UniProtKB - Q9BXS5 (AP1M1_HUMAN)

BLAST

>sp|Q9BXS5|AP1M1_HUMAN AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3
MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
LLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQ
CVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQ
FKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHF
GLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQL
RTQ

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History
Entry version 157 (12 Sep 2018)
Sequence version 3 (23 Jan 2007)
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Protein

AP-1 complex subunit mu-1

Gene

AP1M1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
endosome to melanosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19841138
intracellular protein transport Source: InterPro
melanosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19841138
neutrophil degranulation Source: Reactome
regulation of defense response to virus by virus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Protein transport, Transport

Biological process

Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-2132295 MHC class II antigen presentation R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-6798695 Neutrophil degranulation
SignaLinkⁱ	Q9BXS5
SIGNORⁱ	Q9BXS5

Protein family/group databases

TCDBⁱ	9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

TCDBⁱ

9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AP-1 complex subunit mu-1 Alternative name(s): AP-mu chain family member mu1A Adaptor protein complex AP-1 subunit mu-1 Adaptor-related protein complex 1 subunit mu-1 Clathrin assembly protein complex 1 mu-1 medium chain 1 Clathrin coat assembly protein AP47 Clathrin coat-associated protein AP47 Golgi adaptor HA1/AP1 adaptin mu-1 subunit Mu-adaptin 1 Mu1A-adaptin
Gene namesⁱ	Name:AP1M1 Synonyms:CLTNM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000072958.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13667 AP1M1
MIMⁱ	603535 gene
neXtProtⁱ	NX_Q9BXS5

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000072958
PharmGKBⁱ	PA24848

Polymorphism and mutation databases

BioMutaⁱ	AP1M1
DMDMⁱ	18202738

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000193770	2 – 423	AP-1 complex subunit mu-1Add BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	152	PhosphothreonineCombined sources	1
Modified residueⁱ	154	PhosphothreonineCombined sources	1
Modified residueⁱ	223	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BXS5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXS5
PaxDbⁱ	Q9BXS5
PeptideAtlas More...PeptideAtlasⁱ	Q9BXS5
PRIDEⁱ	Q9BXS5
ProteomicsDBⁱ	79492 79493 [Q9BXS5-2]

PTM databases

iPTMnetⁱ	Q9BXS5
PhosphoSitePlusⁱ	Q9BXS5
SwissPalmⁱ	Q9BXS5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000072958 Expressed in 196 organ(s), highest expression level in testis
CleanExⁱ	HS_AP1M1
ExpressionAtlasⁱ	Q9BXS5 baseline and differential
Genevisibleⁱ	Q9BXS5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045256

HPAⁱ

HPA045256

Interactionⁱ

Subunit structureⁱ

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.By similarity1 Publication

(Microbial infection) Interacts with HIV-1 Nef.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP57L1	Q8IYX8-2	3	EBI-541426,EBI-10181988
DZIP3	Q86Y13	3	EBI-541426,EBI-948630
ETV6	P41212	3	EBI-541426,EBI-1372759
FAM9B	Q8IZU0	3	EBI-541426,EBI-10175124
FXR2	P51116	6	EBI-541426,EBI-740459
HOOK2	Q96ED9	3	EBI-541426,EBI-743290
IKZF1	Q13422	3	EBI-541426,EBI-745305
KRT40	Q6A162	5	EBI-541426,EBI-10171697
KRTAP10-7	P60409	3	EBI-541426,EBI-10172290
LDOC1	O95751	5	EBI-541426,EBI-740738
LZTS2	Q9BRK4	3	EBI-541426,EBI-741037
MTF1	Q14872	3	EBI-541426,EBI-747024
PHC2	Q8IXK0	3	EBI-541426,EBI-713786
PNMA5	Q96PV4	3	EBI-541426,EBI-10171633
RSPH14	Q9UHP6	4	EBI-541426,EBI-748350
RUNDC3A	Q59EK9	4	EBI-541426,EBI-747225
SDCCAG3	Q96C92-2	3	EBI-541426,EBI-10178036
SSX2IP	Q9Y2D8	3	EBI-541426,EBI-2212028
TIFA	Q96CG3	6	EBI-541426,EBI-740711
TNIP1	Q15025	3	EBI-541426,EBI-357849
ZBTB14	O43829	5	EBI-541426,EBI-10176632
ZBTB43	O43298	5	EBI-541426,EBI-740718
ZBTB44	Q8NCP5	3	EBI-541426,EBI-5658292
ZBTB8A	Q96BR9	6	EBI-541426,EBI-742740

