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UniProtKB - Q9BXR6 (FHR5_HUMAN)

Entry version 158 (23 Feb 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Complement factor H-related protein 5

Gene

CFHR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXR6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-977606, Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BXR6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement factor H-related protein 5
Short name:
FHR-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFHR5
Synonyms:CFHL5, FHR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24668, CFHR5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608593, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXR6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134389

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.2 Publications
CFHR5 deficiency (CFHR5D)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA progressive disease characterized by glomerulonephritis, hematuria, renal failure, end-stage renal disease, subendothelial and mesangial glomerular C3 deposits, mesangial matrix expansion, increased glomerular cellularity, and segmental capillary wall thickening. Hematuria may become apparent after respiratory infections.
Related information in OMIM

Keywords - Diseasei

Disease variant, Hemolytic uremic syndrome

Organism-specific databases

DisGeNET

More...DisGeNETi		81494

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CFHR5

MalaCards human disease database

More...MalaCardsi		CFHR5
MIMi614809, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134389

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93581, Atypical hemolytic uremic syndrome with anti-factor H antibodies
329931, C3 glomerulonephritis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134937417

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXR6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CFHR5

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000590019 – 569Complement factor H-related protein 5Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 72PROSITE-ProRule annotation
Disulfide bondi55 ↔ 83PROSITE-ProRule annotation
Disulfide bondi87 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 140PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 189PROSITE-ProRule annotation
Disulfide bondi175 ↔ 201PROSITE-ProRule annotation
Disulfide bondi208 ↔ 251PROSITE-ProRule annotation
Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
Disulfide bondi269 ↔ 311PROSITE-ProRule annotation
Disulfide bondi297 ↔ 322PROSITE-ProRule annotation
Disulfide bondi331 ↔ 370PROSITE-ProRule annotation
Disulfide bondi359 ↔ 381PROSITE-ProRule annotation
Disulfide bondi389 ↔ 431PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi417 ↔ 442PROSITE-ProRule annotation
Disulfide bondi449 ↔ 492PROSITE-ProRule annotation
Disulfide bondi478 ↔ 503PROSITE-ProRule annotation
Disulfide bondi507 ↔ 558PROSITE-ProRule annotation
Disulfide bondi541 ↔ 568PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXR6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXR6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXR6

PeptideAtlas

More...PeptideAtlasi		Q9BXR6

PRoteomics IDEntifications database

More...PRIDEi		Q9BXR6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79486

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1155, 3 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BXR6, 3 sites, 3 N-linked glycans (2 sites), 2 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134389, Expressed in liver and 15 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXR6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134389, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Head-to-tail homodimer and heterodimer with CFHR1 or CFHR2. Binds C3b in vitro.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123503, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9BXR6, 23 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256785

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXR6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXR6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 83Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini85 – 142Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini145 – 203Sushi 3PROSITE-ProRule annotationAdd BLAST59
Domaini206 – 264Sushi 4PROSITE-ProRule annotationAdd BLAST59
Domaini267 – 324Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini329 – 383Sushi 6PROSITE-ProRule annotationAdd BLAST55
Domaini387 – 444Sushi 7PROSITE-ProRule annotationAdd BLAST58
Domaini447 – 505Sushi 8PROSITE-ProRule annotationAdd BLAST59
Domaini507 – 569Sushi 9PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RTVY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154386

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020107_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXR6

Identification of Orthologs from Complete Genome Data

More...OMAi		CINGIWT

Database of Orthologous Groups

More...OrthoDBi		296899at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXR6

