UniProtKB - Q9BXU1 (STK31_HUMAN)

BLAST

>sp|Q9BXU1|STK31_HUMAN Serine/threonine-protein kinase 31 OS=Homo sapiens OX=9606 GN=STK31 PE=2 SV=2
MWVQGHSSRASATESVSFSGIVQMDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMK
IGCSLSEVCPQASSVLGNLDPNKIYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTE
ILNRSDIVEIPLELQFSSVAKKYKLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIK
ATSEDGTVIAQAEYGSVDIGEEVLKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPI
PLWGHRSNQSTFSRPKGHLSEKMTLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKI
KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI
DTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSL
AQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEA
VYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEG
SLISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIA
TVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPD
GSQIEKIKEEITQLRNNVFQEIYHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGG
LLTMSLERDLLDAEPMKELSSKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRA
WREAEGDSGLLPLIFLFLCKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQ
GLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELK
MGKPASPGSDLYAYGCLLLWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSS
MTAEQVLNAECFLMPKEQSVPNPEKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC

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History
Entry version 160 (07 Nov 2018)
Sequence version 2 (03 Apr 2007)
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Protein

Serine/threonine-protein kinase 31

Gene

STK31

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	737	ATPPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	716 – 724	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
nuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

RNA catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
SignaLinkⁱ	Q9BXU1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase 31 (EC:2.7.11.1) Alternative name(s): Serine/threonine-protein kinase NYD-SPK Sugen kinase 396 Short name: SgK396
Gene namesⁱ	Name:STK31 Synonyms:SGK396
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196335.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11407 STK31
MIMⁱ	605790 gene
neXtProtⁱ	NX_Q9BXU1

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56164
Open Targets More...OpenTargetsⁱ	ENSG00000196335
PharmGKBⁱ	PA36214

Chemistry databases

ChEMBLⁱ	CHEMBL6151
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2220

Polymorphism and mutation databases

BioMutaⁱ	STK31
DMDMⁱ	143811463

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086715	1 – 1019	Serine/threonine-protein kinase 31Add BLAST		1019

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXU1
PaxDbⁱ	Q9BXU1
PeptideAtlas More...PeptideAtlasⁱ	Q9BXU1
PRIDEⁱ	Q9BXU1
ProteomicsDBⁱ	79517 79518 [Q9BXU1-2]

PTM databases

iPTMnetⁱ	Q9BXU1
PhosphoSitePlusⁱ	Q9BXU1

Expressionⁱ

Tissue specificityⁱ

Testis specific.

Gene expression databases

Bgeeⁱ	ENSG00000196335 Expressed in 92 organ(s), highest expression level in testis
CleanExⁱ	HS_STK31
ExpressionAtlasⁱ	Q9BXU1 baseline and differential
Genevisibleⁱ	Q9BXU1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023194

HPAⁱ

HPA023194

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	121097, 4 interactors
IntActⁱ	Q9BXU1, 1 interactor
STRINGⁱ	9606.ENSP00000348132

Chemistry databases

BindingDBⁱ

Q9BXU1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXU1
SMRⁱ	Q9BXU1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	78 – 137	TudorPROSITE-ProRule annotationAdd BLAST		60
Domainⁱ	710 – 1019	Protein kinasePROSITE-ProRule annotationAdd BLAST		310

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	298 – 355	Sequence analysisAdd BLAST		58

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IF5N Eukaryota ENOG410XQIZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007287
HOGENOMⁱ	HOG000154440
HOVERGENⁱ	HBG062739
InParanoidⁱ	Q9BXU1
KEGG Orthology (KO) More...KOⁱ	K16316
OMAⁱ	VQQKLYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PO7
PhylomeDBⁱ	Q9BXU1
TreeFamⁱ	TF105335

Family and domain databases

Gene3Dⁱ	2.40.50.90, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR035437 SNase_OB-fold_sf IPR002999 Tudor
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00567 TUDOR, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit SM00333 TUDOR, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS50304 TUDOR, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ 
        60         70         80         90        100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV 
       110        120        130        140        150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI 
       160        170        180        190        200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG 
       210        220        230        240        250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS 
       260        270        280        290        300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI 
       310        320        330        340        350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN 
       360        370        380        390        400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG 
       410        420        430        440        450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM 
       460        470        480        490        500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD 
       510        520        530        540        550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN 
       560        570        580        590        600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA 
       610        620        630        640        650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK 
       660        670        680        690        700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF 
       710        720        730        740        750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV 
       760        770        780        790        800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK 
       810        820        830        840        850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI 
       860        870        880        890        900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK 
       910        920        930        940        950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL 
       960        970        980        990       1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT 
      1010 
ENLDKCMEKT RNGEANFDC

Length:1,019

Mass (Da):115,694

Last modified:April 3, 2007 - v2

Checksum:ⁱC2EFF005A820E102

Isoform 2 (identifier: Q9BXU1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-23: Missing.

