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Entry version 167 (13 Feb 2019)
Sequence version 2 (11 Apr 2003)
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Protein

Histone deacetylase 8

Gene

HDAC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. EC:3.5.1.98

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationNote: Binds 1 divalent metal cation per subunit.

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Its activity is inhibited by trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA), 3-(1-methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide (APHA), 4-dimethylamino-N-(6-hydroxycarbamoyethyl)benzamide-N-hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide (MS-344), 5-(4-methyl-benzoylamino)-biphenyl-3,4'-dicarboxylic acid 3-dimethylamide 4'-hydroxyamide (CRA-A) and butyrate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei101Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei143Proton acceptor1 Publication1
Binding sitei151Substrate; via carbonyl oxygen1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi178Divalent metal cation1 Publication1
Metal bindingi180Divalent metal cation1 Publication1
Metal bindingi267Divalent metal cation1 Publication1
Binding sitei306Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.98 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q9BY41

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9BY41

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Short name:
HD8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDAC8
Synonyms:HDACL1
ORF Names:CDA07
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000147099.19

Human Gene Nomenclature Database

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HGNCi
HGNC:13315 HDAC8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300269 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BY41

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cornelia de Lange syndrome 5 (CDLS5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
See also OMIM:300882
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069140180H → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515416EnsemblClinVar.1
Natural variantiVAR_069141311T → M in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515417EnsemblClinVar.1
Natural variantiVAR_069142320G → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs398122909EnsemblClinVar.1
Natural variantiVAR_069143334H → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515418EnsemblClinVar.1
Wilson-Turner X-linked mental retardation syndrome (WTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males.
See also OMIM:309585

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39S → A: Enhances the deacetylase activity. 1 Publication1
Mutagenesisi39S → E: Decreases the deacetylase activity. 1 Publication1
Mutagenesisi101D → A: Complete loss of catalytical activity. Complete loss of catalytical activity; when associated with F-306. 2 Publications1
Mutagenesisi101D → E: Partial loss of catalytical activity. 2 Publications1
Mutagenesisi101D → L: Complete loss of catalytical activity. 2 Publications1
Mutagenesisi101D → N: Almost complete loss of catalytical activity. 2 Publications1
Mutagenesisi142 – 143HH → AA: Strongly reduces histone deacetylase activity. 1 Publication2
Mutagenesisi143H → A: Loss of catalytic activity. 1 Publication1
Mutagenesisi306Y → F: Loss of catalytic activity. Complete loss of catalytic activity; when associated with A-101. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
55869

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
HDAC8

MalaCards human disease database

More...
MalaCardsi
HDAC8
MIMi300882 phenotype
309585 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147099

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
199 Cornelia de Lange syndrome
3459 Wilson-Turner syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37766

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3192

Drug and drug target database

More...
DrugBanki
DB07350 (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide
DB02565 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide
DB08168 7-AMINO-4-METHYL-CHROMEN-2-ONE
DB05015 Belinostat
DB02917 N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide
DB06603 Panobinostat
DB02546 Vorinostat

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2619

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HDAC8

Domain mapping of disease mutations (DMDM)

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DMDMi
29839394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001147081 – 377Histone deacetylase 8Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BY41

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BY41

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BY41

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BY41

PeptideAtlas

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PeptideAtlasi
Q9BY41

PRoteomics IDEntifications database

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PRIDEi
Q9BY41

ProteomicsDB human proteome resource

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ProteomicsDBi
79574
79577 [Q9BY41-4]
79578 [Q9BY41-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BY41

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BY41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147099 Expressed in 192 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BY41 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BY41 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048560

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120968, 38 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9BY41

Protein interaction database and analysis system

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IntActi
Q9BY41, 19 interactors

Molecular INTeraction database

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MINTi
Q9BY41

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362674

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BY41

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T64X-ray1.90A/B1-377[»]
1T67X-ray2.31A1-377[»]
1T69X-ray2.91A1-377[»]
1VKGX-ray2.20A/B1-377[»]
1W22X-ray2.50A/B1-377[»]
2V5WX-ray2.00A/B1-377[»]
2V5XX-ray2.25A/B1-377[»]
3EW8X-ray1.80A1-377[»]
3EWFX-ray2.50A/B/C/D1-377[»]
3EZPX-ray2.65A/B1-377[»]
3EZTX-ray2.85A/B1-377[»]
3F06X-ray2.55A/B1-377[»]
3F07X-ray3.30A/B/C1-377[»]
3F0RX-ray2.54A/B/C1-377[»]
3MZ3X-ray3.20A/B1-377[»]
3MZ4X-ray1.84A/B1-377[»]
3MZ6X-ray2.00A1-377[»]
3MZ7X-ray1.90A1-377[»]
3RQDX-ray2.14A/B1-377[»]
3SFFX-ray2.00A1-377[»]
3SFHX-ray2.70A1-377[»]
4QA0X-ray2.24A/B1-377[»]
4QA1X-ray1.92A/B/C/D1-377[»]
4QA2X-ray2.38A/B1-377[»]
4QA3X-ray2.88A/B1-377[»]
4QA4X-ray1.98A1-377[»]
4QA5X-ray1.76A/B1-377[»]
4QA6X-ray2.05A/B1-377[»]
4QA7X-ray2.31A1-377[»]
4RN0X-ray1.76A/B1-377[»]
4RN1X-ray2.18A/B1-377[»]
4RN2X-ray2.39A/B1-377[»]
5BWZX-ray1.59A/B1-377[»]
5D1BX-ray2.90A/B1-377[»]
5D1CX-ray1.42A/B1-377[»]
5D1DX-ray2.01A/B1-377[»]
5DC5X-ray1.94A/B1-377[»]
5DC6X-ray1.55A/B1-377[»]
5DC7X-ray2.30A/B1-377[»]
5DC8X-ray1.30A/B1-377[»]
5FCWX-ray1.98A/B1-377[»]
5THSX-ray1.90A/B1-377[»]
5THTX-ray2.41A/B/C/D1-377[»]
5THUX-ray1.95A/B1-377[»]
5THVX-ray1.87A/B1-377[»]
5VI6X-ray1.24A8-377[»]
6HSKX-ray2.10A/B1-377[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BY41

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BY41

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BY41

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 324Histone deacetylaseAdd BLAST311

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1342 Eukaryota
COG0123 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000225180

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057112

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BY41

KEGG Orthology (KO)

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KOi
K11405

Identification of Orthologs from Complete Genome Data

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OMAi
CGYDANA

Database of Orthologous Groups

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OrthoDBi
1557466at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BY41

TreeFam database of animal gene trees

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TreeFami
TF106175

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.800.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10625 PTHR10625, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00850 Hist_deacetyl, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037913 His_deacetylse_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01270 HDASUPER
PR01271 HISDACETLASE

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52768 SSF52768, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 38 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BY41-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL
60 70 80 90 100
HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY
110 120 130 140 150
DCPATEGIFD YAAAIGGATI TAAQCLIDGM CKVAINWSGG WHHAKKDEAS
160 170 180 190 200
GFCYLNDAVL GILRLRRKFE RILYVDLDLH HGDGVEDAFS FTSKVMTVSL
210 220 230 240 250
HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY YQICESVLKE
260 270 280 290 300
VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
310 320 330 340 350
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP
360 370
SCRPDRNEPH RIQQILNYIK GNLKHVV
Length:377
Mass (Da):41,758
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAA1B91894FB5013
GO
Isoform 4 (identifier: Q9BY41-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-146: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):31,935
Checksum:iB69361BAC77E90E2
GO
Isoform 5 (identifier: Q9BY41-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     246-272: SVLKEVYQAFNPKAVVLQLGADTIAGD → RYEPPAPNPGL
     273-377: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,353
Checksum:i175AB23C2589926F
GO
Isoform 6 (identifier: Q9BY41-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-146: Missing.
     185-210: Missing.
     246-256: SVLKEVYQAFN → RYEPPAPNPGL
     257-377: Missing.

