UniProtKB - Q9BXT4 (TDRD1_HUMAN)
Tudor domain-containing protein 1
TDRD1
Functioni
Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 170 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 173 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 181 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 184 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 190 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 194 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 202 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 206 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 170 – 206 | MYND-typePROSITE-ProRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- DNA methylation involved in gamete generation Source: UniProtKB
- gene silencing by RNA Source: UniProtKB
- germ cell development Source: UniProtKB
- meiotic cell cycle Source: UniProtKB-KW
- P granule organization Source: GO_Central
- piRNA metabolic process Source: UniProtKB
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BXT4 |
Reactomei | R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis |
SignaLinki | Q9BXT4 |
SIGNORi | Q9BXT4 |
Names & Taxonomyi
Protein namesi | Recommended name: Tudor domain-containing protein 1Alternative name(s): Cancer/testis antigen 41.1 Short name: CT41.1 |
Gene namesi | Name:TDRD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11712, TDRD1 |
MIMi | 605796, gene |
neXtProti | NX_Q9BXT4 |
VEuPathDBi | HostDB:ENSG00000095627 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity).By similarity
Other locations
- chromatoid body Source: Ensembl
- cytoplasm Source: UniProtKB
- P granule Source: UniProtKB
- pi-body Source: UniProtKB
- ribonucleoprotein complex Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 56165 |
OpenTargetsi | ENSG00000095627 |
PharmGKBi | PA36430 |
Miscellaneous databases
Pharosi | Q9BXT4, Tbio |
Genetic variation databases
BioMutai | TDRD1 |
DMDMi | 206729901 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183161 | 1 – 1180 | Tudor domain-containing protein 1Add BLAST | 1180 |
Proteomic databases
EPDi | Q9BXT4 |
jPOSTi | Q9BXT4 |
MassIVEi | Q9BXT4 |
MaxQBi | Q9BXT4 |
PaxDbi | Q9BXT4 |
PeptideAtlasi | Q9BXT4 |
PRIDEi | Q9BXT4 |
ProteomicsDBi | 79503 [Q9BXT4-1] 79504 [Q9BXT4-2] 79505 [Q9BXT4-3] 79506 [Q9BXT4-4] |
PTM databases
GlyGeni | Q9BXT4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXT4 |
PhosphoSitePlusi | Q9BXT4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000095627, Expressed in secondary oocyte and 78 other tissues |
ExpressionAtlasi | Q9BXT4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000095627, Tissue enriched (testis) |
Interactioni
Subunit structurei
Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4.
Interacts with MAEL.
Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues).
Interacts with TDRD12 (By similarity).
By similarityBinary interactionsi
Isoform 2 [Q9BXT4-2]
With | #Exp. | IntAct |
---|---|---|
TFCP2 [Q12800] | 3 | EBI-10301451,EBI-717422 |
Protein-protein interaction databases
BioGRIDi | 121098, 6 interactors |
IntActi | Q9BXT4, 4 interactors |
MINTi | Q9BXT4 |
STRINGi | 9606.ENSP00000251864 |
Miscellaneous databases
RNActi | Q9BXT4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9BXT4 |
SMRi | Q9BXT4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 312 – 372 | Tudor 1PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 541 – 600 | Tudor 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 762 – 821 | Tudor 3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 990 – 1048 | Tudor 4PROSITE-ProRule annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 66 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 79 – 138 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 450 – 469 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 66 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 79 – 94 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 112 – 127 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 453 – 467 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 170 – 206 | MYND-typePROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2039, Eukaryota |
GeneTreei | ENSGT00940000158754 |
InParanoidi | Q9BXT4 |
OMAi | EYCSAQK |
PhylomeDBi | Q9BXT4 |
TreeFami | TF343710 |
Family and domain databases
CDDi | cd04508, TUDOR, 4 hits |
Gene3Di | 2.40.50.90, 5 hits |
InterProi | View protein in InterPro IPR035437, SNase_OB-fold_sf IPR002999, Tudor IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF00567, TUDOR, 4 hits PF01753, zf-MYND, 1 hit |
SMARTi | View protein in SMART SM00333, TUDOR, 4 hits |
PROSITEi | View protein in PROSITE PS50304, TUDOR, 4 hits PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVKSPFNVM SRNNLEAPPC KMTEPFNFEK NENKLPPHES LRSPGTLPNH
60 70 80 90 100
PNFRLKSSEN GNKKNNFLLC EQTKQYLASQ EDNSVSSNPN GINGEVVGSK
110 120 130 140 150
GDRKKLPAGN SVSPPSAESN SPPKEVNIKP GNNVRPAKSK KLNKLVENSL
160 170 180 190 200
SISNPGLFTS LGPPLRSTTC HRCGLFGSLR CSQCKQTYYC STACQRRDWS
210 220 230 240 250
AHSIVCRPVQ PNFHKLENKS SIETKDVEVN NKSDCPLGVT KEIAIWAERI
260 270 280 290 300
MFSDLRSLQL KKTMEIKGTV TEFKHPGDFY VQLYSSEVLE YMNQLSASLK
310 320 330 340 350
ETYANVHEKD YIPVKGEVCI AKYTVDQTWN RAIIQNVDVQ QKKAHVLYID
360 370 380 390 400
YGNEEIIPLN RIYHLNRNID LFPPCAIKCF VANVIPAEGN WSSDCIKATK
410 420 430 440 450
PLLMEQYCSI KIVDILEEEV VTFAVEVELP NSGKLLDHVL IEMGYGLKPS
460 470 480 490 500
GQDSKKENAD QSDPEDVGKM TTENNIVVDK SDLIPKVLTL NVGDEFCGVV
510 520 530 540 550
AHIQTPEDFF CQQLQSGRKL AELQASLSKY CDQLPPRSDF YPAIGDICCA
560 570 580 590 600
QFSEDDQWYR ASVLAYASEE SVLVGYVDYG NFEILSLMRL CPIIPKLLEL
610 620 630 640 650
PMQAIKCVLA GVKPSLGIWT PEAICLMKKL VQNKIITVKV VDKLENSSLV
660 670 680 690 700
ELIDKSETPH VSVSKVLLDA GFAVGEQSMV TDKPSDVKET SVPLGVEGKV
710 720 730 740 750
NPLEWTWVEL GVDQTVDVVV CVIYSPGEFY CHVLKEDALK KLNDLNKSLA
760 770 780 790 800
EHCQQKLPNG FKAEIGQPCC AFFAGDGSWY RALVKEILPN GHVKVHFVDY
810 820 830 840 850
GNIEEVTADE LRMISSTFLN LPFQGIRCQL ADIQSRNKHW SEEAITRFQM
860 870 880 890 900
CVAGIKLQAR VVEVTENGIG VELTDLSTCY PRIISDVLID EHLVLKSASP
910 920 930 940 950
HKDLPNDRLV NKHELQVHVQ GLQATSSAEQ WKTIELPVDK TIQANVLEII
960 970 980 990 1000
SPNLFYALPK GMPENQEKLC MLTAELLEYC NAPKSRPPYR PRIGDACCAK
1010 1020 1030 1040 1050
YTSDDFWYRA VVLGTSDTDV EVLYADYGNI ETLPLCRVQP ITSSHLALPF
1060 1070 1080 1090 1100
QIIRCSLEGL MELNGSSSQL IIMLLKNFML NQNVMLSVKG ITKNVHTVSV
1110 1120 1130 1140 1150
EKCSENGTVD VADKLVTFGL AKNITPQRQS ALNTEKMYRM NCCCTELQKQ
1160 1170 1180
VEKHEHILLF LLNNSTNQNK FIEMKKLLKS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KV63 | H9KV63_HUMAN | Tudor domain-containing protein 1 | TDRD1 | 1,113 | Annotation score: | ||
H9KV62 | H9KV62_HUMAN | Tudor domain-containing protein 1 | TDRD1 | 1,104 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 251 | M → T in BAG53796 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1140 | M → T in AAK31985 (PubMed:11279525).Curated | 1 | |
Sequence conflicti | 1178 | L → V in AAK31985 (PubMed:11279525).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057321 | 864 | V → L. Corresponds to variant dbSNP:rs7914059Ensembl. | 1 | |
Natural variantiVAR_057322 | 1138 | Y → C. Corresponds to variant dbSNP:rs34112549EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036667 | 1 – 291 | Missing in isoform 4. 1 PublicationAdd BLAST | 291 | |
Alternative sequenceiVSP_036668 | 328 – 375 | Missing in isoform 4. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_035481 | 554 – 610 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 57 | |
Alternative sequenceiVSP_035482 | 775 – 831 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_036669 | 1059 – 1134 | Missing in isoform 4. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_036670 | 1180 | S → KTASLGGKPL in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022023 Genomic DNA No translation available. AK122916 mRNA Translation: BAG53796.1 AK304331 mRNA Translation: BAG65177.1 CH471066 Genomic DNA Translation: EAW49479.1 CH471066 Genomic DNA Translation: EAW49480.1 BC035010 mRNA Translation: AAH35010.1 Sequence problems. BC063133 mRNA Translation: AAH63133.1 AF285606 mRNA Translation: AAK31985.1 Sequence problems. AK024735 mRNA Translation: BAB14982.1 Sequence problems. |
CCDSi | CCDS7588.1 [Q9BXT4-3] |
RefSeqi | NP_942090.1, NM_198795.1 [Q9BXT4-3] XP_005270035.1, XM_005269978.2 [Q9BXT4-3] XP_011538261.1, XM_011539959.2 [Q9BXT4-3] XP_011538262.1, XM_011539960.2 [Q9BXT4-3] XP_011538263.1, XM_011539961.2 [Q9BXT4-3] XP_011538264.1, XM_011539962.1 [Q9BXT4-3] XP_011538265.1, XM_011539963.1 [Q9BXT4-1] |
Genome annotation databases
Ensembli | ENST00000251864.6; ENSP00000251864.2; ENSG00000095627.9 [Q9BXT4-3] |
GeneIDi | 56165 |
KEGGi | hsa:56165 |
UCSCi | uc001lbg.1, human [Q9BXT4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022023 Genomic DNA No translation available. AK122916 mRNA Translation: BAG53796.1 AK304331 mRNA Translation: BAG65177.1 CH471066 Genomic DNA Translation: EAW49479.1 CH471066 Genomic DNA Translation: EAW49480.1 BC035010 mRNA Translation: AAH35010.1 Sequence problems. BC063133 mRNA Translation: AAH63133.1 AF285606 mRNA Translation: AAK31985.1 Sequence problems. AK024735 mRNA Translation: BAB14982.1 Sequence problems. |
CCDSi | CCDS7588.1 [Q9BXT4-3] |
RefSeqi | NP_942090.1, NM_198795.1 [Q9BXT4-3] XP_005270035.1, XM_005269978.2 [Q9BXT4-3] XP_011538261.1, XM_011539959.2 [Q9BXT4-3] XP_011538262.1, XM_011539960.2 [Q9BXT4-3] XP_011538263.1, XM_011539961.2 [Q9BXT4-3] XP_011538264.1, XM_011539962.1 [Q9BXT4-3] XP_011538265.1, XM_011539963.1 [Q9BXT4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5M9N | X-ray | 1.95 | A/B | 460-679 | [»] | |
AlphaFoldDBi | Q9BXT4 | |||||
SMRi | Q9BXT4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121098, 6 interactors |
IntActi | Q9BXT4, 4 interactors |
MINTi | Q9BXT4 |
STRINGi | 9606.ENSP00000251864 |
PTM databases
GlyGeni | Q9BXT4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXT4 |
PhosphoSitePlusi | Q9BXT4 |
Genetic variation databases
BioMutai | TDRD1 |
DMDMi | 206729901 |
Proteomic databases
EPDi | Q9BXT4 |
jPOSTi | Q9BXT4 |
MassIVEi | Q9BXT4 |
MaxQBi | Q9BXT4 |
PaxDbi | Q9BXT4 |
PeptideAtlasi | Q9BXT4 |
PRIDEi | Q9BXT4 |
ProteomicsDBi | 79503 [Q9BXT4-1] 79504 [Q9BXT4-2] 79505 [Q9BXT4-3] 79506 [Q9BXT4-4] |
Protocols and materials databases
Antibodypediai | 31923, 132 antibodies from 24 providers |
DNASUi | 56165 |
Genome annotation databases
Ensembli | ENST00000251864.6; ENSP00000251864.2; ENSG00000095627.9 [Q9BXT4-3] |
GeneIDi | 56165 |
KEGGi | hsa:56165 |
UCSCi | uc001lbg.1, human [Q9BXT4-1] |
Organism-specific databases
CTDi | 56165 |
DisGeNETi | 56165 |
GeneCardsi | TDRD1 |
HGNCi | HGNC:11712, TDRD1 |
HPAi | ENSG00000095627, Tissue enriched (testis) |
MIMi | 605796, gene |
neXtProti | NX_Q9BXT4 |
OpenTargetsi | ENSG00000095627 |
PharmGKBi | PA36430 |
VEuPathDBi | HostDB:ENSG00000095627 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2039, Eukaryota |
GeneTreei | ENSGT00940000158754 |
InParanoidi | Q9BXT4 |
OMAi | EYCSAQK |
PhylomeDBi | Q9BXT4 |
TreeFami | TF343710 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXT4 |
Reactomei | R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis |
SignaLinki | Q9BXT4 |
SIGNORi | Q9BXT4 |
Miscellaneous databases
BioGRID-ORCSi | 56165, 10 hits in 1036 CRISPR screens |
ChiTaRSi | TDRD1, human |
GenomeRNAii | 56165 |
Pharosi | Q9BXT4, Tbio |
PROi | PR:Q9BXT4 |
RNActi | Q9BXT4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095627, Expressed in secondary oocyte and 78 other tissues |
ExpressionAtlasi | Q9BXT4, baseline and differential |
Family and domain databases
CDDi | cd04508, TUDOR, 4 hits |
Gene3Di | 2.40.50.90, 5 hits |
InterProi | View protein in InterPro IPR035437, SNase_OB-fold_sf IPR002999, Tudor IPR002893, Znf_MYND |
Pfami | View protein in Pfam PF00567, TUDOR, 4 hits PF01753, zf-MYND, 1 hit |
SMARTi | View protein in SMART SM00333, TUDOR, 4 hits |
PROSITEi | View protein in PROSITE PS50304, TUDOR, 4 hits PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TDRD1_HUMAN | |
Accessioni | Q9BXT4Primary (citable) accession number: Q9BXT4 Secondary accession number(s): A6NEN3 Q9H7B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | September 23, 2008 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families