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UniProtKB - Q9BXM7 (PINK1_HUMAN)

Entry version 194 (25 May 2022)
Sequence version 1 (01 Jun 2001)
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Protein

Serine/threonine-protein kinase PINK1, mitochondrial

Gene

PINK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:18957282, PubMed:18443288, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:22396657, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24898855, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291, PubMed:32484300, PubMed:20547144).

Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:18443288, PubMed:23620051, PubMed:24898855, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:32484300, PubMed:22396657, PubMed:32047033, PubMed:15087508).

Mediates the translocation and activation of PRKN at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291).

At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains at 'Ser-65', the PINK1-phosphorylated polyubiquitin then recruits PRKN from the cytosol to the OMM where PRKN is fully activated by phosphorylation at 'Ser-65' by PINK1 (PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291).

In damaged mitochondria, mediates the decision between mitophagy or preventing apoptosis by promoting PRKN-dependent poly- or monoubiquitination of VDAC1; polyubiquitination of VDAC1 by PRKN promotes mitophagy, while monoubiquitination of VDAC1 by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033).

When cellular stress results in irreversible mitochondrial damage, functions with PRKN to promote clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:14607334, PubMed:20798600, PubMed:20404107, PubMed:19966284, PubMed:23933751, PubMed:15087508).

The PINK1-PRKN pathway also promotes fission of damaged mitochondria by phosphorylating and thus promoting the PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855).

This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051).

Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300).

Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657).

Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).

By similarity22 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei186ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei362Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi162 – 170ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processAutophagy
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXM7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5205685, PINK1-PRKN Mediated Mitophagy
R-HSA-9614657, FOXO-mediated transcription of cell death genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BXM7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9BXM7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase PINK1, mitochondrial (EC:2.7.11.15 Publications)
Alternative name(s):
BRPK
PTEN-induced putative kinase protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PINK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14581, PINK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608309, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXM7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158828

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini78 – 93Mitochondrial intermembraneSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei94 – 110HelicalSequence analysisAdd BLAST17
Topological domaini111 – 581CytoplasmicSequence analysisAdd BLAST471

