UniProtKB - Q9BY10 (TSCOT_HUMAN)
Protein
Thymic stromal cotransporter homolog
Gene
SLC46A2
Organism
Homo sapiens (Human)
Status
Functioni
May act as a transporter.By similarity
GO - Molecular functioni
- symporter activity Source: UniProtKB
GO - Biological processi
- negative regulation of T cell apoptotic process Source: Ensembl
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Source: FlyBase
- regulation of T cell differentiation Source: Ensembl
- T cell homeostasis Source: Ensembl
- thymus development Source: Ensembl
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BY10 |
Protein family/group databases
TCDBi | 2.A.1.50.2, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Thymic stromal cotransporter homologAlternative name(s): Solute carrier family 46 member 2 |
Gene namesi | Name:SLC46A2 Synonyms:TSCOT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000119457.7 |
HGNCi | HGNC:16055, SLC46A2 |
MIMi | 608956, gene |
neXtProti | NX_Q9BY10 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 44 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 45 – 78 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 79 – 99 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 100 – 108 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 138 | ExtracellularSequence analysis | 9 | |
Transmembranei | 139 – 159 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 172 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 173 – 193 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 194 – 205 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 206 – 226 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 282 | CytoplasmicSequence analysisAdd BLAST | 56 | |
Transmembranei | 283 – 303 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 304 – 320 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 321 – 341 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 342 – 347 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 348 – 368 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 369 – 370 | ExtracellularSequence analysis | 2 | |
Transmembranei | 371 – 391 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 392 – 406 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 407 – 427 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 435 | ExtracellularSequence analysis | 8 | |
Transmembranei | 436 – 456 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 457 – 475 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57864 |
OpenTargetsi | ENSG00000119457 |
PharmGKBi | PA162403790 |
Miscellaneous databases
Pharosi | Q9BY10, Tdark |
Polymorphism and mutation databases
BioMutai | SLC46A2 |
DMDMi | 83287921 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065659 | 1 – 475 | Thymic stromal cotransporter homologAdd BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q9BY10 |
PaxDbi | Q9BY10 |
PeptideAtlasi | Q9BY10 |
PRIDEi | Q9BY10 |
ProteomicsDBi | 79559 |
PTM databases
GlyGeni | Q9BY10, 1 site |
iPTMneti | Q9BY10 |
PhosphoSitePlusi | Q9BY10 |
Expressioni
Tissue specificityi
Strongly expressed in the adult thymus. Expressed in spleen, lymph nodes, thymus, PBL, bone marrow and fetal liver.1 Publication
Gene expression databases
Bgeei | ENSG00000119457, Expressed in upper arm skin and 92 other tissues |
ExpressionAtlasi | Q9BY10, baseline and differential |
Genevisiblei | Q9BY10, HS |
Organism-specific databases
HPAi | ENSG00000119457, Tissue enhanced (ductus deferens, lymphoid tissue, skin) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000363345 |
Miscellaneous databases
RNActi | Q9BY10, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2816, Eukaryota |
GeneTreei | ENSGT00950000183096 |
HOGENOMi | CLU_028365_3_0_1 |
InParanoidi | Q9BY10 |
OMAi | IVAYKQV |
OrthoDBi | 763423at2759 |
PhylomeDBi | Q9BY10 |
TreeFami | TF315701 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BY10-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT
60 70 80 90 100
GGSSNHSASP SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS
110 120 130 140 150
DRYHRKISIC MSLLGFLLSR LGLLLKVLLD WPVEVLYGAA ALNGLFGGFS
160 170 180 190 200
AFWSGVMALG SLGSSEGRRS VRLILIDLML GLAGFCGSMA SGHLFKQMAG
210 220 230 240 250
HSGQGLILTA CSVSCASFAL LYSLLVLKVP ESVAKPSQEL PAVDTVSGTV
260 270 280 290 300
GTYRTLDPDQ LDQQYAVGHP PSPGKAKPHK TTIALLFVGA IIYDLAVVGT
310 320 330 340 350
VDVIPLFVLR EPLGWNQVQV GYGMAAGYTI FITSFLGVLV FSRCFRDTTM
360 370 380 390 400
IMIGMVSFGS GALLLAFVKE TYMFYIARAV MLFALIPVTT IRSAMSKLIK
410 420 430 440 450
GSSYGKVFVI LQLSLALTGV VTSTLYNKIY QLTMDMFVGS CFALSSFLSF
460 470
LAIIPISIVA YKQVPLSPYG DIIEK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R3Y2 | S4R3Y2_HUMAN | Thymic stromal cotransporter homolo... | SLC46A2 | 341 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | V → M in AAH48285 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 380 | V → A in BAB70960 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021050 | 366 | A → V. Corresponds to variant dbSNP:rs16917454EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242557 mRNA Translation: AAK28343.1 AK055571 mRNA Translation: BAB70960.1 AK314414 mRNA Translation: BAG37035.1 AL139041 Genomic DNA No translation available. CH878453 Genomic DNA Translation: EAW50550.1 BC048285 mRNA Translation: AAH48285.1 |
CCDSi | CCDS6786.1 |
RefSeqi | NP_149040.3, NM_033051.3 |
Genome annotation databases
Ensembli | ENST00000374228; ENSP00000363345; ENSG00000119457 |
GeneIDi | 57864 |
KEGGi | hsa:57864 |
UCSCi | uc004bgk.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF242557 mRNA Translation: AAK28343.1 AK055571 mRNA Translation: BAB70960.1 AK314414 mRNA Translation: BAG37035.1 AL139041 Genomic DNA No translation available. CH878453 Genomic DNA Translation: EAW50550.1 BC048285 mRNA Translation: AAH48285.1 |
CCDSi | CCDS6786.1 |
RefSeqi | NP_149040.3, NM_033051.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000363345 |
Protein family/group databases
TCDBi | 2.A.1.50.2, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q9BY10, 1 site |
iPTMneti | Q9BY10 |
PhosphoSitePlusi | Q9BY10 |
Polymorphism and mutation databases
BioMutai | SLC46A2 |
DMDMi | 83287921 |
Proteomic databases
MaxQBi | Q9BY10 |
PaxDbi | Q9BY10 |
PeptideAtlasi | Q9BY10 |
PRIDEi | Q9BY10 |
ProteomicsDBi | 79559 |
Protocols and materials databases
Antibodypediai | 29714, 53 antibodies |
DNASUi | 57864 |
Genome annotation databases
Ensembli | ENST00000374228; ENSP00000363345; ENSG00000119457 |
GeneIDi | 57864 |
KEGGi | hsa:57864 |
UCSCi | uc004bgk.3, human |
Organism-specific databases
CTDi | 57864 |
DisGeNETi | 57864 |
EuPathDBi | HostDB:ENSG00000119457.7 |
GeneCardsi | SLC46A2 |
HGNCi | HGNC:16055, SLC46A2 |
HPAi | ENSG00000119457, Tissue enhanced (ductus deferens, lymphoid tissue, skin) |
MIMi | 608956, gene |
neXtProti | NX_Q9BY10 |
OpenTargetsi | ENSG00000119457 |
PharmGKBi | PA162403790 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2816, Eukaryota |
GeneTreei | ENSGT00950000183096 |
HOGENOMi | CLU_028365_3_0_1 |
InParanoidi | Q9BY10 |
OMAi | IVAYKQV |
OrthoDBi | 763423at2759 |
PhylomeDBi | Q9BY10 |
TreeFami | TF315701 |
Enzyme and pathway databases
PathwayCommonsi | Q9BY10 |
Miscellaneous databases
BioGRID-ORCSi | 57864, 2 hits in 840 CRISPR screens |
GenomeRNAii | 57864 |
Pharosi | Q9BY10, Tdark |
PROi | PR:Q9BY10 |
RNActi | Q9BY10, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119457, Expressed in upper arm skin and 92 other tissues |
ExpressionAtlasi | Q9BY10, baseline and differential |
Genevisiblei | Q9BY10, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSCOT_HUMAN | |
Accessioni | Q9BY10Primary (citable) accession number: Q9BY10 Secondary accession number(s): B1ALK1, Q86VT0, Q96NE2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations