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Entry version 159 (25 May 2022)
Sequence version 2 (23 Sep 2008)
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Protein

Tudor domain-containing protein 1

Gene

TDRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi170Zinc 1PROSITE-ProRule annotation1
Metal bindingi173Zinc 1PROSITE-ProRule annotation1
Metal bindingi181Zinc 2PROSITE-ProRule annotation1
Metal bindingi184Zinc 2PROSITE-ProRule annotation1
Metal bindingi190Zinc 1PROSITE-ProRule annotation1
Metal bindingi194Zinc 1PROSITE-ProRule annotation1
Metal bindingi202Zinc 2PROSITE-ProRule annotation1
Metal bindingi206Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri170 – 206MYND-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BXT4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BXT4

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BXT4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 1
Alternative name(s):
Cancer/testis antigen 41.1
Short name:
CT41.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11712, TDRD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605796, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXT4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000095627

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56165

Open Targets

More...
OpenTargetsi
ENSG00000095627

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36430

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXT4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206729901

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831611 – 1180Tudor domain-containing protein 1Add BLAST1180

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXT4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXT4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXT4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXT4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXT4

PeptideAtlas

More...
PeptideAtlasi
Q9BXT4

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXT4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79503 [Q9BXT4-1]
79504 [Q9BXT4-2]
79505 [Q9BXT4-3]
79506 [Q9BXT4-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9BXT4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXT4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXT4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis and ovary specific. Also expressed in several cancers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095627, Expressed in secondary oocyte and 78 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXT4, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000095627, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4.

Interacts with MAEL.

Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues).

Interacts with TDRD12 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121098, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXT4, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9BXT4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251864

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXT4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9BXT4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BXT4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini312 – 372Tudor 1PROSITE-ProRule annotationAdd BLAST61
Domaini541 – 600Tudor 2PROSITE-ProRule annotationAdd BLAST60
Domaini762 – 821Tudor 3PROSITE-ProRule annotationAdd BLAST60
Domaini990 – 1048Tudor 4PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni79 – 138DisorderedSequence analysisAdd BLAST60
Regioni450 – 469DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 66Polar residuesSequence analysisAdd BLAST22
Compositional biasi79 – 94Polar residuesSequence analysisAdd BLAST16
Compositional biasi112 – 127Polar residuesSequence analysisAdd BLAST16
Compositional biasi453 – 467Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TDRD1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 206MYND-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158754

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXT4

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYCSAQK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXT4

TreeFam database of animal gene trees

More...
TreeFami
TF343710

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04508, TUDOR, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333, TUDOR, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVKSPFNVM SRNNLEAPPC KMTEPFNFEK NENKLPPHES LRSPGTLPNH
60 70 80 90 100
PNFRLKSSEN GNKKNNFLLC EQTKQYLASQ EDNSVSSNPN GINGEVVGSK
110 120 130 140 150
GDRKKLPAGN SVSPPSAESN SPPKEVNIKP GNNVRPAKSK KLNKLVENSL
160 170 180 190 200
SISNPGLFTS LGPPLRSTTC HRCGLFGSLR CSQCKQTYYC STACQRRDWS
210 220 230 240 250
AHSIVCRPVQ PNFHKLENKS SIETKDVEVN NKSDCPLGVT KEIAIWAERI
260 270 280 290 300
MFSDLRSLQL KKTMEIKGTV TEFKHPGDFY VQLYSSEVLE YMNQLSASLK
310 320 330 340 350
ETYANVHEKD YIPVKGEVCI AKYTVDQTWN RAIIQNVDVQ QKKAHVLYID
360 370 380 390 400
YGNEEIIPLN RIYHLNRNID LFPPCAIKCF VANVIPAEGN WSSDCIKATK
410 420 430 440 450
PLLMEQYCSI KIVDILEEEV VTFAVEVELP NSGKLLDHVL IEMGYGLKPS
460 470 480 490 500
GQDSKKENAD QSDPEDVGKM TTENNIVVDK SDLIPKVLTL NVGDEFCGVV
510 520 530 540 550
AHIQTPEDFF CQQLQSGRKL AELQASLSKY CDQLPPRSDF YPAIGDICCA
560 570 580 590 600
QFSEDDQWYR ASVLAYASEE SVLVGYVDYG NFEILSLMRL CPIIPKLLEL
610 620 630 640 650
PMQAIKCVLA GVKPSLGIWT PEAICLMKKL VQNKIITVKV VDKLENSSLV
660 670 680 690 700
ELIDKSETPH VSVSKVLLDA GFAVGEQSMV TDKPSDVKET SVPLGVEGKV
710 720 730 740 750
NPLEWTWVEL GVDQTVDVVV CVIYSPGEFY CHVLKEDALK KLNDLNKSLA
760 770 780 790 800
EHCQQKLPNG FKAEIGQPCC AFFAGDGSWY RALVKEILPN GHVKVHFVDY
810 820 830 840 850
GNIEEVTADE LRMISSTFLN LPFQGIRCQL ADIQSRNKHW SEEAITRFQM
860 870 880 890 900
CVAGIKLQAR VVEVTENGIG VELTDLSTCY PRIISDVLID EHLVLKSASP
910 920 930 940 950
HKDLPNDRLV NKHELQVHVQ GLQATSSAEQ WKTIELPVDK TIQANVLEII
960 970 980 990 1000
SPNLFYALPK GMPENQEKLC MLTAELLEYC NAPKSRPPYR PRIGDACCAK
1010 1020 1030 1040 1050
YTSDDFWYRA VVLGTSDTDV EVLYADYGNI ETLPLCRVQP ITSSHLALPF
1060 1070 1080 1090 1100
QIIRCSLEGL MELNGSSSQL IIMLLKNFML NQNVMLSVKG ITKNVHTVSV
1110 1120 1130 1140 1150
EKCSENGTVD VADKLVTFGL AKNITPQRQS ALNTEKMYRM NCCCTELQKQ
1160 1170 1180
VEKHEHILLF LLNNSTNQNK FIEMKKLLKS
Length:1,180
Mass (Da):132,024
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B024C7D94F1D7E1
GO
Isoform 2 (identifier: Q9BXT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     554-610: Missing.
     775-831: Missing.

Show »
Length:1,066
Mass (Da):119,132
Checksum:iA45D1010B43A7716
GO
Isoform 3 (identifier: Q9BXT4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1180-1180: S → KTASLGGKPL

Show »
Length:1,189
Mass (Da):132,890
Checksum:i13C4483F73426DA6
GO
Isoform 4 (identifier: Q9BXT4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.
     328-375: Missing.
     554-610: Missing.
     1059-1134: Missing.

Show »
Length:708
Mass (Da):79,170
Checksum:iF0ECCC6F3C19BF9F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV63H9KV63_HUMAN
Tudor domain-containing protein 1
TDRD1
1,113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV62H9KV62_HUMAN
Tudor domain-containing protein 1
TDRD1
1,104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35010 differs from that shown. Potential poly-A sequence.Curated
The sequence AAK31985 differs from that shown. Contaminating sequence.Curated
The sequence AAK31985 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14982 differs from that shown. Potential poly-A sequence.Curated
The sequence BAB14982 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti251M → T in BAG53796 (PubMed:14702039).Curated1
Sequence conflicti1140M → T in AAK31985 (PubMed:11279525).Curated1
Sequence conflicti1178L → V in AAK31985 (PubMed:11279525).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057321864V → L. Corresponds to variant dbSNP:rs7914059Ensembl.1
Natural variantiVAR_0573221138Y → C. Corresponds to variant dbSNP:rs34112549EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0366671 – 291Missing in isoform 4. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_036668328 – 375Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_035481554 – 610Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_035482775 – 831Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0366691059 – 1134Missing in isoform 4. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0366701180S → KTASLGGKPL in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC022023 Genomic DNA No translation available.
AK122916 mRNA Translation: BAG53796.1
AK304331 mRNA Translation: BAG65177.1
CH471066 Genomic DNA Translation: EAW49479.1
CH471066 Genomic DNA Translation: EAW49480.1
BC035010 mRNA Translation: AAH35010.1 Sequence problems.
BC063133 mRNA Translation: AAH63133.1
AF285606 mRNA Translation: AAK31985.1 Sequence problems.
AK024735 mRNA Translation: BAB14982.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7588.1 [Q9BXT4-3]

NCBI Reference Sequences

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RefSeqi
NP_942090.1, NM_198795.1 [Q9BXT4-3]
XP_005270035.1, XM_005269978.2 [Q9BXT4-3]
XP_011538261.1, XM_011539959.2 [Q9BXT4-3]
XP_011538262.1, XM_011539960.2 [Q9BXT4-3]
XP_011538263.1, XM_011539961.2 [Q9BXT4-3]
XP_011538264.1, XM_011539962.1 [Q9BXT4-3]
XP_011538265.1, XM_011539963.1 [Q9BXT4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251864.6; ENSP00000251864.2; ENSG00000095627.9 [Q9BXT4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56165

