UniProtKB - Q9BY67 (CADM1_HUMAN)
Cell adhesion molecule 1
CADM1
Functioni
GO - Molecular functioni
- PDZ domain binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- adherens junction organization Source: Reactome
- apoptotic process Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- cell recognition Source: UniProtKB
- detection of stimulus Source: UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- immune system process Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- positive regulation of cytokine secretion Source: UniProtKB
- positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
- spermatogenesis Source: UniProtKB-KW
- susceptibility to natural killer cell mediated cytotoxicity Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Apoptosis, Cell adhesion, Differentiation, Host-virus interaction, Immunity, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9BY67 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-420597, Nectin/Necl trans heterodimerization |
Names & Taxonomyi
Protein namesi | Recommended name: Cell adhesion molecule 1Alternative name(s): Immunoglobulin superfamily member 4 Short name: IgSF4 Nectin-like protein 2 Short name: NECL-2 Spermatogenic immunoglobulin superfamily Short name: SgIgSF Synaptic cell adhesion molecule Short name: SynCAM Tumor suppressor in lung cancer 1 Short name: TSLC-1 |
Gene namesi | Name:CADM1Imported Synonyms:IGSF4By similarity, IGSF4A, NECL21 Publication, SYNCAMBy similarity, TSLC11 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182985.16 |
HGNCi | HGNC:5951, CADM1 |
MIMi | 605686, gene |
neXtProti | NX_Q9BY67 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Other locations
- synapse By similarity
Note: Localized to the basolateral plasma membrane of epithelial cells in gall bladder.By similarity
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell-cell junction Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- synapse Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 45 – 374 | ExtracellularSequence analysisAdd BLAST | 330 | |
Transmembranei | 375 – 395 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 396 – 442 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 406 | Y → A: Nearly abolishes EPB41L3 binding. 1 Publication | 1 | |
Mutagenesisi | 408 | T → A: Strongly reduced affinity for EPB41L3. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 23705 |
OpenTargetsi | ENSG00000182985 |
PharmGKBi | PA29764 |
Miscellaneous databases
Pharosi | Q9BY67, Tbio |
Polymorphism and mutation databases
BioMutai | CADM1 |
DMDMi | 150438862 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 44 | Sequence analysisAdd BLAST | 44 | |
ChainiPRO_0000291968 | 45 – 442 | Cell adhesion molecule 1Sequence analysisAdd BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 124 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 101 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 113 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 165 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 166 ↔ 220 | PROSITE-ProRule annotation | ||
Disulfide bondi | 267 ↔ 313 | PROSITE-ProRule annotation | ||
Glycosylationi | 304 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 422 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-1282 CPTAC-1283 CPTAC-2210 |
EPDi | Q9BY67 |
jPOSTi | Q9BY67 |
MassIVEi | Q9BY67 |
PaxDbi | Q9BY67 |
PeptideAtlasi | Q9BY67 |
PRIDEi | Q9BY67 |
ProteomicsDBi | 25359 38329 79594 [Q9BY67-1] 79595 [Q9BY67-2] |
PTM databases
GlyConnecti | 1101, 11 N-Linked glycans (3 sites) |
GlyGeni | Q9BY67, 12 sites |
iPTMneti | Q9BY67 |
PhosphoSitePlusi | Q9BY67 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182985, Expressed in cerebellum and 257 other tissues |
ExpressionAtlasi | Q9BY67, baseline and differential |
Genevisiblei | Q9BY67, HS |
Organism-specific databases
HPAi | ENSG00000182985, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (via Ig-like V-type domain) (PubMed:12050160, PubMed:23871486).
Interacts with FARP1 (By similarity).
Interacts (via Ig-like V-type domain) with CRTAM (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15811952, PubMed:15781451, PubMed:23871486).
Interacts (via C-terminus) with EPB41L3/DAL1 (PubMed:12234973, PubMed:21131357). The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton (PubMed:12234973).
Interacts (via C-terminus) with MPP2 (via PDZ domain) (By similarity).
Interacts (via C-terminus) with MPP3 (via PDZ domain) (PubMed:13679854).
Interacts (via C-terminus) with MPP6 (via PDZ domain) (By similarity).
By similarity7 Publications(Microbial infection) Interacts with herpes virus 8 proteins vFLIP and vGPCR; these interactions are essential for NF-kappa-B activation.
1 PublicationBinary interactionsi
Hide detailsQ9BY67
GO - Molecular functioni
- PDZ domain binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117218, 16 interactors |
CORUMi | Q9BY67 |
DIPi | DIP-57599N |
IntActi | Q9BY67, 14 interactors |
MINTi | Q9BY67 |
STRINGi | 9606.ENSP00000329797 |
Miscellaneous databases
RNActi | Q9BY67, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BY67 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BY67 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 139 | Ig-like V-typeSequence analysisAdd BLAST | 95 | |
Domaini | 144 – 238 | Ig-like C2-type 1Sequence analysisAdd BLAST | 95 | |
Domaini | 243 – 329 | Ig-like C2-type 2Sequence analysisAdd BLAST | 87 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R1KU, Eukaryota |
GeneTreei | ENSGT00940000156093 |
InParanoidi | Q9BY67 |
OMAi | MLFVYDP |
OrthoDBi | 716894at2759 |
PhylomeDBi | Q9BY67 |
TreeFami | TF334317 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR003585, Neurexin-like |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit SM00409, IG, 3 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASVVLPSGS QCAAAAAAAA PPGLRLRLLL LLFSAAALIP TGDGQNLFTK
60 70 80 90 100
DVTVIEGEVA TISCQVNKSD DSVIQLLNPN RQTIYFRDFR PLKDSRFQLL
110 120 130 140 150
NFSSSELKVS LTNVSISDEG RYFCQLYTDP PQESYTTITV LVPPRNLMID
160 170 180 190 200
IQKDTAVEGE EIEVNCTAMA SKPATTIRWF KGNTELKGKS EVEEWSDMYT
210 220 230 240 250
VTSQLMLKVH KEDDGVPVIC QVEHPAVTGN LQTQRYLEVQ YKPQVHIQMT
260 270 280 290 300
YPLQGLTREG DALELTCEAI GKPQPVMVTW VRVDDEMPQH AVLSGPNLFI
310 320 330 340 350
NNLNKTDNGT YRCEASNIVG KAHSDYMLYV YDPPTTIPPP TTTTTTTTTT
360 370 380 390 400
TTTILTIITD SRAGEEGSIR AVDHAVIGGV VAVVVFAMLC LLIILGRYFA
410 420 430 440
RHKGTYFTHE AKGADDAADA DTAIINAEGG QNNSEEKKEY FI
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX5DQS5 | X5DQS5_HUMAN | Cell adhesion molecule 1 | CADM1 | 443 | Annotation score: | ||
A0A0A0MTJ8 | A0A0A0MTJ8_HUMAN | Cell adhesion molecule 1 | CADM1 | 413 | Annotation score: | ||
A0A087X1W8 | A0A087X1W8_HUMAN | Cell adhesion molecule 1 | CADM1 | 412 | Annotation score: | ||
H0YG94 | H0YG94_HUMAN | Cell adhesion molecule 1 | CADM1 | 188 | Annotation score: | ||
A0A087X0T8 | A0A087X0T8_HUMAN | Cell adhesion molecule 1 | CADM1 | 346 | Annotation score: | ||
F5H372 | F5H372_HUMAN | Cell adhesion molecule 1 | CADM1 | 67 | Annotation score: | ||
F5H125 | F5H125_HUMAN | Cell adhesion molecule 1 | CADM1 | 182 | Annotation score: | ||
F5H8J9 | F5H8J9_HUMAN | Cell adhesion molecule 1 | CADM1 | 110 | Annotation score: | ||
F5H0H5 | F5H0H5_HUMAN | Cell adhesion molecule 1 | CADM1 | 79 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | A → V in CCD32613 (PubMed:22438059).Curated | 1 | |
