UniProtKB - Q9BXM0 (PRAX_HUMAN)
Periaxin
PRX
Functioni
GO - Biological processi
- axon ensheathment Source: UniProtKB
- peripheral nervous system myelin maintenance Source: GO_Central
- regulation of RNA splicing Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BXM0 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination [Q9BXM0-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Periaxin |
Gene namesi | Name:PRX Synonyms:KIAA1620 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105227.14 |
HGNCi | HGNC:13797, PRX |
MIMi | 605725, gene |
neXtProti | NX_Q9BXM0 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination.By similarity
Other locations
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity
Other locations
- Cell junction By similarity
Note: Colocalizes with ACTB at tricellular junctions between eye lens fiber cells.By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell junction Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Dejerine-Sottas syndrome (DSS)1 Publication
Charcot-Marie-Tooth disease 4F (CMT4F)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069093 | 651 | D → N in CMT4F. 1 PublicationCorresponds to variant dbSNP:rs3814290Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 81 – 83 | LRL → QRQ: Nearly abolishes export from the nucleus. 1 Publication | 3 |
Keywords - Diseasei
Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease mutation, Neurodegeneration, NeuropathyOrganism-specific databases
DisGeNETi | 57716 |
GeneReviewsi | PRX |
MalaCardsi | PRX |
MIMi | 145900, phenotype 614895, phenotype |
OpenTargetsi | ENSG00000105227 |
Orphaneti | 99952, Charcot-Marie-Tooth disease type 4F 64748, Dejerine-Sottas syndrome |
PharmGKBi | PA33843 |
Miscellaneous databases
Pharosi | Q9BXM0, Tbio |
Polymorphism and mutation databases
BioMutai | PRX |
DMDMi | 317373270 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058563 | 1 – 1461 | PeriaxinAdd BLAST | 1461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphoserineBy similarity | 1 | |
Modified residuei | 133 | PhosphoserineBy similarity | 1 | |
Modified residuei | 900 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1082 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1349 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1351 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1363 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1401 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1407 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1439 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9BXM0 |
MassIVEi | Q9BXM0 |
PaxDbi | Q9BXM0 |
PeptideAtlasi | Q9BXM0 |
PRIDEi | Q9BXM0 |
ProteomicsDBi | 79452 [Q9BXM0-1] 79453 [Q9BXM0-2] 79454 [Q9BXM0-3] |
PTM databases
iPTMneti | Q9BXM0 |
PhosphoSitePlusi | Q9BXM0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105227, Expressed in trigeminal ganglion and 232 other tissues |
Genevisiblei | Q9BXM0, HS |
Organism-specific databases
HPAi | ENSG00000105227, Group enriched (brain, lung, retina) |
Interactioni
Subunit structurei
Homodimer (via PDZ domain) (PubMed:24675079).
Interacts with SCN10A.
Found in a complex with SCN10A (By similarity).
Interacts with DRP2.
Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity).