TreeFam database of animal gene trees

More...TreeFami		TF326157

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00084, Sushi, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57535, SSF57535, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50923, SUSHI, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BXR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLFSVILI SWVSTVGGEG TLCDFPKIHH GFLYDEEDYN PFSQVPTGEV 
        60         70         80         90        100
FYYSCEYNFV SPSKSFWTRI TCTEEGWSPT PKCLRMCSFP FVKNGHSESS 
       110        120        130        140        150
GLIHLEGDTV QIICNTGYSL QNNEKNISCV ERGWSTPPIC SFTKGECHVP 
       160        170        180        190        200
ILEANVDAQP KKESYKVGDV LKFSCRKNLI RVGSDSVQCY QFGWSPNFPT 
       210        220        230        240        250
CKGQVRSCGP PPQLSNGEVK EIRKEEYGHN EVVEYDCNPN FIINGPKKIQ 
       260        270        280        290        300
CVDGEWTTLP TCVEQVKTCG YIPELEYGYV QPSVPPYQHG VSVEVNCRNE 
       310        320        330        340        350
YAMIGNNMIT CINGIWTELP MCVATHQLKR CKIAGVNIKT LLKLSGKEFN 
       360        370        380        390        400
HNSRIRYRCS DIFRYRHSVC INGKWNPEVD CTEKREQFCP PPPQIPNAQN 
       410        420        430        440        450
MTTTVNYQDG EKVAVLCKEN YLLPEAKEIV CKDGRWQSLP RCVESTAYCG 
       460        470        480        490        500
PPPSINNGDT TSFPLSVYPP GSTVTYRCQS FYKLQGSVTV TCRNKQWSEP 
       510        520        530        540        550
PRCLDPCVVS EENMNKNNIQ LKWRNDGKLY AKTGDAVEFQ CKFPHKAMIS 
       560 
SPPFRAICQE GKFEYPICE
Length:569
Mass (Da):64,419
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FAAE31707B0C112
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04881846P → S. Corresponds to variant dbSNP:rs12097550EnsemblClinVar.1
Natural variantiVAR_069090105L → R Found in patients with atypical hemolytic uremic syndrome. 1 PublicationCorresponds to variant dbSNP:rs318240754EnsemblClinVar.1
Natural variantiVAR_069091195S → T Found in patients with atypical hemolytic uremic syndrome. 1 PublicationCorresponds to variant dbSNP:rs318240755EnsemblClinVar.1
Natural variantiVAR_035827216N → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs147488267EnsemblClinVar.1
Natural variantiVAR_063652277Y → N Found in a patient with atypical hemolytic uremic syndrome. 1 PublicationCorresponds to variant dbSNP:rs318240756EnsemblClinVar.1
Natural variantiVAR_048819356R → H. Corresponds to variant dbSNP:rs35662416EnsemblClinVar.1
Natural variantiVAR_063653379V → L Found in patients with atypical hemolytic uremic syndrome. 1 PublicationCorresponds to variant dbSNP:rs111327589EnsemblClinVar.1
Natural variantiVAR_069092436W → C Found in patients with atypical hemolytic uremic syndrome. 1 PublicationCorresponds to variant dbSNP:rs201265664EnsemblClinVar.1
Natural variantiVAR_048820521L → I. Corresponds to variant dbSNP:rs35957013EnsemblClinVar.1
Natural variantiVAR_048821529L → R. Corresponds to variant dbSNP:rs16840956EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF295327 mRNA Translation: AAK15619.1
BC111773 mRNA Translation: AAI11774.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1387.1

NCBI Reference Sequences

More...RefSeqi		NP_110414.1, NM_030787.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256785; ENSP00000256785; ENSG00000134389

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81494

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81494

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000256785.5; ENSP00000256785.4; NM_030787.4; NP_110414.1

UCSC genome browser

More...UCSCi		uc001gts.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295327 mRNA Translation: AAK15619.1
BC111773 mRNA Translation: AAI11774.1
CCDSiCCDS1387.1
RefSeqiNP_110414.1, NM_030787.3

3D structure databases

SMRiQ9BXR6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123503, 21 interactors
IntActiQ9BXR6, 23 interactors
STRINGi9606.ENSP00000256785

PTM databases

GlyConnecti1155, 3 N-Linked glycans (2 sites)
GlyGeniQ9BXR6, 3 sites, 3 N-linked glycans (2 sites), 2 O-linked glycans (1 site)
iPTMnetiQ9BXR6
PhosphoSitePlusiQ9BXR6

Genetic variation databases

BioMutaiCFHR5
DMDMi23396597

Proteomic databases

jPOSTiQ9BXR6
MassIVEiQ9BXR6
PaxDbiQ9BXR6
PeptideAtlasiQ9BXR6
PRIDEiQ9BXR6
ProteomicsDBi79486

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34475, 196 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		81494

Genome annotation databases

EnsembliENST00000256785; ENSP00000256785; ENSG00000134389
GeneIDi81494
KEGGihsa:81494
MANE-SelectiENST00000256785.5; ENSP00000256785.4; NM_030787.4; NP_110414.1
UCSCiuc001gts.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81494
DisGeNETi81494

GeneCards: human genes, protein and diseases

More...GeneCardsi		CFHR5
GeneReviewsiCFHR5
HGNCiHGNC:24668, CFHR5
HPAiENSG00000134389, Tissue enriched (liver)
MalaCardsiCFHR5
MIMi608593, gene
614809, phenotype
neXtProtiNX_Q9BXR6
OpenTargetsiENSG00000134389
Orphaneti93581, Atypical hemolytic uremic syndrome with anti-factor H antibodies
329931, C3 glomerulonephritis
PharmGKBiPA134937417
VEuPathDBiHostDB:ENSG00000134389

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RTVY, Eukaryota
GeneTreeiENSGT00940000154386
HOGENOMiCLU_020107_6_0_1
InParanoidiQ9BXR6
OMAiCINGIWT
OrthoDBi296899at2759
PhylomeDBiQ9BXR6
TreeFamiTF326157

Enzyme and pathway databases

PathwayCommonsiQ9BXR6
ReactomeiR-HSA-977606, Regulation of Complement cascade
SignaLinkiQ9BXR6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81494, 6 hits in 1029 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CFHR5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81494
PharosiQ9BXR6, Tbio

Protein Ontology

More...PROi		PR:Q9BXR6
RNActiQ9BXR6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134389, Expressed in liver and 15 other tissues
GenevisibleiQ9BXR6, HS

Family and domain databases

CDDicd00033, CCP, 6 hits
InterProiView protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084, Sushi, 7 hits
SMARTiView protein in SMART
SM00032, CCP, 9 hits
SUPFAMiSSF57535, SSF57535, 8 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHR5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXR6
Secondary accession number(s): Q2NKK2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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