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Entry version 131 (11 Dec 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Nucleolar and spindle-associated protein 1

Gene

NUSAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BXS6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar and spindle-associated protein 1
Short name:
NuSAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUSAP1
Synonyms:ANKT
ORF Names:BM-037, PRO0310
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137804.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18538 NUSAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612818 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51203

Open Targets

More...
OpenTargetsi
ENSG00000137804

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134987502

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXS6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUSAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74717631

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020341 – 441Nucleolar and spindle-associated protein 1Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei124Phosphoserine; by ATM1 Publication1
Modified residuei135PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei314PhosphothreonineCombined sources1
Modified residuei338PhosphothreonineCombined sources1
Modified residuei349PhosphothreonineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei411N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.1 Publication
Phosphorylation by ATM in G2/M-phase induces mitotic arrest.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXS6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXS6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXS6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXS6

PeptideAtlas

More...
PeptideAtlasi
Q9BXS6

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXS6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17837
79494 [Q9BXS6-1]
79495 [Q9BXS6-2]
79496 [Q9BXS6-3]
79497 [Q9BXS6-4]
79498 [Q9BXS6-5]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9BXS6

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137804 Expressed in 174 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXS6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXS6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042904
HPA074847

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NHQ13EBI-2555618,EBI-739624

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119376, 41 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXS6, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9BXS6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000453403

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXS6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni237 – 382Interaction with microtubulesBy similarityAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili407 – 432Sequence analysisAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi384 – 390KEN box7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUSAP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGHS Eukaryota
ENOG4111I6V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000054205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXS6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVNRVSF

Database of Orthologous Groups

More...
OrthoDBi
1573441at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXS6

TreeFam database of animal gene trees

More...
TreeFami
TF329459

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026756 NuSAP

The PANTHER Classification System

More...
PANTHERi
PTHR15874 PTHR15874, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16006 NUSAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIIPSLEELD SLKYSDLQNL AKSLGLRANL RATKLLKALK GYIKHEARKG
60 70 80 90 100
NENQDESQTS ASSCDETEIQ ISNQEEAERQ PLGHVTKTRR RCKTVRVDPD
110 120 130 140 150
SQQNHSEIKI SNPTEFQNHE KQESQDLRAT AKVPSPPDEH QEAENAVSSG
160 170 180 190 200
NRDSKVPSEG KKSLYTDESS KPGKNKRTAI TTPNFKKLHE AHFKEMESID
210 220 230 240 250
QYIERKKKHF EEHNSMNELK QQPINKGGVR TPVPPRGRLS VASTPISQRR
260 270 280 290 300
SQGRSCGPAS QSTLGLKGSL KRSAISAAKT GVRFSAATKD NEHKRSLTKT
310 320 330 340 350
PARKSAHVTV SGGTPKGEAV LGTHKLKTIT GNSAAVITPF KLTTEATQTP
360 370 380 390 400
VSNKKPVFDL KASLSRPLNY EPHKGKLKPW GQSKENNYLN QHVNRINFYK
410 420 430 440
KTYKQPHLQT KEEQRKKREQ ERKEKKAKVL GMRRGLILAE D
Length:441
Mass (Da):49,452
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1400E1B9F3FB727F
GO
Isoform 2 (identifier: Q9BXS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     221-221: Missing.

Show »
Length:440
Mass (Da):49,324
Checksum:iE903FADDD7341A2A
GO
Isoform 3 (identifier: Q9BXS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-102: Missing.
     221-221: Missing.

Show »
Length:439
Mass (Da):49,196
Checksum:iBF3DB4438241D00E
GO
Isoform 4 (identifier: Q9BXS6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-116: Missing.
     221-221: Missing.

Show »
Length:425
Mass (Da):47,570
Checksum:iCD3A2D4A1838A7B4
GO
Isoform 5 (identifier: Q9BXS6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-102: Missing.

Show »
Length:440
Mass (Da):49,324
Checksum:i2496DFF76DAE07B5
GO
Isoform 6 (identifier: Q9BXS6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-116: Missing.

Show »
Length:426
Mass (Da):47,698
Checksum:iDF04D86E64347EC2
GO
Isoform 7 (identifier: Q9BXS6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-54: Missing.
     221-221: Missing.
     336-374: Missing.

Show »
Length:378
Mass (Da):42,352
Checksum:i67DC255E553C7481
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMD2H0YMD2_HUMAN
Nucleolar and spindle-associated pr...
NUSAP1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKA7H0YKA7_HUMAN
Nucleolar and spindle-associated pr...
NUSAP1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM18H0YM18_HUMAN
Nucleolar and spindle-associated pr...
NUSAP1
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF24034 differs from that shown. Reason: Frameshift.Curated
The sequence AAF67624 differs from that shown. Reason: Frameshift.Curated
The sequence AAH12887 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33T → D in AL833611 (PubMed:17974005).Curated1
Sequence conflicti43I → V in BAD96539 (Ref. 5) Curated1
Sequence conflicti220K → E in BAD96539 (Ref. 5) Curated1
Sequence conflicti331G → V in BAG56712 (PubMed:14702039).Curated1
Sequence conflicti441D → DQ in AL833611 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05777933T → A. Corresponds to variant dbSNP:rs7178634Ensembl.1
Natural variantiVAR_05778033T → N. Corresponds to variant dbSNP:rs7178777Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04680532 – 54Missing in isoform 7. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_027910102 – 116Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_027911102Missing in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_027912221Missing in isoform 2, isoform 3, isoform 4 and isoform 7. 4 Publications1
Alternative sequenceiVSP_046806336 – 374Missing in isoform 7. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF290612 mRNA Translation: AAK28023.1
AF305711 mRNA Translation: AAG25874.1
AF090915 mRNA Translation: AAF24034.1 Frameshift.
AK023483 mRNA Translation: BAB14586.1
AK293168 mRNA Translation: BAG56712.1
AK222819 mRNA Translation: BAD96539.1
AL833611 mRNA No translation available.
AC087721 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92483.1
CH471125 Genomic DNA Translation: EAW92486.1
BC001308 mRNA Translation: AAH01308.1
BC010838 mRNA Translation: AAH10838.2
BC012887 mRNA Translation: AAH12887.2 Different initiation.
BC024772 mRNA Translation: AAH24772.1
AF217513 mRNA Translation: AAF67624.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45234.1 [Q9BXS6-1]
CCDS45236.1 [Q9BXS6-2]
CCDS58356.1 [Q9BXS6-3]
CCDS58357.1 [Q9BXS6-6]
CCDS58358.1 [Q9BXS6-7]
CCDS73708.1 [Q9BXS6-5]

NCBI Reference Sequences

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RefSeqi
NP_001230071.1, NM_001243142.1 [Q9BXS6-3]
NP_001230072.1, NM_001243143.1 [Q9BXS6-6]
NP_001230073.1, NM_001243144.1 [Q9BXS6-7]
NP_001288065.1, NM_001301136.1 [Q9BXS6-5]
NP_057443.2, NM_016359.4 [Q9BXS6-1]
NP_060924.4, NM_018454.7 [Q9BXS6-2]
XP_005254487.1, XM_005254430.4 [Q9BXS6-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260359; ENSP00000260359; ENSG00000137804 [Q9BXS6-6]
ENST00000414849; ENSP00000400746; ENSG00000137804 [Q9BXS6-2]
ENST00000450592; ENSP00000401014; ENSG00000137804 [Q9BXS6-7]
ENST00000559596; ENSP00000453403; ENSG00000137804 [Q9BXS6-1]
ENST00000560177; ENSP00000453657; ENSG00000137804 [Q9BXS6-5]
ENST00000560747; ENSP00000454097; ENSG00000137804 [Q9BXS6-3]
ENST00000668273; ENSP00000499238; ENSG00000137804 [Q9BXS6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51203

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51203

UCSC genome browser

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UCSCi
uc001znr.5 human [Q9BXS6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290612 mRNA Translation: AAK28023.1
AF305711 mRNA Translation: AAG25874.1
AF090915 mRNA Translation: AAF24034.1 Frameshift.
AK023483 mRNA Translation: BAB14586.1
AK293168 mRNA Translation: BAG56712.1
AK222819 mRNA Translation: BAD96539.1
AL833611 mRNA No translation available.
AC087721 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92483.1
CH471125 Genomic DNA Translation: EAW92486.1
BC001308 mRNA Translation: AAH01308.1
BC010838 mRNA Translation: AAH10838.2
BC012887 mRNA Translation: AAH12887.2 Different initiation.
BC024772 mRNA Translation: AAH24772.1
AF217513 mRNA Translation: AAF67624.1 Frameshift.
CCDSiCCDS45234.1 [Q9BXS6-1]
CCDS45236.1 [Q9BXS6-2]
CCDS58356.1 [Q9BXS6-3]
CCDS58357.1 [Q9BXS6-6]
CCDS58358.1 [Q9BXS6-7]
CCDS73708.1 [Q9BXS6-5]
RefSeqiNP_001230071.1, NM_001243142.1 [Q9BXS6-3]
NP_001230072.1, NM_001243143.1 [Q9BXS6-6]
NP_001230073.1, NM_001243144.1 [Q9BXS6-7]
NP_001288065.1, NM_001301136.1 [Q9BXS6-5]
NP_057443.2, NM_016359.4 [Q9BXS6-1]
NP_060924.4, NM_018454.7 [Q9BXS6-2]
XP_005254487.1, XM_005254430.4 [Q9BXS6-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119376, 41 interactors
IntActiQ9BXS6, 20 interactors
MINTiQ9BXS6
STRINGi9606.ENSP00000453403

PTM databases

CarbonylDBiQ9BXS6
iPTMnetiQ9BXS6
PhosphoSitePlusiQ9BXS6

Polymorphism and mutation databases

BioMutaiNUSAP1
DMDMi74717631

Proteomic databases

EPDiQ9BXS6
jPOSTiQ9BXS6
MassIVEiQ9BXS6
MaxQBiQ9BXS6
PaxDbiQ9BXS6
PeptideAtlasiQ9BXS6
PRIDEiQ9BXS6
ProteomicsDBi17837
79494 [Q9BXS6-1]
79495 [Q9BXS6-2]
79496 [Q9BXS6-3]
79497 [Q9BXS6-4]
79498 [Q9BXS6-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51203

Genome annotation databases

EnsembliENST00000260359; ENSP00000260359; ENSG00000137804 [Q9BXS6-6]
ENST00000414849; ENSP00000400746; ENSG00000137804 [Q9BXS6-2]
ENST00000450592; ENSP00000401014; ENSG00000137804 [Q9BXS6-7]
ENST00000559596; ENSP00000453403; ENSG00000137804 [Q9BXS6-1]
ENST00000560177; ENSP00000453657; ENSG00000137804 [Q9BXS6-5]
ENST00000560747; ENSP00000454097; ENSG00000137804 [Q9BXS6-3]
ENST00000668273; ENSP00000499238; ENSG00000137804 [Q9BXS6-1]
GeneIDi51203
KEGGihsa:51203
UCSCiuc001znr.5 human [Q9BXS6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51203
DisGeNETi51203
EuPathDBiHostDB:ENSG00000137804.12

GeneCards: human genes, protein and diseases

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GeneCardsi
NUSAP1
HGNCiHGNC:18538 NUSAP1
HPAiHPA042904
HPA074847
MIMi612818 gene
neXtProtiNX_Q9BXS6
OpenTargetsiENSG00000137804
PharmGKBiPA134987502

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGHS Eukaryota
ENOG4111I6V LUCA
GeneTreeiENSGT00390000006370
HOGENOMiHOG000054205
InParanoidiQ9BXS6
OMAiHVNRVSF
OrthoDBi1573441at2759
PhylomeDBiQ9BXS6
TreeFamiTF329459

Enzyme and pathway databases

SIGNORiQ9BXS6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NUSAP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51203
PharosiQ9BXS6 Tbio

Protein Ontology

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PROi
PR:Q9BXS6
RNActiQ9BXS6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137804 Expressed in 174 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9BXS6 baseline and differential
GenevisibleiQ9BXS6 HS

Family and domain databases

InterProiView protein in InterPro
IPR026756 NuSAP
PANTHERiPTHR15874 PTHR15874, 2 hits
PfamiView protein in Pfam
PF16006 NUSAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUSAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXS6
Secondary accession number(s): B4DDF1
, E7ERR5, J3KN21, Q53GW2, Q8TBT4, Q96E58, Q96FJ1, Q9GZM9, Q9NZ85, Q9UI70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: December 11, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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