Protein-protein interaction databases

BioGridⁱ	114421, 72 interactors
CORUMⁱ	Q9BXS5
IntActⁱ	Q9BXS5, 87 interactors
Molecular INTeraction database More...MINTⁱ	Q9BXS5
STRINGⁱ	9606.ENSP00000388996

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXS5
SMRⁱ	Q9BXS5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	168 – 421	MHDPROSITE-ProRule annotationAdd BLAST		254

Sequence similaritiesⁱ

Belongs to the adaptor complexes medium subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0937 Eukaryota ENOG410XPFS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062779
HOGENOMⁱ	HOG000173247
HOVERGENⁱ	HBG050516
InParanoidⁱ	Q9BXS5
KEGG Orthology (KO) More...KOⁱ	K12393
OMAⁱ	QQVTPCF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06XI
PhylomeDBⁱ	Q9BXS5
TreeFamⁱ	TF300393

Family and domain databases

InterProⁱ	View protein in InterPro IPR036168 AP2_Mu_C_sf IPR022775 AP_mu_sigma_su IPR001392 Clathrin_mu IPR018240 Clathrin_mu_CS IPR011012 Longin-like_dom_sf IPR028565 MHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00928 Adap_comp_sub, 1 hit PF01217 Clat_adaptor_s, 1 hit
PIRSFⁱ	PIRSF005992 Clathrin_mu, 1 hit
PRINTSⁱ	PR00314 CLATHRINADPT
SUPFAMⁱ	SSF49447 SSF49447, 1 hit SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS00990 CLAT_ADAPTOR_M_1, 1 hit PS00991 CLAT_ADAPTOR_M_2, 1 hit PS51072 MHD, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXS5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL 
        60         70         80         90        100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE 
       110        120        130        140        150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP 
       160        170        180        190        200
ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLVSANGNVL RSEIVGSIKM 
       210        220        230        240        250
RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND 
       260        270        280        290        300
RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ 
       310        320        330        340        350
FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG 
       360        370        380        390        400
GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK 
       410        420 
SGYQALPWVR YITQNGDYQL RTQ

Length:423

Mass (Da):48,587

Last modified:January 23, 2007 - v3

Checksum:ⁱ64EC5E47EA6F8E98

Isoform 2 (identifier: Q9BXS5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
182-182: L → LGKYPGVGWLGHT

« Hide

        10         20         30         40         50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL 
        60         70         80         90        100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE 
       110        120        130        140        150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP 
       160        170        180        190        200
ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLGKYPGVGW LGHTVSANGN 
       210        220        230        240        250
VLRSEIVGSI KMRVFLSGMP ELRLGLNDKV LFDNTGRGKS KSVELEDVKF 
       260        270        280        290        300
HQCVRLSRFE NDRTISFIPP DGEFELMSYR LNTHVKPLIW IESVIEKHSH 
       310        320        330        340        350
SRIEYMIKAK SQFKRRSTAN NVEIHIPVPN DADSPKFKTT VGSVKWVPEN 
       360        370        380        390        400
SEIVWSIKSF PGGKEYLMRA HFGLPSVEAE DKEGKPPISV KFEIPYFTTS 
       410        420        430 
GIQVRYLKII EKSGYQALPW VRYITQNGDY QLRTQ

Note: No experimental confirmation available.

Show »

Length:435

Mass (Da):49,840

Checksum:ⁱEEA5A4B9F17D86D9

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ENJ6	E7ENJ6_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	370	Annotation score:
K7EJL1	K7EJL1_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	351	Annotation score:
K7EQX3	K7EQX3_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	176	Annotation score:
K7ENA7	K7ENA7_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	136	Annotation score:
A0A087WZX7	A0A087WZX7_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	128	Annotation score:
K7EPJ8	K7EPJ8_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	125	Annotation score:
K7EQ90	K7EQ90_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	64	Annotation score:
K7ER75	K7ER75_HUMAN	AP-1 complex subunit mu-1 AP-1 complex subunit mu-1	AP1M1	105	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036536	303	R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs999036825Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042542	182	L → LGKYPGVGWLGHT in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF290613 mRNA Translation: AAK28024.1 DQ059565 mRNA Translation: AAY54246.1 AC020911 Genomic DNA No translation available. BC017469 mRNA Translation: AAH17469.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12342.1 [Q9BXS5-1] CCDS46008.1 [Q9BXS5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001123996.1, NM_001130524.1 [Q9BXS5-2] NP_115882.1, NM_032493.3 [Q9BXS5-1]
UniGeneⁱ	Hs.71040

Genome annotation databases

Ensemblⁱ	ENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1] ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2]
GeneIDⁱ	8907
KEGGⁱ	hsa:8907
UCSC genome browser More...UCSCⁱ	uc002ndu.3 human [Q9BXS5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXS5	AP-1 complex subunit mu-1		BOVIN		423	UniRef100_Q9BXS5
AP-1 complex subunit mu-1		PTEAL		527
AP-1 complex subunit mu-1 isoform X5		TURTR		306
Uncharacterized protein		PANPA		409
Adaptor-related protein complex 1, mu 1 subunit, isoform CRA_a		HUMAN		423
+36
Q9BXS5-2	AP1M1 isoform 3		PANTR		435	UniRef100_A0A2I3SE57
Adaptor-related protein complex 1, mu 1 subunit variant (Fragment)		HUMAN		466
AP-1 complex subunit mu-1 isoform 1		MACMU		435
Uncharacterized protein		Cebus capucinus imitator		435
AP1M1 isoform 3		PONAB		435
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9BXS5	AP-1 complex subunit mu-1		BOVIN		423	UniRef90_Q9BXS5
AP-1 complex subunit mu-1		PTEAL		527
AP-1 complex subunit mu-1 isoform X5		TURTR		306
Uncharacterized protein		PANPA		409
Adaptor-related protein complex 1, mu 1 subunit, isoform CRA_a		HUMAN		423
+68
Q9BXS5-2	Uncharacterized protein		PIG		483	UniRef90_F2Z5I7
Uncharacterized protein		MYOLU		465
Adaptor related protein complex 1 subunit mu 1		CANLF		463
Adaptor related protein complex 1 subunit mu 1		CALJA		462
Adaptor related protein complex 1 subunit mu 1		MONDO		459
+34

Protein	Similar proteins		Species	Score	Length	Source
Q9BXS5	AP-1 complex subunit mu-1		BOVIN		423	UniRef50_Q9BXS5
AP-1 complex subunit mu-1	)	MOUSE		423
AP-1 complex subunit mu-1		RAT		423
AP-1 complex subunit mu-1		PTEAL		527
AP-1 complex subunit mu-1 isoform X5		TURTR		306
+640
Q9BXS5-2	Uncharacterized protein		PIG		483	UniRef50_F2Z5I7
Uncharacterized protein		MYOLU		465
Adaptor related protein complex 1 subunit mu 1		CANLF		463
Adaptor related protein complex 1 subunit mu 1		CALJA		462
Adaptor related protein complex 1 subunit mu 1		MONDO		459
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF290613 mRNA Translation: AAK28024.1 DQ059565 mRNA Translation: AAY54246.1 AC020911 Genomic DNA No translation available. BC017469 mRNA Translation: AAH17469.1
CCDSⁱ	CCDS12342.1 [Q9BXS5-1] CCDS46008.1 [Q9BXS5-2]
RefSeqⁱ	NP_001123996.1, NM_001130524.1 [Q9BXS5-2] NP_115882.1, NM_032493.3 [Q9BXS5-1]
UniGeneⁱ	Hs.71040

3D structure databases

ProteinModelPortalⁱ	Q9BXS5
SMRⁱ	Q9BXS5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114421, 72 interactors
CORUMⁱ	Q9BXS5
IntActⁱ	Q9BXS5, 87 interactors
MINTⁱ	Q9BXS5
STRINGⁱ	9606.ENSP00000388996

Protein family/group databases

TCDBⁱ	9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

TCDBⁱ

9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

PTM databases

iPTMnetⁱ	Q9BXS5
PhosphoSitePlusⁱ	Q9BXS5
SwissPalmⁱ	Q9BXS5

Polymorphism and mutation databases

BioMutaⁱ	AP1M1
DMDMⁱ	18202738

Proteomic databases

EPDⁱ	Q9BXS5
MaxQBⁱ	Q9BXS5
PaxDbⁱ	Q9BXS5
PeptideAtlasⁱ	Q9BXS5
PRIDEⁱ	Q9BXS5
ProteomicsDBⁱ	79492 79493 [Q9BXS5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1] ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2]
GeneIDⁱ	8907
KEGGⁱ	hsa:8907
UCSCⁱ	uc002ndu.3 human [Q9BXS5-1]

Organism-specific databases

CTDⁱ	8907
EuPathDBⁱ	HostDB:ENSG00000072958.8
GeneCardsⁱ	AP1M1
HGNCⁱ	HGNC:13667 AP1M1
HPAⁱ	HPA045256
MIMⁱ	603535 gene
neXtProtⁱ	NX_Q9BXS5
OpenTargetsⁱ	ENSG00000072958
PharmGKBⁱ	PA24848
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0937 Eukaryota ENOG410XPFS LUCA
GeneTreeⁱ	ENSGT00530000062779
HOGENOMⁱ	HOG000173247
HOVERGENⁱ	HBG050516
InParanoidⁱ	Q9BXS5
KOⁱ	K12393
OMAⁱ	QQVTPCF
OrthoDBⁱ	EOG091G06XI
PhylomeDBⁱ	Q9BXS5
TreeFamⁱ	TF300393

Enzyme and pathway databases

Reactomeⁱ	R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-2132295 MHC class II antigen presentation R-HSA-432720 Lysosome Vesicle Biogenesis R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-6798695 Neutrophil degranulation
SignaLinkⁱ	Q9BXS5
SIGNORⁱ	Q9BXS5

Miscellaneous databases

ChiTaRSⁱ	AP1M1 human
GeneWikiⁱ	AP1M1
GenomeRNAiⁱ	8907
Protein Ontology More...PROⁱ	PR:Q9BXS5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000072958 Expressed in 196 organ(s), highest expression level in testis
CleanExⁱ	HS_AP1M1
ExpressionAtlasⁱ	Q9BXS5 baseline and differential
Genevisibleⁱ	Q9BXS5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036168 AP2_Mu_C_sf IPR022775 AP_mu_sigma_su IPR001392 Clathrin_mu IPR018240 Clathrin_mu_CS IPR011012 Longin-like_dom_sf IPR028565 MHD
Pfamⁱ	View protein in Pfam PF00928 Adap_comp_sub, 1 hit PF01217 Clat_adaptor_s, 1 hit
PIRSFⁱ	PIRSF005992 Clathrin_mu, 1 hit
PRINTSⁱ	PR00314 CLATHRINADPT
SUPFAMⁱ	SSF49447 SSF49447, 1 hit SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS00990 CLAT_ADAPTOR_M_1, 1 hit PS00991 CLAT_ADAPTOR_M_2, 1 hit PS51072 MHD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP1M1_HUMAN
Accessionⁱ	Q9BXS5Primary (citable) accession number: Q9BXS5 Secondary accession number(s): Q4TTY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q9BXS5 (AP1M1_HUMAN)

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AP-1 complex subunit mu-1

AP1M1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Cytosol

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