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UniProtKB - Q9BXR0 (TGT_HUMAN)

Protein

Queuine tRNA-ribosyltransferase catalytic subunit 1

Gene

QTRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity).UniRule annotationBy similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotation

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.0056 sec(-1) with tRNA(Tyr) as substrate and 0.00586 sec(-1) with guanine as substrate.1 Publication
  1. KM=0.34 µM for tRNA(Tyr)1 Publication
  2. KM=0.41 µM for guanine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei105Proton acceptorUniRule annotation1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei159SubstrateUniRule annotation1
    Binding sitei202SubstrateUniRule annotation1
    Binding sitei229Substrate; via amide nitrogenUniRule annotation1
    Active sitei279NucleophileUniRule annotation1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi317ZincUniRule annotation1
    Metal bindingi319ZincUniRule annotation1
    Metal bindingi322ZincUniRule annotation1
    Metal bindingi348Zinc; via pros nitrogenUniRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    • tRNA-guanine transglycosylation Source: UniProtKB
    • tRNA modification Source: UniProtKB
    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processtRNA processing
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.4.2.29 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-6782315 tRNA modification in the nucleus and cytosol

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Queuine tRNA-ribosyltransferase catalytic subunit 1UniRule annotation (EC:2.4.2.29UniRule annotation1 Publication)
    Alternative name(s):
    Guanine insertion enzymeUniRule annotation
    tRNA-guanine transglycosylaseUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:QTRT1UniRule annotation
    Synonyms:TGT, TGUT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000213339.8

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:23797 QTRT1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		609615 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9BXR0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi279D → N: Loss of transglycosylase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		81890

    Open Targets

    More...    OpenTargetsi    		ENSG00000213339

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134963074

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL6004

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		QTRT1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		239938842

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001355652 – 403Queuine tRNA-ribosyltransferase catalytic subunit 1Add BLAST402

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    Modified residuei139PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9BXR0

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9BXR0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9BXR0

    PeptideAtlas

    More...    PeptideAtlasi    		Q9BXR0

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9BXR0

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		79483

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9BXR0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9BXR0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000213339 Expressed in 179 organ(s), highest expression level in body of pancreas

    CleanEx database of gene expression profiles

    More...    CleanExi    		HS_QTRT1

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9BXR0 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9BXR0 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA042695
    HPA048651
    HPA049440

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.UniRule annotation1 Publication

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		123623, 18 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9BXR0, 7 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000250237

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9BXR0

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1403
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		Q9BXR0

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9BXR0

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 109Substrate bindingUniRule annotation5
    Regioni260 – 266RNA bindingUniRule annotation7
    Regioni284 – 288RNA binding; important for wobble base 34 recognitionUniRule annotation5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the queuine tRNA-ribosyltransferase family.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3908 Eukaryota
    COG0343 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00530000063679

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000223473

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG101131

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9BXR0

    KEGG Orthology (KO)

    More...    KOi    		K00773

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		GIDLFDC

    Database of Orthologous Groups

    More...    OrthoDBi    		EOG091G09KJ

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9BXR0

    TreeFam database of animal gene trees

    More...    TreeFami    		TF300732

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.20.20.105, 1 hit

    HAMAP database of protein families

    More...    HAMAPi    		MF_00168 Q_tRNA_Tgt, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR004803 TGT
    IPR036511 TGT-like_sf
    IPR002616 tRNA_ribo_trans-like

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01702 TGT, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51713 SSF51713, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00430 Q_tRNA_tgt, 1 hit
    TIGR00449 tgt_general, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9BXR0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAGAATQASL ESAPRIMRLV AECSRSRARA GELWLPHGTV ATPVFMPVGT 
            60         70         80         90        100
    QATMKGITTE QLDALGCRIC LGNTYHLGLR PGPELIQKAN GLHGFMNWPH 
           110        120        130        140        150
    NLLTDSGGFQ MVSLVSLSEV TEEGVRFRSP YDGNETLLSP EKSVQIQNAL 
           160        170        180        190        200
    GSDIIMQLDD VVSSTVTGPR VEEAMYRSIR WLDRCIAAHQ RPDKQNLFAI 
           210        220        230        240        250
    IQGGLDADLR ATCLEEMTKR DVPGFAIGGL SGGESKSQFW RMVALSTSRL 
           260        270        280        290        300
    PKDKPRYLMG VGYATDLVVC VALGCDMFDC VFPTRTARFG SALVPTGNLQ 
           310        320        330        340        350
    LRKKVFEKDF GPIDPECTCP TCQKHSRAFL HALLHSDNTA ALHHLTVHNI 
           360        370        380        390        400
    AYQLQLMSAV RTSIVEKRFP DFVRDFMGAM YGDPTLCPTW ATDALASVGI 

