Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein RTF2 homolog

Gene

RTFDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • mitotic DNA replication termination Source: InterPro
  • site-specific DNA replication termination at RTS1 barrier Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RTF2 homolog
Alternative name(s):
Replication termination factor 2 domain-containing protein 1
Gene namesi
Name:RTFDC1
Synonyms:C20orf43
ORF Names:AD-007, CDA05, HSPC164, HSPC169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000022277.12
HGNCiHGNC:15890 RTFDC1
neXtProtiNX_Q9BY42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022277
PharmGKBiPA25756

Polymorphism and mutation databases

BioMutaiRTFDC1
DMDMi313104242

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794271 – 306Protein RTF2 homologAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY42
MaxQBiQ9BY42
PaxDbiQ9BY42
PeptideAtlasiQ9BY42
PRIDEiQ9BY42
ProteomicsDBi79579

PTM databases

iPTMnetiQ9BY42
PhosphoSitePlusiQ9BY42

Expressioni

Gene expression databases

BgeeiENSG00000022277 Expressed in 223 organ(s), highest expression level in corpus callosum
CleanExiHS_C20orf43
ExpressionAtlasiQ9BY42 baseline and differential
GenevisibleiQ9BY42 HS

Organism-specific databases

HPAiHPA053986

Interactioni

Protein-protein interaction databases

BioGridi119578, 21 interactors
IntActiQ9BY42, 8 interactors
MINTiQ9BY42
STRINGi9606.ENSP00000023939

Structurei

3D structure databases

ProteinModelPortaliQ9BY42
SMRiQ9BY42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rtf2 family.Curated

Phylogenomic databases

eggNOGiKOG3113 Eukaryota
ENOG41113CN LUCA
GeneTreeiENSGT00390000010923
HOVERGENiHBG051164
InParanoidiQ9BY42
PhylomeDBiQ9BY42
TreeFamiTF314621

Family and domain databases

InterProiView protein in InterPro
IPR006735 Rtf2
IPR027799 Rtf2_RING-finger
PANTHERiPTHR12775 PTHR12775, 1 hit
PfamiView protein in Pfam
PF04641 Rtf2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BY42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA
60 70 80 90 100
CELGRLYNKD AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE
110 120 130 140 150
GDKGNTKGDK HDDLQRARFI CPVVGLEMNG RHRFCFLRCC GCVFSERALK
160 170 180 190 200
EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD VLKTRMEERR LRAKLEKKTK
210 220 230 240 250
KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT NLAPKSTAMN
260 270 280 290 300
ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT

HTSYCF
Length:306
Mass (Da):33,887
Last modified:November 30, 2010 - v3
Checksum:i41EBAB29F7D535BF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2L6A2A2L6_HUMAN
Replication termination factor 2
RTF2
230Annotation score:
A0A0A0MQR2A0A0A0MQR2_HUMAN
Replication termination factor 2
RTF2
336Annotation score:
A2A2L5A2A2L5_HUMAN
Replication termination factor 2
RTF2
277Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189R → G in BAA91193 (PubMed:14702039).Curated1
Sequence conflicti194K → N in AAF17212 (PubMed:10931946).Curated1
Sequence conflicti194K → N in AAK14929 (Ref. 3) Curated1
Sequence conflicti195L → R in AAF17212 (PubMed:10931946).Curated1
Sequence conflicti195L → W in AAK14929 (Ref. 3) Curated1
Sequence conflicti199T → P in AAF29128 (PubMed:11042152).Curated1
Sequence conflicti208V → A in AAF29128 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028134159T → A. Corresponds to variant dbSNP:rs6024909Ensembl.1
Natural variantiVAR_028135171M → V6 PublicationsCorresponds to variant dbSNP:rs1059768Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117231 mRNA Translation: AAF17212.1
AF161513 mRNA Translation: AAF29128.1
AF161518 mRNA Translation: AAF29133.1
AF212244 mRNA Translation: AAK14929.1
AK000481 mRNA Translation: BAA91193.1
AL109806 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75539.1
CH471077 Genomic DNA Translation: EAW75540.1
BC003359 mRNA Translation: AAH03359.1
CCDSiCCDS13453.1
RefSeqiNP_001269964.1, NM_001283035.1
NP_001269965.1, NM_001283036.1
NP_001269966.1, NM_001283037.1
NP_057491.2, NM_016407.4
UniGeneiHs.517134

Genome annotation databases

EnsembliENST00000357348; ENSP00000349906; ENSG00000022277
GeneIDi51507
KEGGihsa:51507
UCSCiuc002xxt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117231 mRNA Translation: AAF17212.1
AF161513 mRNA Translation: AAF29128.1
AF161518 mRNA Translation: AAF29133.1
AF212244 mRNA Translation: AAK14929.1
AK000481 mRNA Translation: BAA91193.1
AL109806 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75539.1
CH471077 Genomic DNA Translation: EAW75540.1
BC003359 mRNA Translation: AAH03359.1
CCDSiCCDS13453.1
RefSeqiNP_001269964.1, NM_001283035.1
NP_001269965.1, NM_001283036.1
NP_001269966.1, NM_001283037.1
NP_057491.2, NM_016407.4
UniGeneiHs.517134

3D structure databases

ProteinModelPortaliQ9BY42
SMRiQ9BY42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119578, 21 interactors
IntActiQ9BY42, 8 interactors
MINTiQ9BY42
STRINGi9606.ENSP00000023939

PTM databases

iPTMnetiQ9BY42
PhosphoSitePlusiQ9BY42

Polymorphism and mutation databases

BioMutaiRTFDC1
DMDMi313104242

Proteomic databases

EPDiQ9BY42
MaxQBiQ9BY42
PaxDbiQ9BY42
PeptideAtlasiQ9BY42
PRIDEiQ9BY42
ProteomicsDBi79579

Protocols and materials databases

DNASUi51507
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357348; ENSP00000349906; ENSG00000022277
GeneIDi51507
KEGGihsa:51507
UCSCiuc002xxt.4 human

Organism-specific databases

CTDi51507
EuPathDBiHostDB:ENSG00000022277.12
GeneCardsiRTF2
H-InvDBiHIX0015933
HGNCiHGNC:15890 RTFDC1
HPAiHPA053986
neXtProtiNX_Q9BY42
OpenTargetsiENSG00000022277
PharmGKBiPA25756
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3113 Eukaryota
ENOG41113CN LUCA
GeneTreeiENSGT00390000010923
HOVERGENiHBG051164
InParanoidiQ9BY42
PhylomeDBiQ9BY42
TreeFamiTF314621

Miscellaneous databases

ChiTaRSiRTFDC1 human
GeneWikiiC20orf43
GenomeRNAii51507
PROiPR:Q9BY42

Gene expression databases

BgeeiENSG00000022277 Expressed in 223 organ(s), highest expression level in corpus callosum
CleanExiHS_C20orf43
ExpressionAtlasiQ9BY42 baseline and differential
GenevisibleiQ9BY42 HS

Family and domain databases

InterProiView protein in InterPro
IPR006735 Rtf2
IPR027799 Rtf2_RING-finger
PANTHERiPTHR12775 PTHR12775, 1 hit
PfamiView protein in Pfam
PF04641 Rtf2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BY42
Secondary accession number(s): E1P5Z9
, Q9BYL7, Q9HCV9, Q9NX29, Q9NZZ8, Q9P002, Q9UHW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again