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Protein

Solute carrier family 12 member 9

Gene

SLC12A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cation:chloride symporter activity Source: ProtInc
  • potassium:chloride symporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.30.1.6 the cation-chloride cotransporter (ccc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 12 member 9
Alternative name(s):
Cation-chloride cotransporter 6
Short name:
hCCC6
Cation-chloride cotransporter-interacting protein 1
Short name:
CCC-interacting protein 1
Short name:
hCIP1
Potassium-chloride transporter 9
WO3.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC12A9
Synonyms:CCC6, CIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000146828.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17435 SLC12A9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616861 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 72ExtracellularSequence analysisAdd BLAST15
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 119CytoplasmicSequence analysisAdd BLAST26
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 167ExtracellularSequence analysisAdd BLAST27
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 193CytoplasmicSequence analysis5
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 262ExtracellularSequence analysisAdd BLAST48
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 297CytoplasmicSequence analysisAdd BLAST14
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 338ExtracellularSequence analysisAdd BLAST20
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 390CytoplasmicSequence analysisAdd BLAST31
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 416ExtracellularSequence analysis5
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 466CytoplasmicSequence analysisAdd BLAST29
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 740ExtracellularSequence analysisAdd BLAST253
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 914CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56996

Open Targets

More...
OpenTargetsi
ENSG00000146828

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134921585

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC12A9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314151 – 914Solute carrier family 12 member 9Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXP2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BXP2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXP2

PeptideAtlas

More...
PeptideAtlasi
Q9BXP2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXP2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79472
79473 [Q9BXP2-2]
79474 [Q9BXP2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, brain and kidney. Lower expression in lung, liver and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146828 Expressed in 188 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_SLC12A9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXP2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXP2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067536

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SLC12A1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121311, 31 interactors

Protein interaction database and analysis system

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IntActi
Q9BXP2, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000275730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BXP2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC12A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1288 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000018183

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXP2

KEGG Orthology (KO)

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KOi
K14429

Identification of Orthologs from Complete Genome Data

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OMAi
SNSMTVT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02RC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXP2

TreeFam database of animal gene trees

More...
TreeFami
TF313191

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR030345 SLC12A9

The PANTHER Classification System

More...
PANTHERi
PTHR11827:SF52 PTHR11827:SF52, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASESSPLLA YRLLGEEGVA LPANGAGGPG GASARKLSTF LGVVVPTVLS
60 70 80 90 100
MFSIVVFLRI GFVVGHAGLL QALAMLLVAY FILALTVLSV CAIATNGAVQ
110 120 130 140 150
GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESVLDVFGAD
160 170 180 190 200
ATGPSGLRVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV
210 220 230 240 250
SGSLASVLIS FVAVGPRDIR LTPRPGPNGS SLPPRFGHFT GFNSSTLKDN
260 270 280 290 300
LGAGYAEDYT TGAVMNFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
310 320 330 340 350
GTIVAVAYTF FVYVLLFFLS SFTCDRTLLQ EDYGFFRAIS LWPPLVLIGI
360 370 380 390 400
YATALSASMS SLIGASRILH ALARDDLFGV ILAPAKVVSR GGNPWAAVLY
410 420 430 440 450
SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT
460 470 480 490 500
FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLAA LLTARGGPSS
510 520 530 540 550
WGYVSQALLF HQVRKYLLRL DVRKDHVKFW RPQLLLLVGN PRGALPLLRL
560 570 580 590 600
ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD RAQVKAFVDL
610 620 630 640 650
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP
660 670 680 690 700
ADSTREGSSP ALSTLFPPPR APGSPRALNP QDYVATVADA LKMNKNVVLA
710 720 730 740 750
RASGALPPER LSRGSGGTSQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ
760 770 780 790 800
MATILGMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE
810 820 830 840 850
VVWGEGAGAG EPEAEEEGDF VNSGRGDAEA EALARSANAL VRAQQGRGTG
860 870 880 890 900
GGPGGPEGGD AEGPITALTF LYLPRPPADP ARYPRYLALL ETLTRDLGPT
910
LLVHGVTPVT CTDL
Length:914
Mass (Da):96,110
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8096855B78078CA4
GO
Isoform 2 (identifier: Q9BXP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-149: Missing.
     620-627: GGMKPNTL → ESNSHPLP
     628-914: Missing.

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):57,053
Checksum:i1E36DCF67FB49ACC
GO
Isoform 3 (identifier: Q9BXP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-627: GGMKPNTL → ESNSHPLP
     628-914: Missing.

Note: No experimental confirmation available.
Show »
Length:627
Mass (Da):65,959
Checksum:i36091DE907D29704
GO
Isoform 4 (identifier: Q9BXP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     620-631: GGMKPNTLVLGF → ESGTLLPWGFRS
     632-914: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):66,429
Checksum:iC3C8C3DEE2094DAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0I5C9J0I5_HUMAN
Solute carrier family 12 member 9
SLC12A9
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBD8C9JBD8_HUMAN
Solute carrier family 12 member 9
SLC12A9
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMQ7C9JMQ7_HUMAN
Solute carrier family 12 member 9
SLC12A9
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEK3F8WEK3_HUMAN
Solute carrier family 12 member 9
SLC12A9
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → T in BAH13476 (PubMed:14702039).Curated1
Sequence conflicti222T → S in BAB40456 (Ref. 3) Curated1
Sequence conflicti231S → A in BAB40456 (Ref. 3) Curated1
Sequence conflicti269S → N in AAF88060 (PubMed:10871601).Curated1
Sequence conflicti602L → F in AAF88060 (PubMed:10871601).Curated1
Sequence conflicti857E → K in BAB40456 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03319261 – 149Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_045591620 – 631GGMKP…LVLGF → ESGTLLPWGFRS in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033193620 – 627GGMKPNTL → ESNSHPLP in isoform 2 and isoform 3. 1 Publication8
Alternative sequenceiVSP_033194628 – 914Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST287
Alternative sequenceiVSP_045592632 – 914Missing in isoform 4. 1 PublicationAdd BLAST283

