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Protein

Transmembrane protein 59

Gene

TMEM59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy

Protein family/group databases

TCDBi8.A.84.1.4 the insulin secretion regulator tmem59 (tmem59) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 59
Alternative name(s):
Liver membrane-bound protein
Gene namesi
Name:TMEM59
Synonyms:C1orf8
ORF Names:HSPC001, UNQ169/PRO195
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116209.11
HGNCiHGNC:1239 TMEM59
neXtProtiNX_Q9BXS4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 238ExtracellularSequence analysisAdd BLAST203
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 323CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi268Y → A or F: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1
Mutagenesisi268Y → W: Does not affect ability to activate LC3. 1 Publication1
Mutagenesisi269V → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi272E → A or D: Does not affect ability to activate LC3. No effect on interaction with ATG16L1. 2 Publications1
Mutagenesisi273K → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi277Y → A: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1
Mutagenesisi277Y → W or F: Does not affect ability to activate LC3. 1 Publication1
Mutagenesisi278G → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi280L → A or V: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1

Organism-specific databases

DisGeNETi9528
OpenTargetsiENSG00000116209
PharmGKBiPA25620

Polymorphism and mutation databases

BioMutaiTMEM59
DMDMi18202737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000300336 – 323Transmembrane protein 59Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei303PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BXS4
MaxQBiQ9BXS4
PaxDbiQ9BXS4
PeptideAtlasiQ9BXS4
PRIDEiQ9BXS4
ProteomicsDBi79491

PTM databases

iPTMnetiQ9BXS4
PhosphoSitePlusiQ9BXS4
SwissPalmiQ9BXS4

Expressioni

Gene expression databases

BgeeiENSG00000116209 Expressed in 236 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TMEM59
ExpressionAtlasiQ9BXS4 baseline and differential
GenevisibleiQ9BXS4 HS

Interactioni

Subunit structurei

Interacts with ATG16L1 (via WD repeats).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG16L1Q676U56EBI-7054441,EBI-535909

Protein-protein interaction databases

BioGridi114904, 11 interactors
IntActiQ9BXS4, 6 interactors
MINTiQ9BXS4
STRINGi9606.ENSP00000234831

Structurei

3D structure databases

ProteinModelPortaliQ9BXS4
SMRiQ9BXS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 281ATG16L1-binding motif2 PublicationsAdd BLAST19

Domaini

The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.1 Publication

Sequence similaritiesi

Belongs to the TMEM59 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIST Eukaryota
ENOG410XTCW LUCA
GeneTreeiENSGT00390000008279
HOVERGENiHBG018206
InParanoidiQ9BXS4
OMAiQEPTNLK
OrthoDBiEOG091G0EVN
PhylomeDBiQ9BXS4
TreeFamiTF331226

Family and domain databases

InterProiView protein in InterPro
IPR022065 Uncharacterised_TMEM59
PANTHERiPTHR28652 PTHR28652, 1 hit
PfamiView protein in Pfam
PF12280 BSMAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BXS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR
60 70 80 90 100
ACQLTYPLHT YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC
110 120 130 140 150
TEAYSQSDEQ YACHLGCQNQ LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF
160 170 180 190 200
WSDMMDSAQS FITSSWTFYL QADDGKIVIF QSKPEIQYAP HLEQEPTNLR
210 220 230 240 250
ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW ILTTTLVLSV
260 270 280 290 300
MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR
310 320
SKTEDHEEAG PLPTKVNLAH SEI
Length:323
Mass (Da):36,223
Last modified:June 1, 2001 - v1
Checksum:i0926AB7D12D1B902
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6Z8Q5T6Z8_HUMAN
Transmembrane protein 59, isoform C...
TMEM59 hCG_33694
192Annotation score:
Q5T704Q5T704_HUMAN
Transmembrane protein 59
TMEM59
285Annotation score:
Q5T706Q5T706_HUMAN
Transmembrane protein 59
TMEM59
144Annotation score:
Q5T703Q5T703_HUMAN
Transmembrane protein 59
TMEM59
145Annotation score:

Sequence cautioni

The sequence AAC39890 differs from that shown. Reason: Frameshift at position 6.Curated
The sequence AAH03106 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209Y → SD in AAH16374 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06339746A → V1 PublicationCorresponds to variant dbSNP:rs41294776Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290615 mRNA Translation: AAK28026.1
AF047439 mRNA Translation: AAC39890.1 Frameshift.
AY359029 mRNA Translation: AAQ89388.1
AK075187 mRNA Translation: BAG52079.1
AK075505 mRNA Translation: BAC11658.1
AL353898 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06707.1
BC003106 mRNA Translation: AAH03106.1 Different initiation.
BC016374 mRNA Translation: AAH16374.1
BC095464 mRNA Translation: AAH95464.1
CCDSiCCDS586.1
RefSeqiNP_001291972.1, NM_001305043.1
NP_001291978.1, NM_001305049.1
NP_001291979.1, NM_001305050.1
NP_001291980.1, NM_001305051.1
NP_001291981.1, NM_001305052.1
NP_001291995.1, NM_001305066.1
NP_004863.2, NM_004872.4
UniGeneiHs.118947
Hs.523262
Hs.558618
Hs.684693
Hs.689423

Genome annotation databases

EnsembliENST00000234831; ENSP00000234831; ENSG00000116209
GeneIDi9528
KEGGihsa:9528
UCSCiuc001cwp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290615 mRNA Translation: AAK28026.1
AF047439 mRNA Translation: AAC39890.1 Frameshift.
AY359029 mRNA Translation: AAQ89388.1
AK075187 mRNA Translation: BAG52079.1
AK075505 mRNA Translation: BAC11658.1
AL353898 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06707.1
BC003106 mRNA Translation: AAH03106.1 Different initiation.
BC016374 mRNA Translation: AAH16374.1
BC095464 mRNA Translation: AAH95464.1
CCDSiCCDS586.1
RefSeqiNP_001291972.1, NM_001305043.1
NP_001291978.1, NM_001305049.1
NP_001291979.1, NM_001305050.1
NP_001291980.1, NM_001305051.1
NP_001291981.1, NM_001305052.1
NP_001291995.1, NM_001305066.1
NP_004863.2, NM_004872.4
UniGeneiHs.118947
Hs.523262
Hs.558618
Hs.684693
Hs.689423

3D structure databases

ProteinModelPortaliQ9BXS4
SMRiQ9BXS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114904, 11 interactors
IntActiQ9BXS4, 6 interactors
MINTiQ9BXS4
STRINGi9606.ENSP00000234831

Protein family/group databases

TCDBi8.A.84.1.4 the insulin secretion regulator tmem59 (tmem59) family

PTM databases

iPTMnetiQ9BXS4
PhosphoSitePlusiQ9BXS4
SwissPalmiQ9BXS4

Polymorphism and mutation databases

BioMutaiTMEM59
DMDMi18202737

Proteomic databases

EPDiQ9BXS4
MaxQBiQ9BXS4
PaxDbiQ9BXS4
PeptideAtlasiQ9BXS4
PRIDEiQ9BXS4
ProteomicsDBi79491

Protocols and materials databases

DNASUi9528
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234831; ENSP00000234831; ENSG00000116209
GeneIDi9528
KEGGihsa:9528
UCSCiuc001cwp.4 human

Organism-specific databases

CTDi9528
DisGeNETi9528
EuPathDBiHostDB:ENSG00000116209.11
GeneCardsiTMEM59
HGNCiHGNC:1239 TMEM59
neXtProtiNX_Q9BXS4
OpenTargetsiENSG00000116209
PharmGKBiPA25620
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIST Eukaryota
ENOG410XTCW LUCA
GeneTreeiENSGT00390000008279
HOVERGENiHBG018206
InParanoidiQ9BXS4
OMAiQEPTNLK
OrthoDBiEOG091G0EVN
PhylomeDBiQ9BXS4
TreeFamiTF331226

Miscellaneous databases

ChiTaRSiTMEM59 human
GeneWikiiTMEM59
GenomeRNAii9528
PROiPR:Q9BXS4

Gene expression databases

BgeeiENSG00000116209 Expressed in 236 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TMEM59
ExpressionAtlasiQ9BXS4 baseline and differential
GenevisibleiQ9BXS4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022065 Uncharacterised_TMEM59
PANTHERiPTHR28652 PTHR28652, 1 hit
PfamiView protein in Pfam
PF12280 BSMAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM59_HUMAN
AccessioniPrimary (citable) accession number: Q9BXS4
Secondary accession number(s): B3KQL7
, O75393, Q4VBP9, Q5T705, Q96KX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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