UniProtKB - Q9BXS5 (AP1M1_HUMAN)
AP-1 complex subunit mu-1
AP1M1
Functioni
GO - Molecular functioni
- clathrin adaptor activity Source: GO_Central
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- endosome to melanosome transport Source: UniProtKB
- intracellular protein transport Source: InterPro
- melanosome organization Source: UniProtKB
- neutrophil degranulation Source: Reactome
- post-Golgi vesicle-mediated transport Source: Reactome
- regulation of defense response to virus by virus Source: Reactome
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BXS5 |
Reactomei | R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-2132295, MHC class II antigen presentation R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9BXS5 |
SIGNORi | Q9BXS5 |
Protein family/group databases
TCDBi | 9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: AP-1 complex subunit mu-1Alternative name(s): AP-mu chain family member mu1A Adaptor protein complex AP-1 subunit mu-1 Adaptor-related protein complex 1 subunit mu-1 Clathrin assembly protein complex 1 mu-1 medium chain 1 Clathrin coat assembly protein AP47 Clathrin coat-associated protein AP47 Golgi adaptor HA1/AP1 adaptin mu-1 subunit Mu-adaptin 1 Mu1A-adaptin |
Gene namesi | Name:AP1M1 Synonyms:CLTNM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13667, AP1M1 |
MIMi | 603535, gene |
neXtProti | NX_Q9BXS5 |
VEuPathDBi | HostDB:ENSG00000072958.8 |
Subcellular locationi
Golgi apparatus
Other locations
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: Reactome
- trans-Golgi network membrane Source: Reactome
Lysosome
- lysosomal membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- clathrin adaptor complex Source: InterPro
- clathrin-coated vesicle Source: GO_Central
- clathrin-coated vesicle membrane Source: UniProtKB-SubCell
- cytoplasmic vesicle Source: GO_Central
- cytoplasmic vesicle membrane Source: Reactome
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: UniProtKB
- specific granule membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8907 |
OpenTargetsi | ENSG00000072958 |
PharmGKBi | PA24848 |
Miscellaneous databases
Pharosi | Q9BXS5, Tbio |
Genetic variation databases
BioMutai | AP1M1 |
DMDMi | 18202738 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000193770 | 2 – 423 | AP-1 complex subunit mu-1Add BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 152 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 154 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 223 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BXS5 |
jPOSTi | Q9BXS5 |
MassIVEi | Q9BXS5 |
MaxQBi | Q9BXS5 |
PaxDbi | Q9BXS5 |
PeptideAtlasi | Q9BXS5 |
PRIDEi | Q9BXS5 |
ProteomicsDBi | 79492 [Q9BXS5-1] 79493 [Q9BXS5-2] |
PTM databases
GlyGeni | Q9BXS5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXS5 |
PhosphoSitePlusi | Q9BXS5 |
SwissPalmi | Q9BXS5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072958, Expressed in testis and 210 other tissues |
ExpressionAtlasi | Q9BXS5, baseline and differential |
Genevisiblei | Q9BXS5, HS |
Organism-specific databases
HPAi | ENSG00000072958, Low tissue specificity |
Interactioni
Subunit structurei
Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
Interacts with MARCHF11 (By similarity). Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.
By similarity1 Publication(Microbial infection) Interacts with HIV-1 Nef.
1 PublicationBinary interactionsi
Q9BXS5
GO - Molecular functioni
- clathrin adaptor activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114421, 148 interactors |
ComplexPortali | CPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant |
CORUMi | Q9BXS5 |
IntActi | Q9BXS5, 99 interactors |
MINTi | Q9BXS5 |
STRINGi | 9606.ENSP00000388996 |
Miscellaneous databases
RNActi | Q9BXS5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 421 | MHDPROSITE-ProRule annotationAdd BLAST | 254 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0937, Eukaryota |
GeneTreei | ENSGT00940000157924 |
InParanoidi | Q9BXS5 |
OMAi | GGNKEFL |
PhylomeDBi | Q9BXS5 |
TreeFami | TF300393 |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL
60 70 80 90 100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE
110 120 130 140 150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP
160 170 180 190 200
ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLVSANGNVL RSEIVGSIKM
210 220 230 240 250
RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND
260 270 280 290 300
RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ
310 320 330 340 350
FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK
410 420
SGYQALPWVR YITQNGDYQL RTQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ENJ6 | E7ENJ6_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 370 | Annotation score: | ||
K7EJL1 | K7EJL1_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 351 | Annotation score: | ||
K7EQX3 | K7EQX3_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 176 | Annotation score: | ||
A0A087WZX7 | A0A087WZX7_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 128 | Annotation score: | ||
K7ENA7 | K7ENA7_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 136 | Annotation score: | ||
K7EPJ8 | K7EPJ8_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 125 | Annotation score: | ||
K7EQ90 | K7EQ90_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 64 | Annotation score: | ||
K7ER75 | K7ER75_HUMAN | AP-1 complex subunit mu-1 | AP1M1 | 105 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036536 | 303 | R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs999036825Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042542 | 182 | L → LGKYPGVGWLGHT in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF290613 mRNA Translation: AAK28024.1 DQ059565 mRNA Translation: AAY54246.1 AC020911 Genomic DNA No translation available. BC017469 mRNA Translation: AAH17469.1 |
CCDSi | CCDS12342.1 [Q9BXS5-1] CCDS46008.1 [Q9BXS5-2] |
RefSeqi | NP_001123996.1, NM_001130524.1 [Q9BXS5-2] NP_115882.1, NM_032493.3 [Q9BXS5-1] |
Genome annotation databases
Ensembli | ENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1] ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2] |
GeneIDi | 8907 |
KEGGi | hsa:8907 |
UCSCi | uc002ndu.3, human [Q9BXS5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF290613 mRNA Translation: AAK28024.1 DQ059565 mRNA Translation: AAY54246.1 AC020911 Genomic DNA No translation available. BC017469 mRNA Translation: AAH17469.1 |
CCDSi | CCDS12342.1 [Q9BXS5-1] CCDS46008.1 [Q9BXS5-2] |
RefSeqi | NP_001123996.1, NM_001130524.1 [Q9BXS5-2] NP_115882.1, NM_032493.3 [Q9BXS5-1] |
3D structure databases
SMRi | Q9BXS5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114421, 148 interactors |
ComplexPortali | CPX-5047, Ubiquitous AP-1 Adaptor complex, sigma1a variant CPX-5048, Ubiquitous AP-1 Adaptor complex, sigma1b variant CPX-5049, Ubiquitous AP-1 Adaptor complex, sigma1c variant |
CORUMi | Q9BXS5 |
IntActi | Q9BXS5, 99 interactors |
MINTi | Q9BXS5 |
STRINGi | 9606.ENSP00000388996 |
Protein family/group databases
TCDBi | 9.B.278.1.1, the organellar-targeting adaptor protein complex (o-apc) family |
PTM databases
GlyGeni | Q9BXS5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXS5 |
PhosphoSitePlusi | Q9BXS5 |
SwissPalmi | Q9BXS5 |
Genetic variation databases
BioMutai | AP1M1 |
DMDMi | 18202738 |
Proteomic databases
EPDi | Q9BXS5 |
jPOSTi | Q9BXS5 |
MassIVEi | Q9BXS5 |
MaxQBi | Q9BXS5 |
PaxDbi | Q9BXS5 |
PeptideAtlasi | Q9BXS5 |
PRIDEi | Q9BXS5 |
ProteomicsDBi | 79492 [Q9BXS5-1] 79493 [Q9BXS5-2] |
Protocols and materials databases
Antibodypediai | 27330, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000291439; ENSP00000291439; ENSG00000072958 [Q9BXS5-1] ENST00000444449; ENSP00000388996; ENSG00000072958 [Q9BXS5-2] |
GeneIDi | 8907 |
KEGGi | hsa:8907 |
UCSCi | uc002ndu.3, human [Q9BXS5-1] |
Organism-specific databases
CTDi | 8907 |
DisGeNETi | 8907 |
GeneCardsi | AP1M1 |
HGNCi | HGNC:13667, AP1M1 |
HPAi | ENSG00000072958, Low tissue specificity |
MIMi | 603535, gene |
neXtProti | NX_Q9BXS5 |
OpenTargetsi | ENSG00000072958 |
PharmGKBi | PA24848 |
VEuPathDBi | HostDB:ENSG00000072958.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0937, Eukaryota |
GeneTreei | ENSGT00940000157924 |
InParanoidi | Q9BXS5 |
OMAi | GGNKEFL |
PhylomeDBi | Q9BXS5 |
TreeFami | TF300393 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXS5 |
Reactomei | R-HSA-164940, Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-2132295, MHC class II antigen presentation R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9BXS5 |
SIGNORi | Q9BXS5 |
Miscellaneous databases
BioGRID-ORCSi | 8907, 26 hits in 995 CRISPR screens |
ChiTaRSi | AP1M1, human |
GeneWikii | AP1M1 |
GenomeRNAii | 8907 |
Pharosi | Q9BXS5, Tbio |
PROi | PR:Q9BXS5 |
RNActi | Q9BXS5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072958, Expressed in testis and 210 other tissues |
ExpressionAtlasi | Q9BXS5, baseline and differential |
Genevisiblei | Q9BXS5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AP1M1_HUMAN | |
Accessioni | Q9BXS5Primary (citable) accession number: Q9BXS5 Secondary accession number(s): Q4TTY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families