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Protein

S phase cyclin A-associated protein in the endoplasmic reticulum

Gene

SCAPER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri792 – 816C2H2-typeAdd BLAST25

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
S phase cyclin A-associated protein in the endoplasmic reticulum
Short name:
S phase cyclin A-associated protein in the ER
Alternative name(s):
Zinc finger protein 291
Gene namesi
Name:SCAPER
Synonyms:KIAA1454, ZNF291
ORF Names:MSTP063
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140386.12
HGNCiHGNC:13081 SCAPER
MIMi611611 gene
neXtProtiNX_Q9BY12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26 – 28RNL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi199 – 201RSL → AAA: Loss of CCNA2/CDK2 complex-binding. 1 Publication3
Mutagenesisi678 – 680RAL → AAA: No effect on CCNA2/CDK2 complex-binding. 1 Publication3

Organism-specific databases

DisGeNETi49855
MalaCardsiSCAPER
OpenTargetsiENSG00000140386
PharmGKBiPA162402512

Polymorphism and mutation databases

BioMutaiSCAPER
DMDMi510120715

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475131 – 1400S phase cyclin A-associated protein in the endoplasmic reticulumAdd BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei832PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by the CCNA2/CDK2 complex.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BY12
MaxQBiQ9BY12
PaxDbiQ9BY12
PeptideAtlasiQ9BY12
PRIDEiQ9BY12
ProteomicsDBi79561
79562 [Q9BY12-2]

PTM databases

iPTMnetiQ9BY12
PhosphoSitePlusiQ9BY12

Expressioni

Tissue specificityi

Widely expressed with highest expression in testis.1 Publication

Developmental stagei

Expressed at each stage of the cell cycle, including G0, although the expression is somewhat higher in late G1 and S phases.1 Publication

Gene expression databases

BgeeiENSG00000140386 Expressed in 216 organ(s), highest expression level in corpus callosum
CleanExiHS_SCAPER
ExpressionAtlasiQ9BY12 baseline and differential
GenevisibleiQ9BY12 HS

Organism-specific databases

HPAiHPA046253
HPA061180

Interactioni

Subunit structurei

Interacts with CCNA2/CDK2 complex, but not with CCNA2/CDC2, CCNB1/CDC2 or CCNE1/CDK2 complexes, at multiple phases of the cell cycle, including S and G2/M.1 Publication

Protein-protein interaction databases

BioGridi119067, 7 interactors
IntActiQ9BY12, 5 interactors
STRINGi9606.ENSP00000326924

Structurei

3D structure databases

ProteinModelPortaliQ9BY12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi395 – 770Glu-richAdd BLAST376

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri792 – 816C2H2-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4722 Eukaryota
ENOG410XPXB LUCA
GeneTreeiENSGT00390000011159
HOGENOMiHOG000007543
HOVERGENiHBG101202
InParanoidiQ9BY12
OMAiLMDLLIH
OrthoDBiEOG091G030C
PhylomeDBiQ9BY12
TreeFamiTF324831

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR032446 SCAPER_N
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF16501 SCAPER_N, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BY12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG
60 70 80 90 100
KSKRTIQGTH KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA
110 120 130 140 150
RYWAFLFDNL RRAVDEIYVT CESDQSVVEC KEVLMMLDNY VRDFKALIDW
160 170 180 190 200
IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR HVIPSPSTDR INVTSNARRS
210 220 230 240 250
LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT PAQSCPPMTV
260 270 280 290 300
QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK
310 320 330 340 350
ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST
360 370 380 390 400
LDDVKNSGSI RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA
410 420 430 440 450
EKARIENEMD PSDISNSMAE VLAKKEELAD RLEKANEEAI ASAIAEEEQL
460 470 480 490 500
TREIEAEENN DINIETDNDS DFSASMGSGS VSFCGMSMDW NDVLADYEAR
510 520 530 540 550
ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI AESKKKHEEK
560 570 580 590 600
QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH
610 620 630 640 650
AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ
660 670 680 690 700
RLNELQEERQ RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA
710 720 730 740 750
RIEQQRQEKE KAREDAARER ARDREERLAA LTAAQQEAME ELQKKIQLKH
760 770 780 790 800
DESIRRHMEQ IEQRKEKAAE LSSGRHANTD YAPKLTPYER KKQCSLCNVL
810 820 830 840 850
ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS LKKYIIDIVV
860 870 880 890 900
ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP
910 920 930 940 950
YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD
960 970 980 990 1000
QIAFQAAGGL TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN
1010 1020 1030 1040 1050
CSENCSDVLF SNKITFLMDL LIHQLTVYVP DENNTILGRN TNKQVFEGLT
1060 1070 1080 1090 1100
TGLLKVSAVV LGCLIANRPD GNCQPATPKI PTQEMKNKPS QGDPFNNRVQ
1110 1120 1130 1140 1150
DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA GLLHAMCTLC
1160 1170 1180 1190 1200
FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS
1210 1220 1230 1240 1250
TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM
1260 1270 1280 1290 1300
ASSLLGHCSQ VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL
1310 1320 1330 1340 1350
CQLPFQYFSD PRLIKVLFPS LIAACYNNHQ NKIILEQEMS CVLLATFIQD
1360 1370 1380 1390 1400
LAQTPGQAEN QPYQPKGKCL GSQDYLELAN RFPQQAWEEA RQFFLKKEKK
Length:1,400
Mass (Da):158,287
Last modified:May 29, 2013 - v2
Checksum:i9DBAF02F75CB1AA7
GO
Isoform 2 (identifier: Q9BY12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MMASFQRSNS...WSVPLESKDD → REATPPLRGL...DLGIEENLKS
     416-416: N → NVSAANL
     1236-1244: SIVGAEGLS → VPSIGLYRC
     1245-1400: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:1,265
Mass (Da):142,698
Checksum:i435FBE3ABF98D826
GO
Isoform 3 (identifier: Q9BY12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-257: MMASFQRSNS...MTVQKASRKN → MKTKYIFCNIT

Show »
Length:1,154
Mass (Da):130,935
Checksum:i175334613BCA3513
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BS25H3BS25_HUMAN
S phase cyclin A-associated protein...
SCAPER
767Annotation score:
H3BPM0H3BPM0_HUMAN
S phase cyclin A-associated protein...
SCAPER
747Annotation score:
H3BT27H3BT27_HUMAN
S phase cyclin A-associated protein...
SCAPER
191Annotation score:
H3BQF3H3BQF3_HUMAN
S phase cyclin A-associated protein...
SCAPER
154Annotation score:
H3BR40H3BR40_HUMAN
S phase cyclin A-associated protein...
SCAPER
115Annotation score:
H3BQ61H3BQ61_HUMAN
S phase cyclin A-associated protein...
SCAPER
75Annotation score:
H3BTY2H3BTY2_HUMAN
S phase cyclin A-associated protein...
SCAPER
60Annotation score:
H3BPB0H3BPB0_HUMAN
S phase cyclin A-associated protein...
SCAPER
111Annotation score:
H3BTL8H3BTL8_HUMAN
S phase cyclin A-associated protein...
SCAPER
99Annotation score:
H3BU24H3BU24_HUMAN
S phase cyclin A-associated protein...
SCAPER
62Annotation score:

Sequence cautioni

The sequence AAG47945 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI07416 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAK29205 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in AAK29205 (Ref. 1) Curated1
Sequence conflicti1262S → F in AAG47945 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0199781089P → T2 PublicationsCorresponds to variant dbSNP:rs1607017Ensembl.1
Natural variantiVAR_0599101139A → T. Corresponds to variant dbSNP:rs3743176Ensembl.1
Natural variantiVAR_0528061140A → T. Corresponds to variant dbSNP:rs3743176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0465031 – 257MMASF…ASRKN → MKTKYIFCNIT in isoform 3. 1 PublicationAdd BLAST257
Alternative sequenceiVSP_0314401 – 40MMASF…ESKDD → REATPPLRGLPAPPRHAPFP AGRFEPPRTKQGGRGSHTPW DYVINDLGIEENLKS in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_031441416N → NVSAANL in isoform 2. 1 Publication1
Alternative sequenceiVSP_0314421236 – 1244SIVGAEGLS → VPSIGLYRC in isoform 2. 1 Publication9
Alternative sequenceiVSP_0314431245 – 1400Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242528 mRNA Translation: AAK29205.1 Different initiation.
AB040887 mRNA Translation: BAA95978.1
AL137612 mRNA Translation: CAB70841.1
BX647285 mRNA No translation available.
AC015798 Genomic DNA No translation available.
AC016343 Genomic DNA No translation available.
AC027243 Genomic DNA No translation available.
AC051643 Genomic DNA No translation available.
AC090179 Genomic DNA No translation available.
AC090751 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99218.1
BC015212 mRNA Translation: AAH15212.1 Different initiation.
BC107415 mRNA Translation: AAI07416.1 Sequence problems.
AF119814 mRNA Translation: AAG47945.1 Different initiation.
BT006762 mRNA Translation: AAP35408.1
CCDSiCCDS53961.1 [Q9BY12-3]
CCDS53962.1 [Q9BY12-1]
PIRiT46314
RefSeqiNP_001139395.1, NM_001145923.1 [Q9BY12-3]
NP_065894.2, NM_020843.2 [Q9BY12-1]
XP_005254476.1, XM_005254419.2
XP_016877758.1, XM_017022269.1 [Q9BY12-1]
XP_016877759.1, XM_017022270.1 [Q9BY12-1]
UniGeneiHs.458986

Genome annotation databases

EnsembliENST00000324767; ENSP00000326924; ENSG00000140386 [Q9BY12-1]
ENST00000538941; ENSP00000442190; ENSG00000140386 [Q9BY12-3]
ENST00000563290; ENSP00000454973; ENSG00000140386 [Q9BY12-1]
GeneIDi49855
KEGGihsa:49855
UCSCiuc002bbx.4 human [Q9BY12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCAPE_HUMAN
AccessioniPrimary (citable) accession number: Q9BY12
Secondary accession number(s): F5H7X8
, H3BNR7, Q3B7X7, Q96BS9, Q9H3D8, Q9NT03, Q9P274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 29, 2013
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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