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56165

UCSC genome browser

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UCSCi
uc001lbg.1, human [Q9BXT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022023 Genomic DNA No translation available.
AK122916 mRNA Translation: BAG53796.1
AK304331 mRNA Translation: BAG65177.1
CH471066 Genomic DNA Translation: EAW49479.1
CH471066 Genomic DNA Translation: EAW49480.1
BC035010 mRNA Translation: AAH35010.1 Sequence problems.
BC063133 mRNA Translation: AAH63133.1
AF285606 mRNA Translation: AAK31985.1 Sequence problems.
AK024735 mRNA Translation: BAB14982.1 Sequence problems.
CCDSiCCDS7588.1 [Q9BXT4-3]
RefSeqiNP_942090.1, NM_198795.1 [Q9BXT4-3]
XP_005270035.1, XM_005269978.2 [Q9BXT4-3]
XP_011538261.1, XM_011539959.2 [Q9BXT4-3]
XP_011538262.1, XM_011539960.2 [Q9BXT4-3]
XP_011538263.1, XM_011539961.2 [Q9BXT4-3]
XP_011538264.1, XM_011539962.1 [Q9BXT4-3]
XP_011538265.1, XM_011539963.1 [Q9BXT4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5M9NX-ray1.95A/B460-679[»]
AlphaFoldDBiQ9BXT4
SMRiQ9BXT4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121098, 6 interactors
IntActiQ9BXT4, 4 interactors
MINTiQ9BXT4
STRINGi9606.ENSP00000251864

PTM databases

GlyGeniQ9BXT4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BXT4
PhosphoSitePlusiQ9BXT4

Genetic variation databases

BioMutaiTDRD1
DMDMi206729901

Proteomic databases

EPDiQ9BXT4
jPOSTiQ9BXT4
MassIVEiQ9BXT4
MaxQBiQ9BXT4
PaxDbiQ9BXT4
PeptideAtlasiQ9BXT4
PRIDEiQ9BXT4
ProteomicsDBi79503 [Q9BXT4-1]
79504 [Q9BXT4-2]
79505 [Q9BXT4-3]
79506 [Q9BXT4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31923, 132 antibodies from 24 providers

The DNASU plasmid repository

More...
DNASUi
56165

Genome annotation databases

EnsembliENST00000251864.6; ENSP00000251864.2; ENSG00000095627.9 [Q9BXT4-3]
GeneIDi56165
KEGGihsa:56165
UCSCiuc001lbg.1, human [Q9BXT4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56165
DisGeNETi56165

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TDRD1
HGNCiHGNC:11712, TDRD1
HPAiENSG00000095627, Tissue enriched (testis)
MIMi605796, gene
neXtProtiNX_Q9BXT4
OpenTargetsiENSG00000095627
PharmGKBiPA36430
VEuPathDBiHostDB:ENSG00000095627

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2039, Eukaryota
GeneTreeiENSGT00940000158754
InParanoidiQ9BXT4
OMAiEYCSAQK
PhylomeDBiQ9BXT4
TreeFamiTF343710

Enzyme and pathway databases

PathwayCommonsiQ9BXT4
ReactomeiR-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis
SignaLinkiQ9BXT4
SIGNORiQ9BXT4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56165, 10 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TDRD1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56165
PharosiQ9BXT4, Tbio

Protein Ontology

More...
PROi
PR:Q9BXT4
RNActiQ9BXT4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095627, Expressed in secondary oocyte and 78 other tissues
ExpressionAtlasiQ9BXT4, baseline and differential

Family and domain databases

CDDicd04508, TUDOR, 4 hits
Gene3Di2.40.50.90, 5 hits
InterProiView protein in InterPro
IPR035437, SNase_OB-fold_sf
IPR002999, Tudor
IPR002893, Znf_MYND
PfamiView protein in Pfam
PF00567, TUDOR, 4 hits
PF01753, zf-MYND, 1 hit
SMARTiView protein in SMART
SM00333, TUDOR, 4 hits
PROSITEiView protein in PROSITE
PS50304, TUDOR, 4 hits
PS01360, ZF_MYND_1, 1 hit
PS50865, ZF_MYND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDRD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXT4
Secondary accession number(s): A6NEN3
, A6NMN2, B3KVI4, B4E2L5, D3DRC2, Q4G0Y8, Q6P518, Q9H7B3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: September 23, 2008
Last modified: May 25, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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