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UniProtKB - Q9BXS5 (AP1M1_HUMAN)

Entry version 174 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

AP-1 complex subunit mu-1

Gene

AP1M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin adaptor activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXS5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BXS5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9BXS5

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-1 complex subunit mu-1
Alternative name(s):
AP-mu chain family member mu1A
Adaptor protein complex AP-1 subunit mu-1
Adaptor-related protein complex 1 subunit mu-1
Clathrin assembly protein complex 1 mu-1 medium chain 1
Clathrin coat assembly protein AP47
Clathrin coat-associated protein AP47
Golgi adaptor HA1/AP1 adaptin mu-1 subunit
Mu-adaptin 1
Mu1A-adaptin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP1M1
Synonyms:CLTNM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13667, AP1M1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603535, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXS5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072958.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8907

Open Targets

More...OpenTargetsi		ENSG00000072958

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24848

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXS5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AP1M1

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202738

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937702 – 423AP-1 complex subunit mu-1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei152PhosphothreonineCombined sources1
Modified residuei154PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXS5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXS5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXS5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BXS5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXS5

PeptideAtlas

More...PeptideAtlasi		Q9BXS5

PRoteomics IDEntifications database

More...PRIDEi		Q9BXS5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79492 [Q9BXS5-1]
79493 [Q9BXS5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BXS5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXS5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BXS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072958, Expressed in testis and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BXS5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXS5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072958, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Interacts with MARCHF11 (By similarity). Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.

By similarity1 Publication

(Microbial infection) Interacts with HIV-1 Nef.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BXS5
With#Exp.IntAct
AMOT [A2BDD9]3EBI-541426,EBI-17286414
ARL6IP4 [A0A0C4DG62]3EBI-541426,EBI-12248874
ARNT2 [A0A087WVE9]3EBI-541426,EBI-12808086
ATF4 [P18848]3EBI-541426,EBI-492498
AXIN2 [Q9Y2T1]3EBI-541426,EBI-4400025
BACH2 [Q9BYV9]3EBI-541426,EBI-1642333
BCAR3 [O75815]3EBI-541426,EBI-702336
CASP8 [Q6NVI2]3EBI-541426,EBI-12861768
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-541426,EBI-10181988
DISC1 - isoform 2 [Q9NRI5-2]3EBI-541426,EBI-11988027
DZIP3 [Q86Y13]3EBI-541426,EBI-948630
EFEMP2 [O95967]3EBI-541426,EBI-743414
ENTR1 - isoform 2 [Q96C92-2]3EBI-541426,EBI-10178036
ETV6 [P41212]3EBI-541426,EBI-1372759
EVI5L [Q96CN4]3EBI-541426,EBI-749523
FAM219B [Q5XKK7]3EBI-541426,EBI-12290965
FAM9B [Q8IZU0]3EBI-541426,EBI-10175124
FKBP7 [Q9Y680]3EBI-541426,EBI-3918971
FXR1 - isoform 2 [P51114-2]5EBI-541426,EBI-11022345
FXR2 [P51116]7EBI-541426,EBI-740459
GCSAM [Q8N6F7]3EBI-541426,EBI-10267082
HOOK2 [Q96ED9]3EBI-541426,EBI-743290
HOOK2 - isoform 2 [Q96ED9-2]3EBI-541426,EBI-10961706
IKZF1 [Q13422]3EBI-541426,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-541426,EBI-11522367
KIF24 - isoform 2 [Q5T7B8-2]3EBI-541426,EBI-10213781
KRT40 [Q6A162]6EBI-541426,EBI-10171697
KRTAP10-7 [P60409]6EBI-541426,EBI-10172290
KRTAP10-8 [P60410]3EBI-541426,EBI-10171774
LDOC1 [O95751]6EBI-541426,EBI-740738
LNX1 [Q8TBB1]3EBI-541426,EBI-739832
LRATD2 [Q96KN1]3EBI-541426,EBI-9057780
LRMDA [A0A087WWI0]3EBI-541426,EBI-18393842
LZTS1 [Q9Y250]3EBI-541426,EBI-1216080
LZTS2 [Q9BRK4]3EBI-541426,EBI-741037
MDK [P21741]3EBI-541426,EBI-722444
MEA1 [Q16626]3EBI-541426,EBI-744921
MID2 - isoform 2 [Q9UJV3-2]3EBI-541426,EBI-10172526
MTF1 [Q14872]3EBI-541426,EBI-747024
MYOD1 [P15172]3EBI-541426,EBI-488878
NECAB1 [Q8N987]3EBI-541426,EBI-11956853
NKAP [Q8N5F7]3EBI-541426,EBI-721539
NKAPD1 [Q6ZUT1]3EBI-541426,EBI-3920396
OLIG3 [Q7RTU3]3EBI-541426,EBI-10225049
PAX6 [P26367]3EBI-541426,EBI-747278
PHC2 [Q8IXK0]3EBI-541426,EBI-713786
PICK1 [Q9NRD5]3EBI-541426,EBI-79165
PNMA5 [Q96PV4]3EBI-541426,EBI-10171633
PURB [Q96QR8]3EBI-541426,EBI-2880222
RNF19B [Q6ZMZ0]4EBI-541426,EBI-2466594
ROPN1 [Q9HAT0]3EBI-541426,EBI-1378139
RP9 [Q8TA86]3EBI-541426,EBI-630339
RSPH14 [Q9UHP6]6EBI-541426,EBI-748350
RUNDC3A [Q59EK9]4EBI-541426,EBI-747225
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-541426,EBI-11957366
SDCBP2 [Q9H190]3EBI-541426,EBI-742426
SP4 [Q02446]3EBI-541426,EBI-10198587
SPATA6 - isoform 2 [Q9NWH7-2]3EBI-541426,EBI-17860101
SSX2IP [Q9Y2D8]3EBI-541426,EBI-2212028
TEPSIN [Q96N21]3EBI-541426,EBI-11139477
TFIP11 [Q9UBB9]3EBI-541426,EBI-1105213
THAP6 [Q8TBB0]3EBI-541426,EBI-3925505
TIFA [Q96CG3]7EBI-541426,EBI-740711
TNIP1 [Q15025]3EBI-541426,EBI-357849
TRIM27 [P14373]3EBI-541426,EBI-719493
TRIM41 [Q8WV44]3EBI-541426,EBI-725997
ZBTB14 [O43829]6EBI-541426,EBI-10176632
ZBTB3 [Q9H5J0]3EBI-541426,EBI-7229473
ZBTB43 [O43298]6EBI-541426,EBI-740718
ZBTB44 [Q8NCP5]3EBI-541426,EBI-5658292
ZBTB8A [Q96BR9]7EBI-541426,EBI-742740
ZCCHC17 [Q9NP64]7EBI-541426,EBI-746345
ZNF19 [P17023]3EBI-541426,EBI-12884200
ZNF219 [Q9P2Y4]3EBI-541426,EBI-3937106
ZNF276 [Q8N554]3EBI-541426,EBI-750821
ZNF552 [Q9H707]3EBI-541426,EBI-2555731
ZNF655 [Q8N720]3EBI-541426,EBI-625509
ZNF8 [P17098]3EBI-541426,EBI-2555757
ZRANB1 [Q9UGI0]3EBI-541426,EBI-527853
ZSCAN16 [Q9H4T2]3EBI-541426,EBI-723596

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114421, 148 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant
CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant
CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BXS5

Protein interaction database and analysis system

More...IntActi		Q9BXS5, 99 interactors

Molecular INTeraction database

More...MINTi		Q9BXS5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388996

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXS5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXS5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 421MHDPROSITE-ProRule annotationAdd BLAST254

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0937, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157924

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXS5

Identification of Orthologs from Complete Genome Data

More...OMAi		GGNKEFL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXS5

TreeFam database of animal gene trees

More...TreeFami		TF300393

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00928, Adap_comp_sub, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005992, Clathrin_mu, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00314, CLATHRINADPT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL 
        60         70         80         90        100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE 
       110        120        130        140        150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP 
       160        170        180        190        200
ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLVSANGNVL RSEIVGSIKM 
       210        220        230        240        250
RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND 
       260        270        280        290        300
RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ 
       310        320        330        340        350
FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG 
       360        370        380        390        400
GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK 
       410        420 
SGYQALPWVR YITQNGDYQL RTQ
Length:423
Mass (Da):48,587
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64EC5E47EA6F8E98
GO
Isoform 2 (identifier: Q9BXS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-182: L → LGKYPGVGWLGHT

