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Entry version 160 (08 May 2019)
Sequence version 4 (20 Feb 2007)
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Protein

Pappalysin-2

Gene

PAPPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi733Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei7341
Metal bindingi737Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi743Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M43.005

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pappalysin-2 (EC:3.4.24.-)
Alternative name(s):
Pregnancy-associated plasma protein A2
Short name:
PAPP-A2
Pregnancy-associated plasma protein E1
Short name:
PAPP-E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAPPA2
Synonyms:PLAC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14615 PAPPA2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXP8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi734E → Q: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
60676

Open Targets

More...
OpenTargetsi
ENSG00000116183

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33373

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAPPA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302580

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002924923 – 234Add BLAST212
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029250235 – 1791Pappalysin-2Add BLAST1557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi312 ↔ 403PROSITE-ProRule annotation
Disulfide bondi499 ↔ 793PROSITE-ProRule annotation
Disulfide bondi504 ↔ 828PROSITE-ProRule annotation
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi586 ↔ 600PROSITE-ProRule annotation
Disulfide bondi596 ↔ 612PROSITE-ProRule annotation
Disulfide bondi628 ↔ 644PROSITE-ProRule annotation
Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi754 ↔ 771Or C-754 with C-783PROSITE-ProRule annotation
Disulfide bondi758 ↔ 783Or C-788 with C-771PROSITE-ProRule annotation
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi881 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi884 ↔ 1048PROSITE-ProRule annotation
Disulfide bondi924 ↔ 1003PROSITE-ProRule annotation
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi946 ↔ 951PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1139PROSITE-ProRule annotation
Disulfide bondi1151 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1179PROSITE-ProRule annotation
Disulfide bondi1205 ↔ 1238PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1318PROSITE-ProRule annotation
Glycosylationi1243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1344N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1371 ↔ 1385PROSITE-ProRule annotation
Disulfide bondi1396 ↔ 1448PROSITE-ProRule annotation
Glycosylationi1408N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1423 ↔ 1459PROSITE-ProRule annotation
Glycosylationi1456N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1464 ↔ 1508PROSITE-ProRule annotation
Glycosylationi1476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1479 ↔ 1489PROSITE-ProRule annotation
Disulfide bondi1493 ↔ 1521PROSITE-ProRule annotation
Disulfide bondi1525 ↔ 1579PROSITE-ProRule annotation
Disulfide bondi1541 ↔ 1552PROSITE-ProRule annotation
Disulfide bondi1556 ↔ 1590PROSITE-ProRule annotation
Disulfide bondi1595 ↔ 1633PROSITE-ProRule annotation
Disulfide bondi1608 ↔ 1618PROSITE-ProRule annotation
Disulfide bondi1622 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1653 ↔ 1714PROSITE-ProRule annotation
Disulfide bondi1667 ↔ 1677PROSITE-ProRule annotation
Disulfide bondi1681 ↔ 1729PROSITE-ProRule annotation
Glycosylationi1694N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1733 ↔ 1751PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXP8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXP8

PeptideAtlas

More...
PeptideAtlasi
Q9BXP8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXP8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79480
79481 [Q9BXP8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXP8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116183 Expressed in 153 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BXP8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018412
HPA018430

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121951, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9BXP8, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9BXP8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356634

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BXP8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1393 – 1461Sushi 1PROSITE-ProRule annotationAdd BLAST69
Domaini1462 – 1521Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini1523 – 1592Sushi 3PROSITE-ProRule annotationAdd BLAST70
Domaini1593 – 1648Sushi 4PROSITE-ProRule annotationAdd BLAST56
Domaini1651 – 1731Sushi 5PROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni442 – 754MetalloproteaseAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 174Poly-Thr4
Compositional biasi1654 – 1657Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M43B family.Curated

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4C Eukaryota
ENOG410Y5CU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000067833

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BXP8

KEGG Orthology (KO)

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KOi
K08647

Identification of Orthologs from Complete Genome Data

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OMAi
DGWCDTI

Database of Orthologous Groups

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OrthoDBi
105200at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXP8

