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Entry version 168 (11 Dec 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Serine/threonine-protein kinase 31

Gene

STK31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Ser-854 is present instead of the conserved Asp which is expected to be an active site residue.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei737ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi716 – 724ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BXU1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 31 (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase NYD-SPK
Sugen kinase 396
Short name:
SgK396
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK31
Synonyms:SGK396
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196335.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11407 STK31

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56164

Open Targets

More...
OpenTargetsi
ENSG00000196335

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36214

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXU1 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6151

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2220

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STK31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811463

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867151 – 1019Serine/threonine-protein kinase 31Add BLAST1019

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXU1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXU1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXU1

PeptideAtlas

More...
PeptideAtlasi
Q9BXU1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXU1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5561
79517 [Q9BXU1-1]
79518 [Q9BXU1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196335 Expressed in 92 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXU1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXU1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023194

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121097, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXU1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348132

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BXU1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXU1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BXU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 137TudorPROSITE-ProRule annotationAdd BLAST60
Domaini710 – 1019Protein kinasePROSITE-ProRule annotationAdd BLAST310

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili298 – 355Sequence analysisAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF5N Eukaryota
ENOG410XQIZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154440

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXU1

KEGG Orthology (KO)

More...
KOi
K16316

Identification of Orthologs from Complete Genome Data

More...
OMAi
STNVCEE

Database of Orthologous Groups

More...
OrthoDBi
104495at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXU1

TreeFam database of animal gene trees

More...
TreeFami
TF105335

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF00567 TUDOR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit
SM00333 TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50304 TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWVQGHSSRA SATESVSFSG IVQMDEDTHY DKVEDVVGSH IEDAVTFWAQ
60 70 80 90 100
SINRNKDIMK IGCSLSEVCP QASSVLGNLD PNKIYGGLFS EDQCWYRCKV
110 120 130 140 150
LKIISVEKCL VRYIDYGNTE ILNRSDIVEI PLELQFSSVA KKYKLWGLHI
160 170 180 190 200
PSDQEVTQFD QGTTFLGSLI FEKEIKMRIK ATSEDGTVIA QAEYGSVDIG
210 220 230 240 250
EEVLKKGFAE KCRLASRTDI CEEKKLDPGQ LVLRNLKSPI PLWGHRSNQS
260 270 280 290 300
TFSRPKGHLS EKMTLDLKDE NDAGNLITFP KESLAVGDFN LGSNVSLEKI
310 320 330 340 350
KQDQKLIEEN EKLKTEKDAL LESYKALELK VEQIAQELQQ EKAAAVDLTN
360 370 380 390 400
HLEYTLKTYI DTRMKNLAAK MEILKEMRHV DISVRFGKDL SDAIQVLDEG
410 420 430 440 450
CFTTPASLNG LEIIWAEYSL AQENIKTCEY VSEGNILIAQ RNEMQQKLYM
460 470 480 490 500
SVEDFILEVD ESSLNKRLKT LQDLSVSLEA VYGQAKEGAN SDEILKKFYD
510 520 530 540 550
WKCDKREEFT SVRSETDASL HRLVAWFQRT LKVFDLSVEG SLISEDAMDN
560 570 580 590 600
IDEILEKTES SVCKELEIAL VDQGDADKEI ISNTYSQVLQ KIHSEERLIA
610 620 630 640 650
TVQAKYKDSI EFKKQLIEYL NKSPSVDHLL SIKKTLKSLK ALLRWKLVEK
660 670 680 690 700
SNLEESDDPD GSQIEKIKEE ITQLRNNVFQ EIYHEREEYE MLTSLAQKWF
710 720 730 740 750
PELPLLHPEI GLLKYMNSGG LLTMSLERDL LDAEPMKELS SKRPLVRSEV
760 770 780 790 800
NGQIILLKGY SVDVDTEAKV IERAATYHRA WREAEGDSGL LPLIFLFLCK
810 820 830 840 850
SDPMAYLMVP YYPRANLNAV QANMPLNSEE TLKVMKGVAQ GLHTLHKADI
860 870 880 890 900
IHGSLHQNNV FALNREQGIV GDFDFTKSVS QRASVNMMVG DLSLMSPELK
910 920 930 940 950
MGKPASPGSD LYAYGCLLLW LSVQNQEFEI NKDGIPKVDQ FHLDDKVKSL
960 970 980 990 1000
LCSLICYRSS MTAEQVLNAE CFLMPKEQSV PNPEKDTEYT LYKKEEEIKT
1010
ENLDKCMEKT RNGEANFDC
Length:1,019
Mass (Da):115,694
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2EFF005A820E102
GO
Isoform 2 (identifier: Q9BXU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:996
Mass (Da):113,260
Checksum:iE9D528F7DE7D2CDC
GO
Isoform 3 (identifier: Q9BXU1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     921-943: Missing.

Show »
Length:996
Mass (Da):113,013
Checksum:i753B3B79DBF556E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQW5C9JQW5_HUMAN
Serine/threonine-protein kinase 31
STK31
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPB1C9JPB1_HUMAN
Serine/threonine-protein kinase 31
STK31
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6E7F8W6E7_HUMAN
Serine/threonine-protein kinase 31
STK31
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRQ0E9PRQ0_HUMAN
Serine/threonine-protein kinase 31
STK31
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti300I → F in AAK17193 (Ref. 2) Curated1
Sequence conflicti509F → Y in AAK17193 (Ref. 2) Curated1
Sequence conflicti621 – 623NKS → KKI in AAK31978 (PubMed:11279525).Curated3
Sequence conflicti715Y → C in AAK17193 (Ref. 2) Curated1
Sequence conflicti820V → A in AAK17193 (Ref. 2) Curated1
Sequence conflicti948K → I in AAK17193 (Ref. 2) Curated1
Sequence conflicti963A → G in AAK17193 (Ref. 2) Curated1
Sequence conflicti1000T → P in AAK17193 (Ref. 2) Curated1
Sequence conflicti1010T → P in AAK31978 (PubMed:11279525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03160071Q → H2 PublicationsCorresponds to variant dbSNP:rs6945306Ensembl.1
Natural variantiVAR_041150125S → F1 PublicationCorresponds to variant dbSNP:rs56268851Ensembl.1
Natural variantiVAR_031601261E → K1 PublicationCorresponds to variant dbSNP:rs10264952Ensembl.1
Natural variantiVAR_031602268K → N1 PublicationCorresponds to variant dbSNP:rs10264967Ensembl.1
Natural variantiVAR_041151277I → K1 PublicationCorresponds to variant dbSNP:rs55950645Ensembl.1
Natural variantiVAR_031603362T → P. Corresponds to variant dbSNP:rs35545265Ensembl.1
Natural variantiVAR_051675385R → C. Corresponds to variant dbSNP:rs35995607Ensembl.1
Natural variantiVAR_041152393A → T1 PublicationCorresponds to variant dbSNP:rs56244148Ensembl.1
Natural variantiVAR_031604410G → E1 PublicationCorresponds to variant dbSNP:rs4722266Ensembl.1
Natural variantiVAR_041153489A → P1 PublicationCorresponds to variant dbSNP:rs34414354Ensembl.1
Natural variantiVAR_041154600A → T1 PublicationCorresponds to variant dbSNP:rs55796076Ensembl.1
Natural variantiVAR_041155621N → K1 PublicationCorresponds to variant dbSNP:rs10263079Ensembl.1
Natural variantiVAR_041156623S → I1 PublicationCorresponds to variant dbSNP:rs10247878Ensembl.1
Natural variantiVAR_041157684H → R1 PublicationCorresponds to variant dbSNP:rs41273999Ensembl.1
Natural variantiVAR_041158684H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041159709E → K1 PublicationCorresponds to variant dbSNP:rs56181834Ensembl.1
Natural variantiVAR_041160860V → L in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0411611000T → M1 PublicationCorresponds to variant dbSNP:rs55794023Ensembl.1
Natural variantiVAR_0316051009K → T. Corresponds to variant dbSNP:rs33998018Ensembl.1
Natural variantiVAR_0411621010T → S1 PublicationCorresponds to variant dbSNP:rs56391043Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0243891 – 23Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_045210921 – 943Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF285599 mRNA Translation: AAK31978.1
AF332194 mRNA Translation: AAK17193.1
AK302689 mRNA Translation: BAG63918.1
AC003087 Genomic DNA No translation available.
AC008176 Genomic DNA No translation available.
BC059374 mRNA Translation: AAH59374.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43556.1 [Q9BXU1-2]
CCDS5386.1 [Q9BXU1-1]
CCDS59049.1 [Q9BXU1-3]

NCBI Reference Sequences

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RefSeqi
NP_001247433.1, NM_001260504.1 [Q9BXU1-2]
NP_001247434.1, NM_001260505.1 [Q9BXU1-3]
NP_113602.2, NM_031414.4 [Q9BXU1-1]
NP_116562.2, NM_032944.3 [Q9BXU1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56164

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56164

UCSC genome browser

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UCSCi
uc003sws.6 human [Q9BXU1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285599 mRNA Translation: AAK31978.1
AF332194 mRNA Translation: AAK17193.1
AK302689 mRNA Translation: BAG63918.1
AC003087 Genomic DNA No translation available.
AC008176 Genomic DNA No translation available.
BC059374 mRNA Translation: AAH59374.1
CCDSiCCDS43556.1 [Q9BXU1-2]
CCDS5386.1 [Q9BXU1-1]
CCDS59049.1 [Q9BXU1-3]
RefSeqiNP_001247433.1, NM_001260504.1 [Q9BXU1-2]
NP_001247434.1, NM_001260505.1 [Q9BXU1-3]
NP_113602.2, NM_031414.4 [Q9BXU1-1]
NP_116562.2, NM_032944.3 [Q9BXU1-2]

3D structure databases

SMRiQ9BXU1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121097, 4 interactors
IntActiQ9BXU1, 2 interactors
STRINGi9606.ENSP00000348132

Chemistry databases

BindingDBiQ9BXU1
ChEMBLiCHEMBL6151
GuidetoPHARMACOLOGYi2220

PTM databases

iPTMnetiQ9BXU1
PhosphoSitePlusiQ9BXU1

Polymorphism and mutation databases

BioMutaiSTK31
DMDMi143811463

Proteomic databases

jPOSTiQ9BXU1
MassIVEiQ9BXU1
MaxQBiQ9BXU1
PaxDbiQ9BXU1
PeptideAtlasiQ9BXU1
PRIDEiQ9BXU1
ProteomicsDBi5561
79517 [Q9BXU1-1]
79518 [Q9BXU1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56164

Genome annotation databases

EnsembliENST00000354639; ENSP00000346660; ENSG00000196335 [Q9BXU1-2]
ENST00000355870; ENSP00000348132; ENSG00000196335 [Q9BXU1-1]
ENST00000433467; ENSP00000411852; ENSG00000196335 [Q9BXU1-3]
GeneIDi56164
KEGGihsa:56164
UCSCiuc003sws.6 human [Q9BXU1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56164
DisGeNETi56164
EuPathDBiHostDB:ENSG00000196335.12

GeneCards: human genes, protein and diseases

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GeneCardsi
STK31
HGNCiHGNC:11407 STK31
HPAiHPA023194
MIMi605790 gene
neXtProtiNX_Q9BXU1
OpenTargetsiENSG00000196335
PharmGKBiPA36214

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IF5N Eukaryota
ENOG410XQIZ LUCA
GeneTreeiENSGT00390000007287
HOGENOMiHOG000154440
InParanoidiQ9BXU1
KOiK16316
OMAiSTNVCEE
OrthoDBi104495at2759
PhylomeDBiQ9BXU1
TreeFamiTF105335

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9BXU1

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56164
PharosiQ9BXU1 Tchem

Protein Ontology

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PROi
PR:Q9BXU1
RNActiQ9BXU1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196335 Expressed in 92 organ(s), highest expression level in testis
ExpressionAtlasiQ9BXU1 baseline and differential
GenevisibleiQ9BXU1 HS

Family and domain databases

Gene3Di2.40.50.90, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00567 TUDOR, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SM00333 TUDOR, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50304 TUDOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTK31_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXU1
Secondary accession number(s): B4DZ06
, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: April 3, 2007
Last modified: December 11, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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