RSPO3

Functionⁱ

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720).By similarity4 Publications

GO - Molecular functionⁱ

frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
heparin binding Source: UniProtKB-KW
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22615920

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood vessel remodeling Source: UniProtKB
branching involved in labyrinthine layer morphogenesis Source: Ensembl
positive regulation of canonical Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of non-canonical Wnt signaling pathway Source: UniProtKB
positive regulation of Wnt signaling pathway
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 24431302
positive regulation of Wnt signaling pathway, planar cell polarity pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
regulation of Wnt signaling pathway Source: Reactome
sprouting angiogenesis Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding
Biological process	Sensory transduction, Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4641263 Regulation of FZD by ubiquitination R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
SIGNORⁱ	Q9BXY4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: R-spondin-3 Alternative name(s): Protein with TSP type-1 repeat Short name: hPWTSR Roof plate-specific spondin-3 Short name: hRspo3 Thrombospondin type-1 domain-containing protein 2
Gene namesⁱ	Name:RSPO3 Synonyms:PWTSR, THSD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000146374.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20866 RSPO3
MIMⁱ	610574 gene
neXtProtⁱ	NX_Q9BXY4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	106	F → A: Loss of LGR4/5/6-binding, no effect on WNT3A signaling; when associated with A-110. 1 Publication		1
Mutagenesisⁱ	110	F → A: Loss of LGR4/5/6-binding, no effect on WNT3A signaling; when associated with A-106. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84870
Open Targets More...OpenTargetsⁱ	ENSG00000146374
PharmGKBⁱ	PA134885289

Polymorphism and mutation databases

DMDMⁱ	74752442

DMDMⁱ

74752442

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000234443	22 – 272	R-spondin-3Add BLAST		251

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	41 ↔ 48	PROSITE-ProRule annotation
Disulfide bondⁱ	45 ↔ 54	PROSITE-ProRule annotation
Disulfide bondⁱ	57 ↔ 76	PROSITE-ProRule annotation
Disulfide bondⁱ	80 ↔ 95	PROSITE-ProRule annotation
Disulfide bondⁱ	98 ↔ 105	PROSITE-ProRule annotation
Disulfide bondⁱ	102 ↔ 111	PROSITE-ProRule annotation
Disulfide bondⁱ	114 ↔ 125	PROSITE-ProRule annotation
Disulfide bondⁱ	129 ↔ 142	PROSITE-ProRule annotation
Disulfide bondⁱ	148 ↔ 190	PROSITE-ProRule annotation
Disulfide bondⁱ	159 ↔ 166	PROSITE-ProRule annotation
Disulfide bondⁱ	199 ↔ 206	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q9BXY4
PeptideAtlas More...PeptideAtlasⁱ	Q9BXY4
PRIDEⁱ	Q9BXY4
ProteomicsDBⁱ	79540 79541 [Q9BXY4-2]

PTM databases

iPTMnetⁱ	Q9BXY4
PhosphoSitePlusⁱ	Q9BXY4

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000146374 Expressed in 173 organ(s), highest expression level in myometrium
CleanExⁱ	HS_RSPO3
Genevisibleⁱ	Q9BXY4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029957

HPAⁱ

HPA029957

Interactionⁱ

Subunit structureⁱ

Interacts with the extracellular domain of FZD8 and LRP6 (By similarity). It however does not form a ternary complex with FZD8 and LRP6 (By similarity). Interacts with WNT1 (By similarity). Binds heparin. Interacts with LGR4, LGR5 and LGR6 (PubMed:21727895, PubMed:21909076, PubMed:22615920).By similarity3 Publications

GO - Molecular functionⁱ

frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22615920

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124315, 3 interactors
IntActⁱ	Q9BXY4, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9BXY4
STRINGⁱ	9606.ENSP00000349131

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXY4
SMRⁱ	Q9BXY4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	35 – 86	FU 1Add BLAST	52
Repeatⁱ	92 – 135	FU 2Add BLAST	44
Domainⁱ	147 – 207	TSP type-1PROSITE-ProRule annotationAdd BLAST	61

Domainⁱ

The FU repeats are required for activation and stabilization of beta-catenin.By similarity

Sequence similaritiesⁱ

Belongs to the R-spondin family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG3525 Eukaryota COG1404 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011447
HOGENOMⁱ	HOG000290668
HOVERGENⁱ	HBG082751
InParanoidⁱ	Q9BXY4
OMAⁱ	MECTSIV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FYC
PhylomeDBⁱ	Q9BXY4
TreeFamⁱ	TF331799

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00064 FU, 1 hit
Gene3Dⁱ	2.20.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR006212 Furin_repeat IPR009030 Growth_fac_rcpt_cys_sf IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15913 Furin-like_2, 1 hit
SMARTⁱ	View protein in SMART SM00261 FU, 2 hits SM00209 TSP1, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF82895 SSF82895, 1 hit
PROSITEⁱ	View protein in PROSITE PS50092 TSP1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BXY4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLRLISWLF IILNFMEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD 
        60         70         80         90        100
YNGCLSCKPR LFFALERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA 
       110        120        130        140        150
DCDTCFNKNF CTKCKSGFYL HLGKCLDNCP EGLEANNHTM ECVSIVHCEV 
       160        170        180        190        200
SEWNPWSPCT KKGKTCGFKR GTETRVREII QHPSAKGNLC PPTNETRKCT 
       210        220        230        240        250
VQRKKCQKGE RGKKGRERKR KKPNKGESKE AIPDSKSLES SKEIPEQREN 
       260        270 
KQQQKKRKVQ DKQKSVSVST VH

Length:272

Mass (Da):30,929

Last modified:June 1, 2001 - v1

Checksum:ⁱCACAEC6B7E781189

GO

Isoform 2 (identifier: Q9BXY4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
266-272: VSVSTVH → GIEVTLAEGLTSVSQRTQPTPCRRRYL

« Hide

        10         20         30         40         50
MHLRLISWLF IILNFMEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD 
        60         70         80         90        100
YNGCLSCKPR LFFALERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA 
       110        120        130        140        150
DCDTCFNKNF CTKCKSGFYL HLGKCLDNCP EGLEANNHTM ECVSIVHCEV 
       160        170        180        190        200
SEWNPWSPCT KKGKTCGFKR GTETRVREII QHPSAKGNLC PPTNETRKCT 
       210        220        230        240        250
VQRKKCQKGE RGKKGRERKR KKPNKGESKE AIPDSKSLES SKEIPEQREN 
       260        270        280        290 
KQQQKKRKVQ DKQKSGIEVT LAEGLTSVSQ RTQPTPCRRR YL

Note: No experimental confirmation available.

Show »

Length:292

Mass (Da):33,233

Checksum:ⁱE0B2781ECDD4A6F3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	41	C → R in BAB55051 (PubMed:14702039).Curated		1
Sequence conflictⁱ	170	R → I in BAB55051 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018324	266 – 272	VSVSTVH → GIEVTLAEGLTSVSQRTQPT PCRRRYL in isoform 2. 1 Publication		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF251057 mRNA Translation: AAK34947.1 AK027346 mRNA Translation: BAB55051.1 AK314912 mRNA Translation: BAG37424.1 AL590733 Genomic DNA No translation available. AL031776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48115.1 BC022367 mRNA Translation: AAH22367.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5135.1 [Q9BXY4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_116173.2, NM_032784.4 [Q9BXY4-1]
UniGeneⁱ	Hs.135254

Genome annotation databases

Ensemblⁱ	ENST00000356698; ENSP00000349131; ENSG00000146374 [Q9BXY4-1] ENST00000368317; ENSP00000357300; ENSG00000146374 [Q9BXY4-2]
GeneIDⁱ	84870
KEGGⁱ	hsa:84870
UCSC genome browser More...UCSCⁱ	uc003qar.5 human [Q9BXY4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXY4	R-spondin 3		GORGO		272	UniRef100_Q9BXY4
UPI000020E1DC		HUMAN		203
Q9BXY4-2	R-spondin 3		GORGO		292	UniRef100_G3RXU3

Protein	Similar proteins		Species	Score	Length	Source
Q9BXY4	R-spondin-3		BOVIN		273	UniRef90_Q9BXY4
R-spondin 3		GORGO		272
Uncharacterized protein		HORSE		295
R-spondin 3		AILME		295
R-spondin 3		MACFA		293
+115

