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Entry version 145 (16 Oct 2019)
Sequence version 2 (29 May 2013)
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Protein

S phase cyclin A-associated protein in the endoplasmic reticulum

Gene

SCAPER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri792 – 816C2H2-typeAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S phase cyclin A-associated protein in the endoplasmic reticulum
Short name:
S phase cyclin A-associated protein in the ER
Alternative name(s):
Zinc finger protein 291
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCAPER
Synonyms:KIAA1454, ZNF291
ORF Names:MSTP063
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13081 SCAPER

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611611 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BY12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder and retinitis pigmentosa (IDDRP)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by mild to moderate intellectual disability, retinitis pigmentosa, and attention-deficit hyperactivity disorder observed in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081681620Missing in IDDRP; unknown pathological significance. 1 Publication1
Natural variantiVAR_0816821219S → N in IDDRP; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1305542291EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi26 – 28RNL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi199 – 201RSL → AAA: Loss of CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi678 – 680RAL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3

Keywords - Diseasei

Disease mutation, Mental retardation, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
49855

MalaCards human disease database

More...
MalaCardsi
SCAPER
MIMi618195 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000140386

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
791 Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402512

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BY12

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCAPER

Domain mapping of disease mutations (DMDM)

More...
DMDMi
510120715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475131 – 1400S phase cyclin A-associated protein in the endoplasmic reticulumAdd BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei832PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by the CCNA2/CDK2 complex.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BY12

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BY12

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BY12

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BY12

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BY12

PeptideAtlas

More...
PeptideAtlasi
Q9BY12

PRoteomics IDEntifications database

More...
PRIDEi
Q9BY12

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27620
41275
79561 [Q9BY12-1]
79562 [Q9BY12-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BY12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BY12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high expression in testis. Isoform 1 is detected in various tissues, including retina, fetal and adult brain. Isoform 2 is expressed in the retina at high levels, and in the brain at very low levels (PubMed:28794130).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at each stage of the cell cycle, including G0, although the expression is somewhat higher in late G1 and S phases.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140386 Expressed in 216 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BY12 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BY12 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046253
HPA061180

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249413EBI-308519,EBI-375096

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119067, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BY12, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000454973

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi395 – 770Glu-richAdd BLAST376

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri792 – 816C2H2-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4722 Eukaryota
ENOG410XPXB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007543

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BY12

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEHPLAE

Database of Orthologous Groups

More...
OrthoDBi
82115at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BY12

TreeFam database of animal gene trees

More...
TreeFami
TF324831

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR032446 SCAPER_N
IPR036236 Znf_C2H2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16501 SCAPER_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00451 ZnF_U1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BY12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG
60 70 80 90 100
KSKRTIQGTH KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA
110 120 130 140 150
RYWAFLFDNL RRAVDEIYVT CESDQSVVEC KEVLMMLDNY VRDFKALIDW
160 170 180 190 200
IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR HVIPSPSTDR INVTSNARRS
210 220 230 240 250
LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT PAQSCPPMTV
260 270 280 290 300
QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK
310 320 330 340 350
ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST
360 370 380 390 400
LDDVKNSGSI RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA
410 420 430 440 450
EKARIENEMD PSDISNSMAE VLAKKEELAD RLEKANEEAI ASAIAEEEQL
460 470 480 490 500
TREIEAEENN DINIETDNDS DFSASMGSGS VSFCGMSMDW NDVLADYEAR
510 520 530 540 550
ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI AESKKKHEEK
560 570 580 590 600
QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH
610 620 630 640 650
AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ
660 670 680 690 700
RLNELQEERQ RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA
710 720 730 740 750
RIEQQRQEKE KAREDAARER ARDREERLAA LTAAQQEAME ELQKKIQLKH
760 770 780 790 800
DESIRRHMEQ IEQRKEKAAE LSSGRHANTD YAPKLTPYER KKQCSLCNVL
810 820 830 840 850
ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS LKKYIIDIVV
860 870 880 890 900
ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP
910 920 930 940 950
YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD
960 970 980 990 1000
QIAFQAAGGL TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN
1010 1020 1030 1040 1050
CSENCSDVLF SNKITFLMDL LIHQLTVYVP DENNTILGRN TNKQVFEGLT
1060 1070 1080 1090 1100
TGLLKVSAVV LGCLIANRPD GNCQPATPKI PTQEMKNKPS QGDPFNNRVQ
1110 1120 1130 1140 1150
DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA GLLHAMCTLC
1160 1170 1180 1190 1200
FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS
1210 1220 1230 1240 1250
TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM
1260 1270 1280 1290 1300
ASSLLGHCSQ VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL
1310 1320 1330 1340 1350
CQLPFQYFSD PRLIKVLFPS LIAACYNNHQ NKIILEQEMS CVLLATFIQD
1360 1370 1380 1390 1400
LAQTPGQAEN QPYQPKGKCL GSQDYLELAN RFPQQAWEEA RQFFLKKEKK
Length:1,400
Mass (Da):158,287
Last modified:May 29, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DBAF02F75CB1AA7
GO
Isoform 2 (identifier: Q9BY12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MMASFQRSNS...WSVPLESKDD → REATPPLRGL...DLGIEENLKS
     416-416: N → NVSAANL
     1236-1244: SIVGAEGLS → VPSIGLYRC
     1245-1400: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:1,265
Mass (Da):142,698
Checksum:i435FBE3ABF98D826
GO
Isoform 3 (identifier: Q9BY12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: MMASFQRSNS...MTVQKASRKN → MKTKYIFCNIT

Show »
Length:1,154
Mass (Da):130,935
Checksum:i175334613BCA3513
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPM0H3BPM0_HUMAN
S phase cyclin A-associated protein...
SCAPER
747Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS25H3BS25_HUMAN
S phase cyclin A-associated protein...
SCAPER
767Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR40H3BR40_HUMAN
S phase cyclin A-associated protein...
SCAPER
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPB0H3BPB0_HUMAN
S phase cyclin A-associated protein...
SCAPER
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT27H3BT27_HUMAN
S phase cyclin A-associated protein...
SCAPER
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU24H3BU24_HUMAN
S phase cyclin A-associated protein...
SCAPER
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQF3H3BQF3_HUMAN
S phase cyclin A-associated protein...
SCAPER
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ61H3BQ61_HUMAN
S phase cyclin A-associated protein...
SCAPER
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTY2H3BTY2_HUMAN
S phase cyclin A-associated protein...
SCAPER
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTL8H3BTL8_HUMAN
S phase cyclin A-associated protein...
SCAPER
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG47945 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH15212 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI07416 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAK29205 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in AAK29205 (Ref. 1) Curated1
Sequence conflicti1262S → F in AAG47945 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081681620Missing in IDDRP; unknown pathological significance. 1 Publication1
Natural variantiVAR_0199781089P → T2 PublicationsCorresponds to variant dbSNP:rs1607017Ensembl.1
Natural variantiVAR_0599101139A → T. Corresponds to variant dbSNP:rs3743176Ensembl.1
Natural variantiVAR_0528061140A → T. Corresponds to variant dbSNP:rs3743176Ensembl.1
Natural variantiVAR_0816821219S → N in IDDRP; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1305542291EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0465031 – 257MMASF…ASRKN → MKTKYIFCNIT in isoform 3. 1 PublicationAdd BLAST257
Alternative sequenceiVSP_0314401 – 40MMASF…ESKDD → REATPPLRGLPAPPRHAPFP AGRFEPPRTKQGGRGSHTPW DYVINDLGIEENLKS in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_031441416N → NVSAANL in isoform 2. 1 Publication1
Alternative sequenceiVSP_0314421236 – 1244SIVGAEGLS → VPSIGLYRC in isoform 2. 1 Publication9
Alternative sequenceiVSP_0314431245 – 1400Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF242528 mRNA Translation: AAK29205.1 Different initiation.
AB040887 mRNA Translation: BAA95978.1
AL137612 mRNA Translation: CAB70841.1
BX647285 mRNA No translation available.
AC015798 Genomic DNA No translation available.
AC016343 Genomic DNA No translation available.
AC027243 Genomic DNA No translation available.
AC051643 Genomic DNA No translation available.
AC090179 Genomic DNA No translation available.
AC090751 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99218.1
BC015212 mRNA Translation: AAH15212.1 Different initiation.
BC107415 mRNA Translation: AAI07416.1 Sequence problems.
AF119814 mRNA Translation: AAG47945.1 Different initiation.
BT006762 mRNA Translation: AAP35408.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53961.1 [Q9BY12-3]
CCDS53962.1 [Q9BY12-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46314

NCBI Reference Sequences

More...
RefSeqi
NP_001139395.1, NM_001145923.1 [Q9BY12-3]
NP_065894.2, NM_020843.2 [Q9BY12-1]
XP_005254476.1, XM_005254419.2
XP_016877758.1, XM_017022269.1 [Q9BY12-1]
XP_016877759.1, XM_017022270.1 [Q9BY12-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324767; ENSP00000326924; ENSG00000140386 [Q9BY12-1]
ENST00000538941; ENSP00000442190; ENSG00000140386 [Q9BY12-3]
ENST00000563290; ENSP00000454973; ENSG00000140386 [Q9BY12-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:49855

UCSC genome browser

More...
UCSCi
uc002bbx.4 human [Q9BY12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242528 mRNA Translation: AAK29205.1 Different initiation.
AB040887 mRNA Translation: BAA95978.1
AL137612 mRNA Translation: CAB70841.1
BX647285 mRNA No translation available.
AC015798 Genomic DNA No translation available.
AC016343 Genomic DNA No translation available.
AC027243 Genomic DNA No translation available.
AC051643 Genomic DNA No translation available.
AC090179 Genomic DNA No translation available.
AC090751 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99218.1
BC015212 mRNA Translation: AAH15212.1 Different initiation.
BC107415 mRNA Translation: AAI07416.1 Sequence problems.
AF119814 mRNA Translation: AAG47945.1 Different initiation.
BT006762 mRNA Translation: AAP35408.1
CCDSiCCDS53961.1 [Q9BY12-3]
CCDS53962.1 [Q9BY12-1]
PIRiT46314
RefSeqiNP_001139395.1, NM_001145923.1 [Q9BY12-3]
NP_065894.2, NM_020843.2 [Q9BY12-1]
XP_005254476.1, XM_005254419.2
XP_016877758.1, XM_017022269.1 [Q9BY12-1]
XP_016877759.1, XM_017022270.1 [Q9BY12-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119067, 9 interactors
IntActiQ9BY12, 8 interactors
STRINGi9606.ENSP00000454973

PTM databases

iPTMnetiQ9BY12
PhosphoSitePlusiQ9BY12

Polymorphism and mutation databases

BioMutaiSCAPER
DMDMi510120715

Proteomic databases

EPDiQ9BY12
jPOSTiQ9BY12
MassIVEiQ9BY12
MaxQBiQ9BY12
PaxDbiQ9BY12
PeptideAtlasiQ9BY12
PRIDEiQ9BY12
ProteomicsDBi27620
41275
79561 [Q9BY12-1]
79562 [Q9BY12-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
49855

Genome annotation databases

EnsembliENST00000324767; ENSP00000326924; ENSG00000140386 [Q9BY12-1]
ENST00000538941; ENSP00000442190; ENSG00000140386 [Q9BY12-3]
ENST00000563290; ENSP00000454973; ENSG00000140386 [Q9BY12-1]
GeneIDi49855
KEGGihsa:49855
UCSCiuc002bbx.4 human [Q9BY12-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49855
DisGeNETi49855

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SCAPER
HGNCiHGNC:13081 SCAPER
HPAiHPA046253
HPA061180
MalaCardsiSCAPER
MIMi611611 gene
618195 phenotype
neXtProtiNX_Q9BY12
OpenTargetsiENSG00000140386
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA162402512

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4722 Eukaryota
ENOG410XPXB LUCA
GeneTreeiENSGT00390000011159
HOGENOMiHOG000007543
InParanoidiQ9BY12
OMAiCEHPLAE
OrthoDBi82115at2759
PhylomeDBiQ9BY12
TreeFamiTF324831

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SCAPER human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
49855
PharosiQ9BY12

Protein Ontology

More...
PROi
PR:Q9BY12

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140386 Expressed in 216 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9BY12 baseline and differential
GenevisibleiQ9BY12 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR032446 SCAPER_N
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF16501 SCAPER_N, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCAPE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BY12
Secondary accession number(s): F5H7X8
, H3BNR7, Q3B7X7, Q96BS9, Q9H3D8, Q9NT03, Q9P274
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 29, 2013
Last modified: October 16, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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