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UniProtKB - Q9BXU1 (STK31_HUMAN)
Protein
Serine/threonine-protein kinase 31
Gene
STK31
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 737 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 716 – 724 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9BXU1 |
SignaLinki | Q9BXU1 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 31 (EC:2.7.11.1)Alternative name(s): Serine/threonine-protein kinase NYD-SPK Sugen kinase 396 Short name: SgK396 |
Gene namesi | Name:STK31 Synonyms:SGK396 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11407, STK31 |
MIMi | 605790, gene |
neXtProti | NX_Q9BXU1 |
VEuPathDBi | HostDB:ENSG00000196335 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56164 |
OpenTargetsi | ENSG00000196335 |
PharmGKBi | PA36214 |
Miscellaneous databases
Pharosi | Q9BXU1, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6151 |
GuidetoPHARMACOLOGYi | 2220 |
Genetic variation databases
BioMutai | STK31 |
DMDMi | 143811463 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086715 | 1 – 1019 | Serine/threonine-protein kinase 31Add BLAST | 1019 |
Proteomic databases
MassIVEi | Q9BXU1 |
MaxQBi | Q9BXU1 |
PaxDbi | Q9BXU1 |
PeptideAtlasi | Q9BXU1 |
PRIDEi | Q9BXU1 |
ProteomicsDBi | 5561 79517 [Q9BXU1-1] 79518 [Q9BXU1-2] |
PTM databases
GlyGeni | Q9BXU1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXU1 |
PhosphoSitePlusi | Q9BXU1 |
Expressioni
Tissue specificityi
Testis specific.
Gene expression databases
Bgeei | ENSG00000196335, Expressed in testis and 112 other tissues |
ExpressionAtlasi | Q9BXU1, baseline and differential |
Genevisiblei | Q9BXU1, HS |
Organism-specific databases
HPAi | ENSG00000196335, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121097, 10 interactors |
IntActi | Q9BXU1, 6 interactors |
MINTi | Q9BXU1 |
STRINGi | 9606.ENSP00000348132 |
Chemistry databases
BindingDBi | Q9BXU1 |
Miscellaneous databases
RNActi | Q9BXU1, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 137 | TudorPROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 710 – 1019 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 310 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 298 – 355 | Sequence analysisAdd BLAST | 58 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPJA, Eukaryota |
GeneTreei | ENSGT00390000007287 |
HOGENOMi | CLU_011956_0_0_1 |
InParanoidi | Q9BXU1 |
OMAi | WKCGKRE |
OrthoDBi | 104495at2759 |
PhylomeDBi | Q9BXU1 |
TreeFami | TF105335 |
Family and domain databases
CDDi | cd04508, TUDOR, 1 hit |
Gene3Di | 2.40.50.90, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR035437, SNase_OB-fold_sf IPR002999, Tudor |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00567, TUDOR, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00333, TUDOR, 1 hit |
SUPFAMi | SSF50199, SSF50199, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50304, TUDOR, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ
60 70 80 90 100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV
110 120 130 140 150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI
160 170 180 190 200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG
210 220 230 240 250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS
260 270 280 290 300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN
360 370 380 390 400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG
410 420 430 440 450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM
460 470 480 490 500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD
510 520 530 540 550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN
560 570 580 590 600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
610 620 630 640 650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK
660 670 680 690 700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF
710 720 730 740 750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV
760 770 780 790 800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK
810 820 830 840 850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI
860 870 880 890 900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
910 920 930 940 950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL
960 970 980 990 1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT
1010
ENLDKCMEKT RNGEANFDC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQW5 | C9JQW5_HUMAN | Serine/threonine-protein kinase 31 | STK31 | 159 | Annotation score: | ||
C9JPB1 | C9JPB1_HUMAN | Serine/threonine-protein kinase 31 | STK31 | 140 | Annotation score: | ||
F8W6E7 | F8W6E7_HUMAN | Serine/threonine-protein kinase 31 | STK31 | 93 | Annotation score: | ||
E9PRQ0 | E9PRQ0_HUMAN | Serine/threonine-protein kinase 31 | STK31 | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 300 | I → F in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 509 | F → Y in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 621 – 623 | NKS → KKI in AAK31978 (PubMed:11279525).Curated | 3 | |
Sequence conflicti | 715 | Y → C in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 820 | V → A in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 948 | K → I in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 963 | A → G in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1000 | T → P in AAK17193 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1010 | T → P in AAK31978 (PubMed:11279525).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031600 | 71 | Q → H2 PublicationsCorresponds to variant dbSNP:rs6945306Ensembl. | 1 | |
Natural variantiVAR_041150 | 125 | S → F1 PublicationCorresponds to variant dbSNP:rs56268851Ensembl. | 1 | |
Natural variantiVAR_031601 | 261 | E → K1 PublicationCorresponds to variant dbSNP:rs10264952Ensembl. | 1 | |
Natural variantiVAR_031602 | 268 | K → N1 PublicationCorresponds to variant dbSNP:rs10264967Ensembl. | 1 | |
Natural variantiVAR_041151 | 277 | I → K1 PublicationCorresponds to variant dbSNP:rs55950645Ensembl. | 1 | |
Natural variantiVAR_031603 | 362 | T → P. Corresponds to variant dbSNP:rs35545265Ensembl. | 1 | |
Natural variantiVAR_051675 | 385 | R → C. Corresponds to variant dbSNP:rs35995607Ensembl. | 1 | |
Natural variantiVAR_041152 | 393 | A → T1 PublicationCorresponds to variant dbSNP:rs56244148Ensembl. | 1 | |
Natural variantiVAR_031604 | 410 | G → E1 PublicationCorresponds to variant dbSNP:rs4722266Ensembl. | 1 | |
Natural variantiVAR_041153 | 489 | A → P1 PublicationCorresponds to variant dbSNP:rs34414354Ensembl. | 1 | |
Natural variantiVAR_041154 | 600 | A → T1 PublicationCorresponds to variant dbSNP:rs55796076Ensembl. | 1 | |
Natural variantiVAR_041155 | 621 | N → K1 PublicationCorresponds to variant dbSNP:rs10263079Ensembl. | 1 | |
Natural variantiVAR_041156 | 623 | S → I1 PublicationCorresponds to variant dbSNP:rs10247878Ensembl. | 1 | |
Natural variantiVAR_041157 | 684 | H → R1 PublicationCorresponds to variant dbSNP:rs41273999Ensembl. | 1 | |
Natural variantiVAR_041158 | 684 | H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041159 | 709 | E → K1 PublicationCorresponds to variant dbSNP:rs56181834Ensembl. | 1 | |
Natural variantiVAR_041160 | 860 | V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041161 | 1000 | T → M1 PublicationCorresponds to variant dbSNP:rs55794023Ensembl. | 1 | |
Natural variantiVAR_031605 | 1009 | K → T. Corresponds to variant dbSNP:rs33998018Ensembl. | 1 | |
Natural variantiVAR_041162 | 1010 | T → S1 PublicationCorresponds to variant dbSNP:rs56391043Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024389 | 1 – 23 | Missing in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_045210 | 921 – 943 | Missing in isoform 3. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285599 mRNA Translation: AAK31978.1 AF332194 mRNA Translation: AAK17193.1 AK302689 mRNA Translation: BAG63918.1 AC003087 Genomic DNA No translation available. AC008176 Genomic DNA No translation available. BC059374 mRNA Translation: AAH59374.1 |
