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Entry version 161 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Serrate RNA effector molecule homolog

Gene

SRRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serrate RNA effector molecule homolog
Alternative name(s):
Arsenite-resistance protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRRT
Synonyms:ARS2, ASR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24101 SRRT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614469 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXP5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51593

Open Targets

More...
OpenTargetsi
ENSG00000087087

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164726295

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXP5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRRT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20137457

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209652 – 876Serrate RNA effector molecule homologAdd BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei8PhosphotyrosineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei493PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei544PhosphothreonineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei671PhosphothreonineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei833Omega-N-methylarginineCombined sources1
Modified residuei840Omega-N-methylarginineCombined sources1
Modified residuei850Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXP5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXP5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXP5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXP5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXP5

PeptideAtlas

More...
PeptideAtlasi
Q9BXP5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXP5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79475 [Q9BXP5-1]
79476 [Q9BXP5-2]
79477 [Q9BXP5-3]
79478 [Q9BXP5-4]
79479 [Q9BXP5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXP5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXP5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BXP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087087 Expressed in 232 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXP5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXP5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042858
HPA058379

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NCBP1 and DROSHA (By similarity).

Interacts with CASP8AP2 and ERBB4.

Interacts with LUZP4.

Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).

Interacts with MTREX (PubMed:30842217).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-712721,EBI-466029

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119626, 106 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BXP5

Protein interaction database and analysis system

More...
IntActi
Q9BXP5, 63 interactors

Molecular INTeraction database

More...
MINTi
Q9BXP5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480421

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BXP5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 82Arg-richAdd BLAST73
Compositional biasi258 – 402Glu-richAdd BLAST145
Compositional biasi760 – 828Pro-richAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARS2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2295 Eukaryota
ENOG410XR8S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005492

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXP5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVCHVGV

Database of Orthologous Groups

More...
OrthoDBi
525905at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXP5

TreeFam database of animal gene trees

More...
TreeFami
TF317609

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035979 RBD_domain_sf
IPR039727 SE/Ars2
IPR007042 SERRATE/Ars2_C
IPR021933 SERRATE/Ars2_N

The PANTHER Classification System

More...
PANTHERi
PTHR13165 PTHR13165, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04959 ARS2, 1 hit
PF12066 DUF3546, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXP5-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDSDDEYDR RRRDKFRRER SDYDRSRERD ERRRGDDWND REWDRGRERR
60 70 80 90 100
SRGEYRDYDR NRRERFSPPR HELSPPQKRM RRDWDEHSSD PYHSGYEMPY
110 120 130 140 150
AGGGGGPTYG PPQPWGHPDV HIMQHHVLPI QARLGSIAEI DLGVPPPVMK
160 170 180 190 200
TFKEFLLSLD DSVDETEAVK RYNDYKLDFR RQQMQDFFLA HKDEEWFRSK
210 220 230 240 250
YHPDEVGKRR QEARGALQNR LRVFLSLMET GWFDNLLLDI DKADAIVKML
260 270 280 290 300
DAAVIKMEGG TENDLRILEQ EEEEEQAGKP GEPSKKEEGR AGAGLGDGER
310 320 330 340 350
KTNDKDEKKE DGKQAENDSS NDDKTKKSEG DGDKEEKKED SEKEAKKSSK
360 370 380 390 400
KRNRKHSGDD SFDEGSVSES ESESESGQAE EEKEEAEEAL KEKEKPKEEE
410 420 430 440 450
WEKPKDAAGL ECKPRPLHKT CSLFMRNIAP NISRAEIISL CKRYPGFMRV
460 470 480 490 500
ALSEPQPERR FFRRGWVTFD RSVNIKEICW NLQNIRLREC ELSPGVNRDL
510 520 530 540 550
TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS EPGTPPLPTS
560 570 580 590 600
LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE
610 620 630 640 650
RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP
660 670 680 690 700
PNRISHGEVL EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF
710 720 730 740 750
VTSNTQELGK DKWLCPLSGK KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF
760 770 780 790 800
NNFLTDAKRP ALPEIKPAQP PGPAQILPPG LTPGLPYPHQ TPQGLMPYGQ
810 820 830 840 850
PRPPILGYGA GAVRPAVPTG GPPYPHAPYG AGRGNYDAFR GQGGYPGKPR
860 870
NRMVRGDPRA IVEYRDLDAP DDVDFF
Length:876
Mass (Da):100,666
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB3ABD1325EA98D9
GO
Isoform 2 (identifier: Q9BXP5-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     776-780: ILPPG → S

Show »
Length:872
Mass (Da):100,276
Checksum:i371E6A555F1AADBB
GO
Isoform 3 (identifier: Q9BXP5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.