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        10         20         30         40         50
MDEDTHYDKV EDVVGSHIED AVTFWAQSIN RNKDIMKIGC SLSEVCPQAS 
        60         70         80         90        100
SVLGNLDPNK IYGGLFSEDQ CWYRCKVLKI ISVEKCLVRY IDYGNTEILN 
       110        120        130        140        150
RSDIVEIPLE LQFSSVAKKY KLWGLHIPSD QEVTQFDQGT TFLGSLIFEK 
       160        170        180        190        200
EIKMRIKATS EDGTVIAQAE YGSVDIGEEV LKKGFAEKCR LASRTDICEE 
       210        220        230        240        250
KKLDPGQLVL RNLKSPIPLW GHRSNQSTFS RPKGHLSEKM TLDLKDENDA 
       260        270        280        290        300
GNLITFPKES LAVGDFNLGS NVSLEKIKQD QKLIEENEKL KTEKDALLES 
       310        320        330        340        350
YKALELKVEQ IAQELQQEKA AAVDLTNHLE YTLKTYIDTR MKNLAAKMEI 
       360        370        380        390        400
LKEMRHVDIS VRFGKDLSDA IQVLDEGCFT TPASLNGLEI IWAEYSLAQE 
       410        420        430        440        450
NIKTCEYVSE GNILIAQRNE MQQKLYMSVE DFILEVDESS LNKRLKTLQD 
       460        470        480        490        500
LSVSLEAVYG QAKEGANSDE ILKKFYDWKC DKREEFTSVR SETDASLHRL 
       510        520        530        540        550
VAWFQRTLKV FDLSVEGSLI SEDAMDNIDE ILEKTESSVC KELEIALVDQ 
       560        570        580        590        600
GDADKEIISN TYSQVLQKIH SEERLIATVQ AKYKDSIEFK KQLIEYLNKS 
       610        620        630        640        650
PSVDHLLSIK KTLKSLKALL RWKLVEKSNL EESDDPDGSQ IEKIKEEITQ 
       660        670        680        690        700
LRNNVFQEIY HEREEYEMLT SLAQKWFPEL PLLHPEIGLL KYMNSGGLLT 
       710        720        730        740        750
MSLERDLLDA EPMKELSSKR PLVRSEVNGQ IILLKGYSVD VDTEAKVIER 
       760        770        780        790        800
AATYHRAWRE AEGDSGLLPL IFLFLCKSDP MAYLMVPYYP RANLNAVQAN 
       810        820        830        840        850
MPLNSEETLK VMKGVAQGLH TLHKADIIHG SLHQNNVFAL NREQGIVGDF 
       860        870        880        890        900
DFTKSVSQRA SVNMMVGDLS LMSPELKMGK PASPGSDLYA YGCLLLWLSV 
       910        920        930        940        950
QNQEFEINKD GIPKVDQFHL DDKVKSLLCS LICYRSSMTA EQVLNAECFL 
       960        970        980        990 
MPKEQSVPNP EKDTEYTLYK KEEEIKTENL DKCMEKTRNG EANFDC

Note: No experimental confirmation available.

Show »

Length:996

Mass (Da):113,260

Checksum:ⁱE9D528F7DE7D2CDC

Isoform 3 (identifier: Q9BXU1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
921-943: Missing.

« Hide

        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ 
        60         70         80         90        100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV 
       110        120        130        140        150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI 
       160        170        180        190        200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG 
       210        220        230        240        250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS 
       260        270        280        290        300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI 
       310        320        330        340        350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN 
       360        370        380        390        400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG 
       410        420        430        440        450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM 
       460        470        480        490        500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD 
       510        520        530        540        550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN 
       560        570        580        590        600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA 
       610        620        630        640        650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK 
       660        670        680        690        700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF 
       710        720        730        740        750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV 
       760        770        780        790        800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK 
       810        820        830        840        850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI 
       860        870        880        890        900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK 
       910        920        930        940        950
MGKPASPGSD LYAYGCLLLW DDKVKSLLCS LICYRSSMTA EQVLNAECFL 
       960        970        980        990 
MPKEQSVPNP EKDTEYTLYK KEEEIKTENL DKCMEKTRNG EANFDC

Show »

