Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pappalysin-2

Gene

PAPPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi733Zinc; catalyticPROSITE-ProRule annotation1
Active sitei7341
Metal bindingi737Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi743Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • metalloendopeptidase activity Source: Reactome
  • metallopeptidase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiM43.005

Names & Taxonomyi

Protein namesi
Recommended name:
Pappalysin-2 (EC:3.4.24.-)
Alternative name(s):
Pregnancy-associated plasma protein A2
Short name:
PAPP-A2
Pregnancy-associated plasma protein E1
Short name:
PAPP-E
Gene namesi
Name:PAPPA2
Synonyms:PLAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116183.10
HGNCiHGNC:14615 PAPPA2
neXtProtiNX_Q9BXP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi734E → Q: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi60676
OpenTargetsiENSG00000116183
PharmGKBiPA33373

Polymorphism and mutation databases

BioMutaiPAPPA2
DMDMi126302580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000002924923 – 234Add BLAST212
ChainiPRO_0000029250235 – 1791Pappalysin-2Add BLAST1557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi312 ↔ 403PROSITE-ProRule annotation
Disulfide bondi499 ↔ 793PROSITE-ProRule annotation
Disulfide bondi504 ↔ 828PROSITE-ProRule annotation
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi586 ↔ 600PROSITE-ProRule annotation
Disulfide bondi596 ↔ 612PROSITE-ProRule annotation
Disulfide bondi628 ↔ 644PROSITE-ProRule annotation
Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi754 ↔ 771Or C-754 with C-783PROSITE-ProRule annotation
Disulfide bondi758 ↔ 783Or C-788 with C-771PROSITE-ProRule annotation
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi881 ↔ 1045PROSITE-ProRule annotation
Disulfide bondi884 ↔ 1048PROSITE-ProRule annotation
Disulfide bondi924 ↔ 1003PROSITE-ProRule annotation
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi946 ↔ 951PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1139PROSITE-ProRule annotation
Disulfide bondi1151 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1179PROSITE-ProRule annotation
Disulfide bondi1205 ↔ 1238PROSITE-ProRule annotation
Disulfide bondi1219 ↔ 1318PROSITE-ProRule annotation
Glycosylationi1243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1344N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1371 ↔ 1385PROSITE-ProRule annotation
Disulfide bondi1396 ↔ 1448PROSITE-ProRule annotation
Glycosylationi1408N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1423 ↔ 1459PROSITE-ProRule annotation
Glycosylationi1456N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1464 ↔ 1508PROSITE-ProRule annotation
Glycosylationi1476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1479 ↔ 1489PROSITE-ProRule annotation
Disulfide bondi1493 ↔ 1521PROSITE-ProRule annotation
Disulfide bondi1525 ↔ 1579PROSITE-ProRule annotation
Disulfide bondi1541 ↔ 1552PROSITE-ProRule annotation
Disulfide bondi1556 ↔ 1590PROSITE-ProRule annotation
Disulfide bondi1595 ↔ 1633PROSITE-ProRule annotation
Disulfide bondi1608 ↔ 1618PROSITE-ProRule annotation
Disulfide bondi1622 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1653 ↔ 1714PROSITE-ProRule annotation
Disulfide bondi1667 ↔ 1677PROSITE-ProRule annotation
Disulfide bondi1681 ↔ 1729PROSITE-ProRule annotation
Glycosylationi1694N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1733 ↔ 1751PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ9BXP8
PaxDbiQ9BXP8
PeptideAtlasiQ9BXP8
PRIDEiQ9BXP8
ProteomicsDBi79480
79481 [Q9BXP8-2]

PTM databases

iPTMnetiQ9BXP8
PhosphoSitePlusiQ9BXP8

Expressioni

Tissue specificityi

Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000116183 Expressed in 153 organ(s), highest expression level in placenta
CleanExiHS_PAPPA2
GenevisibleiQ9BXP8 HS

Organism-specific databases

HPAiHPA018412
HPA018430

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi121951, 3 interactors
IntActiQ9BXP8, 3 interactors
MINTiQ9BXP8
STRINGi9606.ENSP00000356634

Structurei

3D structure databases

ProteinModelPortaliQ9BXP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1393 – 1461Sushi 1PROSITE-ProRule annotationAdd BLAST69
Domaini1462 – 1521Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini1523 – 1592Sushi 3PROSITE-ProRule annotationAdd BLAST70
Domaini1593 – 1648Sushi 4PROSITE-ProRule annotationAdd BLAST56
Domaini1651 – 1731Sushi 5PROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 754MetalloproteaseAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi171 – 174Poly-Thr4
Compositional biasi1654 – 1657Poly-Pro4

Sequence similaritiesi

Belongs to the peptidase M43B family.Curated

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IF4C Eukaryota
ENOG410Y5CU LUCA
GeneTreeiENSGT00390000009007
HOGENOMiHOG000067833
HOVERGENiHBG053501
InParanoidiQ9BXP8
KOiK08647
OMAiECTCRDP
OrthoDBiEOG091G026Y
PhylomeDBiQ9BXP8
TreeFamiTF331636

Family and domain databases

CDDicd00033 CCP, 2 hits
cd04275 ZnMc_pappalysin_like, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF1 PTHR19325:SF1, 1 hit
PfamiView protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BXP8-1) [UniParc]FASTAAdd to basket
Also known as: Papp-e(1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCLKILRIS LAILAGWALC SANSELGWTR KKSLVEREHL NQVLLEGERC
60 70 80 90 100
WLGAKVRRPR ASPQHHLFGV YPSRAGNYLR PYPVGEQEIH HTGRSKPDTE
110 120 130 140 150
GNAVSLVPPD LTENPAGLRG AVEEPAAPWV GDSPIGQSEL LGDDDAYLGN
160 170 180 190 200
QRSKESLGEA GIQKGSAMAA TTTTAIFTTL NEPKPETQRR GWAKSRQRRQ
210 220 230 240 250
VWKRRAEDGQ GDSGISSHFQ PWPKHSLKHR VKKSPPEESN QNGGEGSYRE
260 270 280 290 300
AETFNSQVGL PILYFSGRRE RLLLRPEVLA EIPREAFTVE AWVKPEGGQN
310 320 330 340 350
NPAIIAGVFD NCSHTVSDKG WALGIRSGKD KGKRDARFFF SLCTDRVKKA
360 370 380 390 400
TILISHSRYQ PGTWTHVAAT YDGRHMALYV DGTQVASSLD QSGPLNSPFM
410 420 430 440 450
ASCRSLLLGG DSSEDGHYFR GHLGTLVFWS TALPQSHFQH SSQHSSGEEE
460 470 480 490 500
ATDLVLTASF EPVNTEWVPF RDEKYPRLEV LQGFEPEPEI LSPLQPPLCG
510 520 530 540 550
QTVCDNVELI SQYNGYWPLR GEKVIRYQVV NICDDEGLNP IVSEEQIRLQ
560 570 580 590 600
HEALNEAFSR YNISWQLSVH QVHNSTLRHR VVLVNCEPSK IGNDHCDPEC
610 620 630 640 650
EHPLTGYDGG DCRLQGRCYS WNRRDGLCHV ECNNMLNDFD DGDCCDPQVA
660 670 680 690 700
DVRKTCFDPD SPKRAYMSVK ELKEALQLNS THFLNIYFAS SVREDLAGAA
710 720 730 740 750
TWPWDKDAVT HLGGIVLSPA YYGMPGHTDT MIHEVGHVLG LYHVFKGVSE
760 770 780 790 800
RESCNDPCKE TVPSMETGDL CADTAPTPKS ELCREPEPTS DTCGFTRFPG
810 820 830 840 850
APFTNYMSYT DDNCTDNFTP NQVARMHCYL DLVYQQWTES RKPTPIPIPP
860 870 880 890 900
MVIGQTNKSL TIHWLPPISG VVYDRASGSL CGACTEDGTF RQYVHTASSR
910 920 930 940 950
RVCDSSGYWT PEEAVGPPDV DQPCEPSLQA WSPEVHLYHM NMTVPCPTEG
960 970 980 990 1000
CSLELLFQHP VQADTLTLWV TSFFMESSQV LFDTEILLEN KESVHLGPLD
1010 1020 1030 1040 1050
TFCDIPLTIK LHVDGKVSGV KVYTFDERIE IDAALLTSQP HSPLCSGCRP
1060 1070 1080 1090 1100
VRYQVLRDPP FASGLPVVVT HSHRKFTDVE VTPGQMYQYQ VLAEAGGELG
1110 1120 1130 1140 1150
EASPPLNHIH GAPYCGDGKV SERLGEECDD GDLVSGDGCS KVCELEEGFN
1160 1170 1180 1190 1200
CVGEPSLCYM YEGDGICEPF ERKTSIVDCG IYTPKGYLDQ WATRAYSSHE
1210 1220 1230 1240 1250
DKKKCPVSLV TGEPHSLICT SYHPDLPNHR PLTGWFPCVA SENETQDDRS
1260 1270 1280 1290 1300
EQPEGSLKKE DEVWLKVCFN RPGEARAIFI FLTTDGLVPG EHQQPTVTLY
1310 1320 1330 1340 1350
LTDVRGSNHS LGTYGLSCQH NPLIINVTHH QNVLFHHTTS VLLNFSSPRV
1360 1370 1380 1390 1400
GISAVALRTS SRIGLSAPSN CISEDEGQNH QGQSCIHRPC GKQDSCPSLL
1410 1420 1430 1440 1450
LDHADVVNCT SIGPGLMKCA ITCQRGFALQ ASSGQYIRPM QKEILLTCSS
1460 1470 1480 1490 1500
GHWDQNVSCL PVDCGVPDPS LVNYANFSCS EGTKFLKRCS ISCVPPAKLQ
1510 1520 1530 1540 1550
GLSPWLTCLE DGLWSLPEVY CKLECDAPPI ILNANLLLPH CLQDNHDVGT
1560 1570 1580 1590 1600
ICKYECKPGY YVAESAEGKV RNKLLKIQCL EGGIWEQGSC IPVVCEPPPP
1610 1620 1630 1640 1650
VFEGMYECTN GFSLDSQCVL NCNQEREKLP ILCTKEGLWT QEFKLCENLQ
1660 1670 1680 1690 1700
GECPPPPSEL NSVEYKCEQG YGIGAVCSPL CVIPPSDPVM LPENITADTL
1710 1720 1730 1740 1750
EHWMEPVKVQ SIVCTGRRQW HPDPVLVHCI QSCEPFQADG WCDTINNRAY
1760 1770 1780 1790
CHYDGGDCCS STLSSKKVIP FAADCDLDEC TCRDPKAEEN Q
Length:1,791
Mass (Da):198,539
Last modified:February 20, 2007 - v4
Checksum:iF436030821EC6EDD
GO
Isoform 2 (identifier: Q9BXP8-2) [UniParc]FASTAAdd to basket
Also known as: Papp-e(2)

The sequence of this isoform differs from the canonical sequence as follows:
     811-827: DDNCTDNFTPNQVARMH → GITTVLFCFLLRIHGGL
     828-1791: Missing.

Show »
Length:827
Mass (Da):92,136
Checksum:iFB3B6F1E944F7C24
GO

Sequence cautioni

The sequence AAL17779 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL17780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC11134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti447G → E in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti447G → E in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti568S → N in AAL17780 (PubMed:11597188).Curated1
Sequence conflicti846I → T in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti846I → T in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti1343L → P in AAL17779 (PubMed:11597188).Curated1
Sequence conflicti1343L → P in CAC11134 (PubMed:11018262).Curated1
Sequence conflicti1739D → N in CAC11134 (PubMed:11018262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051595171T → S. Corresponds to variant dbSNP:rs36112782Ensembl.1
Natural variantiVAR_0515961657P → R. Corresponds to variant dbSNP:rs34602579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012194811 – 827DDNCT…VARMH → GITTVLFCFLLRIHGGL in isoform 2. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_012195828 – 1791Missing in isoform 2. 2 PublicationsAdd BLAST964

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311940 mRNA Translation: AAK31073.1
AF342989 mRNA Translation: AAL17779.1 Different initiation.
AF342990 mRNA Translation: AAL17780.1 Different initiation.
AL031290 Genomic DNA No translation available.
AL031734 Genomic DNA No translation available.
AL139282 Genomic DNA No translation available.
AL596254 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91003.1
BC117193 mRNA Translation: AAI17194.3
BC117195 mRNA Translation: AAI17196.3
AJ278348 mRNA Translation: CAC11134.1 Different initiation.
CCDSiCCDS41438.1 [Q9BXP8-1]
CCDS41439.1 [Q9BXP8-2]
RefSeqiNP_064714.2, NM_020318.2 [Q9BXP8-1]
NP_068755.2, NM_021936.2 [Q9BXP8-2]
XP_005245479.1, XM_005245422.3 [Q9BXP8-1]
XP_011508159.1, XM_011509857.1 [Q9BXP8-1]
XP_011508160.1, XM_011509858.2 [Q9BXP8-1]
XP_016857512.1, XM_017002023.1 [Q9BXP8-1]
XP_016857513.1, XM_017002024.1 [Q9BXP8-1]
XP_016857514.1, XM_017002025.1 [Q9BXP8-1]
UniGeneiHs.187284

Genome annotation databases

EnsembliENST00000367661; ENSP00000356633; ENSG00000116183 [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183 [Q9BXP8-1]
GeneIDi60676
KEGGihsa:60676
UCSCiuc001gky.2 human [Q9BXP8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311940 mRNA Translation: AAK31073.1
AF342989 mRNA Translation: AAL17779.1 Different initiation.
AF342990 mRNA Translation: AAL17780.1 Different initiation.
AL031290 Genomic DNA No translation available.
AL031734 Genomic DNA No translation available.
AL139282 Genomic DNA No translation available.
AL596254 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91003.1
BC117193 mRNA Translation: AAI17194.3
BC117195 mRNA Translation: AAI17196.3
AJ278348 mRNA Translation: CAC11134.1 Different initiation.
CCDSiCCDS41438.1 [Q9BXP8-1]
CCDS41439.1 [Q9BXP8-2]
RefSeqiNP_064714.2, NM_020318.2 [Q9BXP8-1]
NP_068755.2, NM_021936.2 [Q9BXP8-2]
XP_005245479.1, XM_005245422.3 [Q9BXP8-1]
XP_011508159.1, XM_011509857.1 [Q9BXP8-1]
XP_011508160.1, XM_011509858.2 [Q9BXP8-1]
XP_016857512.1, XM_017002023.1 [Q9BXP8-1]
XP_016857513.1, XM_017002024.1 [Q9BXP8-1]
XP_016857514.1, XM_017002025.1 [Q9BXP8-1]
UniGeneiHs.187284

3D structure databases

ProteinModelPortaliQ9BXP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121951, 3 interactors
IntActiQ9BXP8, 3 interactors
MINTiQ9BXP8
STRINGi9606.ENSP00000356634

Protein family/group databases

MEROPSiM43.005

PTM databases

iPTMnetiQ9BXP8
PhosphoSitePlusiQ9BXP8

Polymorphism and mutation databases

BioMutaiPAPPA2
DMDMi126302580

Proteomic databases

MaxQBiQ9BXP8
PaxDbiQ9BXP8
PeptideAtlasiQ9BXP8
PRIDEiQ9BXP8
ProteomicsDBi79480
79481 [Q9BXP8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367661; ENSP00000356633; ENSG00000116183 [Q9BXP8-2]
ENST00000367662; ENSP00000356634; ENSG00000116183 [Q9BXP8-1]
GeneIDi60676
KEGGihsa:60676
UCSCiuc001gky.2 human [Q9BXP8-1]

Organism-specific databases

CTDi60676
DisGeNETi60676
EuPathDBiHostDB:ENSG00000116183.10
GeneCardsiPAPPA2
HGNCiHGNC:14615 PAPPA2
HPAiHPA018412
HPA018430
neXtProtiNX_Q9BXP8
OpenTargetsiENSG00000116183
PharmGKBiPA33373
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4C Eukaryota
ENOG410Y5CU LUCA
GeneTreeiENSGT00390000009007
HOGENOMiHOG000067833
HOVERGENiHBG053501
InParanoidiQ9BXP8
KOiK08647
OMAiECTCRDP
OrthoDBiEOG091G026Y
PhylomeDBiQ9BXP8
TreeFamiTF331636

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRSiPAPPA2 human
GeneWikiiPAPPA2
GenomeRNAii60676
PROiPR:Q9BXP8

Gene expression databases

BgeeiENSG00000116183 Expressed in 153 organ(s), highest expression level in placenta
CleanExiHS_PAPPA2
GenevisibleiQ9BXP8 HS

Family and domain databases

CDDicd00033 CCP, 2 hits
cd04275 ZnMc_pappalysin_like, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR036116 FN3_sf
IPR006558 LamG-like
IPR011936 Myxo_disulph_rpt
IPR000800 Notch_dom
IPR026918 PAPPA2
IPR008754 Peptidase_M43
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR19325:SF1 PTHR19325:SF1, 1 hit
PfamiView protein in Pfam
PF00066 Notch, 1 hit
PF05572 Peptidase_M43, 1 hit
PF00084 Sushi, 2 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SM00560 LamGL, 1 hit
SM00004 NL, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
SSF57535 SSF57535, 3 hits
TIGRFAMsiTIGR02232 myxo_disulf_rpt, 1 hit
PROSITEiView protein in PROSITE
PS50923 SUSHI, 3 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAPP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXP8
Secondary accession number(s): A9Z1Y8
, Q96PH7, Q96PH8, Q9H4C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again