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Protein

E3 ubiquitin-protein ligase RNF26

Gene

RNF26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379).2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri380 – 422RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • ubiquitin protein ligase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF26Curated (EC:2.3.2.272 Publications)
Alternative name(s):
RING finger protein 26Curated
Gene namesi
Name:RNF26Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173456.4
HGNCiHGNC:14646 RNF26
MIMi606130 gene
neXtProtiNX_Q9BY78

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi382I → R: Strongly decreased E3 ubiquitin-protein ligase activity due to impaired interaction with E2 enzymes. Impaired ability to retain vesicles in the perinuclear cloud. 1 Publication1
Mutagenesisi395C → S: Strongly decreased E3 ubiquitin-protein ligase activity. Impaired ability to mediate ubiquitination of TMEM173/STING. 1 Publication1
Mutagenesisi399C → S: Strongly decreased E3 ubiquitin-protein ligase activity. Impaired ability to mediate ubiquitination of TMEM173/STING. 1 Publication1
Mutagenesisi401C → S: Strongly decreased E3 ubiquitin-protein ligase activity. Impaired ability to mediate ubiquitination of TMEM173/STING. 1 Publication1

Organism-specific databases

DisGeNETi79102
OpenTargetsiENSG00000173456
PharmGKBiPA34430

Polymorphism and mutation databases

BioMutaiRNF26
DMDMi20139692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560681 – 433E3 ubiquitin-protein ligase RNF26Add BLAST433

Proteomic databases

EPDiQ9BY78
PaxDbiQ9BY78
PeptideAtlasiQ9BY78
PRIDEiQ9BY78
ProteomicsDBi79600

PTM databases

iPTMnetiQ9BY78
PhosphoSitePlusiQ9BY78

Expressioni

Tissue specificityi

Ubiquitous. Up-regulated in several cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000173456 Expressed in 187 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_RNF26
GenevisibleiQ9BY78 HS

Organism-specific databases

HPAiHPA027620

Interactioni

Subunit structurei

Interacts with INCA1.1 Publication

Protein-protein interaction databases

BioGridi122549, 35 interactors
IntActiQ9BY78, 9 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BY78
SMRiQ9BY78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri380 – 422RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITZ8 Eukaryota
ENOG410XVCP LUCA
GeneTreeiENSGT00390000016584
HOGENOMiHOG000136849
HOVERGENiHBG054207
InParanoidiQ9BY78
KOiK15693
OMAiCRRGILQ
OrthoDBiEOG091G195F
PhylomeDBiQ9BY78
TreeFamiTF331813

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BY78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVYLVVNG LGLVLDVLTL VLDLNFLLVS SLLASLAWLL AFVYNLPHTV
60 70 80 90 100
LTSLLHLGRG VLLSLLALIE AVVRFTCGGL QALCTLLYSC CSGLESLKLL
110 120 130 140 150
GHLASHGALR SREILHRGVL NVVSSGHALL RQACDICAIA MSLVAYVINS
160 170 180 190 200
LVNICLIGTQ NLFSLVLALW DAVTGPLWRM TDVVAAFLAH ISSSAVAMAI
210 220 230 240 250
LLWTPCQLAL ELLASAARLL ASFVLVNLTG LVLLACVLAV TVTVLHPDFT
260 270 280 290 300
LRLATQALSQ LHARPSYHRL REDVMRLSRL ALGSEAWRRV WSRSLQLASW
310 320 330 340 350
PNRGGAPGAP QGDPMRVFSV RTRRQDTLPE AGRRSEAEEE EARTIRVTPV
360 370 380 390 400
RGRERLNEEE PPGGQDPWKL LKEQEERKKC VICQDQSKTV LLLPCRHLCL
410 420 430
CQACTEILMR HPVYHRNCPL CRRGILQTLN VYL
Length:433
Mass (Da):47,737
Last modified:June 1, 2001 - v1
Checksum:iC23E36A66C3677E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055622 mRNA Translation: BAB40955.1
AK075379 mRNA Translation: BAC11580.1
CH471065 Genomic DNA Translation: EAW67479.1
BC000058 mRNA Translation: AAH00058.1
BC007534 mRNA Translation: AAH07534.1
CCDSiCCDS8419.1
PIRiJC7678
RefSeqiNP_114404.1, NM_032015.4
UniGeneiHs.524084
Hs.744159
Hs.745522

Genome annotation databases

EnsembliENST00000311413; ENSP00000312439; ENSG00000173456
GeneIDi79102
KEGGihsa:79102
UCSCiuc001pwh.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055622 mRNA Translation: BAB40955.1
AK075379 mRNA Translation: BAC11580.1
CH471065 Genomic DNA Translation: EAW67479.1
BC000058 mRNA Translation: AAH00058.1
BC007534 mRNA Translation: AAH07534.1
CCDSiCCDS8419.1
PIRiJC7678
RefSeqiNP_114404.1, NM_032015.4
UniGeneiHs.524084
Hs.744159
Hs.745522

3D structure databases

ProteinModelPortaliQ9BY78
SMRiQ9BY78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122549, 35 interactors
IntActiQ9BY78, 9 interactors

PTM databases

iPTMnetiQ9BY78
PhosphoSitePlusiQ9BY78

Polymorphism and mutation databases

BioMutaiRNF26
DMDMi20139692

Proteomic databases

EPDiQ9BY78
PaxDbiQ9BY78
PeptideAtlasiQ9BY78
PRIDEiQ9BY78
ProteomicsDBi79600

Protocols and materials databases

DNASUi79102
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311413; ENSP00000312439; ENSG00000173456
GeneIDi79102
KEGGihsa:79102
UCSCiuc001pwh.4 human

Organism-specific databases

CTDi79102
DisGeNETi79102
EuPathDBiHostDB:ENSG00000173456.4
GeneCardsiRNF26
H-InvDBiHIX0171332
HGNCiHGNC:14646 RNF26
HPAiHPA027620
MIMi606130 gene
neXtProtiNX_Q9BY78
OpenTargetsiENSG00000173456
PharmGKBiPA34430
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITZ8 Eukaryota
ENOG410XVCP LUCA
GeneTreeiENSGT00390000016584
HOGENOMiHOG000136849
HOVERGENiHBG054207
InParanoidiQ9BY78
KOiK15693
OMAiCRRGILQ
OrthoDBiEOG091G195F
PhylomeDBiQ9BY78
TreeFamiTF331813

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiRNF26 human
GenomeRNAii79102
PROiPR:Q9BY78
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173456 Expressed in 187 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_RNF26
GenevisibleiQ9BY78 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF26_HUMAN
AccessioniPrimary (citable) accession number: Q9BY78
Secondary accession number(s): Q542Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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