CCDSi | CCDS43556.1 [Q9BXU1-2] CCDS5386.1 [Q9BXU1-1] CCDS59049.1 [Q9BXU1-3] |
RefSeqi | NP_001247433.1, NM_001260504.1 [Q9BXU1-2] NP_001247434.1, NM_001260505.1 [Q9BXU1-3] NP_113602.2, NM_031414.4 [Q9BXU1-1] NP_116562.2, NM_032944.3 [Q9BXU1-2] |
Genome annotation databases
Ensembli | ENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2] ENST00000355870; ENSP00000348132; ENSG00000196335 ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3] |
GeneIDi | 56164 |
KEGGi | hsa:56164 |
MANE-Selecti | ENST00000355870.8; ENSP00000348132.3; NM_031414.5; NP_113602.2 |
UCSCi | uc003sws.6, human [Q9BXU1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285599 mRNA Translation: AAK31978.1 AF332194 mRNA Translation: AAK17193.1 AK302689 mRNA Translation: BAG63918.1 AC003087 Genomic DNA No translation available. AC008176 Genomic DNA No translation available. BC059374 mRNA Translation: AAH59374.1 |
CCDSi | CCDS43556.1 [Q9BXU1-2] CCDS5386.1 [Q9BXU1-1] CCDS59049.1 [Q9BXU1-3] |
RefSeqi | NP_001247433.1, NM_001260504.1 [Q9BXU1-2] NP_001247434.1, NM_001260505.1 [Q9BXU1-3] NP_113602.2, NM_031414.4 [Q9BXU1-1] NP_116562.2, NM_032944.3 [Q9BXU1-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121097, 10 interactors |
IntActi | Q9BXU1, 6 interactors |
MINTi | Q9BXU1 |
STRINGi | 9606.ENSP00000348132 |
Chemistry databases
BindingDBi | Q9BXU1 |
ChEMBLi | CHEMBL6151 |
GuidetoPHARMACOLOGYi | 2220 |
PTM databases
GlyGeni | Q9BXU1, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXU1 |
PhosphoSitePlusi | Q9BXU1 |
Genetic variation databases
BioMutai | STK31 |
DMDMi | 143811463 |
Proteomic databases
MassIVEi | Q9BXU1 |
MaxQBi | Q9BXU1 |
PaxDbi | Q9BXU1 |
PeptideAtlasi | Q9BXU1 |
PRIDEi | Q9BXU1 |
ProteomicsDBi | 5561 79517 [Q9BXU1-1] 79518 [Q9BXU1-2] |
Protocols and materials databases
Antibodypediai | 12132, 239 antibodies from 29 providers |
DNASUi | 56164 |
Genome annotation databases
Ensembli | ENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2] ENST00000355870; ENSP00000348132; ENSG00000196335 ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3] |
GeneIDi | 56164 |
KEGGi | hsa:56164 |
MANE-Selecti | ENST00000355870.8; ENSP00000348132.3; NM_031414.5; NP_113602.2 |
UCSCi | uc003sws.6, human [Q9BXU1-1] |
Organism-specific databases
CTDi | 56164 |
DisGeNETi | 56164 |
GeneCardsi | STK31 |
HGNCi | HGNC:11407, STK31 |
HPAi | ENSG00000196335, Tissue enriched (testis) |
MIMi | 605790, gene |
neXtProti | NX_Q9BXU1 |
OpenTargetsi | ENSG00000196335 |
PharmGKBi | PA36214 |
VEuPathDBi | HostDB:ENSG00000196335 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPJA, Eukaryota |
GeneTreei | ENSGT00390000007287 |
HOGENOMi | CLU_011956_0_0_1 |
InParanoidi | Q9BXU1 |
OMAi | WKCGKRE |
OrthoDBi | 104495at2759 |
PhylomeDBi | Q9BXU1 |
TreeFami | TF105335 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9BXU1 |
SignaLinki | Q9BXU1 |
Miscellaneous databases
BioGRID-ORCSi | 56164, 7 hits in 1067 CRISPR screens |
GenomeRNAii | 56164 |
Pharosi | Q9BXU1, Tchem |
PROi | PR:Q9BXU1 |
RNActi | Q9BXU1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196335, Expressed in testis and 112 other tissues |
ExpressionAtlasi | Q9BXU1, baseline and differential |
Genevisiblei | Q9BXU1, HS |
Family and domain databases
CDDi | cd04508, TUDOR, 1 hit |
Gene3Di | 2.40.50.90, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR035437, SNase_OB-fold_sf IPR002999, Tudor |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00567, TUDOR, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00333, TUDOR, 1 hit |
SUPFAMi | SSF50199, SSF50199, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS50304, TUDOR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STK31_HUMAN | |
Accessioni | Q9BXU1Primary (citable) accession number: Q9BXU1 Secondary accession number(s): B4DZ06 Q9BXH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families