TreeFam database of animal gene trees

More...
TreeFami
TF331636

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 2 hits
cd04275 ZnMc_pappalysin_like, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR46130:SF1 PTHR46130:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02232 myxo_disulf_rpt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 3 hits
PS00142 ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BXP8-1) [UniParc]FASTAAdd to basket
Also known as: Papp-e(1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC
60 70 80 90 100
WLGAKVRRPR ASPQHHLFGV YPSRAGNYLR PYPVGEQEIH HTGRSKPDTE
110 120 130 140 150
GNAVSLVPPD LTENPAGLRG AVEEPAAPWV GDSPIGQSEL LGDDDAYLGN
160 170 180 190 200
QRSKESLGEA GIQKGSAMAA TTTTAIFTTL NEPKPETQRR GWAKSRQRRQ
210 220 230 240 250
VWKRRAEDGQ GDSGISSHFQ PWPKHSLKHR VKKSPPEESN QNGGEGSYRE
260 270 280 290 300
AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN
310 320 330 340 350
NPAIIAGVFD NCSHTVSDKG WALGIRSGKD KGKRDARFFF SLCTDRVKKA
360 370 380 390 400
TILISHSRYQ PGTWTHVAAT YDGRHMALYV DGTQVASSLD QSGPLNSPFM
410 420 430 440 450
ASCRSLLLGG DSSEDGHYFR GHLGTLVFWS TALPQSHFQH SSQHSSGEEE
460 470 480 490 500
ATDLVLTASF EPVNTEWVPF RDEKYPRLEV LQGFEPEPEI LSPLQPPLCG
510 520 530 540 550
QTVCDNVELI SQYNGYWPLR GEKVIRYQVV NICDDEGLNP IVSEEQIRLQ
560 570 580 590 600
HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC
610 620 630 640 650
EHPLTGYDGG DCRLQGRCYS WNRRDGLCHV ECNNMLNDFD DGDCCDPQVA
660 670 680 690 700
DVRKTCFDPD SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA
710 720 730 740 750
TWPWDKDAVT HLGGIVLSPA YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE
760 770 780 790 800
RESCNDPCKE TVPSMETGDL CADTAPTPKS ELCREPEPTS DTCGFTRFPG
810 820 830 840 850
APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES RKPTPIPIPP
860 870 880 890 900
MVIGQTNKSL TIHWLPPISG VVYDRASGSL CGACTEDGTF RQYVHTASSR
910 920 930 940 950
RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG
960 970 980 990 1000
CSLELLFQHP VQADTLTLWV TSFFMESSQV LFDTEILLEN KESVHLGPLD
1010 1020 1030 1040 1050
TFCDIPLTIK LHVDGKVSGV KVYTFDERIE IDAALLTSQP HSPLCSGCRP
1060 1070 1080 1090 1100
VRYQVLRDPP FASGLPVVVT HSHRKFTDVE VTPGQMYQYQ VLAEAGGELG
1110 1120 1130 1140 1150
EASPPLNHIH GAPYCGDGKV SERLGEECDD GDLVSGDGCS KVCELEEGFN
1160 1170 1180 1190 1200
CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATRAYSSHE
1210 1220 1230 1240 1250
DKKKCPVSLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SENETQDDRS
1260 1270 1280 1290 1300
EQPEGSLKKE DEVWLKVCFN RPGEARAIFI FLTTDGLVPG EHQQPTVTLY
1310 1320 1330 1340 1350
LTDVRGSNHS LGTYGLSCQH NPLIINVTHH QNVLFHHTTS VLLNFSSPRV
1360 1370 1380 1390 1400
GISAVALRTS SRIGLSAPSN CISEDEGQNH QGQSCIHRPC GKQDSCPSLL
1410 1420 1430 1440 1450
LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASSGQYIRPM QKEILLTCSS
1460 1470 1480 1490 1500
GHWDQNVSCL PVDCGVPDPS LVNYANFSCS EGTKFLKRCS ISCVPPAKLQ
1510 1520 1530 1540 1550
GLSPWLTCLE DGLWSLPEVY CKLECDAPPI ILNANLLLPH CLQDNHDVGT
1560 1570 1580 1590 1600
ICKYECKPGY YVAESAEGKV RNKLLKIQCL EGGIWEQGSC IPVVCEPPPP
1610 1620 1630 1640 1650
VFEGMYECTN GFSLDSQCVL NCNQEREKLP ILCTKEGLWT QEFKLCENLQ
1660 1670 1680 1690 1700
GECPPPPSEL NSVEYKCEQG YGIGAVCSPL CVIPPSDPVM LPENITADTL
1710 1720 1730 1740 1750
EHWMEPVKVQ SIVCTGRRQW HPDPVLVHCI QSCEPFQADG WCDTINNRAY
1760 1770 1780 1790
CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q
Length:1,791
Mass (Da):198,539
Last modified:February 20, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF436030821EC6EDD
GO
Isoform 2 (identifier: Q9BXP8-2) [UniParc]FASTAAdd to basket
Also known as: Papp-e(2)

The sequence of this isoform differs from the canonical sequence as follows:
     811-827: DDNCTDNFTPNQVARMH → GITTVLFCFLLRIHGGL
     828-1791: Missing.

