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Entry version 122 (25 May 2022)
Sequence version 2 (05 Oct 2010)
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Protein

Testis-expressed protein 15

Gene

TEX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity).

Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity).

PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity).

Not required for piRNA biosynthesis (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, DNA damage, DNA repair, Meiosis, RNA-mediated gene silencing, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BXT5

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-912446, Meiotic recombination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BXT5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-expressed protein 15
Alternative name(s):
Cancer/testis antigen 42
Short name:
CT42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEX15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11738, TEX15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605795, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXT5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000133863

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 25 (SPGF25)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects that result in severe oligozoospermia or azoospermia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080904710 – 2789Missing in SPGF25. 1 PublicationCorresponds to variant dbSNP:rs864309485Add BLAST2080
Natural variantiVAR_080905807 – 2789Missing in SPGF25. 1 PublicationAdd BLAST1983
Natural variantiVAR_0809062312 – 2789Missing in SPGF25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs763654373Add BLAST478

Keywords - Diseasei

Disease variant

Organism-specific databases

MalaCards human disease database

More...
MalaCardsi
TEX15
MIMi617960, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000133863

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36455

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXT5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TEX15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002444831 – 2789Testis-expressed protein 15Add BLAST2789

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXT5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXT5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXT5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXT5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXT5

PeptideAtlas

More...
PeptideAtlasi
Q9BXT5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXT5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79507

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9BXT5

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis, predominantly in germ cells (PubMed:11279525, PubMed:26199321). Low expression, if any, in ovary (PubMed:11279525, PubMed:26199321). Also expressed in several cancers (PubMed:12704671).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133863, Expressed in female gonad and 68 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXT5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXT5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000133863, Group enriched (brain, endometrium, smooth muscle, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIWIL4 and PIWIL2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121088, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXT5, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9BXT5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256246

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXT5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni34 – 99DisorderedSequence analysisAdd BLAST66
Regioni169 – 191DisorderedSequence analysisAdd BLAST23
Regioni1063 – 1166DisorderedSequence analysisAdd BLAST104
Regioni2303 – 2331DisorderedSequence analysisAdd BLAST29
Regioni2351 – 2379DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 48Polar residuesSequence analysisAdd BLAST15
Compositional biasi60 – 99Polar residuesSequence analysisAdd BLAST40
Compositional biasi1063 – 1079Basic residuesSequence analysisAdd BLAST17
Compositional biasi1080 – 1103Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1104 – 1166Polar residuesSequence analysisAdd BLAST63
Compositional biasi2364 – 2379Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TEX15 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QW6W, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006260

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000620_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXT5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXT5

TreeFam database of animal gene trees

More...
TreeFami
TF332375

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026616, TEX15
IPR032765, TEX15_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22380, PTHR22380, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15326, TEX15, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BXT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD
60 70 80 90 100
PRLMRREESM GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV
110 120 130 140 150
PGDCAVLTNG LDTPCFKTSV NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK
160 170 180 190 200
DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR AQQESGNAYT KEYSSHIFQD
210 220 230 240 250
SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN FADLEDSSKH
260 270 280 290 300
EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL
310 320 330 340 350
ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG
360 370 380 390 400
NIHTSLAIAQ KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI
410 420 430 440 450
SSYNIETAHD SSNCSITREH ICVHRKNENE PVSLENIQRD YKETAYVEDR
460 470 480 490 500
GQDHNLFCNS QLSNDIWLNV NFKKQTDREN QNEAKENSAS CVENNIENIY
510 520 530 540 550
GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN LICREDNAVS
560 570 580 590 600
AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA
610 620 630 640 650
AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT
660 670 680 690 700
DKNKSQESFH QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN
710 720 730 740 750
MLCEEFVTSY KALKSRISWE GLLALDNGEM EVLESTTGRE NSDQHYSKES
760 770 780 790 800
NYFYSSTQNN ETELTSPILL PDLQIKITNI FRPGFSPTAD SLALKDSFCT
810 820 830 840 850
HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD NIRQESGPVS
860 870 880 890 900
NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK
910 920 930 940 950
TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ
960 970 980 990 1000
DSSECFSSLS QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA
1010 1020 1030 1040 1050
VVHLKKAHRR VHTSLQLITK VGEERKGPLP KSYAIICNNF WESCDLQGYS
1060 1070 1080 1090 1100
SVSQRKYYST KHFSSKRKYD KRRKKRAPKA DISKSLTHVS KHKSYKTSGE
1110 1120 1130 1140 1150
KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS TSQSTSQSVY
1160 1170 1180 1190 1200
YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS
1210 1220 1230 1240 1250
KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN
1260 1270 1280 1290 1300
DCDATCIGHT KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK
1310 1320 1330 1340 1350
WTDPIERPKQ NIITGNFLMG PLNLTLIASK KYSIPQLSAA AVTDSEGESS
1360 1370 1380 1390 1400
KSYLDKQRIL TVDSFAASST VPHCEQSCRE KELLKTEQCS SGNCLHTDGN
1410 1420 1430 1440 1450
ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD NVKGSSSETC
1460 1470 1480 1490 1500
IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES
1510 1520 1530 1540 1550
CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD
1560 1570 1580 1590 1600
SQSDLTLHSE IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD
1610 1620 1630 1640 1650
FKEKHCSANH TALIANLSQI LQRADEASSL QILQEETKVC LNILPLFVEA
1660 1670 1680 1690 1700
FERKQECSVE QILISRELLV DQNLWNNCKH TLKPCAVDTL VELQMMMETI
1710 1720 1730 1740 1750
QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ SNFYPGFQGR
1760 1770 1780 1790 1800
LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC
1810 1820 1830 1840 1850
SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG
1860 1870 1880 1890 1900
KQDHLWIIIE MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER
1910 1920 1930 1940 1950
TQSFSKKYSQ KKDEERLLRV NKCAFSKLQK IYDTLSKDLN NEPISPIGLE
1960 1970 1980 1990 2000
EDTIIASRKS DHPINEATIS IENSKFNSNL LAHPDICCIS EILDQAEFAD
2010 2020 2030 2040 2050
LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV LDVVINHSHE
2060 2070 2080 2090 2100
AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP
2110 2120 2130 2140 2150
ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN
2160 2170 2180 2190 2200
CSYAIHLLSR ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE
2210 2220 2230 2240 2250
LEYNYNQFST LLKNVMSAPR KDLGKMAHIR KVMKTIEHMK MICTKNAELT
2260 2270 2280 2290 2300
ISFFLCQMLY NRRKILQLKR KEKMNIHIVK PGENNNKFSI STMLPPVSEC
2310 2320 2330 2340 2350
INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD MKDVTKINRE
2360 2370 2380 2390 2400
KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP
2410 2420 2430 2440 2450
LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD
2460 2470 2480 2490 2500
KKDCAAFAIC DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET
2510 2520 2530 2540 2550
DVSLVPDASV LSKPIFCFVK DVHPDLEMND TVFELQDNDI VNSSIKNSSC
2560 2570 2580 2590 2600
MTSPEPICIQ NKIPTLQINK LQPTETESED KYMKDTLNPN TVHTFGASGH
2610 2620 2630 2640 2650
ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA CNPTYNSSEH
2660 2670 2680 2690 2700
LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST
2710 2720 2730 2740 2750
AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY
2760 2770 2780
ASHQPLPQAT YPYLPNRFVP PEVPWVYAPW HQESFHPGH
Length:2,789
Mass (Da):315,336
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1065EDD045C67BF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PS94A0A1W2PS94_HUMAN
Testis-expressed protein 15
TEX15
3,176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y358A0A2R8Y358_HUMAN
Testis-expressed protein 15
TEX15
3,172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060394104C → R1 PublicationCorresponds to variant dbSNP:rs323347Ensembl.1
Natural variantiVAR_060395383P → L. Corresponds to variant dbSNP:rs9297162Ensembl.1
Natural variantiVAR_080904710 – 2789Missing in SPGF25. 1 PublicationCorresponds to variant dbSNP:rs864309485Add BLAST2080
Natural variantiVAR_080905807 – 2789Missing in SPGF25. 1 PublicationAdd BLAST1983
Natural variantiVAR_0603961035I → V1 PublicationCorresponds to variant dbSNP:rs323346Ensembl.1
Natural variantiVAR_0603971311N → S1 PublicationCorresponds to variant dbSNP:rs323345Ensembl.1
Natural variantiVAR_0603981337L → V1 PublicationCorresponds to variant dbSNP:rs323344Ensembl.1
Natural variantiVAR_0603991439K → R1 PublicationCorresponds to variant dbSNP:rs323343Ensembl.1
Natural variantiVAR_0617112138D → N. Corresponds to variant dbSNP:rs60474250Ensembl.1
Natural variantiVAR_0809062312 – 2789Missing in SPGF25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs763654373Add BLAST478

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF285605 mRNA Translation: AAK31984.1
AC009314 Genomic DNA No translation available.
AC090281 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_112561.2, NM_031271.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000256246.5; ENSP00000256246.2; ENSG00000133863.9

UCSC genome browser

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UCSCi
uc003xil.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285605 mRNA Translation: AAK31984.1
AC009314 Genomic DNA No translation available.
AC090281 Genomic DNA No translation available.
RefSeqiNP_112561.2, NM_031271.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121088, 17 interactors
IntActiQ9BXT5, 8 interactors
MINTiQ9BXT5
STRINGi9606.ENSP00000256246

PTM databases

CarbonylDBiQ9BXT5
iPTMnetiQ9BXT5
PhosphoSitePlusiQ9BXT5

Genetic variation databases

BioMutaiTEX15
DMDMi308153507

Proteomic databases

EPDiQ9BXT5
jPOSTiQ9BXT5
MassIVEiQ9BXT5
MaxQBiQ9BXT5
PaxDbiQ9BXT5
PeptideAtlasiQ9BXT5
PRIDEiQ9BXT5
ProteomicsDBi79507

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51904, 17 antibodies from 11 providers

Genome annotation databases

EnsembliENST00000256246.5; ENSP00000256246.2; ENSG00000133863.9
UCSCiuc003xil.4, human

Organism-specific databases

GeneCards: human genes, protein and diseases

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GeneCardsi
TEX15
HGNCiHGNC:11738, TEX15
HPAiENSG00000133863, Group enriched (brain, endometrium, smooth muscle, testis)
MalaCardsiTEX15
MIMi605795, gene
617960, phenotype
neXtProtiNX_Q9BXT5
OpenTargetsiENSG00000133863
Orphaneti399805, Male infertility with azoospermia or oligozoospermia due to single gene mutation
PharmGKBiPA36455
VEuPathDBiHostDB:ENSG00000133863

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QW6W, Eukaryota
GeneTreeiENSGT00390000006260
HOGENOMiCLU_000620_0_0_1
InParanoidiQ9BXT5
PhylomeDBiQ9BXT5
TreeFamiTF332375

Enzyme and pathway databases

PathwayCommonsiQ9BXT5
ReactomeiR-HSA-912446, Meiotic recombination
SignaLinkiQ9BXT5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56154, 10 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TEX15, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56154
PharosiQ9BXT5, Tbio

Protein Ontology

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PROi
PR:Q9BXT5
RNActiQ9BXT5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133863, Expressed in female gonad and 68 other tissues
ExpressionAtlasiQ9BXT5, baseline and differential
GenevisibleiQ9BXT5, HS

Family and domain databases

InterProiView protein in InterPro
IPR026616, TEX15
IPR032765, TEX15_dom
PANTHERiPTHR22380, PTHR22380, 1 hit
PfamiView protein in Pfam
PF15326, TEX15, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEX15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXT5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 5, 2010
Last modified: May 25, 2022
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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