UniProtKB - Q9BXL7 (CAR11_HUMAN)
Caspase recruitment domain-containing protein 11
CARD11
Functioni
Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734).
Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195).
Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955).
Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).
Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308).
Stimulates the phosphorylation of BCL10 (PubMed:11356195).
Also activates the TORC1 signaling pathway (PubMed:28628108).
7 PublicationsActivity regulationi
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- guanylate kinase activity Source: UniProtKB
- protein self-association Source: UniProtKB
GO - Biological processi
- B cell differentiation Source: Ensembl
- B cell proliferation Source: Ensembl
- homeostasis of number of cells Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of T cell receptor signaling pathway Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- regulation of apoptotic process Source: InterPro
- regulation of B cell differentiation Source: Ensembl
- regulation of T cell differentiation Source: Ensembl
- T cell costimulation Source: UniProtKB
- thymic T cell selection Source: Ensembl
- TORC1 signaling Source: UniProtKB
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q9BXL7 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling |
SignaLinki | Q9BXL7 |
SIGNORi | Q9BXL7 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase recruitment domain-containing protein 111 PublicationAlternative name(s): CARD-containing MAGUK protein 11 Publication Short name: Carma 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16393, CARD11 |
MIMi | 607210, gene |
neXtProti | NX_Q9BXL7 |
VEuPathDBi | HostDB:ENSG00000198286 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Membrane raft 1 Publication
Note: Colocalized with DPP4 in membrane rafts.1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- immunological synapse Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- CBM complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- membrane raft Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
B-cell expansion with NFKB and T-cell anergy (BENTA)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069710 | 123 | G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar. | 1 | |
Natural variantiVAR_069711 | 134 | E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar. | 1 |
Immunodeficiency 11 A (IMD11A)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079158 | 945 – 1154 | Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST | 210 |
Immunodeficiency 11B with atopic dermatitis (IMD11B)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079284 | 57 | E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_079285 | 194 | L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_079286 | 975 | R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | C → A: Abolished homodimerization. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 84433 |
MalaCardsi | CARD11 |
MIMi | 615206, phenotype 616452, phenotype 617638, phenotype |
OpenTargetsi | ENSG00000198286 |
Orphaneti | 464336, BENTA disease 300324, Persistent polyclonal B-cell lymphocytosis 357237, Severe combined immunodeficiency due to CARD11 deficiency |
PharmGKBi | PA26073 |
Miscellaneous databases
Pharosi | Q9BXL7, Tbio |
Genetic variation databases
BioMutai | CARD11 |
DMDMi | 172046231 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144086 | 1 – 1154 | Caspase recruitment domain-containing protein 11Add BLAST | 1154 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 | InterchainCombined sources1 Publication | ||
Modified residuei | 448 | PhosphoserineCombined sources | 1 | |
Modified residuei | 466 | PhosphoserineCombined sources | 1 | |
Modified residuei | 512 | PhosphoserineCombined sources | 1 | |
Modified residuei | 535 | PhosphoserineCombined sources | 1 | |
Modified residuei | 559 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 644 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 652 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 886 | PhosphoserineCombined sources | 1 | |
Modified residuei | 925 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Isopeptide bond, PhosphoproteinProteomic databases
EPDi | Q9BXL7 |
jPOSTi | Q9BXL7 |
MassIVEi | Q9BXL7 |
MaxQBi | Q9BXL7 |
PaxDbi | Q9BXL7 |
PeptideAtlasi | Q9BXL7 |
PRIDEi | Q9BXL7 |
ProteomicsDBi | 79450 |
PTM databases
iPTMneti | Q9BXL7 |
PhosphoSitePlusi | Q9BXL7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198286, Expressed in granulocyte and 177 other tissues |
ExpressionAtlasi | Q9BXL7, baseline and differential |
Genevisiblei | Q9BXL7, HS |
Organism-specific databases
HPAi | ENSG00000198286, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (PubMed:24224005). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (PubMed:24074955).
Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:11278692, PubMed:11356195, PubMed:27777308, PubMed:24074955, PubMed:31296852).
Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108, PubMed:24074955).
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217).
Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (PubMed:17287217).
8 PublicationsBinary interactionsi
Q9BXL7
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- protein self-association Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124073, 32 interactors |
CORUMi | Q9BXL7 |
DIPi | DIP-41797N |
IntActi | Q9BXL7, 18 interactors |
MINTi | Q9BXL7 |
STRINGi | 9606.ENSP00000380150 |
Miscellaneous databases
RNActi | Q9BXL7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9BXL7 |
SMRi | Q9BXL7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 110 | CARDPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 667 – 755 | PDZAdd BLAST | 89 | |
Domaini | 973 – 1140 | Guanylate kinase-likeAdd BLAST | 168 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 111 – 128 | Linker1 PublicationAdd BLAST | 18 | |
Regioni | 450 – 666 | Inhibitory domain (ID)1 PublicationAdd BLAST | 217 | |
Regioni | 460 – 626 | DisorderedSequence analysisAdd BLAST | 167 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 130 – 449 | Sequence analysisAdd BLAST | 320 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 462 – 477 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 534 – 566 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 572 – 591 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 611 – 626 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000158573 |
HOGENOMi | CLU_009760_1_0_1 |
InParanoidi | Q9BXL7 |
OMAi | MWSSVEE |
OrthoDBi | 115953at2759 |
PhylomeDBi | Q9BXL7 |
TreeFami | TF351139 |
Family and domain databases
CDDi | cd08808, CARD_CARD11_CARMA1, 1 hit |
Gene3Di | 1.10.533.10, 1 hit 2.30.42.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033538, CARD11 IPR042141, CARD_CARD11 IPR011029, DEATH-like_dom_sf IPR027417, P-loop_NTPase IPR036034, PDZ_sf |
PANTHERi | PTHR14559:SF4, PTHR14559:SF4, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK
60 70 80 90 100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP
110 120 130 140 150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC
160 170 180 190 200
ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD
210 220 230 240 250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS
260 270 280 290 300
LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA
310 320 330 340 350
ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK
360 370 380 390 400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK
410 420 430 440 450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP
460 470 480 490 500
RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM
510 520 530 540 550
NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK
560 570 580 590 600
MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD
610 620 630 640 650
LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR
660 670 680 690 700
PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL
710 720 730 740 750
AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH
760 770 780 790 800
YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV
810 820 830 840 850
VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM
860 870 880 890 900
HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL
910 920 930 940 950
QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP
960 970 980 990 1000
ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME
1010 1020 1030 1040 1050
FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK
1060 1070 1080 1090 1100
HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL
1110 1120 1130 1140 1150
RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD
EDQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BY05 | H7BY05_HUMAN | Caspase recruitment domain-containi... | CARD11 | 271 | Annotation score: | ||
E2QRC0 | E2QRC0_HUMAN | Caspase recruitment domain-containi... | CARD11 | 73 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 815 | L → P in AAG53402 (PubMed:11278692).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079284 | 57 | E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_069710 | 123 | G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar. | 1 | |
Natural variantiVAR_069711 | 134 | E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar. | 1 | |
Natural variantiVAR_079285 | 194 | L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_028117 | 670 | T → M. Corresponds to variant dbSNP:rs3735134Ensembl. | 1 | |