Show »
Length:827
Mass (Da):92,136
Checksum:iFB3B6F1E944F7C24
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL17779 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL17780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC11134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti447G → E in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti447G → E in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti568S → N in AAL17780 (PubMed:11597188).Curated1
Sequence conflicti846I → T in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti846I → T in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti1343L → P in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti1343L → P in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti1739D → N in CAC11134 (PubMed:11018262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051595171T → S. Corresponds to variant dbSNP:rs36112782Ensembl.1
Natural variantiVAR_0515961657P → R. Corresponds to variant dbSNP:rs34602579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012194811 – 827DDNCT…VARMH → GITTVLFCFLLRIHGGL in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_012195828 – 1791Missing in isoform 2. 2 PublicationsAdd BLAST964

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF311940 mRNA Translation: AAK31073.1
AF342989 mRNA Translation: AAL17779.1 Different initiation.
AF342990 mRNA Translation: AAL17780.1 Different initiation.
AL031290 Genomic DNA No translation available.
AL031734 Genomic DNA No translation available.
AL139282 Genomic DNA No translation available.
AL596254 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91003.1
BC117193 mRNA Translation: AAI17194.3
BC117195 mRNA Translation: AAI17196.3
AJ278348 mRNA Translation: CAC11134.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41438.1 [Q9BXP8-1]
CCDS41439.1 [Q9BXP8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_064714.2, NM_020318.2 [Q9BXP8-1]
NP_068755.2, NM_021936.2 [Q9BXP8-2]
XP_005245479.1, XM_005245422.3 [Q9BXP8-1]
XP_011508159.1, XM_011509857.1 [Q9BXP8-1]
XP_011508160.1, XM_011509858.2 [Q9BXP8-1]
XP_016857512.1, XM_017002023.1 [Q9BXP8-1]
XP_016857513.1, XM_017002024.1 [Q9BXP8-1]
XP_016857514.1, XM_017002025.1 [Q9BXP8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367661; ENSP00000356633; ENSG00000116183 [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183 [Q9BXP8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60676

UCSC genome browser

More...
UCSCi
uc001gky.2 human [Q9BXP8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311940 mRNA Translation: AAK31073.1
AF342989 mRNA Translation: AAL17779.1 Different initiation.
AF342990 mRNA Translation: AAL17780.1 Different initiation.
AL031290 Genomic DNA No translation available.
AL031734 Genomic DNA No translation available.
AL139282 Genomic DNA No translation available.
AL596254 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91003.1
BC117193 mRNA Translation: AAI17194.3
BC117195 mRNA Translation: AAI17196.3
AJ278348 mRNA Translation: CAC11134.1 Different initiation.
CCDSiCCDS41438.1 [Q9BXP8-1]
CCDS41439.1 [Q9BXP8-2]
RefSeqiNP_064714.2, NM_020318.2 [Q9BXP8-1]
NP_068755.2, NM_021936.2 [Q9BXP8-2]
XP_005245479.1, XM_005245422.3 [Q9BXP8-1]
XP_011508159.1, XM_011509857.1 [Q9BXP8-1]
XP_011508160.1, XM_011509858.2 [Q9BXP8-1]
XP_016857512.1, XM_017002023.1 [Q9BXP8-1]
XP_016857513.1, XM_017002024.1 [Q9BXP8-1]
XP_016857514.1, XM_017002025.1 [Q9BXP8-1]

3D structure databases

SMRiQ9BXP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121951, 3 interactors
IntActiQ9BXP8, 3 interactors
MINTiQ9BXP8
STRINGi9606.ENSP00000356634

Protein family/group databases

MEROPSiM43.005

PTM databases

iPTMnetiQ9BXP8
PhosphoSitePlusiQ9BXP8

Polymorphism and mutation databases

BioMutaiPAPPA2
DMDMi126302580

Proteomic databases

MaxQBiQ9BXP8
PaxDbiQ9BXP8
PeptideAtlasiQ9BXP8
PRIDEiQ9BXP8
ProteomicsDBi79480
79481 [Q9BXP8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367661; ENSP00000356633; ENSG00000116183 [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183 [Q9BXP8-1]
GeneIDi60676
KEGGihsa:60676
UCSCiuc001gky.2 human [Q9BXP8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60676
DisGeNETi60676

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PAPPA2
HGNCiHGNC:14615 PAPPA2
HPAiHPA018412
HPA018430
neXtProtiNX_Q9BXP8
OpenTargetsiENSG00000116183
PharmGKBiPA33373

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF4C Eukaryota
ENOG410Y5CU LUCA
GeneTreeiENSGT00940000158543
HOGENOMiHOG000067833
InParanoidiQ9BXP8
KOiK08647
OMAiDGWCDTI
OrthoDBi105200at2759
PhylomeDBiQ9BXP8
TreeFamiTF331636

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAPPA2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PAPPA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60676

Protein Ontology

More...
PROi
PR:Q9BXP8

Gene expression databases

BgeeiENSG00000116183 Expressed in 153 organ(s), highest expression level in placenta
GenevisibleiQ9BXP8 HS

Family and domain databases

CDDicd00033 CCP, 2 hits
cd04275 ZnMc_pappalysin_like, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR46130:SF1 PTHR46130:SF1, 1 hit
PfamiView protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
PS00142 ZINC_PROTEASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXP8
Secondary accession number(s): A9Z1Y8
, Q96PH7, Q96PH8, Q9H4C9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 160 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
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