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinson disease 6 (PARK6)26 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn early-onset form of Parkinson disease, a neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. PARK6 pathogenesis involves respiratory complex I deficiency causing mitochondrial depolarization and dysfunction. Inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04656892C → F in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553145550Ensembl.1
Natural variantiVAR_062773125C → G in PARK6. 1 Publication1
Natural variantiVAR_064344126Q → P in PARK6; strongly reduces interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs775809722Ensembl.1
Natural variantiVAR_046574147R → H in PARK6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs138050841Ensembl.1
Natural variantiVAR_046575168A → P in PARK6; no effect on autophosphorylation; localizes to the mitochondria and immunogold experiments reveal that both wild-type and mutant proteins face the mitochondrial intermembrane space. 4 PublicationsCorresponds to variant dbSNP:rs768091663EnsemblClinVar.1
Natural variantiVAR_078934170V → G in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553145929Ensembl.1
Natural variantiVAR_046577196P → L in PARK6. 1 PublicationCorresponds to variant dbSNP:rs138302371EnsemblClinVar.1
Natural variantiVAR_046578217A → D in PARK6. 1 PublicationCorresponds to variant dbSNP:rs74315360EnsemblClinVar.1
Natural variantiVAR_046581240E → K in PARK6. 2 PublicationsCorresponds to variant dbSNP:rs573931674Ensembl.1
Natural variantiVAR_046584268L → V in PARK6. 2 PublicationsCorresponds to variant dbSNP:rs372280083EnsemblClinVar.1
Natural variantiVAR_046585271H → Q in PARK6. 1 PublicationCorresponds to variant dbSNP:rs28940284EnsemblClinVar.1
Natural variantiVAR_046587279R → H in PARK6. 1 PublicationCorresponds to variant dbSNP:rs74315358EnsemblClinVar.1
Natural variantiVAR_062774280A → T in PARK6; early-onset. 1 PublicationCorresponds to variant dbSNP:rs772510148EnsemblClinVar.1
Natural variantiVAR_018994309G → D in PARK6; fails to maintain mitochondrial membrane potential; full-length mutant has no effect on autophosphorylation; strongly reduces interaction with PRKN; decreases PRKN and SNCAIP ubiquitination and degradation; decreases Drp1 phosphorylation. 5 PublicationsCorresponds to variant dbSNP:rs74315355EnsemblClinVar.1
Natural variantiVAR_046589313T → M in PARK6; decreases PRKN and SNCAIP ubiquitination and degradation; slightly decreases Drp1 phosphorylation. 4 PublicationsCorresponds to variant dbSNP:rs74315359EnsemblClinVar.1
Natural variantiVAR_046593347L → P in PARK6; strongly reduces interaction with PRKN; reduced ubiquitination of MIRO1. 5 PublicationsCorresponds to variant dbSNP:rs28940285EnsemblClinVar.1
Natural variantiVAR_062775369L → P in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1195888869Ensembl.1
Natural variantiVAR_062776386G → A in PARK6; abolishes kinase activity. 2 Publications1
Natural variantiVAR_046596388C → R in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553146806EnsemblClinVar.1
Natural variantiVAR_062778407R → Q in PARK6; early-onset. 1 PublicationCorresponds to variant dbSNP:rs556540177EnsemblClinVar.1
Natural variantiVAR_062779409G → V in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553146818Ensembl.1
Natural variantiVAR_046599417E → G in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553146822Ensembl.1
Natural variantiVAR_078935456 – 581Missing in PARK6. 1 PublicationAdd BLAST126
Natural variantiVAR_046605464R → H in PARK6. 1 PublicationCorresponds to variant dbSNP:rs764328076Ensembl.1
Natural variantiVAR_046607489L → P in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553146903Ensembl.1
Natural variantiVAR_084338492 – 581Missing in PARK6; mitochondria are deformed and dysfunctional with decreased mitochondrial membrane potential; shows increased apoptosis; increased oxidative stress; decreased phosphorylation of DNM1L and Drp1. 3 PublicationsCorresponds to variant dbSNP:rs34208370Add BLAST90
Natural variantiVAR_046610534Q → QQ in PARK6. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi112 – 117EEKQAE → AAKQAA in 3EA; impaired ability to localize to the outer mitochondrial membrane. 1 Publication6
Mutagenesisi219K → A: Abolishes MFN2 phosphorylation and interaction with PRKN; when associated with ALA-362 and ALA-384. 1 Publication1
Mutagenesisi219K → M: Loss of enzyme activity and impaired localization of PRKN to mitochondria; when associated with A-362 and A-384. 2 Publications1
Mutagenesisi362D → A: Abolishes MFN2 phosphorylation and interaction with PRKN; when associated with A-219 and A-384. Loss of enzyme activity and impaired localization of PRKN to mitochondria; when associated with M-219 and A-384. 3 Publications1
Mutagenesisi384D → A: Abolishes MFN2 phosphorylation and interaction with PRKN; when associated with A-219 and A-362. Loss of enzyme activity and impaired localization of PRKN to mitochondria; when associated with M-219 and A-362. 3 Publications1
Mutagenesisi384D → N: Loss of activity. Abolishes Drp1 phosphorylation. No effect on localization to mitochondria. 1 Publication1

Keywords - Diseasei

Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		65018

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PINK1

MalaCards human disease database

More...MalaCardsi		PINK1
MIMi168600, phenotype
605909, phenotype

Open Targets

More...OpenTargetsi		ENSG00000158828

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2828, Young-onset Parkinson disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33325

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXM7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3337330

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PINK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		48428484

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 77MitochondrionSequence analysisAdd BLAST77
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002436978 – 581Serine/threonine-protein kinase PINK1, mitochondrialAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei228Phosphoserine; by autocatalysis1 Publication1
Modified residuei402Phosphoserine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved (PubMed:19229105, PubMed:22354088, PubMed:30733118). In healthy cells, the precursor is continuously imported into the inner mitochondrial membrane (IMM), where it is proteolytically cleaved by mitochondrial-processing peptidase (MPP) and then undergoes further proteolytic cleavage by PARL or AFG3L2 to give rise to the 52 kDa short form (PubMed:19229105, PubMed:22354088). The 52 kDa short form is then released into the cytosol where it rapidly undergoes proteasome-dependent degradation (PubMed:20404107). In unhealthy cells, when cellular stress conditions lead to the loss of mitochondrial membrane potential, mitochondrial import is impaired leading to the precursor accumulating on the outer mitochondrial membrane (OMM) (PubMed:20404107, PubMed:30733118). If accumulation at the OMM fails and it is imported into the depolarized mitochondria, it undergoes cleavage by the IMM protease OMA1, promoting its subsequent degradation by the proteasome (PubMed:30733118).4 Publications
Autophosphorylated (PubMed:20404107, PubMed:22910362, PubMed:18957282). Loss of mitochondrial membrane potential results in the precursor accumulating on the outer mitochondrial membrane (OMM) where it is activated by autophosphorylation (PubMed:20404107, PubMed:22910362, PubMed:18957282). Autophosphorylation at Ser-228 and Ser-402 is sufficient and essential for selective recruitment of PRKN to depolarized mitochondria, via PINK1-dependent phosphorylation of ubiquitin and maybe PRKN (PubMed:22910362, PubMed:18957282).3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXM7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXM7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXM7

PeptideAtlas

More...PeptideAtlasi		Q9BXM7

PRoteomics IDEntifications database

More...PRIDEi		Q9BXM7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79455 [Q9BXM7-1]
79456 [Q9BXM7-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9BXM7

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXM7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXM7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158828, Expressed in tendon and 249 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXM7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158828, Tissue enhanced (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKN (PubMed:20798600, PubMed:19966284).

Interacts with FBXO7 (PubMed:23933751).

Forms a complex with PRKN and PARK7 (PubMed:19229105).

Interacts with NENF (PubMed:31536960).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122376, 683 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BXM7

Database of interacting proteins

More...DIPi		DIP-29427N

Protein interaction database and analysis system

More...IntActi		Q9BXM7, 38 interactors

Molecular INTeraction database

More...MINTi		Q9BXM7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364204

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXM7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9BXM7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXM7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 511Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST356

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 117Required for outer membrane localization1 Publication7
Regioni189 – 208DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4158, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001206

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022208_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXM7

Identification of Orthologs from Complete Genome Data

More...OMAi		MMILQLL

Database of Orthologous Groups

More...OrthoDBi		314975at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXM7

TreeFam database of animal gene trees

More...TreeFami		TF313183

Family and domain databases

Conserved Domains Database

More...CDDi		cd14018, STKc_PINK1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR040110, PINK1_STKc
IPR000719, Prot_kinase_dom
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q9BXM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA 
        60         70         80         90        100
GPGAEPRRVG LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV 
       110        120        130        140        150
FLAFGLGLGL IEEKQAESRR AVSACQEIQA IFTQKSKPGP DPLDTRRLQG 
       160        170        180        190        200
FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ NLEVTKSTGL LPGRGPGTSA 
       210        220        230        240        250
PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE LVPASRVALA 
       260        270        280        290        300
GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 
       310        320        330        340        350
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV 
       360        370        380        390        400
DHLVQQGIAH RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF 
       410        420        430        440        450
SSWYVDRGGN GCLMAPEVST ARPGPRAVID YSKADAWAVG AIAYEIFGLV 
       460        470        480        490        500
NPFYGQGKAH LESRSYQEAQ LPALPESVPP DVRQLVRALL QREASKRPSA 
       510        520        530        540        550
RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL ANRLTEKCCV 
       560        570        580 
ETKMKMLFLA NLECETLCQA ALLLCSWRAA L
Length:581
Mass (Da):62,769
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i721FE01F63263A64
GO
Isoform 2Curated (identifier: Q9BXM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-320: LGHGRTLFLVMKN → MCGSQRPSPLSTS

