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Protein

Protein MAK16 homolog

Gene

MAK16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MAK16 homolog
Alternative name(s):
NNP78
Protein RBM13
Gene namesi
Name:MAK16
Synonyms:RBM13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000198042.10
HGNCiHGNC:13703 MAK16
neXtProtiNX_Q9BXY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84549
OpenTargetsiENSG00000198042
PharmGKBiPA162394925

Polymorphism and mutation databases

BioMutaiMAK16
DMDMi71152029

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037941 – 300Protein MAK16 homologAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki55Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei197PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BXY0
MaxQBiQ9BXY0
PaxDbiQ9BXY0
PeptideAtlasiQ9BXY0
PRIDEiQ9BXY0
ProteomicsDBi79539

2D gel databases

SWISS-2DPAGEiQ9BXY0

PTM databases

iPTMnetiQ9BXY0
PhosphoSitePlusiQ9BXY0
SwissPalmiQ9BXY0

Expressioni

Gene expression databases

BgeeiENSG00000198042 Expressed in 215 organ(s), highest expression level in amniotic fluid
CleanExiHS_MAK16
ExpressionAtlasiQ9BXY0 baseline and differential
GenevisibleiQ9BXY0 HS

Organism-specific databases

HPAiHPA044417
HPA050574

Interactioni

Protein-protein interaction databases

BioGridi124134, 69 interactors
IntActiQ9BXY0, 12 interactors
STRINGi9606.ENSP00000353246

Structurei

3D structure databases

ProteinModelPortaliQ9BXY0
SMRiQ9BXY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 249Asp-richAdd BLAST52
Compositional biasi255 – 259Poly-Glu5

Sequence similaritiesi

Belongs to the MAK16 family.Curated

Phylogenomic databases

eggNOGiKOG3064 Eukaryota
COG5129 LUCA
GeneTreeiENSGT00390000012859
HOGENOMiHOG000201538
HOVERGENiHBG055328
InParanoidiQ9BXY0
KOiK14831
OMAiDIYNFSQ
OrthoDBiEOG091G0KSQ
PhylomeDBiQ9BXY0
TreeFamiTF105759

Family and domain databases

InterProiView protein in InterPro
IPR029004 L28e/Mak16
IPR006958 Mak16
PfamiView protein in Pfam
PF04874 Mak16, 1 hit
PF01778 Ribosomal_L28e, 1 hit
PIRSFiPIRSF003352 MAK16, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BXY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSDDVIWDT LGNKQFCSFK IRTKTQSFCR NEYSLTGLCN RSSCPLANSQ
60 70 80 90 100
YATIKEEKGQ CYLYMKVIER AAFPRRLWER VRLSKNYEKA LEQIDENLIY
110 120 130 140 150
WPRFIRHKCK QRFTKITQYL IRIRKLTLKR QRKLVPLSKK VERREKRREE
160 170 180 190 200
KALIAAQLDN AIEKELLERL KQDTYGDIYN FPIHAFDKAL EQQEAESDSS
210 220 230 240 250
DTEEKDDDDD DEEDVGKREF VEDGEVDESD ISDFEDMDKL DASSDEDQDG
260 270 280 290 300
KSSSEEEEEK ALSAKHKGKM PLRGPLQRKR AYVEIEYEQE TEPVAKAKTT
Length:300
Mass (Da):35,369
Last modified:July 19, 2005 - v2
Checksum:i2A757589C4749760
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBV6H0YBV6_HUMAN
Protein MAK16 homolog
MAK16
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200S → L in BAB55134 (PubMed:14702039).Curated1
Sequence conflicti281A → V in AAH39740 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023076277Q → R2 PublicationsCorresponds to variant dbSNP:rs6468171Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251062 mRNA Translation: AAK34952.1
AK027469 mRNA Translation: BAB55134.1
AK314491 mRNA Translation: BAG37091.1
CH471080 Genomic DNA Translation: EAW63400.1
BC028230 mRNA Translation: AAH28230.1
BC039740 mRNA Translation: AAH39740.1
BC050528 mRNA Translation: AAH50528.1
CCDSiCCDS6089.1
RefSeqiNP_115898.2, NM_032509.3
UniGeneiHs.583805

Genome annotation databases

EnsembliENST00000360128; ENSP00000353246; ENSG00000198042
GeneIDi84549
KEGGihsa:84549
UCSCiuc003xjj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251062 mRNA Translation: AAK34952.1
AK027469 mRNA Translation: BAB55134.1
AK314491 mRNA Translation: BAG37091.1
CH471080 Genomic DNA Translation: EAW63400.1
BC028230 mRNA Translation: AAH28230.1
BC039740 mRNA Translation: AAH39740.1
BC050528 mRNA Translation: AAH50528.1
CCDSiCCDS6089.1
RefSeqiNP_115898.2, NM_032509.3
UniGeneiHs.583805

3D structure databases

ProteinModelPortaliQ9BXY0
SMRiQ9BXY0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124134, 69 interactors
IntActiQ9BXY0, 12 interactors
STRINGi9606.ENSP00000353246

PTM databases

iPTMnetiQ9BXY0
PhosphoSitePlusiQ9BXY0
SwissPalmiQ9BXY0

Polymorphism and mutation databases

BioMutaiMAK16
DMDMi71152029

2D gel databases

SWISS-2DPAGEiQ9BXY0

Proteomic databases

EPDiQ9BXY0
MaxQBiQ9BXY0
PaxDbiQ9BXY0
PeptideAtlasiQ9BXY0
PRIDEiQ9BXY0
ProteomicsDBi79539

Protocols and materials databases

DNASUi84549
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360128; ENSP00000353246; ENSG00000198042
GeneIDi84549
KEGGihsa:84549
UCSCiuc003xjj.4 human

Organism-specific databases

CTDi84549
DisGeNETi84549
EuPathDBiHostDB:ENSG00000198042.10
GeneCardsiMAK16
HGNCiHGNC:13703 MAK16
HPAiHPA044417
HPA050574
neXtProtiNX_Q9BXY0
OpenTargetsiENSG00000198042
PharmGKBiPA162394925
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3064 Eukaryota
COG5129 LUCA
GeneTreeiENSGT00390000012859
HOGENOMiHOG000201538
HOVERGENiHBG055328
InParanoidiQ9BXY0
KOiK14831
OMAiDIYNFSQ
OrthoDBiEOG091G0KSQ
PhylomeDBiQ9BXY0
TreeFamiTF105759

Miscellaneous databases

GeneWikiiRBM13
GenomeRNAii84549
PROiPR:Q9BXY0

Gene expression databases

BgeeiENSG00000198042 Expressed in 215 organ(s), highest expression level in amniotic fluid
CleanExiHS_MAK16
ExpressionAtlasiQ9BXY0 baseline and differential
GenevisibleiQ9BXY0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029004 L28e/Mak16
IPR006958 Mak16
PfamiView protein in Pfam
PF04874 Mak16, 1 hit
PF01778 Ribosomal_L28e, 1 hit
PIRSFiPIRSF003352 MAK16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAK16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXY0
Secondary accession number(s): B2RB44
, Q5U5T1, Q86UC4, Q96SY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 10, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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