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Entry version 155 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Solute carrier family 26 member 6

Gene

SLC26A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.
Isoform 4: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters) (By similarity). Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). Isoform 4, isoform 5 and isoform 6 chloride, bicarbonate and sulfate transport activities are inhibited by DIDS.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processAnion exchange, Antiport, Ion transport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427601 Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.7 the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 26 member 6
Alternative name(s):
Anion exchange transporter
Pendrin-like protein 1
Short name:
Pendrin-L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14472 SLC26A6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610068 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXS9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 115CytoplasmicSequence analysisAdd BLAST115
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 186ExtracellularSequence analysisAdd BLAST50
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 263CytoplasmicSequence analysisAdd BLAST56
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 293ExtracellularSequence analysis9
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 347CytoplasmicSequence analysisAdd BLAST33
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 379ExtracellularSequence analysisAdd BLAST11
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 416CytoplasmicSequence analysisAdd BLAST16
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 484ExtracellularSequence analysisAdd BLAST47
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 759CytoplasmicSequence analysisAdd BLAST254

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi568 – 570DVD → NVN: Does not inhibit cell membrane localization. Inhibits interaction with CA2 and bicarbonate transport. 1 Publication3
Mutagenesisi574S → A: Does not inhibit interaction with CA2. Inhibits interaction with CA2 and bicarbonate transport in PMA-induced cells. 1 Publication1
Mutagenesisi603S → A: Does not inhibit interaction with CA2. Does not inhibit interaction with CA2 and bicarbonate transport in PMA-induced cells. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
65010

Open Targets

More...
OpenTargetsi
ENSG00000225697

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37889

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXS9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A6

Domain mapping of disease mutations (DMDM)

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DMDMi
20140224

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801711 – 759Solute carrier family 26 member 6Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei574Phosphoserine; by PKC1 Publication1
Modified residuei603Phosphoserine; by PKC1 Publication1
Modified residuei616PhosphoserineCombined sources1
Modified residuei752PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BXS9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BXS9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BXS9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BXS9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BXS9

PeptideAtlas

More...
PeptideAtlasi
Q9BXS9

PRoteomics IDEntifications database

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PRIDEi
Q9BXS9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4656
79499 [Q9BXS9-1]
79500 [Q9BXS9-2]
79501 [Q9BXS9-3]
82188

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BXS9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BXS9

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9BXS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain. Isoform 4 is ubiquitously expressed. Isoform 6 is expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis and ovary. Isoform 5 is expressed weakly in placenta, lung, liver and pancreas.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by pro-inflammatory cytokine IFN gamma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000225697 Expressed in 137 organ(s), highest expression level in body of stomach

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BXS9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BXS9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048363

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport.

Interacts with CFTR, SLC26A3 and SLC9A3R1 (By similarity). Isoform 4 interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Isoform 4 and isoform 5 interact with SLC9A3R1 (via the PDZ domains). Isoform 4 and isoform 5 interact with SLC9A3R2 (via the PDZ domains).

Interacts with AHCYL1; the interaction increases SLC26A6 activity (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122373, 20 interactors

Protein interaction database and analysis system

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IntActi
Q9BXS9, 32 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000378920

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BXS9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini530 – 742STASPROSITE-ProRule annotationAdd BLAST213

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006546

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BXS9

KEGG Orthology (KO)

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KOi
K14704

Identification of Orthologs from Complete Genome Data

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OMAi
MAACHAP

Database of Orthologous Groups

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OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BXS9

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030323 SLC26A6
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF113 PTHR11814:SF113, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXS9-1) [UniParc]FASTAAdd to basket
Also known as: SLC26A6b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA
60 70 80 90 100
PRTHQWRTWL QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV
110 120 130 140 150
AIMQLPQGLA YALLAGLPPV FGLYSSFYPV FIYFLFGTSR HISVGTFAVM
160 170 180 190 200
SVMVGSVTES LAPQALNDSM INETARDAAR VQVASTLSVL VGLFQVGLGL
210 220 230 240 250
IHFGFVVTYL SEPLVRGYTT AAAVQVFVSQ LKYVFGLHLS SHSGPLSLIY
260 270 280 290 300
TVLEVCWKLP QSKVGTVVTA AVAGVVLVVV KLLNDKLQQQ LPMPIPGELL
310 320 330 340 350
TLIGATGISY GMGLKHRFEV DVVGNIPAGL VPPVAPNTQL FSKLVGSAFT
360 370 380 390 400
IAVVGFAIAI SLGKIFALRH GYRVDSNQEL VALGLSNLIG GIFQCFPVSC
410 420 430 440 450
SMSRSLVQES TGGNSQVAGA ISSLFILLII VKLGELFHDL PKAVLAAIII
460 470 480 490 500
VNLKGMLRQL SDMRSLWKAN RADLLIWLVT FTATILLNLD LGLVVAVIFS
510 520 530 540 550
LLLVVVRTQM PHYSVLGQVP DTDIYRDVAE YSEAKEVRGV KVFRSSATVY
560 570 580 590 600
FANAEFYSDA LKQRCGVDVD FLISQKKKLL KKQEQLKLKQ LQKEEKLRKQ
610 620 630 640 650
AASPKGASVS INVNTSLEDM RSNNVEDCKM MQVSSGDKME DATANGQEDS
660 670 680 690 700
KAPDGSTLKA LGLPQPDFHS LILDLGALSF VDTVCLKSLK NIFHDFREIE
710 720 730 740 750
VEVYMAACHS PVVSQLEAGH FFDASITKKH LFASVHDAVT FALQHPRPVP

DSPVSVTRL
Length:759
Mass (Da):82,967
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63CB0B756C9675C6
GO
Isoform 2 (identifier: Q9BXS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     602-631: ASPKGASVSINVNTSLEDMRSNNVEDCKMM → GPLLSACLAPQ

Note: No experimental confirmation available.
Show »
Length:740
Mass (Da):80,807
Checksum:i9BBFAB68E0D8B2C5
GO
Isoform 3 (identifier: Q9BXS9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-632: Missing.

Show »
Length:758
Mass (Da):82,839
Checksum:i6CC16170D6F9F01C
GO
Isoform 4 (identifier: Q9BXS9-4) [UniParc]FASTAAdd to basket
Also known as: SLC26A6a

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     632-632: Missing.

Show »
Length:737
Mass (Da):80,782
Checksum:i1AFAFB8DEDB69E6E
GO
Isoform 5 (identifier: Q9BXS9-5) [UniParc]FASTAAdd to basket
Also known as: SLC26A6c

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     264-301: Missing.
     632-632: Missing.

Show »
Length:699
Mass (Da):76,876
Checksum:i8E03EA6F5DE56EFC
GO
Isoform 6 (identifier: Q9BXS9-6) [UniParc]FASTAAdd to basket
Also known as: SLC26A6d

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     632-759: QVSSGDKMED...PDSPVSVTRL → VRLEVGKEVT...SGSVVICHRI

Show »
Length:671
Mass (Da):73,817
Checksum:iB2C9AD808C256713
GO
Isoform 7 (identifier: Q9BXS9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-216: GTFAVMSVMV...VTYLSEPLVR → ATPGPLPLLT...PLWATVPHLL
     217-252: Missing.

Note: No experimental confirmation available.
Show »
Length:723
Mass (Da):79,159
Checksum:iA3D9F408FD3DD9F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAC1G3XAC1_HUMAN
Solute carrier family 26 member 6
SLC26A6 hCG_1999608
651Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFT5A0A0C4DFT5_HUMAN
Solute carrier family 26 member 6
SLC26A6
738Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6Y3C9J6Y3_HUMAN
Solute carrier family 26 member 6
SLC26A6
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKR6C9JKR6_HUMAN
Solute carrier family 26 member 6
SLC26A6
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ36H7BZ36_HUMAN
Solute carrier family 26 member 6
SLC26A6
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZJ6H7BZJ6_HUMAN
Solute carrier family 26 member 6
SLC26A6
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C291H7C291_HUMAN
Solute carrier family 26 member 6
SLC26A6
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZB1H7BZB1_HUMAN
Solute carrier family 26 member 6
SLC26A6
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9I8F8W9I8_HUMAN
Solute carrier family 26 member 6
SLC26A6
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012776206V → M1 PublicationCorresponds to variant dbSNP:rs13324142Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468071 – 21Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_055273145 – 216GTFAV…EPLVR → ATPGPLPLLTAPGRPTGGAG PDPLRLRGHLPVRTSCPRLY HSCSCAGLRLTAQVCVWPPS EQPLWATVPHLL in isoform 7. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_055274217 – 252Missing in isoform 7. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_047851264 – 301Missing in isoform 5. CuratedAdd BLAST38
Alternative sequenceiVSP_006169602 – 631ASPKG…DCKMM → GPLLSACLAPQ in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_047852632 – 759QVSSG…SVTRL → VRLEVGKEVTAVSCRDAGST CLMRNAMDPAAVGSRVLRRW QEEWGGWVRYSSGSVVICHR I in isoform 6. CuratedAdd BLAST128
Alternative sequenceiVSP_040127632Missing in isoform 3, isoform 4 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF279265 mRNA Translation: AAF81911.1
AF288410 mRNA Translation: AAK19153.1
AF416721 mRNA Translation: AAN07094.1
AB033288 mRNA Translation: BAB69041.1
AK297695 mRNA Translation: BAG60053.1
AC121252 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64901.1
CH471055 Genomic DNA Translation: EAW64903.1
BC017697 mRNA Translation: AAH17697.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43087.1 [Q9BXS9-1]
CCDS46824.1 [Q9BXS9-2]
CCDS46825.1 [Q9BXS9-3]
CCDS63628.1 [Q9BXS9-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001035544.1, NM_001040454.1
NP_001268661.1, NM_001281732.1 [Q9BXS9-7]
NP_001268662.1, NM_001281733.1
NP_075062.2, NM_022911.2 [Q9BXS9-1]
NP_599025.2, NM_134263.2 [Q9BXS9-3]
NP_602298.2, NM_134426.2 [Q9BXS9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383733; ENSP00000373239; ENSG00000225697 [Q9BXS9-2]
ENST00000395550; ENSP00000378920; ENSG00000225697 [Q9BXS9-1]
ENST00000420764; ENSP00000404684; ENSG00000225697 [Q9BXS9-3]
ENST00000455886; ENSP00000401066; ENSG00000225697 [Q9BXS9-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
65010

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:65010

UCSC genome browser

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UCSCi
uc003cug.4 human [Q9BXS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279265 mRNA Translation: AAF81911.1
AF288410 mRNA Translation: AAK19153.1
AF416721 mRNA Translation: AAN07094.1
AB033288 mRNA Translation: BAB69041.1
AK297695 mRNA Translation: BAG60053.1
AC121252 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64901.1
CH471055 Genomic DNA Translation: EAW64903.1
BC017697 mRNA Translation: AAH17697.1
CCDSiCCDS43087.1 [Q9BXS9-1]
CCDS46824.1 [Q9BXS9-2]
CCDS46825.1 [Q9BXS9-3]
CCDS63628.1 [Q9BXS9-7]
RefSeqiNP_001035544.1, NM_001040454.1
NP_001268661.1, NM_001281732.1 [Q9BXS9-7]
NP_001268662.1, NM_001281733.1
NP_075062.2, NM_022911.2 [Q9BXS9-1]
NP_599025.2, NM_134263.2 [Q9BXS9-3]
NP_602298.2, NM_134426.2 [Q9BXS9-2]

3D structure databases

SMRiQ9BXS9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122373, 20 interactors
IntActiQ9BXS9, 32 interactors
STRINGi9606.ENSP00000378920

Protein family/group databases

TCDBi2.A.53.2.7 the sulfate permease (sulp) family

PTM databases

iPTMnetiQ9BXS9
PhosphoSitePlusiQ9BXS9
SwissPalmiQ9BXS9

Polymorphism and mutation databases

BioMutaiSLC26A6
DMDMi20140224

Proteomic databases

EPDiQ9BXS9
jPOSTiQ9BXS9
MassIVEiQ9BXS9
MaxQBiQ9BXS9
PaxDbiQ9BXS9
PeptideAtlasiQ9BXS9
PRIDEiQ9BXS9
ProteomicsDBi4656
79499 [Q9BXS9-1]
79500 [Q9BXS9-2]
79501 [Q9BXS9-3]
82188

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
65010

Genome annotation databases

EnsembliENST00000383733; ENSP00000373239; ENSG00000225697 [Q9BXS9-2]
ENST00000395550; ENSP00000378920; ENSG00000225697 [Q9BXS9-1]
ENST00000420764; ENSP00000404684; ENSG00000225697 [Q9BXS9-3]
ENST00000455886; ENSP00000401066; ENSG00000225697 [Q9BXS9-7]
GeneIDi65010
KEGGihsa:65010
UCSCiuc003cug.4 human [Q9BXS9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65010
DisGeNETi65010

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC26A6
HGNCiHGNC:14472 SLC26A6
HPAiHPA048363
MIMi610068 gene
neXtProtiNX_Q9BXS9
OpenTargetsiENSG00000225697
PharmGKBiPA37889

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00950000182695
HOGENOMiHOG000006546
InParanoidiQ9BXS9
KOiK14704
OMAiMAACHAP
OrthoDBi690428at2759
PhylomeDBiQ9BXS9
TreeFamiTF313784

Enzyme and pathway databases

ReactomeiR-HSA-427601 Multifunctional anion exchangers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC26A6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC26A6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65010
PharosiQ9BXS9

Protein Ontology

More...
PROi
PR:Q9BXS9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000225697 Expressed in 137 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ9BXS9 baseline and differential
GenevisibleiQ9BXS9 HS

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030323 SLC26A6
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF113 PTHR11814:SF113, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXS9
Secondary accession number(s): B4DMZ1
, Q548A7, Q96Q90, Q9NQU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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