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Protein

Membrane-spanning 4-domains subfamily A member 8

Gene

MS4A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 8
Alternative name(s):
Four-span transmembrane protein 4
Membrane-spanning 4-domains subfamily A member 8B
Gene namesi
Name:MS4A8
Synonyms:4SPAN4, MS4A8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166959.7
HGNCiHGNC:13380 MS4A8
MIMi606549 gene
neXtProtiNX_Q9BY19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 98ExtracellularSequence analysis3
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 136CytoplasmicSequence analysisAdd BLAST17
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 180ExtracellularSequence analysisAdd BLAST23
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 250CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83661
OpenTargetsiENSG00000166959
PharmGKBiPA31126

Polymorphism and mutation databases

BioMutaiMS4A8
DMDMi29611827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586451 – 250Membrane-spanning 4-domains subfamily A member 8Add BLAST250

Proteomic databases

PaxDbiQ9BY19
PRIDEiQ9BY19
ProteomicsDBi79568

PTM databases

iPTMnetiQ9BY19
PhosphoSitePlusiQ9BY19

Expressioni

Tissue specificityi

Expressed by hematopoietic tissues and cells lines.

Gene expression databases

BgeeiENSG00000166959
CleanExiHS_MS4A8B
ExpressionAtlasiQ9BY19 baseline and differential
GenevisibleiQ9BY19 HS

Organism-specific databases

HPAiHPA007318
HPA007319

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300226

Structurei

3D structure databases

ProteinModelPortaliQ9BY19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ1J Eukaryota
ENOG4112CBR LUCA
GeneTreeiENSGT00730000110654
HOGENOMiHOG000247023
HOVERGENiHBG052386
InParanoidiQ9BY19
KOiK22190
OMAiFPFWGGI
OrthoDBiEOG091G0IBB
PhylomeDBiQ9BY19
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030424 MS4A8
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF118 PTHR23320:SF118, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BY19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSMTSAVPV ANSVLVVAPH NGYPVTPGIM SHVPLYPNSQ PQVHLVPGNP
60 70 80 90 100
PSLVSNVNGQ PVQKALKEGK TLGAIQIIIG LAHIGLGSIM ATVLVGEYLS
110 120 130 140 150
ISFYGGFPFW GGLWFIISGS LSVAAENQPY SYCLLSGSLG LNIVSAICSA
160 170 180 190 200
VGVILFITDL SIPHPYAYPD YYPYAWGVNP GMAISGVLLV FCLLEFGIAC
210 220 230 240 250
ASSHFGCQLV CCQSSNVSVI YPNIYAANPV ITPEPVTSPP SYSSEIQANK
Length:250
Mass (Da):26,290
Last modified:June 1, 2001 - v1
Checksum:iC1176E1FFDBD99B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → R in AAH22895 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05352395V → L. Corresponds to variant dbSNP:rs35956659Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237905 mRNA Translation: AAK37414.1
AF350504 mRNA Translation: AAL56224.1
BC022895 mRNA Translation: AAH22895.1
CCDSiCCDS7990.1
RefSeqiNP_113645.1, NM_031457.1
UniGeneiHs.150878

Genome annotation databases

EnsembliENST00000300226; ENSP00000300226; ENSG00000166959
GeneIDi83661
KEGGihsa:83661
UCSCiuc001npv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiM4A8_HUMAN
AccessioniPrimary (citable) accession number: Q9BY19
Secondary accession number(s): Q8TCA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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