    TLG
    Length:403
    Mass (Da):44,048
    Last modified:June 16, 2009 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E30F3C7BF47A106
    GO
    Isoform 2 (identifier: Q9BXR0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-225: SIRWLDRCIA...EMTKRDVPGF → PLGLVTGALL...AGRRSPGHLP
         226-403: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:225
    Mass (Da):24,015
    Checksum:iC62B238F305E24A9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    K7EPI1K7EPI1_HUMAN
    Queuine tRNA-ribosyltransferase cat...
    QTRT1
    		124Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EJ21K7EJ21_HUMAN
    Queuine tRNA-ribosyltransferase cat...
    QTRT1
    		203Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EL95K7EL95_HUMAN
    Queuine tRNA-ribosyltransferase cat...
    QTRT1
    		136Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ESP6K7ESP6_HUMAN
    Queuine tRNA-ribosyltransferase cat...
    QTRT1
    		180Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH15350 differs from that shown. Reason: Erroneous initiation.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056470178 – 225SIRWL…DVPGF → PLGLVTGALLQVNPLAGPVH CSPSAAGQAEPLRHYPGWAG RRSPGHLP in isoform 2. 1 PublicationAdd BLAST48
    Alternative sequenceiVSP_056471226 – 403Missing in isoform 2. 1 PublicationAdd BLAST178

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF302783 mRNA Translation: AAG60033.1
    AF302784 mRNA Translation: AAG60034.1
    AK294166 mRNA Translation: BAG57488.1
    AC011475 Genomic DNA No translation available.
    BC015350 mRNA Translation: AAH15350.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12248.1 [Q9BXR0-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_112486.1, NM_031209.2 [Q9BXR0-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.631638

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000250237; ENSP00000250237; ENSG00000213339 [Q9BXR0-1]
    ENST00000421333; ENSP00000389126; ENSG00000213339 [Q9BXR0-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		81890

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:81890

    UCSC genome browser

    More...    UCSCi    		uc002mpr.4 human [Q9BXR0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF302783 mRNA Translation: AAG60033.1
    AF302784 mRNA Translation: AAG60034.1
    AK294166 mRNA Translation: BAG57488.1
    AC011475 Genomic DNA No translation available.
    BC015350 mRNA Translation: AAH15350.1 Different initiation.
    CCDSiCCDS12248.1 [Q9BXR0-1]
    RefSeqiNP_112486.1, NM_031209.2 [Q9BXR0-1]
    UniGeneiHs.631638

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6H42X-ray2.45A/B11-403[»]
    6H45X-ray2.40A/B12-403[»]
    ProteinModelPortaliQ9BXR0
    SMRiQ9BXR0
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123623, 18 interactors
    IntActiQ9BXR0, 7 interactors
    STRINGi9606.ENSP00000250237

    Chemistry databases

    BindingDBiQ9BXR0
    ChEMBLiCHEMBL6004

    PTM databases

    iPTMnetiQ9BXR0
    PhosphoSitePlusiQ9BXR0

    Polymorphism and mutation databases

    BioMutaiQTRT1
    DMDMi239938842

    Proteomic databases

    EPDiQ9BXR0
    MaxQBiQ9BXR0
    PaxDbiQ9BXR0
    PeptideAtlasiQ9BXR0
    PRIDEiQ9BXR0
    ProteomicsDBi79483

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		81890
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000250237; ENSP00000250237; ENSG00000213339 [Q9BXR0-1]
    ENST00000421333; ENSP00000389126; ENSG00000213339 [Q9BXR0-2]
    GeneIDi81890
    KEGGihsa:81890
    UCSCiuc002mpr.4 human [Q9BXR0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		81890
    DisGeNETi81890
    EuPathDBiHostDB:ENSG00000213339.8

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		QTRT1
    HGNCiHGNC:23797 QTRT1
    HPAiHPA042695
    HPA048651
    HPA049440
    MIMi609615 gene
    neXtProtiNX_Q9BXR0
    OpenTargetsiENSG00000213339
    PharmGKBiPA134963074

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3908 Eukaryota
    COG0343 LUCA
    GeneTreeiENSGT00530000063679
    HOGENOMiHOG000223473
    HOVERGENiHBG101131
    InParanoidiQ9BXR0
    KOiK00773
    OMAiGIDLFDC
    OrthoDBiEOG091G09KJ
    PhylomeDBiQ9BXR0
    TreeFamiTF300732

    Enzyme and pathway databases

    BRENDAi2.4.2.29 2681
    ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		QTRT1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		81890

    Protein Ontology

    More...    PROi    		PR:Q9BXR0

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000213339 Expressed in 179 organ(s), highest expression level in body of pancreas
    CleanExiHS_QTRT1
    ExpressionAtlasiQ9BXR0 baseline and differential
    GenevisibleiQ9BXR0 HS

    Family and domain databases

    Gene3Di3.20.20.105, 1 hit
    HAMAPiMF_00168 Q_tRNA_Tgt, 1 hit
    InterProiView protein in InterPro
    IPR004803 TGT
    IPR036511 TGT-like_sf
    IPR002616 tRNA_ribo_trans-like
    PfamiView protein in Pfam
    PF01702 TGT, 1 hit
    SUPFAMiSSF51713 SSF51713, 1 hit
    TIGRFAMsiTIGR00430 Q_tRNA_tgt, 1 hit
    TIGR00449 tgt_general, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGT_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXR0
    Secondary accession number(s): B4DFM7, Q96BQ4, Q9BXQ9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: June 16, 2009
    Last modified: December 5, 2018
    This is version 155 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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