UniProtKB - Q9BXL8 (CDCA4_HUMAN)
Protein
Cell division cycle-associated protein 4
Gene
CDCA4
Organism
Homo sapiens (Human)
Status
Functioni
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).By similarity1 Publication
GO - Biological processi
- chromatin-mediated maintenance of transcription Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BXL8 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle-associated protein 4Alternative name(s): Hematopoietic progenitor protein |
Gene namesi | Name:CDCA4 Synonyms:HEPP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170779.10 |
HGNCi | HGNC:14625, CDCA4 |
MIMi | 612270, gene |
neXtProti | NX_Q9BXL8 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55038 |
OpenTargetsi | ENSG00000170779 |
PharmGKBi | PA26277 |
Miscellaneous databases
Pharosi | Q9BXL8, Tbio |
Polymorphism and mutation databases
BioMutai | CDCA4 |
DMDMi | 32699606 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191617 | 1 – 241 | Cell division cycle-associated protein 4Add BLAST | 241 |
Proteomic databases
EPDi | Q9BXL8 |
MassIVEi | Q9BXL8 |
MaxQBi | Q9BXL8 |
PaxDbi | Q9BXL8 |
PeptideAtlasi | Q9BXL8 |
PRIDEi | Q9BXL8 |
ProteomicsDBi | 79451 |
PTM databases
iPTMneti | Q9BXL8 |
PhosphoSitePlusi | Q9BXL8 |
Expressioni
Tissue specificityi
Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.1 Publication
Inductioni
By E2F1.1 Publication
Gene expression databases
Bgeei | ENSG00000170779, Expressed in female gonad and 197 other tissues |
ExpressionAtlasi | Q9BXL8, baseline and differential |
Genevisiblei | Q9BXL8, HS |
Organism-specific databases
HPAi | ENSG00000170779, Tissue enhanced (bone) |
Interactioni
Binary interactionsi
Hide detailsQ9BXL8
Protein-protein interaction databases
BioGRIDi | 120367, 39 interactors |
IntActi | Q9BXL8, 34 interactors |
MINTi | Q9BXL8 |
STRINGi | 9606.ENSP00000337226 |
Miscellaneous databases
RNActi | Q9BXL8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 77 | SERTAPROSITE-ProRule annotationAdd BLAST | 48 |
Phylogenomic databases
eggNOGi | ENOG502QWNU, Eukaryota |
GeneTreei | ENSGT00530000063867 |
HOGENOMi | CLU_065586_1_0_1 |
InParanoidi | Q9BXL8 |
OMAi | QCPADRL |
OrthoDBi | 1511674at2759 |
PhylomeDBi | Q9BXL8 |
TreeFami | TF101069 |
Family and domain databases
InterProi | View protein in InterPro IPR009263, SERTA_dom |
Pfami | View protein in Pfam PF06031, SERTA, 1 hit |
PROSITEi | View protein in PROSITE PS51053, SERTA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BXL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFARGLKRKC VGHEEDVEGA LAGLKTVSSY SLQRQSLLDM SLVKLQLCHM
60 70 80 90 100
LVEPNLCRSV LIANTVRQIQ EEMTQDGTWR TVAPQAAERA PLDRLVSTEI
110 120 130 140 150
LCRAAWGQEG AHPAPGLGDG HTQGPVSDLC PVTSAQAPRH LQSSAWEMDG
160 170 180 190 200
PRENRGSFHK SLDQIFETLE TKNPSCMEEL FSDVDSPYYD LDTVLTGMMG
210 220 230 240
GARPGPCEGL EGLAPATPGP SSSCKSDLGE LDHVVEILVE T
Sequence cautioni
The sequence BAA91373 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | D → N in AAH25263 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322239 mRNA Translation: AAK31075.1 BC011736 mRNA Translation: AAH11736.1 BC025263 mRNA Translation: AAH25263.1 AK000771 mRNA Translation: BAA91373.1 Different initiation. |
CCDSi | CCDS9996.1 |
RefSeqi | NP_060425.2, NM_017955.3 NP_663747.1, NM_145701.2 |
Genome annotation databases
Ensembli | ENST00000336219; ENSP00000337226; ENSG00000170779 ENST00000392590; ENSP00000376369; ENSG00000170779 |
GeneIDi | 55038 |
KEGGi | hsa:55038 |
UCSCi | uc001yqa.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322239 mRNA Translation: AAK31075.1 BC011736 mRNA Translation: AAH11736.1 BC025263 mRNA Translation: AAH25263.1 AK000771 mRNA Translation: BAA91373.1 Different initiation. |
CCDSi | CCDS9996.1 |
RefSeqi | NP_060425.2, NM_017955.3 NP_663747.1, NM_145701.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120367, 39 interactors |
IntActi | Q9BXL8, 34 interactors |
MINTi | Q9BXL8 |
STRINGi | 9606.ENSP00000337226 |
PTM databases
iPTMneti | Q9BXL8 |
PhosphoSitePlusi | Q9BXL8 |
Polymorphism and mutation databases
BioMutai | CDCA4 |
DMDMi | 32699606 |
Proteomic databases
EPDi | Q9BXL8 |
MassIVEi | Q9BXL8 |
MaxQBi | Q9BXL8 |
PaxDbi | Q9BXL8 |
PeptideAtlasi | Q9BXL8 |
PRIDEi | Q9BXL8 |
ProteomicsDBi | 79451 |
Protocols and materials databases
Antibodypediai | 28296, 192 antibodies |
DNASUi | 55038 |
Genome annotation databases
Ensembli | ENST00000336219; ENSP00000337226; ENSG00000170779 ENST00000392590; ENSP00000376369; ENSG00000170779 |
GeneIDi | 55038 |
KEGGi | hsa:55038 |
UCSCi | uc001yqa.3, human |
Organism-specific databases
CTDi | 55038 |
DisGeNETi | 55038 |
EuPathDBi | HostDB:ENSG00000170779.10 |
GeneCardsi | CDCA4 |
HGNCi | HGNC:14625, CDCA4 |
HPAi | ENSG00000170779, Tissue enhanced (bone) |
MIMi | 612270, gene |
neXtProti | NX_Q9BXL8 |
OpenTargetsi | ENSG00000170779 |
PharmGKBi | PA26277 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWNU, Eukaryota |
GeneTreei | ENSGT00530000063867 |
HOGENOMi | CLU_065586_1_0_1 |
InParanoidi | Q9BXL8 |
OMAi | QCPADRL |
OrthoDBi | 1511674at2759 |
PhylomeDBi | Q9BXL8 |
TreeFami | TF101069 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXL8 |
Miscellaneous databases
BioGRID-ORCSi | 55038, 7 hits in 842 CRISPR screens |
ChiTaRSi | CDCA4, human |
GenomeRNAii | 55038 |
Pharosi | Q9BXL8, Tbio |
PROi | PR:Q9BXL8 |
RNActi | Q9BXL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170779, Expressed in female gonad and 197 other tissues |
ExpressionAtlasi | Q9BXL8, baseline and differential |
Genevisiblei | Q9BXL8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009263, SERTA_dom |
Pfami | View protein in Pfam PF06031, SERTA, 1 hit |
PROSITEi | View protein in PROSITE PS51053, SERTA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDCA4_HUMAN | |
Accessioni | Q9BXL8Primary (citable) accession number: Q9BXL8 Secondary accession number(s): Q8TB18, Q9NWK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM