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Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

PECR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei179Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi23 – 47NADPBy similarityAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB
  • trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03889-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.38 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-389599 Alpha-oxidation of phytanate
R-HSA-9033241 Peroxisomal protein import

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00094

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001094

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Short name:
TERP
Alternative name(s):
2,4-dienoyl-CoA reductase-related protein
Short name:
DCR-RP
HPDHase
Short chain dehydrogenase/reductase family 29C member 1
pVI-ARL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PECR
Synonyms:SDR29C1
ORF Names:PRO1004
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115425.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18281 PECR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605843 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BY49

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi303Missing : Abolishes localization to peroxisomes. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55825

Open Targets

More...
OpenTargetsi
ENSG00000115425

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134967510

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00173 Adenine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PECR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62287123

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000547401 – 303Peroxisomal trans-2-enoyl-CoA reductaseAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32N6-succinyllysineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei179PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BY49

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BY49

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BY49

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BY49

PeptideAtlas

More...
PeptideAtlasi
Q9BY49

PRoteomics IDEntifications database

More...
PRIDEi
Q9BY49

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79584
79585 [Q9BY49-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BY49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BY49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Not induced by IR.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115425 Expressed in 218 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_PECR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BY49 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BY49 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021593
HPA022539

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120932, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BY49, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXMX-ray1.90A/B/C/D1-303[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BY49

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BY49

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BY49

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi301 – 303Microbody targeting signal3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0725 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156882

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105268

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BY49

KEGG Orthology (KO)

More...
KOi
K07753

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPDHDNW

Database of Orthologous Groups

More...
OrthoDBi
1194344at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BY49

TreeFam database of animal gene trees

More...
TreeFami
TF315256

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BY49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR
60 70 80 90 100
KLERLKSAAD ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDTFGK
110 120 130 140 150
INFLVNNGGG QFLSPAEHIS SKGWHAVLET NLTGTFYMCK AVYSSWMKEH
160 170 180 190 200
GGSIVNIIVP TKAGFPLAVH SGAARAGVYN LTKSLALEWA CSGIRINCVA
210 220 230 240 250
PGVIYSQTAV ENYGSWGQSF FEGSFQKIPA KRIGVPEEVS SVVCFLLSPA
260 270 280 290 300
ASFITGQSVD VDGGRSLYTH SYEVPDHDNW PKGAGDLSVV KKMKETFKEK

AKL
Length:303
Mass (Da):32,544
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCCE6AB89F58382C
GO
Isoform 2 (identifier: Q9BY49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:157
Mass (Da):16,834
Checksum:i8215EB7A51D81D48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DJS2B4DJS2_HUMAN
Peroxisomal trans-2-enoyl-CoA reduc...
PECR
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF69798 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22I → F in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti129E → R in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti135T → S in CAB89810 (PubMed:11669066).Curated1
Sequence conflicti248S → P in CAG33426 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021535149E → K. Corresponds to variant dbSNP:rs1429148Ensembl.1
Natural variantiVAR_021536297F → L. Corresponds to variant dbSNP:rs9288513Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0132601 – 146Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF232009 mRNA Translation: AAF69798.1 Different initiation.
AJ250303 mRNA Translation: CAB89810.1
AF212234 mRNA Translation: AAK14920.1
AF119841 mRNA Translation: AAF69595.1
CR457145 mRNA Translation: CAG33426.1
AK315795 mRNA Translation: BAG38139.1
AC010686 Genomic DNA Translation: AAY14657.1
BC002529 mRNA Translation: AAH02529.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33375.1 [Q9BY49-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060911.2, NM_018441.5 [Q9BY49-1]
XP_011509780.1, XM_011511478.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.281680

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265322; ENSP00000265322; ENSG00000115425 [Q9BY49-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55825

UCSC genome browser

More...
UCSCi
uc002vft.4 human [Q9BY49-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232009 mRNA Translation: AAF69798.1 Different initiation.
AJ250303 mRNA Translation: CAB89810.1
AF212234 mRNA Translation: AAK14920.1
AF119841 mRNA Translation: AAF69595.1
CR457145 mRNA Translation: CAG33426.1
AK315795 mRNA Translation: BAG38139.1
AC010686 Genomic DNA Translation: AAY14657.1
BC002529 mRNA Translation: AAH02529.1
CCDSiCCDS33375.1 [Q9BY49-1]
RefSeqiNP_060911.2, NM_018441.5 [Q9BY49-1]
XP_011509780.1, XM_011511478.2
UniGeneiHs.281680

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YXMX-ray1.90A/B/C/D1-303[»]
ProteinModelPortaliQ9BY49
SMRiQ9BY49
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120932, 13 interactors
IntActiQ9BY49, 2 interactors
STRINGi9606.ENSP00000265322

Chemistry databases

DrugBankiDB00173 Adenine
SwissLipidsiSLP:000001094

PTM databases

iPTMnetiQ9BY49
PhosphoSitePlusiQ9BY49

Polymorphism and mutation databases

BioMutaiPECR
DMDMi62287123

Proteomic databases

EPDiQ9BY49
jPOSTiQ9BY49
MaxQBiQ9BY49
PaxDbiQ9BY49
PeptideAtlasiQ9BY49
PRIDEiQ9BY49
ProteomicsDBi79584
79585 [Q9BY49-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55825
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265322; ENSP00000265322; ENSG00000115425 [Q9BY49-1]
GeneIDi55825
KEGGihsa:55825
UCSCiuc002vft.4 human [Q9BY49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55825
DisGeNETi55825
EuPathDBiHostDB:ENSG00000115425.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PECR
HGNCiHGNC:18281 PECR
HPAiHPA021593
HPA022539
MIMi605843 gene
neXtProtiNX_Q9BY49
OpenTargetsiENSG00000115425
PharmGKBiPA134967510

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000156882
HOVERGENiHBG105268
InParanoidiQ9BY49
KOiK07753
OMAiVPDHDNW
OrthoDBi1194344at2759
PhylomeDBiQ9BY49
TreeFamiTF315256

Enzyme and pathway databases

UniPathwayi
UPA00094

BioCyciMetaCyc:HS03889-MONOMER
BRENDAi1.3.1.38 2681
ReactomeiR-HSA-389599 Alpha-oxidation of phytanate
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PECR human
EvolutionaryTraceiQ9BY49

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PECR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55825

Protein Ontology

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PROi
PR:Q9BY49

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115425 Expressed in 218 organ(s), highest expression level in liver
CleanExiHS_PECR
ExpressionAtlasiQ9BY49 baseline and differential
GenevisibleiQ9BY49 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPECR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BY49
Secondary accession number(s): B2RE42
, Q53TC4, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: January 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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