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UniProtKB - Q9BXS4 (TMM59_HUMAN)

Entry version 160 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Transmembrane protein 59

Gene

TMEM59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921).

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278).

Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXS4

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.84.1.4, the insulin secretion regulator tmem59 (tmem59) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 59
Alternative name(s):
Liver membrane-bound protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM59
Synonyms:C1orf8
ORF Names:HSPC001, UNQ169/PRO195
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1239, TMEM59

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXS4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116209.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 238ExtracellularSequence analysisAdd BLAST203
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 323CytoplasmicSequence analysisAdd BLAST64

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi268Y → A or F: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1
Mutagenesisi268Y → W: Does not affect ability to activate LC3. 1 Publication1
Mutagenesisi269V → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi272E → A or D: Does not affect ability to activate LC3. No effect on interaction with ATG16L1. 2 Publications1
Mutagenesisi273K → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi277Y → A: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1
Mutagenesisi277Y → W or F: Does not affect ability to activate LC3. 1 Publication1
Mutagenesisi278G → A: No effect on interaction with ATG16L1. 1 Publication1
Mutagenesisi280L → A or V: Impaired ability to activate LC3. Impaired interaction with ATG16L1. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		9528

Open Targets

More...OpenTargetsi		ENSG00000116209

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25620

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXS4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM59

Domain mapping of disease mutations (DMDM)

More...DMDMi		18202737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000300336 – 323Transmembrane protein 59Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei303PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXS4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXS4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXS4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BXS4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXS4

PeptideAtlas

More...PeptideAtlasi		Q9BXS4

PRoteomics IDEntifications database

More...PRIDEi		Q9BXS4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79491

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BXS4, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXS4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BXS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116209, Expressed in C1 segment of cervical spinal cord and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BXS4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXS4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116209, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATG16L1 (via WD repeats).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114904, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q9BXS4, 9 interactors

Molecular INTeraction database

More...MINTi		Q9BXS4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000234831

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXS4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXS4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi263 – 281ATG16L1-binding motif2 PublicationsAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM59 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUIS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059747_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXS4

Identification of Orthologs from Complete Genome Data

More...OMAi		INSSWIL

Database of Orthologous Groups

More...OrthoDBi		1102891at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXS4

TreeFam database of animal gene trees

More...TreeFami		TF331226

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022065, Uncharacterised_TMEM59

The PANTHER Classification System

More...PANTHERi		PTHR28652, PTHR28652, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12280, BSMAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BXS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR 
        60         70         80         90        100
ACQLTYPLHT YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC 
       110        120        130        140        150
TEAYSQSDEQ YACHLGCQNQ LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF 
       160        170        180        190        200
WSDMMDSAQS FITSSWTFYL QADDGKIVIF QSKPEIQYAP HLEQEPTNLR 
       210        220        230        240        250
ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW ILTTTLVLSV 
       260        270        280        290        300
MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR 
       310        320 
SKTEDHEEAG PLPTKVNLAH SEI
Length:323
Mass (Da):36,223
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0926AB7D12D1B902
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6Z8Q5T6Z8_HUMAN
Transmembrane protein 59
TMEM59 hCG_33694
192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T704Q5T704_HUMAN
Transmembrane protein 59
TMEM59
285Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T706Q5T706_HUMAN
Transmembrane protein 59
TMEM59
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T703Q5T703_HUMAN
Transmembrane protein 59
TMEM59
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC39890 differs from that shown. Reason: Frameshift.Curated
The sequence AAH03106 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209Y → SD in AAH16374 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06339746A → V1 PublicationCorresponds to variant dbSNP:rs41294776Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF290615 mRNA Translation: AAK28026.1
AF047439 mRNA Translation: AAC39890.1 Frameshift.
AY359029 mRNA Translation: AAQ89388.1
AK075187 mRNA Translation: BAG52079.1
AK075505 mRNA Translation: BAC11658.1
AL353898 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06707.1
BC003106 mRNA Translation: AAH03106.1 Different initiation.
BC016374 mRNA Translation: AAH16374.1
BC095464 mRNA Translation: AAH95464.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS586.1

