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Entry version 179 (22 Apr 2020)
Sequence version 2 (27 Mar 2002)
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Protein

Oxysterol-binding protein-related protein 1

Gene

OSBPL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-2132295 MHC class II antigen presentation

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001534

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 1
Short name:
ORP-1
Short name:
OSBP-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBPL1A
Synonyms:ORP1, OSBP8, OSBPL1, OSBPL1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16398 OSBPL1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXW6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114876

Open Targets

More...
OpenTargetsi
ENSG00000141447

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32826

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXW6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OSBPL1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20143880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003671 – 950Oxysterol-binding protein-related protein 1Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei499PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXW6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXW6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXW6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXW6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXW6

PeptideAtlas

More...
PeptideAtlasi
Q9BXW6

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXW6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6854
79527 [Q9BXW6-1]
79528 [Q9BXW6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXW6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXW6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141447 Expressed in corpus callosum and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXW6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXW6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141447 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VAPA (By similarity).

Interacts with the GTP-bound form of RAB7A.

Interacts with OAS1B (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125379, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXW6, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320291

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXW6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1950
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BXW6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Repeati175 – 204ANK 3Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 334PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 237Interaction with RAB7A1 PublicationAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili430 – 463Sequence analysisAdd BLAST34
Coiled coili877 – 913Sequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1737 Eukaryota
ENOG410XP9E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155295

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007105_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXW6

KEGG Orthology (KO)

More...
KOi
K20174

Identification of Orthologs from Complete Genome Data

More...
OMAi
SVRCFDD

Database of Orthologous Groups

More...
OrthoDBi
863978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXW6

TreeFam database of animal gene trees

More...
TreeFami
TF320922

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10972 PTHR10972, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q9BXW6-1) [UniParc]FASTAAdd to basket
Also known as: OSBPL1B, OSBP8L, ORP1L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTEAEQQLL HHARNGNAEE VRQLLETMAR NEVIADINCK GRSKSNLGWT
60 70 80 90 100
PLHLACYFGH RQVVQDLLKA GAEVNVLNDM GDTPLHRAAF TGRKELVMLL
110 120 130 140 150
LEYNADTTIV NGSGQTAKEV THAEEIRSML EAVERTQQRK LEELLLAAAR
160 170 180 190 200
EGKTTELTAL LNRPNPPDVN CSDQLGNTPL HCAAYRAHKQ CALKLLRSGA
210 220 230 240 250
DPNLKNKNDQ KPLDLAQGAE MKHILVGNKV IYKALKRYEG PLWKSSRFFG
260 270 280 290 300
WRLFWVVLEH GVLSWYRKQP DAVHNIYRQG CKHLTQAVCT VKSTDSCLFF
310 320 330 340 350
IKCFDDTIHG FRVPKNSLQQ SREDWLEAIE EHSAYSTHYC SQDQLTDEEE
360 370 380 390 400
EDTVSAADLK KSLEKAQSCQ QRLDREISNF LKMIKECDMA KEMLPSFLQK
410 420 430 440 450
VEVVSEASRE TCVALTDCLN LFTKQEGVRN FKLEQEQEKN KILSEALETL
460 470 480 490 500
ATEHHELEQS LVKGSPPASI LSEDEFYDAL SDSESERSLS RLEAVTARSF
510 520 530 540 550
EEEGEHLGSR KHRMSEEKDC GGGDALSNGI KKHRTSLPSP MFSRNDFSIW
560 570 580 590 600
SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSLSDPV
610 620 630 640 650
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS
660 670 680 690 700
HHPPISAFHA EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLEHN
710 720 730 740 750
EAYTWTNPTC CVHNIIVGKL WIEQYGNVEI INHKTGDKCV LNFKPCGLFG
760 770 780 790 800
KELHKVEGYI QDKSKKKLCA LYGKWTECLY SVDPATFDAY KKNDKKNTEE
810 820 830 840 850
KKNSKQMSTS EELDEMPVPD SESVFIIPGS VLLWRIAPRP PNSAQMYNFT
860 870 880 890 900
SFAMVLNEVD KDMESVIPKT DCRLRPDIRA MENGEIDQAS EEKKRLEEKQ
910 920 930 940 950
RAARKNRSKS EEDWKTRWFH QGPNPYNGAQ DWIYSGSYWD RNYFNLPDIY
Length:950
Mass (Da):108,470
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDDA26CA27B65F63
GO
Isoform A (identifier: Q9BXW6-2) [UniParc]FASTAAdd to basket
Also known as: OSBPL1A, OSBP8S

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.

Show »
Length:437
Mass (Da):50,253
Checksum:i4723A83A95737985
GO
Isoform 4 (identifier: Q9BXW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-382: Missing.