Show »
Length:274
Mass (Da):30,104
Checksum:iC54C628F879B4BED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209P → A in AAH28215 (PubMed:15489334).Curated1
Sequence conflicti419S → P in BAC11484 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04656667L → F1 PublicationCorresponds to variant dbSNP:rs763142730Ensembl.1
Natural variantiVAR_04656768R → P1 PublicationCorresponds to variant dbSNP:rs1385309950Ensembl.1
Natural variantiVAR_04656892C → F in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553145550Ensembl.1
Natural variantiVAR_04656998R → W1 PublicationCorresponds to variant dbSNP:rs575668171Ensembl.1
Natural variantiVAR_046570111I → S1 PublicationCorresponds to variant dbSNP:rs1553145560Ensembl.1
Natural variantiVAR_046571115Q → L2 PublicationsCorresponds to variant dbSNP:rs148871409EnsemblClinVar.1
Natural variantiVAR_046572124A → V1 PublicationCorresponds to variant dbSNP:rs1274588239Ensembl.1
Natural variantiVAR_062773125C → G in PARK6. 1 Publication1
Natural variantiVAR_064344126Q → P in PARK6; strongly reduces interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs775809722Ensembl.1
Natural variantiVAR_046573145T → M1 PublicationCorresponds to variant dbSNP:rs45604240EnsemblClinVar.1
Natural variantiVAR_046574147R → H in PARK6; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs138050841Ensembl.1
Natural variantiVAR_041010148L → W1 PublicationCorresponds to variant dbSNP:rs56297806Ensembl.1
Natural variantiVAR_046575168A → P in PARK6; no effect on autophosphorylation; localizes to the mitochondria and immunogold experiments reveal that both wild-type and mutant proteins face the mitochondrial intermembrane space. 4 PublicationsCorresponds to variant dbSNP:rs768091663EnsemblClinVar.1
Natural variantiVAR_078934170V → G in PARK6. 1 PublicationCorresponds to variant dbSNP:rs1553145929Ensembl.1
Natural variantiVAR_046576186K → N1 PublicationCorresponds to variant dbSNP:rs143204084Ensembl.1
Natural variantiVAR_046577196P → L in PARK6. 1 PublicationCorresponds to variant dbSNP:rs138302371EnsemblClinVar.1
Natural variantiVAR_041011196P → S1 PublicationCorresponds to variant dbSNP:rs35802484Ensembl.1
Natural variantiVAR_041012209P → L1 PublicationCorresponds to variant dbSNP:rs34677717EnsemblClinVar.1
Natural variantiVAR_041013215P → L in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371854396EnsemblClinVar.1
Natural variantiVAR_046578217A → D in PARK6. 1 PublicationCorresponds to variant dbSNP:rs74315360EnsemblClinVar.1
Natural variantiVAR_046579231E → G1 PublicationCorresponds to variant dbSNP:rs1303935100Ensembl.1
Natural variantiVAR_046580235N → I1 PublicationCorresponds to variant dbSNP:rs1557562082Ensembl.1
Natural variantiVAR_046581240E → K in PARK6. 2 PublicationsCorresponds to variant dbSNP:rs573931674Ensembl.1
Natural variantiVAR_046582257T → I. Corresponds to variant dbSNP:rs370906995EnsemblClinVar.1
Natural variantiVAR_046583263R → G1 PublicationCorresponds to variant dbSNP:rs1553146419Ensembl.1
Natural variantiVAR_046584268L → V in PARK6. 2 PublicationsCorresponds to variant dbSNP:rs372280083EnsemblClinVar.1
Natural variantiVAR_046585271H → Q in PARK6. 1 PublicationCorresponds to variant dbSNP:rs28940284EnsemblClinVar.1
Natural variantiVAR_046586276R → Q1 PublicationCorresponds to variant dbSNP:rs548506734EnsemblClinVar.1
Natural variantiVAR_046587279R → H in PARK6. 1 PublicationCorresponds to variant dbSNP:rs74315358EnsemblClinVar.1
Natural variantiVAR_062774280A → T in PARK6; early-onset. 1 PublicationCorresponds to variant dbSNP:rs772510148EnsemblClinVar.1
Natural variantiVAR_046588296P → L2 PublicationsCorresponds to variant dbSNP:rs779060308EnsemblClinVar.1
Natural variantiVAR_018993305P → L. Corresponds to variant dbSNP:rs7349186Ensembl.1
Natural variantiVAR_018994309G → D in PARK6; fails to maintain mitochondrial membrane potential; full-length mutant has no effect on autophosphorylation; strongly reduces interaction with PRKN; decreases PRKN and SNCAIP ubiquitination and degradation; decreases Drp1 phosphorylation. 5 PublicationsCorresponds to variant dbSNP:rs74315355EnsemblClinVar.1
Natural variantiVAR_046589313T → M in PARK6; decreases PRKN and SNCAIP ubiquitination and degradation; slightly decreases Drp1 phosphorylation. 4 PublicationsCorresponds to variant dbSNP:rs74315359EnsemblClinVar.1
Natural variantiVAR_046590317V → I2 PublicationsCorresponds to variant dbSNP:rs200949139Ensembl.1
Natural variantiVAR_046591318M → L1 PublicationCorresponds to variant dbSNP:rs139226733EnsemblClinVar.1
Natural variantiVAR_046592322P → L1 PublicationCorresponds to variant dbSNP:rs768019187Ensembl.1
Natural variantiVAR_041014339A → T4 PublicationsCorresponds to variant dbSNP:rs55831733EnsemblClinVar.1
Natural variantiVAR_018995340A → T7 Publications