Sequence conflicti | 153 | K → R in AAF69029 (PubMed:15893517).Curated | 1 | |
Sequence conflicti | 333 – 359 | PPTTI…LTIIT → TTATTEPAVHGLTQLPNSAE ELDSEDLS in BAC11657 (PubMed:14702039).CuratedAdd BLAST | 27 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061309 | 285 | D → E. Corresponds to variant dbSNP:rs45525440Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052461 | 332 – 333 | DP → GT in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_047405 | 333 – 360 | Missing in isoform 5. 2 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_052462 | 334 – 442 | Missing in isoform 2. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_047406 | 359 | T → TDTTATTEPAVHGLTQLPNS AEELDSEDLS in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_047407 | 359 | T → TDTTATTEPAVH in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132811 mRNA Translation: AAF69029.1 HE586496 mRNA Translation: CCD32610.1 HE586497 mRNA Translation: CCD32611.1 HE586498 mRNA Translation: CCD32612.1 HE586499 mRNA Translation: CCD32613.1 KJ534791 mRNA Translation: AHW56431.1 KJ534794 mRNA Translation: AHW56434.1 AB094146 mRNA Translation: BAC66178.1 AK075502 mRNA Translation: BAC11657.1 AP000462 Genomic DNA No translation available. AP000465 Genomic DNA No translation available. AP003174 Genomic DNA No translation available. AP003179 Genomic DNA No translation available. AP005020 Genomic DNA No translation available. BC125102 mRNA Translation: AAI25103.1 Frameshift. |
CCDSi | CCDS53711.1 [Q9BY67-5] CCDS73398.1 [Q9BY67-4] CCDS73399.1 [Q9BY67-3] CCDS8373.1 [Q9BY67-1] |
RefSeqi | NP_001091987.1, NM_001098517.1 [Q9BY67-5] NP_001287972.1, NM_001301043.1 [Q9BY67-3] NP_001287973.1, NM_001301044.1 [Q9BY67-4] NP_001287974.1, NM_001301045.1 NP_055148.3, NM_014333.3 [Q9BY67-1] |
Genome annotation databases
Ensembli | ENST00000331581; ENSP00000329797; ENSG00000182985 [Q9BY67-3] ENST00000452722; ENSP00000395359; ENSG00000182985 [Q9BY67-1] ENST00000537058; ENSP00000439817; ENSG00000182985 [Q9BY67-4] ENST00000542447; ENSP00000439176; ENSG00000182985 [Q9BY67-5] |
GeneIDi | 23705 |
KEGGi | hsa:23705 |
UCSCi | uc001ppk.4, human [Q9BY67-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132811 mRNA Translation: AAF69029.1 HE586496 mRNA Translation: CCD32610.1 HE586497 mRNA Translation: CCD32611.1 HE586498 mRNA Translation: CCD32612.1 HE586499 mRNA Translation: CCD32613.1 KJ534791 mRNA Translation: AHW56431.1 KJ534794 mRNA Translation: AHW56434.1 AB094146 mRNA Translation: BAC66178.1 AK075502 mRNA Translation: BAC11657.1 AP000462 Genomic DNA No translation available. AP000465 Genomic DNA No translation available. AP003174 Genomic DNA No translation available. AP003179 Genomic DNA No translation available. AP005020 Genomic DNA No translation available. BC125102 mRNA Translation: AAI25103.1 Frameshift. |
CCDSi | CCDS53711.1 [Q9BY67-5] CCDS73398.1 [Q9BY67-4] CCDS73399.1 [Q9BY67-3] CCDS8373.1 [Q9BY67-1] |