Show »
Length:875
Mass (Da):100,537
Checksum:iDC5CB52638E5A1E4
GO
Isoform 4 (identifier: Q9BXP5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.
     776-780: ILPPG → S

Show »
Length:871
Mass (Da):100,147
Checksum:i2A1153687E90090B
GO
Isoform 5 (identifier: Q9BXP5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     196-231: Missing.
     387-387: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):96,222
Checksum:iDD73F667E8ADFB67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3A1H7C3A1_HUMAN
Serrate RNA effector molecule homol...
SRRT
499Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUL9C9JUL9_HUMAN
Serrate RNA effector molecule homol...
SRRT
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0U8H7C0U8_HUMAN
Serrate RNA effector molecule homol...
SRRT
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1K0H7C1K0_HUMAN
Serrate RNA effector molecule homol...
SRRT
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSP6A0A0A0MSP6_HUMAN
Serrate RNA effector molecule homol...
SRRT
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEP7A0A286YEP7_HUMAN
Serrate RNA effector molecule homol...
SRRT
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0F4A0A087X0F4_HUMAN
Serrate RNA effector molecule homol...
SRRT
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD17774 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM00189 differs from that shown. Reason: Frameshift.Curated
The sequence BAG58876 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAL23816 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106G → GG in CAB46374 (PubMed:11230166).Curated1
Sequence conflicti119D → E in AAM00189 (Ref. 2) Curated1
Sequence conflicti303N → Y in AAM00189 (Ref. 2) Curated1
Sequence conflicti311D → Y in BAG64018 (PubMed:14702039).Curated1
Sequence conflicti443R → K in BAG64018 (PubMed:14702039).Curated1
Sequence conflicti498R → W in CAB46374 (PubMed:11230166).Curated1
Sequence conflicti728V → A in CAB46374 (PubMed:11230166).Curated1
Sequence conflicti744K → R in CAB46374 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038122196 – 231Missing in isoform 5. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_038123387Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_032502388Missing in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_000324776 – 780ILPPG → S in isoform 2 and isoform 4. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF312032 Genomic DNA Translation: AAK21005.1
AF312032 Genomic DNA Translation: AAK21006.1
AF248955 mRNA Translation: AAM00189.1 Frameshift.
AL096723 mRNA Translation: CAB46374.2
AK296131 mRNA Translation: BAG58876.1 Different initiation.
AK302820 mRNA Translation: BAG64018.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23815.1
CH236956 Genomic DNA Translation: EAL23816.1 Sequence problems.
CH471091 Genomic DNA Translation: EAW76467.1
BC000082 mRNA Translation: AAH00082.2
BC069249 mRNA Translation: AAH69249.1
BC109117 mRNA Translation: AAI09118.1
AF082871 mRNA Translation: AAD17774.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34709.1 [Q9BXP5-1]
CCDS47665.1 [Q9BXP5-2]
CCDS47666.1 [Q9BXP5-3]
CCDS47667.1 [Q9BXP5-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12455

NCBI Reference Sequences

More...
RefSeqi
NP_001122324.1, NM_001128852.1 [Q9BXP5-3]
NP_001122325.1, NM_001128853.1 [Q9BXP5-2]
NP_001122326.1, NM_001128854.1 [Q9BXP5-4]
NP_056992.4, NM_015908.5 [Q9BXP5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611405; ENSP00000480421; ENSG00000087087 [Q9BXP5-1]
ENST00000614484; ENSP00000481173; ENSG00000087087 [Q9BXP5-3]
ENST00000618262; ENSP00000478341; ENSG00000087087 [Q9BXP5-2]
ENST00000618411; ENSP00000483556; ENSG00000087087 [Q9BXP5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51593

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51593

UCSC genome browser

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UCSCi
uc032zzu.2 human [Q9BXP5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA Translation: AAK21005.1
AF312032 Genomic DNA Translation: AAK21006.1
AF248955 mRNA Translation: AAM00189.1 Frameshift.
AL096723 mRNA Translation: CAB46374.2
AK296131 mRNA Translation: BAG58876.1 Different initiation.
AK302820 mRNA Translation: BAG64018.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23815.1
CH236956 Genomic DNA Translation: EAL23816.1 Sequence problems.
CH471091 Genomic DNA Translation: EAW76467.1
BC000082 mRNA Translation: AAH00082.2
BC069249 mRNA Translation: AAH69249.1
BC109117 mRNA Translation: AAI09118.1
AF082871 mRNA Translation: AAD17774.1 Different initiation.
CCDSiCCDS34709.1 [Q9BXP5-1]
CCDS47665.1 [Q9BXP5-2]
CCDS47666.1 [Q9BXP5-3]
CCDS47667.1 [Q9BXP5-4]
PIRiT12455
RefSeqiNP_001122324.1, NM_001128852.1 [Q9BXP5-3]
NP_001122325.1, NM_001128853.1 [Q9BXP5-2]
NP_001122326.1, NM_001128854.1 [Q9BXP5-4]
NP_056992.4, NM_015908.5 [Q9BXP5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OO6X-ray2.80C/F/I/L/O/R/U/X832-876[»]
6F7JX-ray3.22A171-270[»]
B409-764[»]
6F7PX-ray3.70A/B147-270[»]
C/D409-764[»]
6F7SX-ray3.37A/B147-270[»]
C/D409-568[»]
C/D600-764[»]
6F8DX-ray3.48A/B171-270[»]
C/D409-764[»]
SMRiQ9BXP5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119626, 106 interactors
CORUMiQ9BXP5
IntActiQ9BXP5, 63 interactors
MINTiQ9BXP5
STRINGi9606.ENSP00000480421

PTM databases

iPTMnetiQ9BXP5
PhosphoSitePlusiQ9BXP5
SwissPalmiQ9BXP5

Polymorphism and mutation databases

BioMutaiSRRT
DMDMi20137457

Proteomic databases

EPDiQ9BXP5
jPOSTiQ9BXP5
MassIVEiQ9BXP5
MaxQBiQ9BXP5
PaxDbiQ9BXP5
PeptideAtlasiQ9BXP5
PRIDEiQ9BXP5
ProteomicsDBi79475 [Q9BXP5-1]
79476 [Q9BXP5-2]
79477 [Q9BXP5-3]
79478 [Q9BXP5-4]
79479 [Q9BXP5-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51593

Genome annotation databases

EnsembliENST00000611405; ENSP00000480421; ENSG00000087087 [Q9BXP5-1]
ENST00000614484; ENSP00000481173; ENSG00000087087 [Q9BXP5-3]
ENST00000618262; ENSP00000478341; ENSG00000087087 [Q9BXP5-2]
ENST00000618411; ENSP00000483556; ENSG00000087087 [Q9BXP5-4]
GeneIDi51593
KEGGihsa:51593
UCSCiuc032zzu.2 human [Q9BXP5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51593
DisGeNETi51593

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRRT
HGNCiHGNC:24101 SRRT
HPAiHPA042858
HPA058379
MIMi614469 gene
neXtProtiNX_Q9BXP5
OpenTargetsiENSG00000087087
PharmGKBiPA164726295

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2295 Eukaryota
ENOG410XR8S LUCA
GeneTreeiENSGT00390000005492
InParanoidiQ9BXP5
OMAiFVCHVGV
OrthoDBi525905at2759
PhylomeDBiQ9BXP5
TreeFamiTF317609

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SRRT human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51593
PharosiQ9BXP5

Protein Ontology

More...
PROi
PR:Q9BXP5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000087087 Expressed in 232 organ(s), highest expression level in testis
ExpressionAtlasiQ9BXP5 baseline and differential
GenevisibleiQ9BXP5 HS

Family and domain databases

InterProiView protein in InterPro
IPR035979 RBD_domain_sf
IPR039727 SE/Ars2
IPR007042 SERRATE/Ars2_C
IPR021933 SERRATE/Ars2_N
PANTHERiPTHR13165 PTHR13165, 2 hits
PfamiView protein in Pfam
PF04959 ARS2, 1 hit
PF12066 DUF3546, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRRT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXP5
Secondary accession number(s): A4D2E5
, A4D2E6, A6NK22, B4DJL4, B4DZA6, O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4, Q9Y4S4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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