Length:996

Mass (Da):113,013

Checksum:ⁱ753B3B79DBF556E8

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JQW5	C9JQW5_HUMAN	Serine/threonine-protein kinase 31 Serine/threonine-protein kinase 31	STK31	159	Annotation score:
C9JPB1	C9JPB1_HUMAN	Serine/threonine-protein kinase 31 Serine/threonine-protein kinase 31	STK31	140	Annotation score:
F8W6E7	F8W6E7_HUMAN	Serine/threonine-protein kinase 31 Serine/threonine-protein kinase 31	STK31	93	Annotation score:
E9PRQ0	E9PRQ0_HUMAN	Serine/threonine-protein kinase 31 Serine/threonine-protein kinase 31	STK31	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	300	I → F in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	509	F → Y in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	621 – 623	NKS → KKI in AAK31978 (PubMed:11279525).Curated	3
Sequence conflictⁱ	715	Y → C in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	820	V → A in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	948	K → I in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	963	A → G in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	1000	T → P in AAK17193 (Ref. 2) Curated	1
Sequence conflictⁱ	1010	T → P in AAK31978 (PubMed:11279525).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031600	71	Q → H2 PublicationsCorresponds to variant dbSNP:rs6945306Ensembl.	1
Natural variantⁱVAR_041150	125	S → F1 PublicationCorresponds to variant dbSNP:rs56268851Ensembl.	1
Natural variantⁱVAR_031601	261	E → K1 PublicationCorresponds to variant dbSNP:rs10264952Ensembl.	1
Natural variantⁱVAR_031602	268	K → N1 PublicationCorresponds to variant dbSNP:rs10264967Ensembl.	1
Natural variantⁱVAR_041151	277	I → K1 PublicationCorresponds to variant dbSNP:rs55950645Ensembl.	1
Natural variantⁱVAR_031603	362	T → P. Corresponds to variant dbSNP:rs35545265Ensembl.	1
Natural variantⁱVAR_051675	385	R → C. Corresponds to variant dbSNP:rs35995607Ensembl.	1
Natural variantⁱVAR_041152	393	A → T1 PublicationCorresponds to variant dbSNP:rs56244148Ensembl.	1
Natural variantⁱVAR_031604	410	G → E1 PublicationCorresponds to variant dbSNP:rs4722266Ensembl.	1
Natural variantⁱVAR_041153	489	A → P1 PublicationCorresponds to variant dbSNP:rs34414354Ensembl.	1
Natural variantⁱVAR_041154	600	A → T1 PublicationCorresponds to variant dbSNP:rs55796076Ensembl.	1
Natural variantⁱVAR_041155	621	N → K1 PublicationCorresponds to variant dbSNP:rs10263079Ensembl.	1
Natural variantⁱVAR_041156	623	S → I1 PublicationCorresponds to variant dbSNP:rs10247878Ensembl.	1
Natural variantⁱVAR_041157	684	H → R1 PublicationCorresponds to variant dbSNP:rs41273999Ensembl.	1
Natural variantⁱVAR_041158	684	H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041159	709	E → K1 PublicationCorresponds to variant dbSNP:rs56181834Ensembl.	1
Natural variantⁱVAR_041160	860	V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041161	1000	T → M1 PublicationCorresponds to variant dbSNP:rs55794023Ensembl.	1
Natural variantⁱVAR_031605	1009	K → T. Corresponds to variant dbSNP:rs33998018Ensembl.	1
Natural variantⁱVAR_041162	1010	T → S1 PublicationCorresponds to variant dbSNP:rs56391043Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024389	1 – 23	Missing in isoform 2. 1 PublicationAdd BLAST		23
Alternative sequenceⁱVSP_045210	921 – 943	Missing in isoform 3. 1 PublicationAdd BLAST		23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF285599 mRNA Translation: AAK31978.1 AF332194 mRNA Translation: AAK17193.1 AK302689 mRNA Translation: BAG63918.1 AC003087 Genomic DNA No translation available. AC008176 Genomic DNA No translation available. BC059374 mRNA Translation: AAH59374.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43556.1 [Q9BXU1-2] CCDS5386.1 [Q9BXU1-1] CCDS59049.1 [Q9BXU1-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001247433.1, NM_001260504.1 [Q9BXU1-2] NP_001247434.1, NM_001260505.1 [Q9BXU1-3] NP_113602.2, NM_031414.4 [Q9BXU1-1] NP_116562.2, NM_032944.3 [Q9BXU1-2]
UniGeneⁱ	Hs.309767

Genome annotation databases

Ensemblⁱ	ENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2] ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1] ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]
GeneIDⁱ	56164
KEGGⁱ	hsa:56164
UCSC genome browser More...UCSCⁱ	uc003sws.6 human [Q9BXU1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9BXU1	Uncharacterized protein		MACMU		1034	UniRef90_Q9BXU1
Serine/threonine kinase 31, isoform CRA_a		HUMAN		1019
STK31 isoform 1		PANTR		1019
STK31 isoform 1		PONAB		1019
Serine/threonine kinase 31		CALJA		1019
+73
Q9BXU1-3	Serine/threonine kinase 31		SAIBB		996	UniRef90_Q9BXU1-3
Uncharacterized protein		MACMU		996
Uncharacterized protein		MACFA		996
Serine/threonine kinase 31		CALJA		996
STK31 isoform 4		PONAB		996
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9BXU1	Serine/threonine-protein kinase 31		MOUSE		1018	UniRef50_Q9BXU1
Uncharacterized protein		MACMU		1034
STK31 isoform 1		PONAB		1019
Uncharacterized protein		CERAT		1019
Serine/threonine kinase 31, isoform CRA_a		HUMAN		1019
+305
Q9BXU1-3	STK31 isoform 4		PONAB		996	UniRef50_Q9BXU1-3
Uncharacterized protein		MANLE		996
STK31 isoform 4		PANTR		996
Serine/threonine kinase 31		CALJA		996
Uncharacterized protein		CERAT		996
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF285599 mRNA Translation: AAK31978.1 AF332194 mRNA Translation: AAK17193.1 AK302689 mRNA Translation: BAG63918.1 AC003087 Genomic DNA No translation available. AC008176 Genomic DNA No translation available. BC059374 mRNA Translation: AAH59374.1
CCDSⁱ	CCDS43556.1 [Q9BXU1-2] CCDS5386.1 [Q9BXU1-1] CCDS59049.1 [Q9BXU1-3]
RefSeqⁱ	NP_001247433.1, NM_001260504.1 [Q9BXU1-2] NP_001247434.1, NM_001260505.1 [Q9BXU1-3] NP_113602.2, NM_031414.4 [Q9BXU1-1] NP_116562.2, NM_032944.3 [Q9BXU1-2]
UniGeneⁱ	Hs.309767

3D structure databases

ProteinModelPortalⁱ	Q9BXU1
SMRⁱ	Q9BXU1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121097, 4 interactors
IntActⁱ	Q9BXU1, 1 interactor
STRINGⁱ	9606.ENSP00000348132

Chemistry databases

BindingDBⁱ	Q9BXU1
ChEMBLⁱ	CHEMBL6151
GuidetoPHARMACOLOGYⁱ	2220

PTM databases

iPTMnetⁱ	Q9BXU1
PhosphoSitePlusⁱ	Q9BXU1

Polymorphism and mutation databases

BioMutaⁱ	STK31
DMDMⁱ	143811463

Proteomic databases

MaxQBⁱ	Q9BXU1
PaxDbⁱ	Q9BXU1
PeptideAtlasⁱ	Q9BXU1
PRIDEⁱ	Q9BXU1
ProteomicsDBⁱ	79517 79518 [Q9BXU1-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56164
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2] ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1] ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]
GeneIDⁱ	56164
KEGGⁱ	hsa:56164
UCSCⁱ	uc003sws.6 human [Q9BXU1-1]

Organism-specific databases

CTDⁱ	56164
DisGeNETⁱ	56164
EuPathDBⁱ	HostDB:ENSG00000196335.12
GeneCardsⁱ	STK31
H-InvDBⁱ	HIX0006524
HGNCⁱ	HGNC:11407 STK31
HPAⁱ	HPA023194
MIMⁱ	605790 gene
neXtProtⁱ	NX_Q9BXU1
OpenTargetsⁱ	ENSG00000196335
PharmGKBⁱ	PA36214
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF5N Eukaryota ENOG410XQIZ LUCA
GeneTreeⁱ	ENSGT00390000007287
HOGENOMⁱ	HOG000154440
HOVERGENⁱ	HBG062739
InParanoidⁱ	Q9BXU1
KOⁱ	K16316
OMAⁱ	VQQKLYM
OrthoDBⁱ	EOG091G0PO7
PhylomeDBⁱ	Q9BXU1
TreeFamⁱ	TF105335

Enzyme and pathway databases

BRENDAⁱ	2.7.11.1 2681
SignaLinkⁱ	Q9BXU1

Miscellaneous databases

GenomeRNAiⁱ	56164
Protein Ontology More...PROⁱ	PR:Q9BXU1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196335 Expressed in 92 organ(s), highest expression level in testis
CleanExⁱ	HS_STK31
ExpressionAtlasⁱ	Q9BXU1 baseline and differential
Genevisibleⁱ	Q9BXU1 HS

Family and domain databases

Gene3Dⁱ	2.40.50.90, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR035437 SNase_OB-fold_sf IPR002999 Tudor
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00567 TUDOR, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit SM00333 TUDOR, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS50304 TUDOR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STK31_HUMAN
Accessionⁱ	Q9BXU1Primary (citable) accession number: Q9BXU1 Secondary accession number(s): B4DZ06 , B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	April 3, 2007
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q9BXU1 (STK31_HUMAN)

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Serine/threonine-protein kinase 31

STK31

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Keywords - Domainⁱ

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