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF284422 mRNA Translation: AAF88060.1
AF312032 Genomic DNA Translation: AAK21008.1
AF312032 Genomic DNA Translation: AAK21009.1
AB033284 mRNA Translation: BAB40456.1
AK301411 mRNA Translation: BAH13476.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23818.1
CH471091 Genomic DNA Translation: EAW76475.1
CH471091 Genomic DNA Translation: EAW76476.1
CH471091 Genomic DNA Translation: EAW76483.1
CH471091 Genomic DNA Translation: EAW76480.1
CH471091 Genomic DNA Translation: EAW76484.1
CH471091 Genomic DNA Translation: EAW76485.1
BC000154 mRNA Translation: AAH00154.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5707.1 [Q9BXP2-1]
CCDS59068.1 [Q9BXP2-4]
CCDS59069.1 [Q9BXP2-2]

NCBI Reference Sequences

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RefSeqi
NP_001254741.1, NM_001267812.1 [Q9BXP2-4]
NP_001254743.1, NM_001267814.1 [Q9BXP2-2]
NP_064631.2, NM_020246.3 [Q9BXP2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.521087

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354161; ENSP00000275730; ENSG00000146828 [Q9BXP2-1]
ENST00000415287; ENSP00000413796; ENSG00000146828 [Q9BXP2-2]
ENST00000540482; ENSP00000443702; ENSG00000146828 [Q9BXP2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56996

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56996

UCSC genome browser

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UCSCi
uc003uwp.5 human [Q9BXP2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284422 mRNA Translation: AAF88060.1
AF312032 Genomic DNA Translation: AAK21008.1
AF312032 Genomic DNA Translation: AAK21009.1
AB033284 mRNA Translation: BAB40456.1
AK301411 mRNA Translation: BAH13476.1
AC011895 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23818.1
CH471091 Genomic DNA Translation: EAW76475.1
CH471091 Genomic DNA Translation: EAW76476.1
CH471091 Genomic DNA Translation: EAW76483.1
CH471091 Genomic DNA Translation: EAW76480.1
CH471091 Genomic DNA Translation: EAW76484.1
CH471091 Genomic DNA Translation: EAW76485.1
BC000154 mRNA Translation: AAH00154.1
CCDSiCCDS5707.1 [Q9BXP2-1]
CCDS59068.1 [Q9BXP2-4]
CCDS59069.1 [Q9BXP2-2]
RefSeqiNP_001254741.1, NM_001267812.1 [Q9BXP2-4]
NP_001254743.1, NM_001267814.1 [Q9BXP2-2]
NP_064631.2, NM_020246.3 [Q9BXP2-1]
UniGeneiHs.521087

3D structure databases

ProteinModelPortaliQ9BXP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121311, 31 interactors
IntActiQ9BXP2, 2 interactors
STRINGi9606.ENSP00000275730

Protein family/group databases

TCDBi2.A.30.1.6 the cation-chloride cotransporter (ccc) family

PTM databases

iPTMnetiQ9BXP2
PhosphoSitePlusiQ9BXP2

Polymorphism and mutation databases

BioMutaiSLC12A9
DMDMi74752435

Proteomic databases

EPDiQ9BXP2
MaxQBiQ9BXP2
PaxDbiQ9BXP2
PeptideAtlasiQ9BXP2
PRIDEiQ9BXP2
ProteomicsDBi79472
79473 [Q9BXP2-2]
79474 [Q9BXP2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354161; ENSP00000275730; ENSG00000146828 [Q9BXP2-1]
ENST00000415287; ENSP00000413796; ENSG00000146828 [Q9BXP2-2]
ENST00000540482; ENSP00000443702; ENSG00000146828 [Q9BXP2-4]
GeneIDi56996
KEGGihsa:56996
UCSCiuc003uwp.5 human [Q9BXP2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56996
DisGeNETi56996
EuPathDBiHostDB:ENSG00000146828.17

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC12A9

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0201124
HGNCiHGNC:17435 SLC12A9
HPAiHPA067536
MIMi616861 gene
neXtProtiNX_Q9BXP2
OpenTargetsiENSG00000146828
PharmGKBiPA134921585

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1288 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000159400
HOGENOMiHOG000018183
HOVERGENiHBG106223
InParanoidiQ9BXP2
KOiK14429
OMAiSNSMTVT
OrthoDBiEOG091G02RC
PhylomeDBiQ9BXP2
TreeFamiTF313191

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC12A9 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC12A9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56996

Protein Ontology

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PROi
PR:Q9BXP2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146828 Expressed in 188 organ(s), highest expression level in blood
CleanExiHS_SLC12A9
ExpressionAtlasiQ9BXP2 baseline and differential
GenevisibleiQ9BXP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR030345 SLC12A9
PANTHERiPTHR11827:SF52 PTHR11827:SF52, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS12A9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXP2
Secondary accession number(s): B7Z740
, D6W5X0, D6W5X2, F5H8C2, Q9BWL2, Q9BXP1, Q9BYI0, Q9NQR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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