Identified in a complex with EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, VIM and spectrin (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 121739, 7 interactors |
IntActi | Q9BXM0, 11 interactors |
STRINGi | 9606.ENSP00000326018 |
Miscellaneous databases
RNActi | Q9BXM0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BXM0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 99 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Repeati | 431 – 435 | 1 | 5 | |
Repeati | 439 – 443 | 2 | 5 | |
Repeati | 447 – 451 | 3 | 5 | |
Repeati | 455 – 459 | 4 | 5 | |
Repeati | 463 – 467 | 5 | 5 | |
Repeati | 468 – 472 | 6 | 5 | |
Repeati | 473 – 477 | 7 | 5 | |
Repeati | 481 – 485 | 8 | 5 | |
Repeati | 486 – 490 | 9 | 5 | |
Repeati | 494 – 498 | 10 | 5 | |
Repeati | 499 – 503 | 11 | 5 | |
Repeati | 507 – 511 | 12 | 5 | |
Repeati | 512 – 516 | 13 | 5 | |
Repeati | 520 – 524 | 14 | 5 | |
Repeati | 525 – 529 | 15 | 5 | |
Repeati | 533 – 537 | 16 | 5 | |
Repeati | 538 – 542 | 17 | 5 | |
Repeati | 546 – 550 | 18 | 5 | |
Repeati | 551 – 555 | 19 | 5 | |
Repeati | 559 – 563 | 20 | 5 | |
Repeati | 564 – 568 | 21 | 5 | |
Repeati | 572 – 576 | 22 | 5 | |
Repeati | 577 – 581 | 23 | 5 | |
Repeati | 582 – 586 | 24 | 5 | |
Repeati | 590 – 594 | 25 | 5 | |
Repeati | 595 – 599 | 26 | 5 | |
Repeati | 600 – 604 | 27 | 5 | |
Repeati | 608 – 612 | 28 | 5 | |
Repeati | 613 – 617 | 29 | 5 | |
Repeati | 618 – 622 | 30 | 5 | |
Repeati | 626 – 630 | 31 | 5 | |
Repeati | 631 – 635 | 32 | 5 | |
Repeati | 636 – 640 | 33 | 5 | |
Repeati | 644 – 648 | 34 | 5 | |
Repeati | 649 – 653 | 35 | 5 | |
Repeati | 654 – 658 | 36 | 5 | |
Repeati | 662 – 666 | 37 | 5 | |
Repeati | 670 – 674 | 38 | 5 | |
Repeati | 675 – 679 | 39 | 5 | |
Repeati | 683 – 687 | 40 | 5 | |
Repeati | 688 – 692 | 41 | 5 | |
Repeati | 696 – 700 | 42 | 5 | |
Repeati | 701 – 705 | 43 | 5 | |
Repeati | 706 – 710 | 44 | 5 | |
Repeati | 714 – 718 | 45 | 5 | |
Repeati | 719 – 723 | 46 | 5 | |
Repeati | 724 – 728 | 47 | 5 | |
Repeati | 732 – 736 | 48 | 5 | |
Repeati | 737 – 741 | 49 | 5 | |
Repeati | 742 – 746 | 50 | 5 | |
Repeati | 750 – 754 | 51 | 5 | |
Repeati | 755 – 759 | 52 | 5 | |
Repeati | 760 – 764 | 53 | 5 | |
Repeati | 771 – 775 | 54 | 5 | |
Repeati | 779 – 783 | 55 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 431 – 783 | 55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]-[AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER]Add BLAST | 353 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 70 – 84 | Nuclear export signal1 PublicationAdd BLAST | 15 | |
Motifi | 118 – 196 | Nuclear localization signalBy similarityAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 118 – 196 | Arg/Lys-rich (basic)Add BLAST | 79 | |
Compositional biasi | 1098 – 1235 | Glu-rich (acidic)Add BLAST | 138 | |
Compositional biasi | 1353 – 1361 | Poly-Glu | 9 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QS7Y, Eukaryota |
