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Protein

AP-1 complex subunit mu-1

Gene

AP1M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ9BXS5
SIGNORiQ9BXS5

Protein family/group databases

TCDBi9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit mu-1
Alternative name(s):
AP-mu chain family member mu1A
Adaptor protein complex AP-1 subunit mu-1
Adaptor-related protein complex 1 subunit mu-1
Clathrin assembly protein complex 1 mu-1 medium chain 1
Clathrin coat assembly protein AP47
Clathrin coat-associated protein AP47
Golgi adaptor HA1/AP1 adaptin mu-1 subunit
Mu-adaptin 1
Mu1A-adaptin
Gene namesi
Name:AP1M1
Synonyms:CLTNM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000072958.8
HGNCiHGNC:13667 AP1M1
MIMi603535 gene
neXtProtiNX_Q9BXS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072958
PharmGKBiPA24848

Polymorphism and mutation databases

BioMutaiAP1M1
DMDMi18202738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001937702 – 423AP-1 complex subunit mu-1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei152PhosphothreonineCombined sources1
Modified residuei154PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BXS5
MaxQBiQ9BXS5
PaxDbiQ9BXS5
PeptideAtlasiQ9BXS5
PRIDEiQ9BXS5
ProteomicsDBi79492
79493 [Q9BXS5-2]

PTM databases

iPTMnetiQ9BXS5
PhosphoSitePlusiQ9BXS5
SwissPalmiQ9BXS5

Expressioni

Gene expression databases

BgeeiENSG00000072958 Expressed in 196 organ(s), highest expression level in testis
CleanExiHS_AP1M1
ExpressionAtlasiQ9BXS5 baseline and differential
GenevisibleiQ9BXS5 HS

Organism-specific databases

HPAiHPA045256

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.By similarity1 Publication
(Microbial infection) Interacts with HIV-1 Nef.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114421, 72 interactors
CORUMiQ9BXS5
IntActiQ9BXS5, 87 interactors
MINTiQ9BXS5
STRINGi9606.ENSP00000388996

Structurei

3D structure databases

ProteinModelPortaliQ9BXS5
SMRiQ9BXS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 421MHDPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiQ9BXS5
KOiK12393
OMAiQQVTPCF
OrthoDBiEOG091G06XI
PhylomeDBiQ9BXS5
TreeFamiTF300393

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BXS5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL
60 70 80 90 100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE
110 120 130 140 150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP
160 170 180 190 200
ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLVSANGNVL RSEIVGSIKM
210 220 230 240 250
RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND
260 270 280 290 300
RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ
310 320 330 340 350
FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK
410 420
SGYQALPWVR YITQNGDYQL RTQ
Length:423
Mass (Da):48,587
Last modified:January 23, 2007 - v3
Checksum:i64EC5E47EA6F8E98
GO
Isoform 2 (identifier: Q9BXS5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-182: L → LGKYPGVGWLGHT

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):49,840
Checksum:iEEA5A4B9F17D86D9
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENJ6E7ENJ6_HUMAN
AP-1 complex subunit mu-1
AP1M1
370Annotation score:
K7EJL1K7EJL1_HUMAN
AP-1 complex subunit mu-1
AP1M1
351Annotation score:
K7EQX3K7EQX3_HUMAN
AP-1 complex subunit mu-1
AP1M1
176Annotation score:
K7ENA7K7ENA7_HUMAN
AP-1 complex subunit mu-1
AP1M1
136Annotation score:
A0A087WZX7A0A087WZX7_HUMAN
AP-1 complex subunit mu-1
AP1M1
128Annotation score:
K7EPJ8K7EPJ8_HUMAN
AP-1 complex subunit mu-1
AP1M1
125Annotation score:
K7EQ90K7EQ90_HUMAN
AP-1 complex subunit mu-1
AP1M1
64Annotation score:
K7ER75K7ER75_HUMAN
AP-1 complex subunit mu-1
AP1M1
105Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036536303R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs999036825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042542182L → LGKYPGVGWLGHT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290613 mRNA Translation: AAK28024.1
DQ059565 mRNA Translation: AAY54246.1
AC020911 Genomic DNA No translation available.
BC017469 mRNA Translation: AAH17469.1
CCDSiCCDS12342.1 [Q9BXS5-1]
CCDS46008.1 [Q9BXS5-2]
RefSeqiNP_001123996.1, NM_001130524.1 [Q9BXS5-2]
NP_115882.1, NM_032493.3 [Q9BXS5-1]
UniGeneiHs.71040

Genome annotation databases

EnsembliENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1]
ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2]
GeneIDi8907
KEGGihsa:8907
UCSCiuc002ndu.3 human [Q9BXS5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAP1M1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXS5
Secondary accession number(s): Q4TTY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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