 1 Publication1
Mutagenesisi453D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi469S → A: Loss of enzyme activity. 1 Publication1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2530

MalaCards human disease database

More...
MalaCardsi
FUT8
MIMi618005 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000033170

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28435

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3596087

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUT8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138326

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805261 – 575Alpha-(1,6)-fucosyltransferaseAdd BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi204 ↔ 2661 Publication
Disulfide bondi212 ↔ 2301 Publication
Disulfide bondi218 ↔ 2221 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei278PhosphoserineBy similarity1
Disulfide bondi465 ↔ 4721 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by PKDCC/VLK.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BYC5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BYC5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BYC5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BYC5

PeptideAtlas

More...
PeptideAtlasi
Q9BYC5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BYC5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79611
79612 [Q9BYC5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000033170 Expressed in 232 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BYC5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BYC5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017129
HPA040863
HPA043410

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108806, 44 interactors

Protein interaction database and analysis system

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IntActi
Q9BYC5, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353910

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DE0X-ray2.61X68-575[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BYC5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYC5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BYC5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 493GT23PROSITE-ProRule annotationAdd BLAST288
Domaini502 – 563SH3PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni365 – 366Important for donor substrate binding2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi299 – 305SH3-bindingSequence analysis7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3705 Eukaryota
ENOG410YHM8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007175

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG028260

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BYC5

KEGG Orthology (KO)

More...
KOi
K00717

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCKLNKG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BYC5

TreeFam database of animal gene trees

More...
TreeFami
TF106108

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11792 SH3_Fut8, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015827 Fut8
IPR035653 Fut8_SH3
IPR027350 GT23_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR13132:SF35 PTHR13132:SF35, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14604 SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000472 Alpha1_6FUT_euk, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51659 GT23, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYC5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL
60 70 80 90 100
ERLKQQNEDL RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY
110 120 130 140 150
KKQTRNGLGK DHEILRRRIE NGAKELWFFL QSELKKLKNL EGNELQRHAD
160 170 180 190 200
EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR EKEAKDLTEL VQRRITYLQN
210 220 230 240 250
PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT LILESQNWRY
260 270 280 290 300
ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR
310 320 330 340 350
PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT
360 370 380 390 400
KKLGFKHPVI GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD
410 420 430 440 450
KKRVYLATDD PSLLKEAKTK YPNYEFISDN SISWSAGLHN RYTENSLRGV
460 470 480 490 500
ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ TLHPDASANF HSLDDIYYFG
510 520 530 540 550
GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS KGVNRKLGRT
560 570
GLYPSYKVRE KIETVKYPTY PEAEK
Length:575
Mass (Da):66,516
Last modified:March 5, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AE24A93881E18D0
GO
Isoform 2 (identifier: Q9BYC5-2) [UniParc]FASTAAdd to basket
Also known as: Retinal

The sequence of this isoform differs from the canonical sequence as follows:
     280-329: EVKDKNVQVV...HGDPAVWWVS → TPIMNLLVITLFPGQLDCTIDTQKIHFVE
     330-575: Missing.

Show »
Length:308
Mass (Da):35,795
Checksum:iFB52A33CFD91A366
GO
Isoform 3 (identifier: Q9BYC5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: Missing.

Show »
Length:412
Mass (Da):47,255
Checksum:i837F36AF48E7E4C3
GO
Isoform 4 (identifier: Q9BYC5-4) [UniParc]FASTAAdd to basket
Also known as: Retina-1, Retina-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRPWTGSWRWIMLI → MHRQIWHLHWTLVR
     15-420: Missing.

Note: Seems to be only expressed in retina, inactive as a fucosyltransferase.
Show »
Length:169
Mass (Da):19,520
Checksum:i0ACD43AA0F56AB31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAD2G3XAD2_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8 hCG_22125
446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V509G3V509_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5E3G3V5E3_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V530G3V530_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5Z4G3V5Z4_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4A8G3V4A8_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V443G3V443_HUMAN
Alpha-(1,6)-fucosyltransferase
FUT8
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214I → T in BAG57538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054038101K → Q. Corresponds to variant dbSNP:rs2229678Ensembl.1
Natural variantiVAR_080978239 – 575Missing in CDGF; drastic decrease of protein level in patient's fibroblasts and complete loss of total core fucosylated N-glycans in serum and fibroblasts compared to controls. 1 PublicationAdd BLAST337
Natural variantiVAR_033537267T → K. Corresponds to variant dbSNP:rs35949016Ensembl.1
Natural variantiVAR_080979315 – 557Missing in CDGF; complete loss of total core fucosylated N-glycans in patient's serum and fibroblasts compared to controls. 1 PublicationAdd BLAST243
Natural variantiVAR_080980337R → G in CDGF; drastic decrease of protein level in patient's fibroblasts and complete loss of total core fucosylated N-glycans in serum and fibroblasts compared to controls. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468371 – 163Missing in isoform 3. 1 PublicationAdd BLAST163
Alternative sequenceiVSP_0533611 – 14MRPWT…WIMLI → MHRQIWHLHWTLVR in isoform 4. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_05336215 – 420Missing in isoform 4. 2 PublicationsAdd BLAST406
Alternative sequenceiVSP_001807280 – 329EVKDK…VWWVS → TPIMNLLVITLFPGQLDCTI DTQKIHFVE in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_001808330 – 575Missing in isoform 2. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D89289 mRNA Translation: BAA19764.1
AH005745 Genomic DNA Translation: AAB92372.2
Y17979 mRNA Translation: CAA76988.1
Y17976 mRNA Translation: CAA76985.1
Y17977 mRNA Translation: CAA76986.1
Y17978 mRNA Translation: CAA76987.1
AB049828 Genomic DNA Translation: BAB40975.1
AB049740 mRNA Translation: BAB40929.2
AB032573 Genomic DNA Translation: BAA92859.2
AB032573 Genomic DNA Translation: BAA92858.1
AJ514324 mRNA Translation: CAD55804.1
AJ514325 mRNA Translation: CAD55805.1
AK294242 mRNA Translation: BAG57538.1
AL109847 Genomic DNA No translation available.
AL161871 Genomic DNA No translation available.
AL355840 Genomic DNA No translation available.
AL359236 Genomic DNA No translation available.
BC093889 mRNA Translation: AAH93889.1
BC101816 mRNA Translation: AAI01817.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9775.1 [Q9BYC5-1]
CCDS9776.2 [Q9BYC5-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5432

NCBI Reference Sequences

More...
RefSeqi
NP_004471.4, NM_004480.4 [Q9BYC5-3]
NP_835368.1, NM_178155.2 [Q9BYC5-1]
NP_835369.1, NM_178156.2 [Q9BYC5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.597649
Hs.654961

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342677; ENSP00000345865; ENSG00000033170 [Q9BYC5-2]
ENST00000360689; ENSP00000353910; ENSG00000033170 [Q9BYC5-1]
ENST00000394586; ENSP00000378087; ENSG00000033170 [Q9BYC5-1]
ENST00000557164; ENSP00000452433; ENSG00000033170 [Q9BYC5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2530

UCSC genome browser

More...
UCSCi
uc001xin.3 human [Q9BYC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 8

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89289 mRNA Translation: BAA19764.1
AH005745 Genomic DNA Translation: AAB92372.2
Y17979 mRNA Translation: CAA76988.1
Y17976 mRNA Translation: CAA76985.1
Y17977 mRNA Translation: CAA76986.1
Y17978 mRNA Translation: CAA76987.1
AB049828 Genomic DNA Translation: BAB40975.1
AB049740 mRNA Translation: BAB40929.2
AB032573 Genomic DNA Translation: BAA92859.2
AB032573 Genomic DNA Translation: BAA92858.1
AJ514324 mRNA Translation: CAD55804.1
AJ514325 mRNA Translation: CAD55805.1
AK294242 mRNA Translation: BAG57538.1
AL109847 Genomic DNA No translation available.
AL161871 Genomic DNA No translation available.
AL355840 Genomic DNA No translation available.
AL359236 Genomic DNA No translation available.
BC093889 mRNA Translation: AAH93889.1
BC101816 mRNA Translation: AAI01817.1
CCDSiCCDS9775.1 [Q9BYC5-1]
CCDS9776.2 [Q9BYC5-3]
PIRiJC5432
RefSeqiNP_004471.4, NM_004480.4 [Q9BYC5-3]
NP_835368.1, NM_178155.2 [Q9BYC5-1]
NP_835369.1, NM_178156.2 [Q9BYC5-1]
UniGeneiHs.597649
Hs.654961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DE0X-ray2.61X68-575[»]
ProteinModelPortaliQ9BYC5
SMRiQ9BYC5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108806, 44 interactors
IntActiQ9BYC5, 6 interactors
STRINGi9606.ENSP00000353910

Chemistry databases

ChEMBLiCHEMBL3596087

Protein family/group databases

CAZyiGT23 Glycosyltransferase Family 23

PTM databases

iPTMnetiQ9BYC5
PhosphoSitePlusiQ9BYC5

Polymorphism and mutation databases

BioMutaiFUT8
DMDMi20138326

Proteomic databases

EPDiQ9BYC5
jPOSTiQ9BYC5
MaxQBiQ9BYC5
PaxDbiQ9BYC5
PeptideAtlasiQ9BYC5
PRIDEiQ9BYC5
ProteomicsDBi79611
79612 [Q9BYC5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2530
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342677; ENSP00000345865; ENSG00000033170 [Q9BYC5-2]
ENST00000360689; ENSP00000353910; ENSG00000033170 [Q9BYC5-1]
ENST00000394586; ENSP00000378087; ENSG00000033170 [Q9BYC5-1]
ENST00000557164; ENSP00000452433; ENSG00000033170 [Q9BYC5-3]
GeneIDi2530
KEGGihsa:2530
UCSCiuc001xin.3 human [Q9BYC5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2530
DisGeNETi2530
EuPathDBiHostDB:ENSG00000033170.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FUT8
HGNCiHGNC:4019 FUT8
HPAiCAB017129
HPA040863
HPA043410
MalaCardsiFUT8
MIMi602589 gene
618005 phenotype
neXtProtiNX_Q9BYC5
OpenTargetsiENSG00000033170
PharmGKBiPA28435

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3705 Eukaryota
ENOG410YHM8 LUCA
GeneTreeiENSGT00530000063737
HOGENOMiHOG000007175
HOVERGENiHBG028260
InParanoidiQ9BYC5
KOiK00717
OMAiVCKLNKG
PhylomeDBiQ9BYC5
TreeFamiTF106108

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS00491-MONOMER
BRENDAi2.4.1.68 2681
ReactomeiR-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FUT8 human
EvolutionaryTraceiQ9BYC5

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FUT8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2530

Protein Ontology

More...
PROi
PR:Q9BYC5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000033170 Expressed in 232 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9BYC5 baseline and differential
GenevisibleiQ9BYC5 HS

Family and domain databases

CDDicd11792 SH3_Fut8, 1 hit
InterProiView protein in InterPro
IPR015827 Fut8
IPR035653 Fut8_SH3
IPR027350 GT23_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR13132:SF35 PTHR13132:SF35, 1 hit
PfamiView protein in Pfam
PF14604 SH3_9, 1 hit
PIRSFiPIRSF000472 Alpha1_6FUT_euk, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51659 GT23, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUT8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYC5
Secondary accession number(s): B4DFS7
, G3V5N0, O00235, Q8IUA5, Q9BYC6, Q9P2U5, Q9P2U6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: February 13, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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