RefSeqi | NP_001091987.1, NM_001098517.1 [Q9BY67-5] NP_001287972.1, NM_001301043.1 [Q9BY67-3] NP_001287973.1, NM_001301044.1 [Q9BY67-4] NP_001287974.1, NM_001301045.1 NP_055148.3, NM_014333.3 [Q9BY67-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BIN | X-ray | 2.30 | B | 400-411 | [»] | |
4H5S | X-ray | 1.70 | B | 45-144 | [»] | |
SMRi | Q9BY67 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117218, 16 interactors |
CORUMi | Q9BY67 |
DIPi | DIP-57599N |
IntActi | Q9BY67, 14 interactors |
MINTi | Q9BY67 |
STRINGi | 9606.ENSP00000329797 |
PTM databases
GlyConnecti | 1101, 11 N-Linked glycans (3 sites) |
GlyGeni | Q9BY67, 12 sites |
iPTMneti | Q9BY67 |
PhosphoSitePlusi | Q9BY67 |
Polymorphism and mutation databases
BioMutai | CADM1 |
DMDMi | 150438862 |
Proteomic databases
CPTACi | CPTAC-1282 CPTAC-1283 CPTAC-2210 |
EPDi | Q9BY67 |
jPOSTi | Q9BY67 |
MassIVEi | Q9BY67 |
PaxDbi | Q9BY67 |
PeptideAtlasi | Q9BY67 |
PRIDEi | Q9BY67 |
ProteomicsDBi | 25359 38329 79594 [Q9BY67-1] 79595 [Q9BY67-2] |
Protocols and materials databases
ABCDi | Q9BY67, 12 sequenced antibodies |
Antibodypediai | 32257, 627 antibodies |
Genome annotation databases
Ensembli | ENST00000331581; ENSP00000329797; ENSG00000182985 [Q9BY67-3] ENST00000452722; ENSP00000395359; ENSG00000182985 [Q9BY67-1] ENST00000537058; ENSP00000439817; ENSG00000182985 [Q9BY67-4] ENST00000542447; ENSP00000439176; ENSG00000182985 [Q9BY67-5] |
GeneIDi | 23705 |
KEGGi | hsa:23705 |
UCSCi | uc001ppk.4, human [Q9BY67-1] |
Organism-specific databases
CTDi | 23705 |
DisGeNETi | 23705 |
EuPathDBi | HostDB:ENSG00000182985.16 |
GeneCardsi | CADM1 |
HGNCi | HGNC:5951, CADM1 |
HPAi | ENSG00000182985, Low tissue specificity |
MIMi | 605686, gene |
neXtProti | NX_Q9BY67 |
OpenTargetsi | ENSG00000182985 |
PharmGKBi | PA29764 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R1KU, Eukaryota |
GeneTreei | ENSGT00940000156093 |
InParanoidi | Q9BY67 |
OMAi | MLFVYDP |
OrthoDBi | 716894at2759 |
PhylomeDBi | Q9BY67 |
TreeFami | TF334317 |
Enzyme and pathway databases
PathwayCommonsi | Q9BY67 |
Reactomei | R-HSA-418990, Adherens junctions interactions R-HSA-420597, Nectin/Necl trans heterodimerization |
Miscellaneous databases
BioGRID-ORCSi | 23705, 3 hits in 845 CRISPR screens |
ChiTaRSi | CADM1, human |
EvolutionaryTracei | Q9BY67 |
GeneWikii | Cell_adhesion_molecule_1 |
GenomeRNAii | 23705 |
Pharosi | Q9BY67, Tbio |
PROi | PR:Q9BY67 |
RNActi | Q9BY67, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182985, Expressed in cerebellum and 257 other tissues |
ExpressionAtlasi | Q9BY67, baseline and differential |
Genevisiblei | Q9BY67, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR003585, Neurexin-like |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit SM00409, IG, 3 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADM1_HUMAN | |
Accessioni | Q9BY67Primary (citable) accession number: Q9BY67 Secondary accession number(s): A4FVB5 X5D2C8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 26, 2007 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations