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UniProtKB - Q9BY07 (S4A5_HUMAN)

Entry version 146 (17 Jun 2020)
Sequence version 2 (08 Apr 2008)
Previous versions | rss
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Protein

Electrogenic sodium bicarbonate cotransporter 4

Gene

SLC4A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na+:HCO3- stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na+:HCO3- cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by 4,4'-di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425381 Bicarbonate transporters

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.31.2.8 the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electrogenic sodium bicarbonate cotransporter 4
Alternative name(s):
NBCe2
Solute carrier family 4 member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A5Imported
Synonyms:NBC4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000188687.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:18168 SLC4A5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606757 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BY07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 521CytoplasmicSequence analysisAdd BLAST521
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei522 – 544HelicalSequence analysisAdd BLAST23
Topological domaini545 – 555ExtracellularSequence analysisAdd BLAST11
Transmembranei556 – 587HelicalSequence analysisAdd BLAST32
Topological domaini588 – 606CytoplasmicSequence analysisAdd BLAST19
Transmembranei607 – 628HelicalSequence analysisAdd BLAST22
Topological domaini629 – 742ExtracellularSequence analysisAdd BLAST114
Transmembranei743 – 762HelicalSequence analysisAdd BLAST20
Topological domaini763 – 773CytoplasmicSequence analysisAdd BLAST11
Transmembranei774 – 795HelicalSequence analysisAdd BLAST22
Topological domaini796 – 828ExtracellularSequence analysisAdd BLAST33
Transmembranei829 – 847HelicalSequence analysisAdd BLAST19
Topological domaini848 – 866CytoplasmicSequence analysisAdd BLAST19
Transmembranei867 – 883HelicalSequence analysisAdd BLAST17
Topological domaini884 – 888ExtracellularSequence analysis5
Transmembranei889 – 908HelicalSequence analysisAdd BLAST20
Topological domaini909 – 928CytoplasmicSequence analysisAdd BLAST20
Transmembranei929 – 948HelicalSequence analysisAdd BLAST20
Topological domaini949 – 953ExtracellularSequence analysis5
Transmembranei954 – 971HelicalSequence analysisAdd BLAST18
Topological domaini972 – 1016CytoplasmicSequence analysisAdd BLAST45
Transmembranei1017 – 1034HelicalSequence analysisAdd BLAST18
Topological domaini1035 – 1039ExtracellularSequence analysis5
Transmembranei1040 – 1057HelicalSequence analysisAdd BLAST18
Topological domaini1058 – 1137CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57835

Open Targets

More...OpenTargetsi		ENSG00000188687

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164742397

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BY07 Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01390 Sodium bicarbonate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC4A5

Domain mapping of disease mutations (DMDM)

More...DMDMi		182691595

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289201 – 1137Electrogenic sodium bicarbonate cotransporter 4Add BLAST1137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi679 ↔ 681By similarity
Disulfide bondi725 ↔ 737By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BY07

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BY07

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BY07

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BY07

PeptideAtlas

More...PeptideAtlasi		Q9BY07

PRoteomics IDEntifications database

More...PRIDEi		Q9BY07

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79546 [Q9BY07-1]
79547 [Q9BY07-2]
79548 [Q9BY07-3]
79549 [Q9BY07-4]
79550 [Q9BY07-5]
79551 [Q9BY07-6]
79552 [Q9BY07-7]
79553 [Q9BY07-8]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2038

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BY07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BY07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000188687 Expressed in thyroid gland and 90 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BY07 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BY07 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000188687 Tissue enriched (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121791, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9BY07, 1 interactor

Molecular INTeraction database

More...MINTi		Q9BY07

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000251768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BY07 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BY07

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi433 – 497Gly-richSequence analysisAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002289_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BY07

KEGG Orthology (KO)

More...KOi		K13857

Identification of Orthologs from Complete Genome Data

More...OMAi		YVTTYKC

Database of Orthologous Groups

More...OrthoDBi		265068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BY07

TreeFam database of animal gene trees

More...TreeFami		TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...PANTHERi		PTHR11453 PTHR11453, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00834 ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9BY07-1) [UniParc]FASTAAdd to basket
Also known as: NBC4a1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVKEEKAGV GKLDHTNHRR RFPDQKECPP IHIGLPVPTY PQRKTDQKGH 
        60         70         80         90        100
LSGLQKVHWG LRPDQPQQEL TGPGSGASSQ DSSMDLISRT RSPAAEQLQD 
       110        120        130        140        150
ILGEEDEAPN PTLFTEMDTL QHDGDQMEWK ESARWIKFEE KVEEGGERWS 
       160        170        180        190        200
KPHVSTLSLH SLFELRTCLQ TGTVLLDLDS GSLPQIIDDV IEKQIEDGLL 
       210        220        230        240        250
RPELRERVSY VLLRRHRHQT KKPIHRSLAD IGKSVSTTNR SPARSPGAGP 
       260        270        280        290        300
SLHHSTEDLR MRQSANYGRL CHAQSRSMND ISLTPNTDQR KNKFMKKIPK 
       310        320        330        340        350
DSEASNVLVG EVDFLDQPFI AFVRLIQSAM LGGVTEVPVP TRFLFILLGP 
       360        370        380        390        400
SGRAKSYNEI GRAIATLMVD DLFSDVAYKA RNREDLIAGI DEFLDEVIVL 
       410        420        430        440        450
PPGEWDPNIR IEPPKKVPSA DKRKSVFSLA ELGQMNGSVG GGGGAPGGGN 
       460        470        480        490        500
GGGGGGGSGG GAGSGGAGGT SSGDDGEMPA MHEIGEELIW TGRFFGGLCL 
       510        520        530        540        550
DIKRKLPWFP SDFYDGFHIQ SISAILFIYL GCITNAITFG GLLGDATDNY 
       560        570        580        590        600
QGVMESFLGT AMAGSLFCLF SGQPLIILSS TGPILIFEKL LFDFSKGNGL 
       610        620        630        640        650
DYMEFRLWIG LHSAVQCLIL VATDASFIIK YITRFTEEGF STLISFIFIY 
       660        670        680        690        700
DAIKKMIGAF KYYPINMDFK PNFITTYKCE CVAPDTVNTT VFNASAPLAP 
       710        720        730        740        750
DTNASLYNLL NLTALDWSLL SKKECLSYGG RLLGNSCKFI PDLALMSFIL 
       760        770        780        790        800
FFGTYSMTLT LKKFKFSRYF PTKVRALVAD FSIVFSILMF CGIDACFGLE 
       810        820        830        840        850
TPKLHVPSVI KPTRPDRGWF VAPFGKNPWW VYPASILPAL LVTILIFMDQ 
       860        870        880        890        900
QITAVIVNRK ENKLKKAAGY HLDLFWVGIL MALCSFMGLP WYVAATVISI 
       910        920        930        940        950
AHIDSLKMET ETSAPGEQPQ FLGVREQRVT GIIVFILTGI SVFLAPILKC 
       960        970        980        990       1000
IPLPVLYGVF LYMGVASLNG IQMGTGGSEF KIQKKLTPFW ERCKLFLMPA 
      1010       1020       1030       1040       1050
KHQPDHAFLR HVPLRRIHLF TLVQILCLAV LWILKSTVAA IIFPVMILGL 
      1060       1070       1080       1090       1100
IIVRRLLDFI FSQHDLAWID NILPEKEKKE TDKKRKRKKG AHEDCDEEPQ 
      1110       1120       1130 
FPPPSVIKIP MESVQSDPQN GIHCIARKRS SSWSYSL
Length:1,137
Mass (Da):126,255
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED4E4A4DC2CA17F1
GO
Isoform 22 Publications (identifier: Q9BY07-2) [UniParc]FASTAAdd to basket
Also known as: NBC4b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1046-1046: M → MSLSTTD

Show »
Length:1,143
Mass (Da):126,860
Checksum:i3C32B411955873FD
GO
Isoform 31 Publication (identifier: Q9BY07-3) [UniParc]FASTAAdd to basket
Also known as: NBC4c1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     973-988: Missing.

Show »
Length:1,121
Mass (Da):124,551
Checksum:iDC17DB7C69ABD27D
GO
Isoform 41 Publication (identifier: Q9BY07-4) [UniParc]FASTAAdd to basket
Also known as: NBC4d1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     950-1046: Missing.

Show »
Length:1,040
Mass (Da):115,240
Checksum:iFEE31CEF13F4F57B
GO
Isoform 5 (identifier: Q9BY07-5) [UniParc]FASTAAdd to basket
Also known as: isoform d variant

The sequence of this isoform differs from the canonical sequence as follows:
     88-91: SRTR → EHKG
     866-993: KAAGYHLDLF...KKLTPFWERC → GTESNRHHRL...HLFPARPGLD
     994-1137: Missing.

Note: Incomplete sequence.Curated
Show »
Length:993
Mass (Da):108,663
Checksum:i9C45DA4AC127035F
GO
Isoform 61 Publication (identifier: Q9BY07-6) [UniParc]FASTAAdd to basket
Also known as: NBC4f1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     774-811: Missing.
     866-924: Missing.
     973-988: Missing.
     1046-1046: M → MSLSTTD
     1071-1075: NILPE → KIEFP
     1076-1137: Missing.

Show »
Length:968
Mass (Da):107,526
Checksum:i61243CD7DF614154
GO
Isoform 71 Publication (identifier: Q9BY07-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-91: ECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLISRTR → G
     774-811: Missing.
     973-988: Missing.

Show »
Length:1,019
Mass (Da):113,390
Checksum:i93AAC3C3E0649931
GO
Isoform 81 Publication (identifier: Q9BY07-8) [UniParc]FASTAAdd to basket
Also known as: NBC4e1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1068-1137: Missing.

Show »
Length:1,067
Mass (Da):118,125
Checksum:i7D1BA0C19F65AC3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQT3E7EQT3_HUMAN
Anion exchange protein
SLC4A5 hCG_1988260
998Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVY3A0A1B0GVY3_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A5
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JU12C9JU12_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A5
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW32C9JW32_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A5
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUV9A0A1B0GUV9_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A5
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNL6C9JNL6_HUMAN
Electrogenic sodium bicarbonate cot...
SLC4A5
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG18492 differs from that shown. Reason: Frameshift.Curated
The sequence AAL50802 differs from that shown. Reason: Frameshift.Curated
The sequence EAW99691 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti612H → Y in AAL48291 (PubMed:12388414).Curated1
Sequence conflicti612H → Y in AAL50802 (PubMed:12388414).Curated1
Sequence conflicti699A → T in AAL48291 (PubMed:12388414).Curated1
Sequence conflicti759L → R in AAL50802 (PubMed:12388414).Curated1
Sequence conflicti813T → P in AAK26741 (PubMed:11087115).Curated1
Sequence conflicti896T → M in AAL48291 (PubMed:12388414).Curated1
Sequence conflicti923G → R in AAL48291 (PubMed:12388414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048350251S → N. Corresponds to variant dbSNP:rs17009792Ensembl.1
Natural variantiVAR_061032253H → Y1 PublicationCorresponds to variant dbSNP:rs55651232Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05277027 – 91ECPPI…ISRTR → G in isoform 7. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_05277188 – 91SRTR → EHKG in isoform 5. 1 Publication4
Alternative sequenceiVSP_052772774 – 811Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_052773866 – 993KAAGY…FWERC → GTESNRHHRLHPDGNLCLPG SHPKVYPPAGAVRSLPLHGR GLPEWHPVLGTLQALPDASQ APAGPCLPAARAAAPDPPLH PGADPLPGGALDPQIHGGCH HLPGHDPGPHHRSKASGFHL FPARPGLD in isoform 5. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_052774866 – 924Missing in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_052775950 – 1046Missing in isoform 4. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_052776973 – 988Missing in isoform 3, isoform 6 and isoform 7. 4 PublicationsAdd BLAST16
Alternative sequenceiVSP_052777994 – 1137Missing in isoform 5. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_0527781046M → MSLSTTD in isoform 2 and isoform 6. 3 Publications1
Alternative sequenceiVSP_0527791068 – 1137Missing in isoform 8. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0527801071 – 1075NILPE → KIEFP in isoform 6. 1 Publication5
Alternative sequenceiVSP_0527811076 – 1137Missing in isoform 6. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF207661 mRNA Translation: AAG18492.1 Frameshift.
AF243499 mRNA Translation: AAK26741.1
AF293338 mRNA Translation: AAK97073.1
AF293337 mRNA Translation: AAK97072.1
AF452248 mRNA Translation: AAL48291.1
AF453528 mRNA Translation: AAL50802.1 Frameshift.
CH471053 Genomic DNA Translation: EAW99690.1
CH471053 Genomic DNA Translation: EAW99691.1 Frameshift.
CH471053 Genomic DNA Translation: EAW99693.1
BC109221 mRNA Translation: AAI09222.1
AB209752 mRNA Translation: BAD92989.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1936.1 [Q9BY07-1]
CCDS1937.1 [Q9BY07-3]

NCBI Reference Sequences

More...RefSeqi		NP_067019.3, NM_021196.3 [Q9BY07-1]
NP_597812.1, NM_133478.2 [Q9BY07-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346834; ENSP00000251768; ENSG00000188687 [Q9BY07-1]
ENST00000358683; ENSP00000351513; ENSG00000188687 [Q9BY07-7]
ENST00000377632; ENSP00000366859; ENSG00000188687 [Q9BY07-4]
ENST00000377634; ENSP00000366861; ENSG00000188687 [Q9BY07-1]
ENST00000394019; ENSP00000377587; ENSG00000188687 [Q9BY07-3]
ENST00000423644; ENSP00000395804; ENSG00000188687 [Q9BY07-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57835

UCSC genome browser

More...UCSCi		uc002skn.3 human [Q9BY07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207661 mRNA Translation: AAG18492.1 Frameshift.
AF243499 mRNA Translation: AAK26741.1
AF293338 mRNA Translation: AAK97073.1
AF293337 mRNA Translation: AAK97072.1
AF452248 mRNA Translation: AAL48291.1
AF453528 mRNA Translation: AAL50802.1 Frameshift.
CH471053 Genomic DNA Translation: EAW99690.1
CH471053 Genomic DNA Translation: EAW99691.1 Frameshift.
CH471053 Genomic DNA Translation: EAW99693.1
BC109221 mRNA Translation: AAI09222.1
AB209752 mRNA Translation: BAD92989.1
CCDSiCCDS1936.1 [Q9BY07-1]
CCDS1937.1 [Q9BY07-3]
RefSeqiNP_067019.3, NM_021196.3 [Q9BY07-1]
NP_597812.1, NM_133478.2 [Q9BY07-3]

3D structure databases

SMRiQ9BY07
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121791, 1 interactor
IntActiQ9BY07, 1 interactor
MINTiQ9BY07
STRINGi9606.ENSP00000251768

Chemistry databases

DrugBankiDB01390 Sodium bicarbonate

Protein family/group databases

TCDBi2.A.31.2.8 the anion exchanger (ae) family

PTM databases

GlyConnecti2038
iPTMnetiQ9BY07
PhosphoSitePlusiQ9BY07

Polymorphism and mutation databases

BioMutaiSLC4A5
DMDMi182691595

Proteomic databases

jPOSTiQ9BY07
MassIVEiQ9BY07
MaxQBiQ9BY07
PaxDbiQ9BY07
PeptideAtlasiQ9BY07
PRIDEiQ9BY07
ProteomicsDBi79546 [Q9BY07-1]
79547 [Q9BY07-2]
79548 [Q9BY07-3]
79549 [Q9BY07-4]
79550 [Q9BY07-5]
79551 [Q9BY07-6]
79552 [Q9BY07-7]
79553 [Q9BY07-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47475 64 antibodies

Genome annotation databases

EnsembliENST00000346834; ENSP00000251768; ENSG00000188687 [Q9BY07-1]
ENST00000358683; ENSP00000351513; ENSG00000188687 [Q9BY07-7]
ENST00000377632; ENSP00000366859; ENSG00000188687 [Q9BY07-4]
ENST00000377634; ENSP00000366861; ENSG00000188687 [Q9BY07-1]
ENST00000394019; ENSP00000377587; ENSG00000188687 [Q9BY07-3]
ENST00000423644; ENSP00000395804; ENSG00000188687 [Q9BY07-3]
GeneIDi57835
KEGGihsa:57835
UCSCiuc002skn.3 human [Q9BY07-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57835
DisGeNETi57835
EuPathDBiHostDB:ENSG00000188687.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC4A5
HGNCiHGNC:18168 SLC4A5
HPAiENSG00000188687 Tissue enriched (retina)
MIMi606757 gene
neXtProtiNX_Q9BY07
OpenTargetsiENSG00000188687
PharmGKBiPA164742397

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000157488
HOGENOMiCLU_002289_5_0_1
InParanoidiQ9BY07
KOiK13857
OMAiYVTTYKC
OrthoDBi265068at2759
PhylomeDBiQ9BY07
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-HSA-425381 Bicarbonate transporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57835 93 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC4A5 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC4A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57835
PharosiQ9BY07 Tbio

Protein Ontology

More...PROi		PR:Q9BY07
RNActiQ9BY07 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000188687 Expressed in thyroid gland and 90 other tissues
ExpressionAtlasiQ9BY07 baseline and differential
GenevisibleiQ9BY07 HS

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BY07
Secondary accession number(s): Q32MA7
, Q59EQ9, Q8WXD3, Q8WXD7, Q96DS7, Q96DS8, Q9HBU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 17, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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