Note: Gene prediction based on EST data.
Show »
Length:139
Mass (Da):15,685
Checksum:iE46FD4F32AAABC43
GO
Isoform 7 (identifier: Q9BY41-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-158: DEASGFCYLNDA → ETCVYVALYKAF
     159-377: Missing.

Note: Gene prediction based on EST data.
Show »
Length:158
Mass (Da):17,439
Checksum:iF7EFADF18566BB00
GO
Isoform 8 (identifier: Q9BY41-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-377: Missing.

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):16,050
Checksum:i5234C861058EAE1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 38 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NGJ7A6NGJ7_HUMAN
Histone deacetylase
HDAC8
417Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITZ3A0A3B3ITZ3_HUMAN
Histone deacetylase
HDAC8
375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT04A0A3B3IT04_HUMAN
Histone deacetylase
HDAC8
375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS68A0A3B3IS68_HUMAN
Histone deacetylase
HDAC8
403Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISJ4A0A3B3ISJ4_HUMAN
Histone deacetylase
HDAC8
414Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVA8E7EVA8_HUMAN
Histone deacetylase 8
HDAC8
344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NFW1A6NFW1_HUMAN
Histone deacetylase 8
HDAC8
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRI9A0A3B3IRI9_HUMAN
Histone deacetylase 8
HDAC8
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IT84A0A3B3IT84_HUMAN
Histone deacetylase 8
HDAC8
337Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRP8A0A3B3IRP8_HUMAN
Histone deacetylase 8
HDAC8
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK14930 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31L → P in AAH50433 (PubMed:15489334).Curated1
Sequence conflicti179L → V no nucleotide entry (PubMed:10756090).Curated1
Sequence conflicti223R → W in AAF73428 (PubMed:10926844).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069140180H → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515416EnsemblClinVar.1
Natural variantiVAR_069141311T → M in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515417EnsemblClinVar.1
Natural variantiVAR_069142320G → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs398122909EnsemblClinVar.1
Natural variantiVAR_069143334H → R in CDLS5. 1 PublicationCorresponds to variant dbSNP:rs397515418EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04342656 – 146Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_047502147 – 377Missing in isoform 8. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_046832147 – 158DEASG…YLNDA → ETCVYVALYKAF in isoform 7. CuratedAdd BLAST12
Alternative sequenceiVSP_046833159 – 377Missing in isoform 7. CuratedAdd BLAST219
Alternative sequenceiVSP_046834185 – 210Missing in isoform 6. CuratedAdd BLAST26
Alternative sequenceiVSP_043427246 – 272SVLKE…TIAGD → RYEPPAPNPGL in isoform 5. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_046835246 – 256SVLKEVYQAFN → RYEPPAPNPGL in isoform 6. CuratedAdd BLAST11
Alternative sequenceiVSP_046836257 – 377Missing in isoform 6. CuratedAdd BLAST121
Alternative sequenceiVSP_007177273 – 377Missing in isoform 5. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF230097 mRNA Translation: AAF73076.1
AF245664 mRNA Translation: AAF73428.1
AJ277724 mRNA Translation: CAB90213.1
BQ189619 mRNA No translation available.
AK296641 mRNA Translation: BAG59242.1
AK300895 mRNA Translation: BAG62534.1
AA376331 mRNA No translation available.
AI159768 mRNA No translation available.
T99283 mRNA No translation available.
AF212246 mRNA Translation: AAK14930.1 Sequence problems.
AL133500 Genomic DNA No translation available.
BX295542 Genomic DNA No translation available.
BC050433 mRNA Translation: AAH50433.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14420.1 [Q9BY41-1]
CCDS55448.1 [Q9BY41-6]
CCDS55449.1 [Q9BY41-4]
CCDS55450.1 [Q9BY41-8]
CCDS55451.1 [Q9BY41-5]
CCDS55452.1 [Q9BY41-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001159890.1, NM_001166418.1 [Q9BY41-4]
NP_001159891.1, NM_001166419.1 [Q9BY41-5]
NP_001159892.1, NM_001166420.1 [Q9BY41-8]
NP_001159894.1, NM_001166422.1 [Q9BY41-7]
NP_001159920.1, NM_001166448.1 [Q9BY41-6]
NP_060956.1, NM_018486.2 [Q9BY41-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.310536

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373554; ENSP00000362655; ENSG00000147099 [Q9BY41-8]
ENST00000373556; ENSP00000362657; ENSG00000147099 [Q9BY41-7]
ENST00000373559; ENSP00000362660; ENSG00000147099 [Q9BY41-6]
ENST00000373573; ENSP00000362674; ENSG00000147099 [Q9BY41-1]
ENST00000373589; ENSP00000362691; ENSG00000147099 [Q9BY41-4]
ENST00000439122; ENSP00000414486; ENSG00000147099 [Q9BY41-5]
ENST00000649116; ENSP00000497925; ENSG00000147099 [Q9BY41-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55869

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55869

UCSC genome browser

More...
UCSCi
uc004eau.3 human [Q9BY41-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230097 mRNA Translation: AAF73076.1
AF245664 mRNA Translation: AAF73428.1
AJ277724 mRNA Translation: CAB90213.1
BQ189619 mRNA No translation available.
AK296641 mRNA Translation: BAG59242.1
AK300895 mRNA Translation: BAG62534.1
AA376331 mRNA No translation available.
AI159768 mRNA No translation available.
T99283 mRNA No translation available.
AF212246 mRNA Translation: AAK14930.1 Sequence problems.
AL133500 Genomic DNA No translation available.
BX295542 Genomic DNA No translation available.
BC050433 mRNA Translation: AAH50433.1
CCDSiCCDS14420.1 [Q9BY41-1]
CCDS55448.1 [Q9BY41-6]
CCDS55449.1 [Q9BY41-4]
CCDS55450.1 [Q9BY41-8]
CCDS55451.1 [Q9BY41-5]
CCDS55452.1 [Q9BY41-7]
RefSeqiNP_001159890.1, NM_001166418.1 [Q9BY41-4]
NP_001159891.1, NM_001166419.1 [Q9BY41-5]
NP_001159892.1, NM_001166420.1 [Q9BY41-8]
NP_001159894.1, NM_001166422.1 [Q9BY41-7]
NP_001159920.1, NM_001166448.1 [Q9BY41-6]
NP_060956.1, NM_018486.2 [Q9BY41-1]
UniGeneiHs.310536

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T64X-ray1.90A/B1-377[»]
1T67X-ray2.31A1-377[»]
1T69X-ray2.91A1-377[»]
1VKGX-ray2.20A/B1-377[»]
1W22X-ray2.50A/B1-377[»]
2V5WX-ray2.00A/B1-377[»]
2V5XX-ray2.25A/B1-377[»]
3EW8X-ray1.80A1-377[»]
3EWFX-ray2.50A/B/C/D1-377[»]
3EZPX-ray2.65A/B1-377[»]
3EZTX-ray2.85A/B1-377[»]
3F06X-ray2.55A/B1-377[»]
3F07X-ray3.30A/B/C1-377[»]
3F0RX-ray2.54A/B/C1-377[»]
3MZ3X-ray3.20A/B1-377[»]
3MZ4X-ray1.84A/B1-377[»]
3MZ6X-ray2.00A1-377[»]
3MZ7X-ray1.90A1-377[»]
3RQDX-ray2.14A/B1-377[»]
3SFFX-ray2.00A1-377[»]
3SFHX-ray2.70A1-377[»]
4QA0X-ray2.24A/B1-377[»]
4QA1X-ray1.92A/B/C/D1-377[»]
4QA2X-ray2.38A/B1-377[»]
4QA3X-ray2.88A/B1-377[»]
4QA4X-ray1.98A1-377[»]
4QA5X-ray1.76A/B1-377[»]
4QA6X-ray2.05A/B1-377[»]
4QA7X-ray2.31A1-377[»]
4RN0X-ray1.76A/B1-377[»]
4RN1X-ray2.18A/B1-377[»]
4RN2X-ray2.39A/B1-377[»]
5BWZX-ray1.59A/B1-377[»]
5D1BX-ray2.90A/B1-377[»]
5D1CX-ray1.42A/B1-377[»]
5D1DX-ray2.01A/B1-377[»]
5DC5X-ray1.94A/B1-377[»]
5DC6X-ray1.55A/B1-377[»]
5DC7X-ray2.30A/B1-377[»]
5DC8X-ray1.30A/B1-377[»]
5FCWX-ray1.98A/B1-377[»]
5THSX-ray1.90A/B1-377[»]
5THTX-ray2.41A/B/C/D1-377[»]
5THUX-ray1.95A/B1-377[»]
5THVX-ray1.87A/B1-377[»]
5VI6X-ray1.24A8-377[»]
6HSKX-ray2.10A/B1-377[»]
ProteinModelPortaliQ9BY41
SMRiQ9BY41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120968, 38 interactors
ELMiQ9BY41
IntActiQ9BY41, 19 interactors
MINTiQ9BY41
STRINGi9606.ENSP00000362674

Chemistry databases

BindingDBiQ9BY41
ChEMBLiCHEMBL3192
DrugBankiDB07350 (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide
DB02565 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide
DB08168 7-AMINO-4-METHYL-CHROMEN-2-ONE
DB05015 Belinostat
DB02917 N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide
DB06603 Panobinostat
DB02546 Vorinostat
GuidetoPHARMACOLOGYi2619

PTM databases

iPTMnetiQ9BY41
PhosphoSitePlusiQ9BY41

Polymorphism and mutation databases

BioMutaiHDAC8
DMDMi29839394

Proteomic databases

EPDiQ9BY41
jPOSTiQ9BY41
MaxQBiQ9BY41
PaxDbiQ9BY41
PeptideAtlasiQ9BY41
PRIDEiQ9BY41
ProteomicsDBi79574
79577 [Q9BY41-4]
79578 [Q9BY41-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373554; ENSP00000362655; ENSG00000147099 [Q9BY41-8]
ENST00000373556; ENSP00000362657; ENSG00000147099 [Q9BY41-7]
ENST00000373559; ENSP00000362660; ENSG00000147099 [Q9BY41-6]
ENST00000373573; ENSP00000362674; ENSG00000147099 [Q9BY41-1]
ENST00000373589; ENSP00000362691; ENSG00000147099 [Q9BY41-4]
ENST00000439122; ENSP00000414486; ENSG00000147099 [Q9BY41-5]
ENST00000649116; ENSP00000497925; ENSG00000147099 [Q9BY41-8]
GeneIDi55869
KEGGihsa:55869
UCSCiuc004eau.3 human [Q9BY41-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55869
DisGeNETi55869
EuPathDBiHostDB:ENSG00000147099.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HDAC8
GeneReviewsiHDAC8
HGNCiHGNC:13315 HDAC8
HPAiHPA048560
MalaCardsiHDAC8
MIMi300269 gene
300882 phenotype
309585 phenotype
neXtProtiNX_Q9BY41
OpenTargetsiENSG00000147099
Orphaneti199 Cornelia de Lange syndrome
3459 Wilson-Turner syndrome
PharmGKBiPA37766

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00940000157843
HOGENOMiHOG000225180
HOVERGENiHBG057112
InParanoidiQ9BY41
KOiK11405
OMAiCGYDANA
OrthoDBi1557466at2759
PhylomeDBiQ9BY41
TreeFamiTF106175

Enzyme and pathway databases

BRENDAi3.5.1.98 2681
ReactomeiR-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
SABIO-RKiQ9BY41
SIGNORiQ9BY41

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HDAC8 human
EvolutionaryTraceiQ9BY41

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HDAC8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55869

Protein Ontology

More...
PROi
PR:Q9BY41

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147099 Expressed in 192 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ9BY41 baseline and differential
GenevisibleiQ9BY41 HS

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDAC8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BY41
Secondary accession number(s): A6ND12
, A6ND61, A6NET3, A6NJR3, A8MQ62, B4DKN0, B4DV22, Q86VC8, Q9NP76, Q9NYH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: February 13, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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