GeneTreei | ENSGT00940000160366 |
HOGENOMi | CLU_1758219_0_0_1 |
InParanoidi | Q9BXM0 |
OMAi | GPDVEMK |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q9BXM0 |
TreeFami | TF350595 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEARSRSAEE LRRAELVEII VETEAQTGVS GINVAGGGKE GIFVRELRED
60 70 80 90 100
SPAARSLSLQ EGDQLLSARV FFENFKYEDA LRLLQCAEPY KVSFCLKRTV
110 120 130 140 150
PTGDLALRPG TVSGYEIKGP RAKVAKLNIQ SLSPVKKKKM VPGALGVPAD
160 170 180 190 200
LAPVDVEFSF PKFSRLRRGL KAEAVKGPVP AAPARRRLQL PRLRVREVAE
210 220 230 240 250
EAQAARLAAA APPPRKAKVE AEVAAGARFT APQVELVGPR LPGAEVGVPQ
260 270 280 290 300
VSAPKAAPSA EAAGGFALHL PTLGLGAPAP PAVEAPAVGI QVPQVELPAL
310 320 330 340 350
PSLPTLPTLP CLETREGAVS VVVPTLDVAA PTVGVDLALP GAEVEARGEA
360 370 380 390 400
PEVALKMPRL SFPRFGARAK EVAEAKVAKV SPEARVKGPR LRMPTFGLSL
410 420 430 440 450
LEPRPAAPEV VESKLKLPTI KMPSLGIGVS GPEVKVPKGP EVKLPKAPEV
460 470 480 490 500
KLPKVPEAAL PEVRLPEVEL PKVSEMKLPK VPEMAVPEVR LPEVELPKVS
510 520 530 540 550
EMKLPKVPEM AVPEVRLPEV QLLKVSEMKL PKVPEMAVPE VRLPEVQLPK
560 570 580 590 600
VSEMKLPEVS EVAVPEVRLP EVQLPKVPEM KVPEMKLPKV PEMKLPEMKL
610 620 630 640 650
PEVQLPKVPE MAVPDVHLPE VQLPKVPEMK LPEMKLPEVK LPKVPEMAVP
660 670 680 690 700
DVHLPEVQLP KVPEMKLPKM PEMAVPEVRL PEVQLPKVSE MKLPKVPEMA
710 720 730 740 750
VPDVHLPEVQ LPKVCEMKVP DMKLPEIKLP KVPEMAVPDV HLPEVQLPKV
760 770 780 790 800
SEIRLPEMQV PKVPDVHLPK APEVKLPRAP EVQLKATKAE QAEGMEFGFK
810 820 830 840 850
MPKMTMPKLG RAESPSRGKP GEAGAEVSGK LVTLPCLQPE VDGEAHVGVP
860 870 880 890 900
SLTLPSVELD LPGALGLQGQ VPAAKMGKGE RVEGPEVAAG VREVGFRVPS
910 920 930 940 950
VEIVTPQLPA VEIEEGRLEM IETKVKPSSK FSLPKFGLSG PKVAKAEAEG
960 970 980 990 1000
AGRATKLKVS KFAISLPKAR VGAEAEAKGA GEAGLLPALD LSIPQLSLDA
1010 1020 1030 1040 1050
HLPSGKVEVA GADLKFKGPR FALPKFGVRG RDTEAAELVP GVAELEGKGW
1060 1070 1080 1090 1100
GWDGRVKMPK LKMPSFGLAR GKEAEVQGDR ASPGEKAEST AVQLKIPEVE
1110 1120 1130 1140 1150
LVTLGAQEEG RAEGAVAVSG MQLSGLKVST AGQVVTEGHD AGLRMPPLGI
1160 1170 1180 1190 1200
SLPQVELTGF GEAGTPGQQA QSTVPSAEGT AGYRVQVPQV TLSLPGAQVA
1210 1220 1230 1240 1250
GGELLVGEGV FKMPTVTVPQ LELDVGLSRE AQAGEAATGE GGLRLKLPTL
1260 1270 1280 1290 1300
GARARVGGEG AEEQPPGAER TFCLSLPDVE LSPSGGNHAE YQVAEGEGEA
1310 1320 1330 1340 1350
GHKLKVRLPR FGLVRAKEGA EEGEKAKSPK LRLPRVGFSQ SEMVTGEGSP
1360 1370 1380 1390 1400
SPEEEEEEEE EGSGEGASGR RGRVRVRLPR VGLAAPSKAS RGQEGDAAPK
1410 1420 1430 1440 1450
SPVREKSPKF RFPRVSLSPK ARSGSGDQEE GGLRVRLPSV GFSETGAPGP
1460
ARMEGAQAAA V
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KBF1 | A0A669KBF1_HUMAN | Periaxin | PRX | 1,556 | Annotation score: | ||
A0A6Q8PFM7 | A0A6Q8PFM7_HUMAN | Periaxin | PRX | 93 | Annotation score: | ||
A0A6Q8PFP7 | A0A6Q8PFP7_HUMAN | Periaxin | PRX | 97 | Annotation score: | ||
A0A6Q8PFW6 | A0A6Q8PFW6_HUMAN | Periaxin | PRX | 82 | Annotation score: | ||