NCBI Reference Sequences

More...RefSeqi		NP_001291972.1, NM_001305043.1
NP_001291978.1, NM_001305049.1
NP_001291979.1, NM_001305050.1
NP_001291980.1, NM_001305051.1
NP_001291981.1, NM_001305052.1
NP_001291995.1, NM_001305066.1
NP_004863.2, NM_004872.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000234831; ENSP00000234831; ENSG00000116209

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9528

UCSC genome browser

More...UCSCi		uc001cwp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290615 mRNA Translation: AAK28026.1
AF047439 mRNA Translation: AAC39890.1 Frameshift.
AY359029 mRNA Translation: AAQ89388.1
AK075187 mRNA Translation: BAG52079.1
AK075505 mRNA Translation: BAC11658.1
AL353898 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06707.1
BC003106 mRNA Translation: AAH03106.1 Different initiation.
BC016374 mRNA Translation: AAH16374.1
BC095464 mRNA Translation: AAH95464.1
CCDSiCCDS586.1
RefSeqiNP_001291972.1, NM_001305043.1
NP_001291978.1, NM_001305049.1
NP_001291979.1, NM_001305050.1
NP_001291980.1, NM_001305051.1
NP_001291981.1, NM_001305052.1
NP_001291995.1, NM_001305066.1
NP_004863.2, NM_004872.4

3D structure databases

SMRiQ9BXS4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114904, 24 interactors
IntActiQ9BXS4, 9 interactors
MINTiQ9BXS4
STRINGi9606.ENSP00000234831

Protein family/group databases

TCDBi8.A.84.1.4, the insulin secretion regulator tmem59 (tmem59) family

PTM databases

GlyGeniQ9BXS4, 1 site
iPTMnetiQ9BXS4
PhosphoSitePlusiQ9BXS4
SwissPalmiQ9BXS4

Genetic variation databases

BioMutaiTMEM59
DMDMi18202737

Proteomic databases

EPDiQ9BXS4
jPOSTiQ9BXS4
MassIVEiQ9BXS4
MaxQBiQ9BXS4
PaxDbiQ9BXS4
PeptideAtlasiQ9BXS4
PRIDEiQ9BXS4
ProteomicsDBi79491

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46893, 91 antibodies

The DNASU plasmid repository

More...DNASUi		9528

Genome annotation databases

EnsembliENST00000234831; ENSP00000234831; ENSG00000116209
GeneIDi9528
KEGGihsa:9528
UCSCiuc001cwp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9528
DisGeNETi9528

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM59
HGNCiHGNC:1239, TMEM59
HPAiENSG00000116209, Low tissue specificity
neXtProtiNX_Q9BXS4
OpenTargetsiENSG00000116209
PharmGKBiPA25620
VEuPathDBiHostDB:ENSG00000116209.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUIS, Eukaryota
GeneTreeiENSGT00390000008279
HOGENOMiCLU_059747_1_0_1
InParanoidiQ9BXS4
OMAiINSSWIL
OrthoDBi1102891at2759
PhylomeDBiQ9BXS4
TreeFamiTF331226

Enzyme and pathway databases

PathwayCommonsiQ9BXS4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9528, 5 hits in 963 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM59, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TMEM59

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9528
PharosiQ9BXS4, Tbio

Protein Ontology

More...PROi		PR:Q9BXS4
RNActiQ9BXS4, protein

Gene expression databases

BgeeiENSG00000116209, Expressed in C1 segment of cervical spinal cord and 249 other tissues
ExpressionAtlasiQ9BXS4, baseline and differential
GenevisibleiQ9BXS4, HS

Family and domain databases

InterProiView protein in InterPro
IPR022065, Uncharacterised_TMEM59
PANTHERiPTHR28652, PTHR28652, 1 hit
PfamiView protein in Pfam
PF12280, BSMAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM59_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXS4
Secondary accession number(s): B3KQL7
, O75393, Q4VBP9, Q5T705, Q96KX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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