Show »
Length:435
Mass (Da):49,840
Checksum:iEEA5A4B9F17D86D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENJ6E7ENJ6_HUMAN
AP-1 complex subunit mu-1
AP1M1
370Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJL1K7EJL1_HUMAN
AP-1 complex subunit mu-1
AP1M1
351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQX3K7EQX3_HUMAN
AP-1 complex subunit mu-1
AP1M1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZX7A0A087WZX7_HUMAN
AP-1 complex subunit mu-1
AP1M1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENA7K7ENA7_HUMAN
AP-1 complex subunit mu-1
AP1M1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPJ8K7EPJ8_HUMAN
AP-1 complex subunit mu-1
AP1M1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ90K7EQ90_HUMAN
AP-1 complex subunit mu-1
AP1M1
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER75K7ER75_HUMAN
AP-1 complex subunit mu-1
AP1M1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036536303R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs999036825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042542182L → LGKYPGVGWLGHT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF290613 mRNA Translation: AAK28024.1
DQ059565 mRNA Translation: AAY54246.1
AC020911 Genomic DNA No translation available.
BC017469 mRNA Translation: AAH17469.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12342.1 [Q9BXS5-1]
CCDS46008.1 [Q9BXS5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001123996.1, NM_001130524.1 [Q9BXS5-2]
NP_115882.1, NM_032493.3 [Q9BXS5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1]
ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8907

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8907

UCSC genome browser

More...UCSCi		uc002ndu.3, human [Q9BXS5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290613 mRNA Translation: AAK28024.1
DQ059565 mRNA Translation: AAY54246.1
AC020911 Genomic DNA No translation available.
BC017469 mRNA Translation: AAH17469.1
CCDSiCCDS12342.1 [Q9BXS5-1]
CCDS46008.1 [Q9BXS5-2]
RefSeqiNP_001123996.1, NM_001130524.1 [Q9BXS5-2]
NP_115882.1, NM_032493.3 [Q9BXS5-1]

3D structure databases

SMRiQ9BXS5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114421, 148 interactors
ComplexPortaliCPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant
CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant
CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant
CORUMiQ9BXS5
IntActiQ9BXS5, 99 interactors
MINTiQ9BXS5
STRINGi9606.ENSP00000388996

Protein family/group databases

TCDBi9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family

PTM databases

GlyGeniQ9BXS5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BXS5
PhosphoSitePlusiQ9BXS5
SwissPalmiQ9BXS5

Genetic variation databases

BioMutaiAP1M1
DMDMi18202738

Proteomic databases

EPDiQ9BXS5
jPOSTiQ9BXS5
MassIVEiQ9BXS5
MaxQBiQ9BXS5
PaxDbiQ9BXS5
PeptideAtlasiQ9BXS5
PRIDEiQ9BXS5
ProteomicsDBi79492 [Q9BXS5-1]
79493 [Q9BXS5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27330, 166 antibodies

Genome annotation databases

EnsembliENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1]
ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2]
GeneIDi8907
KEGGihsa:8907
UCSCiuc002ndu.3, human [Q9BXS5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8907
DisGeNETi8907

GeneCards: human genes, protein and diseases

More...GeneCardsi		AP1M1
HGNCiHGNC:13667, AP1M1
HPAiENSG00000072958, Low tissue specificity
MIMi603535, gene
neXtProtiNX_Q9BXS5
OpenTargetsiENSG00000072958
PharmGKBiPA24848
VEuPathDBiHostDB:ENSG00000072958.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0937, Eukaryota
GeneTreeiENSGT00940000157924
InParanoidiQ9BXS5
OMAiGGNKEFL
PhylomeDBiQ9BXS5
TreeFamiTF300393

Enzyme and pathway databases

PathwayCommonsiQ9BXS5
ReactomeiR-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295, MHC class II antigen presentation
R-HSA-432720, Lysosome Vesicle Biogenesis
R-HSA-432722, Golgi Associated Vesicle Biogenesis
R-HSA-6798695, Neutrophil degranulation
SignaLinkiQ9BXS5
SIGNORiQ9BXS5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8907, 26 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AP1M1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AP1M1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8907
PharosiQ9BXS5, Tbio

Protein Ontology

More...PROi		PR:Q9BXS5
RNActiQ9BXS5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072958, Expressed in testis and 210 other tissues
ExpressionAtlasiQ9BXS5, baseline and differential
GenevisibleiQ9BXS5, HS

Family and domain databases

InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PIRSFiPIRSF005992, Clathrin_mu, 1 hit
PRINTSiPR00314, CLATHRINADPT
SUPFAMiSSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP1M1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXS5
Secondary accession number(s): Q4TTY5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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