Show »
Length:568
Mass (Da):65,095
Checksum:i4D2331E52BE3632C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSB8J3QSB8_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER58E7ER58_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRT6J3KRT6_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSG6J3KSG6_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTA6J3KTA6_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLA2J3QLA2_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRU5A0A1W2PRU5_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS61J3QS61_HUMAN
Oxysterol-binding protein-related p...
OSBPL1A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG53407 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti735T → A in AK001079 (PubMed:14702039).Curated1
Sequence conflicti841P → S in AAL40662 (PubMed:11735225).Curated1
Sequence conflicti844A → G in AAL40662 (PubMed:11735225).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053547810S → P1 PublicationCorresponds to variant dbSNP:rs35693789Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0037791 – 513Missing in isoform A. 3 PublicationsAdd BLAST513
Alternative sequenceiVSP_0454431 – 382Missing in isoform 4. 1 PublicationAdd BLAST382

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF392449 mRNA Translation: AAL40662.1
AF392450 mRNA Translation: AAL40663.1
AF274714 mRNA Translation: AAK15154.1
AF323726 mRNA Translation: AAG53407.2 Sequence problems.
AK001079 mRNA No translation available.
AK301862 mRNA Translation: BAH13569.1
AC023983 Genomic DNA No translation available.
AC090772 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS11884.1 [Q9BXW6-1]
CCDS11885.1 [Q9BXW6-2]
CCDS56056.1 [Q9BXW6-4]

NCBI Reference Sequences

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RefSeqi
NP_001229437.1, NM_001242508.1 [Q9BXW6-4]
NP_060500.3, NM_018030.4 [Q9BXW6-2]
NP_542164.2, NM_080597.3 [Q9BXW6-1]
XP_016881022.1, XM_017025533.1 [Q9BXW6-2]
XP_016881023.1, XM_017025534.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000319481; ENSP00000320291; ENSG00000141447 [Q9BXW6-1]
ENST00000357041; ENSP00000349545; ENSG00000141447 [Q9BXW6-4]
ENST00000399443; ENSP00000382372; ENSG00000141447 [Q9BXW6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114876

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:114876

UCSC genome browser

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UCSCi
uc002kvd.5 human [Q9BXW6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392449 mRNA Translation: AAL40662.1
AF392450 mRNA Translation: AAL40663.1
AF274714 mRNA Translation: AAK15154.1
AF323726 mRNA Translation: AAG53407.2 Sequence problems.
AK001079 mRNA No translation available.
AK301862 mRNA Translation: BAH13569.1
AC023983 Genomic DNA No translation available.
AC090772 Genomic DNA No translation available.
CCDSiCCDS11884.1 [Q9BXW6-1]
CCDS11885.1 [Q9BXW6-2]
CCDS56056.1 [Q9BXW6-4]
RefSeqiNP_001229437.1, NM_001242508.1 [Q9BXW6-4]
NP_060500.3, NM_018030.4 [Q9BXW6-2]
NP_542164.2, NM_080597.3 [Q9BXW6-1]
XP_016881022.1, XM_017025533.1 [Q9BXW6-2]
XP_016881023.1, XM_017025534.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5ZM5X-ray2.60A534-950[»]
5ZM6X-ray2.70A/B524-950[»]
5ZM7X-ray3.40A524-950[»]
6IYBX-ray2.09B/D5-152[»]
SMRiQ9BXW6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi125379, 26 interactors
IntActiQ9BXW6, 21 interactors
STRINGi9606.ENSP00000320291

Chemistry databases

SwissLipidsiSLP:000001534

PTM databases

iPTMnetiQ9BXW6
PhosphoSitePlusiQ9BXW6

Polymorphism and mutation databases

BioMutaiOSBPL1A
DMDMi20143880

Proteomic databases

EPDiQ9BXW6
jPOSTiQ9BXW6
MassIVEiQ9BXW6
MaxQBiQ9BXW6
PaxDbiQ9BXW6
PeptideAtlasiQ9BXW6
PRIDEiQ9BXW6
ProteomicsDBi6854
79527 [Q9BXW6-1]
79528 [Q9BXW6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22086 187 antibodies

Genome annotation databases

EnsembliENST00000319481; ENSP00000320291; ENSG00000141447 [Q9BXW6-1]
ENST00000357041; ENSP00000349545; ENSG00000141447 [Q9BXW6-4]
ENST00000399443; ENSP00000382372; ENSG00000141447 [Q9BXW6-2]
GeneIDi114876
KEGGihsa:114876
UCSCiuc002kvd.5 human [Q9BXW6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114876
DisGeNETi114876

GeneCards: human genes, protein and diseases

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GeneCardsi
OSBPL1A
HGNCiHGNC:16398 OSBPL1A
HPAiENSG00000141447 Tissue enhanced (skeletal)
MIMi606730 gene
neXtProtiNX_Q9BXW6
OpenTargetsiENSG00000141447
PharmGKBiPA32826

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00940000155295
HOGENOMiCLU_007105_5_1_1
InParanoidiQ9BXW6
KOiK20174
OMAiSVRCFDD
OrthoDBi863978at2759
PhylomeDBiQ9BXW6
TreeFamiTF320922

Enzyme and pathway databases

ReactomeiR-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-2132295 MHC class II antigen presentation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OSBPL1A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OSBPL1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
114876
PharosiQ9BXW6 Tbio

Protein Ontology

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PROi
PR:Q9BXW6
RNActiQ9BXW6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141447 Expressed in corpus callosum and 229 other tissues
ExpressionAtlasiQ9BXW6 baseline and differential
GenevisibleiQ9BXW6 HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 2 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXW6
Secondary accession number(s): B7Z7D3, Q9BZF5, Q9NW87
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 27, 2002
Last modified: April 22, 2020
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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