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Protein

Serine/threonine-protein kinase 31

Gene

STK31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei737ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi716 – 724ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nuclease activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9BXU1

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase NYD-SPK
Sugen kinase 396
Short name:
SgK396
Gene namesi
Name:STK31
Synonyms:SGK396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000196335.12
HGNCiHGNC:11407 STK31
MIMi605790 gene
neXtProtiNX_Q9BXU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi56164
OpenTargetsiENSG00000196335
PharmGKBiPA36214

Chemistry databases

ChEMBLiCHEMBL6151
GuidetoPHARMACOLOGYi2220

Polymorphism and mutation databases

BioMutaiSTK31
DMDMi143811463

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867151 – 1019Serine/threonine-protein kinase 31Add BLAST1019

Proteomic databases

MaxQBiQ9BXU1
PaxDbiQ9BXU1
PeptideAtlasiQ9BXU1
PRIDEiQ9BXU1
ProteomicsDBi79517
79518 [Q9BXU1-2]

PTM databases

iPTMnetiQ9BXU1
PhosphoSitePlusiQ9BXU1

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000196335 Expressed in 92 organ(s), highest expression level in testis
CleanExiHS_STK31
ExpressionAtlasiQ9BXU1 baseline and differential
GenevisibleiQ9BXU1 HS

Organism-specific databases

HPAiHPA023194

Interactioni

Protein-protein interaction databases

BioGridi121097, 4 interactors
IntActiQ9BXU1, 1 interactor
STRINGi9606.ENSP00000348132

Chemistry databases

BindingDBiQ9BXU1

Structurei

3D structure databases

ProteinModelPortaliQ9BXU1
SMRiQ9BXU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 137TudorPROSITE-ProRule annotationAdd BLAST60
Domaini710 – 1019Protein kinasePROSITE-ProRule annotationAdd BLAST310

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili298 – 355Sequence analysisAdd BLAST58

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF5N Eukaryota
ENOG410XQIZ LUCA
GeneTreeiENSGT00390000007287
HOGENOMiHOG000154440
HOVERGENiHBG062739
InParanoidiQ9BXU1
KOiK16316
OMAiVQQKLYM
OrthoDBiEOG091G0PO7
PhylomeDBiQ9BXU1
TreeFamiTF105335

Family and domain databases

Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50304 TUDOR, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ
60 70 80 90 100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV
110 120 130 140 150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI
160 170 180 190 200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG
210 220 230 240 250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS
260 270 280 290 300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN
360 370 380 390 400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG
410 420 430 440 450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM
460 470 480 490 500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD
510 520 530 540 550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN
560 570 580 590 600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
610 620 630 640 650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK
660 670 680 690 700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF
710 720 730 740 750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV
760 770 780 790 800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK
810 820 830 840 850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI
860 870 880 890 900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
910 920 930 940 950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL
960 970 980 990 1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT
1010
ENLDKCMEKT RNGEANFDC
Length:1,019
Mass (Da):115,694
Last modified:April 3, 2007 - v2
Checksum:iC2EFF005A820E102
GO
Isoform 2 (identifier: Q9BXU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Note: No experimental confirmation available.
Show »
Length:996
Mass (Da):113,260
Checksum:iE9D528F7DE7D2CDC
GO
Isoform 3 (identifier: Q9BXU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-943: Missing.