A0A6Q8PGB6 | A0A6Q8PGB6_HUMAN | Periaxin | PRX | 1,415 | Annotation score: | ||
A0A6Q8PGK2 | A0A6Q8PGK2_HUMAN | Periaxin | PRX | 57 | Annotation score: | ||
A0A6Q8PH11 | A0A6Q8PH11_HUMAN | Periaxin | PRX | 70 | Annotation score: | ||
A0A6Q8PHM6 | A0A6Q8PHM6_HUMAN | Periaxin | PRX | 50 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013056 | 406 | A → T1 PublicationCorresponds to variant dbSNP:rs117336941Ensembl. | 1 | |
Natural variantiVAR_013057 | 495 | E → Q1 PublicationCorresponds to variant dbSNP:rs146789340Ensembl. | 1 | |
Natural variantiVAR_073295 | 525 | V → A Rare polymorphism. 1 PublicationCorresponds to variant dbSNP:rs149715830Ensembl. | 1 | |
Natural variantiVAR_069093 | 651 | D → N in CMT4F. 1 PublicationCorresponds to variant dbSNP:rs3814290Ensembl. | 1 | |
Natural variantiVAR_013058 | 882 | V → A2 PublicationsCorresponds to variant dbSNP:rs268671Ensembl. | 1 | |
Natural variantiVAR_013059 | 921 | I → M1 PublicationCorresponds to variant dbSNP:rs268673Ensembl. | 1 | |
Natural variantiVAR_013060 | 935 | K → E1 Publication | 1 | |
Natural variantiVAR_013061 | 1083 | P → R1 PublicationCorresponds to variant dbSNP:rs3745202Ensembl. | 1 | |
Natural variantiVAR_013062 | 1132 | G → R2 PublicationsCorresponds to variant dbSNP:rs268674Ensembl. | 1 | |
Natural variantiVAR_013063 | 1259 | E → K1 PublicationCorresponds to variant dbSNP:rs751742049Ensembl. | 1 | |
Natural variantiVAR_073296 | 1335 | R → Q Found in a patient with a complex hereditary motor and sensory neuropathy form associated with dysarthria, joints hypermobility and cerebellar signs; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_013064 | 1359 | Missing 1 Publication | 1 | |
Natural variantiVAR_013065 | 1411 | R → C1 PublicationCorresponds to variant dbSNP:rs533966999Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040352 | 1 – 139 | Missing in isoform 3. 1 PublicationAdd BLAST | 139 | |
Alternative sequenceiVSP_004363 | 128 – 147 | NIQSL…GALGV → VRVLSPAPALDCPSDPVSAP in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_004364 | 148 – 1461 | Missing in isoform 2. 1 PublicationAdd BLAST | 1314 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF321191 mRNA Translation: AAK19279.1 AF321192 mRNA Translation: AAK19280.1 AB046840 mRNA Translation: BAB13446.1 Sequence problems. AC010271 Genomic DNA No translation available. BC067266 mRNA Translation: AAH67266.1 |
CCDSi | CCDS12556.1 [Q9BXM0-2] CCDS33028.1 [Q9BXM0-1] |
RefSeqi | NP_066007.1, NM_020956.2 [Q9BXM0-2] NP_870998.2, NM_181882.2 [Q9BXM0-1] XP_011525473.1, XM_011527171.2 [Q9BXM0-1] |
Genome annotation databases
Ensembli | ENST00000291825; ENSP00000291825; ENSG00000105227 [Q9BXM0-2] ENST00000324001; ENSP00000326018; ENSG00000105227 [Q9BXM0-1] ENST00000673881; ENSP00000501070; ENSG00000105227 [Q9BXM0-3] |
GeneIDi | 57716 |
KEGGi | hsa:57716 |
