CDCA4

Functionⁱ

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).By similarity1 Publication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division cycle-associated protein 4 Alternative name(s): Hematopoietic progenitor protein
Gene namesⁱ	Name:CDCA4 Synonyms:HEPP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170779.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14625 CDCA4
MIMⁱ	612270 gene
neXtProtⁱ	NX_Q9BXL8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55038
Open Targets More...OpenTargetsⁱ	ENSG00000170779
PharmGKBⁱ	PA26277

Polymorphism and mutation databases

BioMutaⁱ	CDCA4
DMDMⁱ	32699606

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191617	1 – 241	Cell division cycle-associated protein 4Add BLAST		241

Proteomic databases

EPDⁱ	Q9BXL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXL8
PaxDbⁱ	Q9BXL8
PeptideAtlas More...PeptideAtlasⁱ	Q9BXL8
PRIDEⁱ	Q9BXL8
ProteomicsDBⁱ	79451

PTM databases

iPTMnetⁱ	Q9BXL8
PhosphoSitePlusⁱ	Q9BXL8

Expressionⁱ

Tissue specificityⁱ

Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication

Inductionⁱ

By E2F1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170779 Expressed in 182 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CDCA4
ExpressionAtlasⁱ	Q9BXL8 baseline and differential
Genevisibleⁱ	Q9BXL8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059416 HPA064971

HPAⁱ

HPA059416
HPA064971

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KDM1A	O60341	2	EBI-1773949,EBI-710124
PRMT6	Q96LA8	2	EBI-1773949,EBI-912440
SUV39H1	O43463	2	EBI-1773949,EBI-349968
SUV39H2	Q9H5I1	2	EBI-1773949,EBI-723127

Protein-protein interaction databases

BioGridⁱ	120367, 25 interactors
IntActⁱ	Q9BXL8, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q9BXL8
STRINGⁱ	9606.ENSP00000337226

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	30 – 77	SERTAPROSITE-ProRule annotationAdd BLAST		48

Phylogenomic databases

eggNOGⁱ	ENOG410IM11 Eukaryota ENOG4111IXT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063867
HOGENOMⁱ	HOG000111497
HOVERGENⁱ	HBG050861
InParanoidⁱ	Q9BXL8
OMAⁱ	QEEMTQD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HZO
PhylomeDBⁱ	Q9BXL8
TreeFamⁱ	TF101069

Family and domain databases

InterProⁱ	View protein in InterPro IPR009263 SERTA_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06031 SERTA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51053 SERTA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BXL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM 
        60         70         80         90        100
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI 
       110        120        130        140        150
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG 
       160        170        180        190        200
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG 
       210        220        230        240 
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T

Length:241

Mass (Da):26,114

Last modified:June 1, 2001 - v1

Checksum:ⁱ9693647E77865D7A

GO

Sequence cautionⁱ

The sequence BAA91373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	93	D → N in AAH25263 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF322239 mRNA Translation: AAK31075.1 BC011736 mRNA Translation: AAH11736.1 BC025263 mRNA Translation: AAH25263.1 AK000771 mRNA Translation: BAA91373.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9996.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060425.2, NM_017955.3 NP_663747.1, NM_145701.2
UniGeneⁱ	Hs.34045

Genome annotation databases

Ensemblⁱ	ENST00000336219; ENSP00000337226; ENSG00000170779 ENST00000392590; ENSP00000376369; ENSG00000170779
GeneIDⁱ	55038
KEGGⁱ	hsa:55038
UCSC genome browser More...UCSCⁱ	uc001yqa.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL8	Cell division cycle associated 4, isoform CRA_a		HUMAN		241	UniRef100_Q9BXL8

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL8	Cell division cycle associated 4, isoform CRA_a		HUMAN		241	UniRef90_Q9BXL8
CDCA4 isoform 1		PANTR		241
Cell division cycle associated 4		CALJA		241
CDCA4 isoform 1		PONAB		241
Uncharacterized protein		COLAP		241
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL8	Cell division cycle-associated protein 4		MOUSE		237	UniRef50_Q9BXL8
Cell division cycle associated 4, isoform CRA_a		HUMAN		241
Uncharacterized protein		CERAT		241
Cell division cycle associated 4		CALJA		241
Uncharacterized protein		MANLE		241
+137

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF322239 mRNA Translation: AAK31075.1 BC011736 mRNA Translation: AAH11736.1 BC025263 mRNA Translation: AAH25263.1 AK000771 mRNA Translation: BAA91373.1 Different initiation.
CCDSⁱ	CCDS9996.1
RefSeqⁱ	NP_060425.2, NM_017955.3 NP_663747.1, NM_145701.2
UniGeneⁱ	Hs.34045

3D structure databases

ProteinModelPortalⁱ	Q9BXL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120367, 25 interactors
IntActⁱ	Q9BXL8, 29 interactors
MINTⁱ	Q9BXL8
STRINGⁱ	9606.ENSP00000337226

PTM databases

iPTMnetⁱ	Q9BXL8
PhosphoSitePlusⁱ	Q9BXL8

Polymorphism and mutation databases

BioMutaⁱ	CDCA4
DMDMⁱ	32699606

Proteomic databases

EPDⁱ	Q9BXL8
MaxQBⁱ	Q9BXL8
PaxDbⁱ	Q9BXL8
PeptideAtlasⁱ	Q9BXL8
PRIDEⁱ	Q9BXL8
ProteomicsDBⁱ	79451

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55038
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000336219; ENSP00000337226; ENSG00000170779 ENST00000392590; ENSP00000376369; ENSG00000170779
GeneIDⁱ	55038
KEGGⁱ	hsa:55038
UCSCⁱ	uc001yqa.3 human

Organism-specific databases

CTDⁱ	55038
DisGeNETⁱ	55038
EuPathDBⁱ	HostDB:ENSG00000170779.10
GeneCardsⁱ	CDCA4
H-InvDBⁱ	HIX0172337
HGNCⁱ	HGNC:14625 CDCA4
HPAⁱ	HPA059416 HPA064971
MIMⁱ	612270 gene
neXtProtⁱ	NX_Q9BXL8
OpenTargetsⁱ	ENSG00000170779
PharmGKBⁱ	PA26277
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IM11 Eukaryota ENOG4111IXT LUCA
GeneTreeⁱ	ENSGT00530000063867
HOGENOMⁱ	HOG000111497
HOVERGENⁱ	HBG050861
InParanoidⁱ	Q9BXL8
OMAⁱ	QEEMTQD
OrthoDBⁱ	EOG091G0HZO
PhylomeDBⁱ	Q9BXL8
TreeFamⁱ	TF101069

Miscellaneous databases

ChiTaRSⁱ	CDCA4 human
GenomeRNAiⁱ	55038
Protein Ontology More...PROⁱ	PR:Q9BXL8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170779 Expressed in 182 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CDCA4
ExpressionAtlasⁱ	Q9BXL8 baseline and differential
Genevisibleⁱ	Q9BXL8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009263 SERTA_dom
Pfamⁱ	View protein in Pfam PF06031 SERTA, 1 hit
PROSITEⁱ	View protein in PROSITE PS51053 SERTA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDCA4_HUMAN
Accessionⁱ	Q9BXL8Primary (citable) accession number: Q9BXL8 Secondary accession number(s): Q8TB18, Q9NWK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BXL8 (CDCA4_HUMAN)

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Cell division cycle-associated protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