Show »
Length:996
Mass (Da):113,013
Checksum:i753B3B79DBF556E8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQW5C9JQW5_HUMAN
Serine/threonine-protein kinase 31
STK31
159Annotation score:
C9JPB1C9JPB1_HUMAN
Serine/threonine-protein kinase 31
STK31
140Annotation score:
F8W6E7F8W6E7_HUMAN
Serine/threonine-protein kinase 31
STK31
93Annotation score:
E9PRQ0E9PRQ0_HUMAN
Serine/threonine-protein kinase 31
STK31
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300I → F in AAK17193 (Ref. 2) Curated1
Sequence conflicti509F → Y in AAK17193 (Ref. 2) Curated1
Sequence conflicti621 – 623NKS → KKI in AAK31978 (PubMed:11279525).Curated3
Sequence conflicti715Y → C in AAK17193 (Ref. 2) Curated1
Sequence conflicti820V → A in AAK17193 (Ref. 2) Curated1
Sequence conflicti948K → I in AAK17193 (Ref. 2) Curated1
Sequence conflicti963A → G in AAK17193 (Ref. 2) Curated1
Sequence conflicti1000T → P in AAK17193 (Ref. 2) Curated1
Sequence conflicti1010T → P in AAK31978 (PubMed:11279525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03160071Q → H2 PublicationsCorresponds to variant dbSNP:rs6945306Ensembl.1
Natural variantiVAR_041150125S → F1 PublicationCorresponds to variant dbSNP:rs56268851Ensembl.1
Natural variantiVAR_031601261E → K1 PublicationCorresponds to variant dbSNP:rs10264952Ensembl.1
Natural variantiVAR_031602268K → N1 PublicationCorresponds to variant dbSNP:rs10264967Ensembl.1
Natural variantiVAR_041151277I → K1 PublicationCorresponds to variant dbSNP:rs55950645Ensembl.1
Natural variantiVAR_031603362T → P. Corresponds to variant dbSNP:rs35545265Ensembl.1
Natural variantiVAR_051675385R → C. Corresponds to variant dbSNP:rs35995607Ensembl.1
Natural variantiVAR_041152393A → T1 PublicationCorresponds to variant dbSNP:rs56244148Ensembl.1
Natural variantiVAR_031604410G → E1 PublicationCorresponds to variant dbSNP:rs4722266Ensembl.1
Natural variantiVAR_041153489A → P1 PublicationCorresponds to variant dbSNP:rs34414354Ensembl.1
Natural variantiVAR_041154600A → T1 PublicationCorresponds to variant dbSNP:rs55796076Ensembl.1
Natural variantiVAR_041155621N → K1 PublicationCorresponds to variant dbSNP:rs10263079Ensembl.1
Natural variantiVAR_041156623S → I1 PublicationCorresponds to variant dbSNP:rs10247878Ensembl.1
Natural variantiVAR_041157684H → R1 PublicationCorresponds to variant dbSNP:rs41273999Ensembl.1
Natural variantiVAR_041158684H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041159709E → K1 PublicationCorresponds to variant dbSNP:rs56181834Ensembl.1
Natural variantiVAR_041160860V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411611000T → M1 PublicationCorresponds to variant dbSNP:rs55794023Ensembl.1
Natural variantiVAR_0316051009K → T. Corresponds to variant dbSNP:rs33998018Ensembl.1
Natural variantiVAR_0411621010T → S1 PublicationCorresponds to variant dbSNP:rs56391043Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0243891 – 23Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_045210921 – 943Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA Translation: AAK31978.1
AF332194 mRNA Translation: AAK17193.1
AK302689 mRNA Translation: BAG63918.1
AC003087 Genomic DNA No translation available.
AC008176 Genomic DNA No translation available.
BC059374 mRNA Translation: AAH59374.1
CCDSiCCDS43556.1 [Q9BXU1-2]
CCDS5386.1 [Q9BXU1-1]
CCDS59049.1 [Q9BXU1-3]
RefSeqiNP_001247433.1, NM_001260504.1 [Q9BXU1-2]
NP_001247434.1, NM_001260505.1 [Q9BXU1-3]
NP_113602.2, NM_031414.4 [Q9BXU1-1]
NP_116562.2, NM_032944.3 [Q9BXU1-2]
UniGeneiHs.309767

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]
GeneIDi56164
KEGGihsa:56164
UCSCiuc003sws.6 human [Q9BXU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA Translation: AAK31978.1
AF332194 mRNA Translation: AAK17193.1
AK302689 mRNA Translation: BAG63918.1
AC003087 Genomic DNA No translation available.
AC008176 Genomic DNA No translation available.
BC059374 mRNA Translation: AAH59374.1
CCDSiCCDS43556.1 [Q9BXU1-2]
CCDS5386.1 [Q9BXU1-1]
CCDS59049.1 [Q9BXU1-3]
RefSeqiNP_001247433.1, NM_001260504.1 [Q9BXU1-2]
NP_001247434.1, NM_001260505.1 [Q9BXU1-3]
NP_113602.2, NM_031414.4 [Q9BXU1-1]
NP_116562.2, NM_032944.3 [Q9BXU1-2]
UniGeneiHs.309767

3D structure databases

ProteinModelPortaliQ9BXU1
SMRiQ9BXU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121097, 4 interactors
IntActiQ9BXU1, 1 interactor
STRINGi9606.ENSP00000348132

Chemistry databases

BindingDBiQ9BXU1
ChEMBLiCHEMBL6151
GuidetoPHARMACOLOGYi2220

PTM databases

iPTMnetiQ9BXU1
PhosphoSitePlusiQ9BXU1

Polymorphism and mutation databases

BioMutaiSTK31
DMDMi143811463

Proteomic databases

MaxQBiQ9BXU1
PaxDbiQ9BXU1
PeptideAtlasiQ9BXU1
PRIDEiQ9BXU1
ProteomicsDBi79517
79518 [Q9BXU1-2]

Protocols and materials databases

DNASUi56164
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]
GeneIDi56164
KEGGihsa:56164
UCSCiuc003sws.6 human [Q9BXU1-1]

Organism-specific databases

CTDi56164
DisGeNETi56164
EuPathDBiHostDB:ENSG00000196335.12
GeneCardsiSTK31
H-InvDBiHIX0006524
HGNCiHGNC:11407 STK31
HPAiHPA023194
MIMi605790 gene
neXtProtiNX_Q9BXU1
OpenTargetsiENSG00000196335
PharmGKBiPA36214
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5N Eukaryota
ENOG410XQIZ LUCA
GeneTreeiENSGT00390000007287
HOGENOMiHOG000154440
HOVERGENiHBG062739
InParanoidiQ9BXU1
KOiK16316
OMAiVQQKLYM
OrthoDBiEOG091G0PO7
PhylomeDBiQ9BXU1
TreeFamiTF105335

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9BXU1

Miscellaneous databases

GenomeRNAii56164
PROiPR:Q9BXU1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196335 Expressed in 92 organ(s), highest expression level in testis
CleanExiHS_STK31
ExpressionAtlasiQ9BXU1 baseline and differential
GenevisibleiQ9BXU1 HS

Family and domain databases

Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50304 TUDOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTK31_HUMAN
AccessioniPrimary (citable) accession number: Q9BXU1
Secondary accession number(s): B4DZ06
, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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