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Protein

Microtubule-associated proteins 1A/1B light chain 3C

Gene

MAP1LC3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).2 Publications

GO - Molecular functioni

  • microtubule binding Source: GO_Central
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • aggrephagy Source: UniProtKB
  • autophagosome assembly Source: GO_Central
  • autophagosome maturation Source: UniProtKB
  • autophagy of mitochondrion Source: GO_Central
  • cellular response to nitrogen starvation Source: GO_Central
  • cellular response to starvation Source: UniProtKB
  • macroautophagy Source: UniProtKB

Keywordsi

Biological processAutophagy, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SIGNORiQ9BXW4

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated proteins 1A/1B light chain 3C
Alternative name(s):
Autophagy-related protein LC3 C
Autophagy-related ubiquitin-like modifier LC3 C
MAP1 light chain 3-like protein 3
MAP1A/MAP1B light chain 3 C
Short name:
MAP1A/MAP1B LC3 C
Microtubule-associated protein 1 light chain 3 gamma
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197769.5
HGNCiHGNC:13353 MAP1LC3C
MIMi609605 gene
neXtProtiNX_Q9BXW4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi126G → A: No processing of precursor. 1 Publication1

Organism-specific databases

DisGeNETi440738
OpenTargetsiENSG00000197769
PharmGKBiPA142671482

Polymorphism and mutation databases

BioMutaiMAP1LC3C
DMDMi84028113

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000172041 – 126Microtubule-associated proteins 1A/1B light chain 3CAdd BLAST126
PropeptideiPRO_0000017205127 – 147Removed in mature formAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi126Phosphatidylethanolamine amidated glycine1 Publication1

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).1 Publication
The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127Cleavage; by ATG4BBy similarity2

Keywords - PTMi

Lipoprotein

Proteomic databases

PaxDbiQ9BXW4
PRIDEiQ9BXW4
ProteomicsDBi79526

Expressioni

Tissue specificityi

Most abundant in placenta, lung and ovary.1 Publication

Gene expression databases

BgeeiENSG00000197769 Expressed in 136 organ(s), highest expression level in esophagus
CleanExiHS_MAP1LC3C
GenevisibleiQ9BXW4 HS

Organism-specific databases

HPAiHPA072670

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with ATG13 (PubMed:24290141). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDR81; recruits MAP1LC3C to ubiquitinated protein aggregates in the aggrephagy process (PubMed:28404643).By similarity10 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi136855, 29 interactors
DIPiDIP-57020N
ELMiQ9BXW4
IntActiQ9BXW4, 68 interactors
MINTiQ9BXW4
STRINGi9606.ENSP00000349785

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BXW4
SMRiQ9BXW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiKOG1654 Eukaryota
ENOG4111JAT LUCA
GeneTreeiENSGT00390000012937
HOGENOMiHOG000232034
HOVERGENiHBG051706
InParanoidiQ9BXW4
KOiK10435
OMAiTQFVTII
OrthoDBiEOG091G18ST
PhylomeDBiQ9BXW4
TreeFamiTF312964

Family and domain databases

CDDicd01611 GABARAP, 1 hit
InterProiView protein in InterPro
IPR004241 Atg8-like
IPR027731 MAP1A/MAP1B_LC3C
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10969 PTHR10969, 1 hit
PTHR10969:SF41 PTHR10969:SF41, 1 hit
PfamiView protein in Pfam
PF02991 Atg8, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPQKIPSV RPFKQRKSLA IRQEEVAGIR AKFPNKIPVV VERYPRETFL
60 70 80 90 100
PPLDKTKFLV PQELTMTQFL SIIRSRMVLR ATEAFYLLVN NKSLVSMSAT
110 120 130 140
MAEIYRDYKD EDGFVYMTYA SQETFGCLES AAPRDGSSLE DRPCNPL
Length:147
Mass (Da):16,852
Last modified:June 1, 2001 - v1
Checksum:iD3DFA8EE5985C3AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276659 mRNA Translation: AAK35152.1
BX571673 Genomic DNA No translation available.
BC127722 mRNA Translation: AAI27723.1
BC132986 mRNA Translation: AAI32987.1
BC132988 mRNA Translation: AAI32989.1
CCDSiCCDS31074.1
RefSeqiNP_001004343.1, NM_001004343.2
XP_005273196.1, XM_005273139.3
UniGeneiHs.534971

Genome annotation databases

EnsembliENST00000357246; ENSP00000349785; ENSG00000197769
GeneIDi440738
KEGGihsa:440738
UCSCiuc001hzk.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276659 mRNA Translation: AAK35152.1
BX571673 Genomic DNA No translation available.
BC127722 mRNA Translation: AAI27723.1
BC132986 mRNA Translation: AAI32987.1
BC132988 mRNA Translation: AAI32989.1
CCDSiCCDS31074.1
RefSeqiNP_001004343.1, NM_001004343.2
XP_005273196.1, XM_005273139.3
UniGeneiHs.534971

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NCNNMR-A1-126[»]
3VVWX-ray2.50B1-126[»]
3WAMX-ray1.75A8-125[»]
3WAPX-ray3.10A8-125[»]
5DPWX-ray2.19A/C/E/G/I/K/M/O8-125[»]
ProteinModelPortaliQ9BXW4
SMRiQ9BXW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136855, 29 interactors
DIPiDIP-57020N
ELMiQ9BXW4
IntActiQ9BXW4, 68 interactors
MINTiQ9BXW4
STRINGi9606.ENSP00000349785

Polymorphism and mutation databases

BioMutaiMAP1LC3C
DMDMi84028113

Proteomic databases

PaxDbiQ9BXW4
PRIDEiQ9BXW4
ProteomicsDBi79526

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357246; ENSP00000349785; ENSG00000197769
GeneIDi440738
KEGGihsa:440738
UCSCiuc001hzk.3 human

Organism-specific databases

CTDi440738
DisGeNETi440738
EuPathDBiHostDB:ENSG00000197769.5
GeneCardsiMAP1LC3C
HGNCiHGNC:13353 MAP1LC3C
HPAiHPA072670
MIMi609605 gene
neXtProtiNX_Q9BXW4
OpenTargetsiENSG00000197769
PharmGKBiPA142671482
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1654 Eukaryota
ENOG4111JAT LUCA
GeneTreeiENSGT00390000012937
HOGENOMiHOG000232034
HOVERGENiHBG051706
InParanoidiQ9BXW4
KOiK10435
OMAiTQFVTII
OrthoDBiEOG091G18ST
PhylomeDBiQ9BXW4
TreeFamiTF312964

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SIGNORiQ9BXW4

Miscellaneous databases

GenomeRNAii440738
PROiPR:Q9BXW4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197769 Expressed in 136 organ(s), highest expression level in esophagus
CleanExiHS_MAP1LC3C
GenevisibleiQ9BXW4 HS

Family and domain databases

CDDicd01611 GABARAP, 1 hit
InterProiView protein in InterPro
IPR004241 Atg8-like
IPR027731 MAP1A/MAP1B_LC3C
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10969 PTHR10969, 1 hit
PTHR10969:SF41 PTHR10969:SF41, 1 hit
PfamiView protein in Pfam
PF02991 Atg8, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMLP3C_HUMAN
AccessioniPrimary (citable) accession number: Q9BXW4
Secondary accession number(s): A0PJY8, A2RUP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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