Protein	Similar proteins		Species	Score	Length	Source
Q9BXY4	R-spondin-3		BOVIN		273	UniRef50_Q9BXY4
R-spondin 3		GORGO		272
R-spondin 3		AILME		295
Uncharacterized protein		HORSE		295
Uncharacterized protein		MACMU		293
+180

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF251057 mRNA Translation: AAK34947.1 AK027346 mRNA Translation: BAB55051.1 AK314912 mRNA Translation: BAG37424.1 AL590733 Genomic DNA No translation available. AL031776 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48115.1 BC022367 mRNA Translation: AAH22367.1
CCDSⁱ	CCDS5135.1 [Q9BXY4-1]
RefSeqⁱ	NP_116173.2, NM_032784.4 [Q9BXY4-1]
UniGeneⁱ	Hs.135254

3D structure databases

ProteinModelPortalⁱ	Q9BXY4
SMRⁱ	Q9BXY4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124315, 3 interactors
IntActⁱ	Q9BXY4, 2 interactors
MINTⁱ	Q9BXY4
STRINGⁱ	9606.ENSP00000349131

PTM databases

iPTMnetⁱ	Q9BXY4
PhosphoSitePlusⁱ	Q9BXY4

Polymorphism and mutation databases

DMDMⁱ	74752442

DMDMⁱ

74752442

Proteomic databases

PaxDbⁱ	Q9BXY4
PeptideAtlasⁱ	Q9BXY4
PRIDEⁱ	Q9BXY4
ProteomicsDBⁱ	79540 79541 [Q9BXY4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84870
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356698; ENSP00000349131; ENSG00000146374 [Q9BXY4-1] ENST00000368317; ENSP00000357300; ENSG00000146374 [Q9BXY4-2]
GeneIDⁱ	84870
KEGGⁱ	hsa:84870
UCSCⁱ	uc003qar.5 human [Q9BXY4-1]

Organism-specific databases

CTDⁱ	84870
DisGeNETⁱ	84870
EuPathDBⁱ	HostDB:ENSG00000146374.13
GeneCardsⁱ	RSPO3
HGNCⁱ	HGNC:20866 RSPO3
HPAⁱ	HPA029957
MIMⁱ	610574 gene
neXtProtⁱ	NX_Q9BXY4
OpenTargetsⁱ	ENSG00000146374
PharmGKBⁱ	PA134885289
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3525 Eukaryota COG1404 LUCA
GeneTreeⁱ	ENSGT00390000011447
HOGENOMⁱ	HOG000290668
HOVERGENⁱ	HBG082751
InParanoidⁱ	Q9BXY4
OMAⁱ	MECTSIV
OrthoDBⁱ	EOG091G0FYC
PhylomeDBⁱ	Q9BXY4
TreeFamⁱ	TF331799

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4641263 Regulation of FZD by ubiquitination R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling
SIGNORⁱ	Q9BXY4

Miscellaneous databases

ChiTaRSⁱ	RSPO3 human
GeneWikiⁱ	RSPO3
GenomeRNAiⁱ	84870
Protein Ontology More...PROⁱ	PR:Q9BXY4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000146374 Expressed in 173 organ(s), highest expression level in myometrium
CleanExⁱ	HS_RSPO3
Genevisibleⁱ	Q9BXY4 HS

Family and domain databases

CDDⁱ	cd00064 FU, 1 hit
Gene3Dⁱ	2.20.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR006212 Furin_repeat IPR009030 Growth_fac_rcpt_cys_sf IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
Pfamⁱ	View protein in Pfam PF15913 Furin-like_2, 1 hit
SMARTⁱ	View protein in SMART SM00261 FU, 2 hits SM00209 TSP1, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF82895 SSF82895, 1 hit
PROSITEⁱ	View protein in PROSITE PS50092 TSP1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RSPO3_HUMAN
Accessionⁱ	Q9BXY4Primary (citable) accession number: Q9BXY4 Secondary accession number(s): B2RC27, Q5VTV4, Q96K87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BXY4 (RSPO3_HUMAN)

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R-spondin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