Natural variantiVAR_028118 | 694 | S → L. Corresponds to variant dbSNP:rs3735133EnsemblClinVar. | 1 | |
Natural variantiVAR_079158 | 945 – 1154 | Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST | 210 | |
Natural variantiVAR_079286 | 975 | R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322641 mRNA Translation: AAG53402.1 Different initiation. AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems. BC111719 mRNA Translation: AAI11720.2 Different initiation. AF352576 mRNA Translation: AAL34460.1 |
CCDSi | CCDS5336.2 |
RefSeqi | NP_001311210.1, NM_001324281.1 NP_115791.3, NM_032415.5 XP_011513888.1, XM_011515586.2 |
Genome annotation databases
Ensembli | ENST00000396946.9; ENSP00000380150.4; ENSG00000198286.10 |
GeneIDi | 84433 |
KEGGi | hsa:84433 |
MANE-Selecti | ENST00000396946.9; ENSP00000380150.4; NM_032415.7; NP_115791.3 |
UCSCi | uc003smv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322641 mRNA Translation: AAG53402.1 Different initiation. AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems. BC111719 mRNA Translation: AAI11720.2 Different initiation. AF352576 mRNA Translation: AAL34460.1 |
CCDSi | CCDS5336.2 |
RefSeqi | NP_001311210.1, NM_001324281.1 NP_115791.3, NM_032415.5 XP_011513888.1, XM_011515586.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JUP | X-ray | 3.20 | A/B | 21-116 | [»] | |
4LWD | X-ray | 1.79 | A | 18-110 | [»] | |
AlphaFoldDBi | Q9BXL7 | |||||
SMRi | Q9BXL7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124073, 32 interactors |
CORUMi | Q9BXL7 |
DIPi | DIP-41797N |
IntActi | Q9BXL7, 18 interactors |
MINTi | Q9BXL7 |
STRINGi | 9606.ENSP00000380150 |
PTM databases
iPTMneti | Q9BXL7 |
PhosphoSitePlusi | Q9BXL7 |
Genetic variation databases
BioMutai | CARD11 |
DMDMi | 172046231 |
Proteomic databases
EPDi | Q9BXL7 |
jPOSTi | Q9BXL7 |
MassIVEi | Q9BXL7 |
MaxQBi | Q9BXL7 |
PaxDbi | Q9BXL7 |
PeptideAtlasi | Q9BXL7 |
PRIDEi | Q9BXL7 |
ProteomicsDBi | 79450 |
Protocols and materials databases
Antibodypediai | 11155, 323 antibodies from 45 providers |
DNASUi | 84433 |
Genome annotation databases
Ensembli | ENST00000396946.9; ENSP00000380150.4; ENSG00000198286.10 |
GeneIDi | 84433 |
KEGGi | hsa:84433 |
MANE-Selecti | ENST00000396946.9; ENSP00000380150.4; NM_032415.7; NP_115791.3 |
UCSCi | uc003smv.5, human |
Organism-specific databases
CTDi | 84433 |
DisGeNETi | 84433 |
GeneCardsi | CARD11 |
HGNCi | HGNC:16393, CARD11 |
HPAi | ENSG00000198286, Tissue enhanced (lymphoid) |
MalaCardsi | CARD11 |
MIMi | 607210, gene 615206, phenotype 616452, phenotype 617638, phenotype |
neXtProti | NX_Q9BXL7 |
OpenTargetsi | ENSG00000198286 |
Orphaneti | 464336, BENTA disease 300324, Persistent polyclonal B-cell lymphocytosis 357237, Severe combined immunodeficiency due to CARD11 deficiency |
PharmGKBi | PA26073 |
VEuPathDBi | HostDB:ENSG00000198286 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000158573 |
HOGENOMi | CLU_009760_1_0_1 |
InParanoidi | Q9BXL7 |
OMAi | MWSSVEE |
OrthoDBi | 115953at2759 |
PhylomeDBi | Q9BXL7 |
TreeFami | TF351139 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXL7 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling |
SignaLinki | Q9BXL7 |
SIGNORi | Q9BXL7 |
Miscellaneous databases
BioGRID-ORCSi | 84433, 25 hits in 1083 CRISPR screens |
ChiTaRSi | CARD11, human |
GeneWikii | CARD11 |
GenomeRNAii | 84433 |
Pharosi | Q9BXL7, Tbio |
PROi | PR:Q9BXL7 |
RNActi | Q9BXL7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198286, Expressed in granulocyte and 177 other tissues |
ExpressionAtlasi | Q9BXL7, baseline and differential |
Genevisiblei | Q9BXL7, HS |
Family and domain databases
CDDi | cd08808, CARD_CARD11_CARMA1, 1 hit |
Gene3Di | 1.10.533.10, 1 hit 2.30.42.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033538, CARD11 IPR042141, CARD_CARD11 IPR011029, DEATH-like_dom_sf IPR027417, P-loop_NTPase IPR036034, PDZ_sf |
PANTHERi | PTHR14559:SF4, PTHR14559:SF4, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAR11_HUMAN | |
Accessioni | Q9BXL7Primary (citable) accession number: Q9BXL7 Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | February 26, 2008 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references