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Protein

G-protein coupled receptor 87

Gene

GPR87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 87
Alternative name(s):
G-protein coupled receptor 95
Gene namesi
Name:GPR87
Synonyms:GPR95
ORF Names:FKSG78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000138271.5
HGNCiHGNC:4538 GPR87
MIMi606379 gene
neXtProtiNX_Q9BY21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini69 – 75CytoplasmicSequence analysis7
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 116ExtracellularSequence analysisAdd BLAST20
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 159CytoplasmicSequence analysisAdd BLAST22
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 208ExtracellularSequence analysisAdd BLAST28
Transmembranei209 – 229Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini230 – 256CytoplasmicSequence analysisAdd BLAST27
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 297ExtracellularSequence analysisAdd BLAST20
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 358CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53836
OpenTargetsiENSG00000138271
PharmGKBiPA28931

Chemistry databases

GuidetoPHARMACOLOGYi122

Polymorphism and mutation databases

BioMutaiGPR87
DMDMi37537842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695951 – 358G-protein coupled receptor 87Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BY21
PeptideAtlasiQ9BY21
PRIDEiQ9BY21
ProteomicsDBi79569

PTM databases

iPTMnetiQ9BY21
PhosphoSitePlusiQ9BY21

Expressioni

Tissue specificityi

Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.1 Publication

Inductioni

By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.1 Publication

Gene expression databases

BgeeiENSG00000138271 Expressed in 91 organ(s), highest expression level in tongue squamous epithelium
CleanExiHS_GPR87
GenevisibleiQ9BY21 HS

Organism-specific databases

HPAiHPA066313

Interactioni

Protein-protein interaction databases

IntActiQ9BY21, 1 interactor
MINTiQ9BY21
STRINGi9606.ENSP00000260843

Structurei

3D structure databases

ProteinModelPortaliQ9BY21
SMRiQ9BY21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE7G Eukaryota
ENOG410YEMD LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG108228
InParanoidiQ9BY21
KOiK08389
OMAiLSACNVC
OrthoDBiEOG091G09RZ
PhylomeDBiQ9BY21
TreeFamiTF330969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008109 P2Y13_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01735 P2Y13PRNCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BY21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFNLTLAKL PNNELHGQES HNSGNRSDGP GKNTTLHNEF DTIVLPVLYL
60 70 80 90 100
IIFVASILLN GLAVWIFFHI RNKTSFIFYL KNIVVADLIM TLTFPFRIVH
110 120 130 140 150
DAGFGPWYFK FILCRYTSVL FYANMYTSIV FLGLISIDRY LKVVKPFGDS
160 170 180 190 200
RMYSITFTKV LSVCVWVIMA VLSLPNIILT NGQPTEDNIH DCSKLKSPLG
210 220 230 240 250
VKWHTAVTYV NSCLFVAVLV ILIGCYIAIS RYIHKSSRQF ISQSSRKRKH
260 270 280 290 300
NQSIRVVVAV FFTCFLPYHL CRIPFTFSHL DRLLDESAQK ILYYCKEITL
310 320 330 340 350
FLSACNVCLD PIIYFFMCRS FSRRLFKKSN IRTRSESIRS LQSVRRSEVR

IYYDYTDV
Length:358
Mass (Da):41,436
Last modified:June 1, 2001 - v1
Checksum:iFDF157295BE5D10F
GO

Sequence cautioni

The sequence AAK29069 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → N in BAB55366 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035760191D → Y in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055921205T → M. Corresponds to variant dbSNP:rs35521104Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031548 mRNA Translation: BAD83583.1
AF411114 mRNA Translation: AAL26485.1
AF237763 mRNA Translation: AAK01858.1
EU883576 mRNA Translation: ACG60650.1
AK027784 mRNA Translation: BAB55366.1
CH471052 Genomic DNA Translation: EAW78808.1
BC009540 mRNA Translation: AAH09540.2
BC112941 mRNA Translation: AAI12942.1
BC117565 mRNA Translation: AAI17566.1
BC132888 mRNA Translation: AAI32889.1
BC132890 mRNA Translation: AAI32891.1
AF345566 mRNA Translation: AAK29069.1 Different initiation.
CCDSiCCDS3157.1
RefSeqiNP_076404.3, NM_023915.3
UniGeneiHs.591292

Genome annotation databases

EnsembliENST00000260843; ENSP00000260843; ENSG00000138271
GeneIDi53836
KEGGihsa:53836
UCSCiuc003eyt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPR87_HUMAN
AccessioniPrimary (citable) accession number: Q9BY21
Secondary accession number(s): Q5KU35, Q96JZ8, Q9BXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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