UCSCi | uc002onr.4, human [Q9BXM0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Inherited peripheral neuropathies mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF321191 mRNA Translation: AAK19279.1 AF321192 mRNA Translation: AAK19280.1 AB046840 mRNA Translation: BAB13446.1 Sequence problems. AC010271 Genomic DNA No translation available. BC067266 mRNA Translation: AAH67266.1 |
CCDSi | CCDS12556.1 [Q9BXM0-2] CCDS33028.1 [Q9BXM0-1] |
RefSeqi | NP_066007.1, NM_020956.2 [Q9BXM0-2] NP_870998.2, NM_181882.2 [Q9BXM0-1] XP_011525473.1, XM_011527171.2 [Q9BXM0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CMZ | X-ray | 2.70 | A/B/C | 14-104 | [»] | |
SMRi | Q9BXM0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121739, 7 interactors |
IntActi | Q9BXM0, 11 interactors |
STRINGi | 9606.ENSP00000326018 |
PTM databases
iPTMneti | Q9BXM0 |
PhosphoSitePlusi | Q9BXM0 |
Polymorphism and mutation databases
BioMutai | PRX |
DMDMi | 317373270 |
Proteomic databases
jPOSTi | Q9BXM0 |
MassIVEi | Q9BXM0 |
PaxDbi | Q9BXM0 |
PeptideAtlasi | Q9BXM0 |
PRIDEi | Q9BXM0 |
ProteomicsDBi | 79452 [Q9BXM0-1] 79453 [Q9BXM0-2] 79454 [Q9BXM0-3] |
Protocols and materials databases
Antibodypediai | 959, 65 antibodies |
Genome annotation databases
Ensembli | ENST00000291825; ENSP00000291825; ENSG00000105227 [Q9BXM0-2] ENST00000324001; ENSP00000326018; ENSG00000105227 [Q9BXM0-1] ENST00000673881; ENSP00000501070; ENSG00000105227 [Q9BXM0-3] |
GeneIDi | 57716 |
KEGGi | hsa:57716 |
UCSCi | uc002onr.4, human [Q9BXM0-1] |
Organism-specific databases
CTDi | 57716 |
DisGeNETi | 57716 |
EuPathDBi | HostDB:ENSG00000105227.14 |
GeneCardsi | PRX |
GeneReviewsi | PRX |
HGNCi | HGNC:13797, PRX |
HPAi | ENSG00000105227, Group enriched (brain, lung, retina) |
MalaCardsi | PRX |
MIMi | 145900, phenotype 605725, gene 614895, phenotype |
neXtProti | NX_Q9BXM0 |
OpenTargetsi | ENSG00000105227 |
Orphaneti | 99952, Charcot-Marie-Tooth disease type 4F 64748, Dejerine-Sottas syndrome |
PharmGKBi | PA33843 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS7Y, Eukaryota |
GeneTreei | ENSGT00940000160366 |
HOGENOMi | CLU_1758219_0_0_1 |
InParanoidi | Q9BXM0 |
OMAi | GPDVEMK |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q9BXM0 |
TreeFami | TF350595 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXM0 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination [Q9BXM0-1] |
Miscellaneous databases
BioGRID-ORCSi | 57716, 9 hits in 845 CRISPR screens |
ChiTaRSi | PRX, human |
GeneWikii | PRX_(gene) |
GenomeRNAii | 57716 |
Pharosi | Q9BXM0, Tbio |
PROi | PR:Q9BXM0 |
RNActi | Q9BXM0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105227, Expressed in trigeminal ganglion and 232 other tissues |
Genevisiblei | Q9BXM0, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRAX_HUMAN | |
Accessioni | Q9BXM0Primary (citable) accession number: Q9BXM0 Secondary accession number(s): Q9BXL9, Q9HCF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations