UniProtKB - Q9BXL7 (CAR11_HUMAN)
Protein
Caspase recruitment domain-containing protein 11
Gene
CARD11
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.4 Publications
Caution
Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
- guanylate kinase activity Source: UniProtKB
GO - Biological processi
- B cell differentiation Source: Ensembl
- B cell proliferation Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Reactome
- homeostasis of number of cells Source: Ensembl
- I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of T cell receptor signaling pathway Source: UniProtKB
- regulation of apoptotic process Source: InterPro
- regulation of B cell differentiation Source: Ensembl
- regulation of T cell differentiation Source: Ensembl
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell costimulation Source: UniProtKB
- T cell receptor signaling pathway Source: Reactome
- thymic T cell selection Source: Ensembl
- TORC1 signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9BXL7 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling |
SignaLinki | Q9BXL7 |
SIGNORi | Q9BXL7 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase recruitment domain-containing protein 11Alternative name(s): CARD-containing MAGUK protein 1 Short name: Carma 1 |
Gene namesi | Name:CARD11 Synonyms:CARMA11 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16393, CARD11 |
MIMi | 607210, gene |
neXtProti | NX_Q9BXL7 |
VEuPathDBi | HostDB:ENSG00000198286.9 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- Membrane raft 1 Publication
Note: Colocalized with DPP4 in membrane rafts.1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- immunological synapse Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- CBM complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- membrane raft Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
B-cell expansion with NFKB and T-cell anergy (BENTA)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069710 | 123 | G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar. | 1 | |
Natural variantiVAR_069711 | 134 | E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar. | 1 |
Immunodeficiency 11 A (IMD11A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079158 | 945 – 1154 | Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST | 210 |
Immunodeficiency 11B with atopic dermatitis (IMD11B)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079284 | 57 | E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_079285 | 194 | L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_079286 | 975 | R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 84433 |
MalaCardsi | CARD11 |
MIMi | 615206, phenotype 616452, phenotype 617638, phenotype |
OpenTargetsi | ENSG00000198286 |
Orphaneti | 464336, BENTA disease 300324, Persistent polyclonal B-cell lymphocytosis 357237, Severe combined immunodeficiency due to CARD11 deficiency |
PharmGKBi | PA26073 |
Miscellaneous databases
Pharosi | Q9BXL7, Tbio |
Genetic variation databases
BioMutai | CARD11 |
DMDMi | 172046231 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144086 | 1 – 1154 | Caspase recruitment domain-containing protein 11Add BLAST | 1154 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 448 | PhosphoserineCombined sources | 1 | |
Modified residuei | 466 | PhosphoserineCombined sources | 1 | |
Modified residuei | 512 | PhosphoserineCombined sources | 1 | |
Modified residuei | 535 | PhosphoserineCombined sources | 1 | |
Modified residuei | 559 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 593 | PhosphoserineCombined sources | 1 | |
Modified residuei | 644 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 652 | Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity | 1 | |
Modified residuei | 886 | PhosphoserineCombined sources | 1 | |
Modified residuei | 925 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BXL7 |
jPOSTi | Q9BXL7 |
MassIVEi | Q9BXL7 |
MaxQBi | Q9BXL7 |
PaxDbi | Q9BXL7 |
PeptideAtlasi | Q9BXL7 |
PRIDEi | Q9BXL7 |
ProteomicsDBi | 79450 |
PTM databases
iPTMneti | Q9BXL7 |
PhosphoSitePlusi | Q9BXL7 |
Expressioni
Tissue specificityi
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.1 Publication
Gene expression databases
Bgeei | ENSG00000198286, Expressed in granulocyte and 176 other tissues |
ExpressionAtlasi | Q9BXL7, baseline and differential |
Genevisiblei | Q9BXL7, HS |
Organism-specific databases
HPAi | ENSG00000198286, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction.
Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).
Interacts with BCL10; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108).
4 PublicationsBinary interactionsi
Hide detailsQ9BXL7
GO - Molecular functioni
- CARD domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124073, 30 interactors |
CORUMi | Q9BXL7 |
DIPi | DIP-41797N |
IntActi | Q9BXL7, 16 interactors |
MINTi | Q9BXL7 |
STRINGi | 9606.ENSP00000380150 |
Miscellaneous databases
RNActi | Q9BXL7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BXL7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 110 | CARDPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 667 – 755 | PDZAdd BLAST | 89 | |
Domaini | 973 – 1140 | Guanylate kinase-likeAdd BLAST | 168 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 130 – 449 | Sequence analysisAdd BLAST | 320 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000158573 |
HOGENOMi | CLU_009760_1_0_1 |
InParanoidi | Q9BXL7 |
OMAi | MHRGSRD |
OrthoDBi | 115953at2759 |
PhylomeDBi | Q9BXL7 |
TreeFami | TF351139 |
Family and domain databases
CDDi | cd08808, CARD_CARD11_CARMA1, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033538, CARD11 IPR042141, CARD_CARD11 IPR011029, DEATH-like_dom_sf IPR027417, P-loop_NTPase IPR036034, PDZ_sf |
PANTHERi | PTHR14559:SF4, PTHR14559:SF4, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9BXL7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK
60 70 80 90 100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP
110 120 130 140 150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC
160 170 180 190 200
ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD
210 220 230 240 250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS
260 270 280 290 300
LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA
310 320 330 340 350
ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK
360 370 380 390 400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK
410 420 430 440 450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP
460 470 480 490 500
RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM
510 520 530 540 550
NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK
560 570 580 590 600
MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD
610 620 630 640 650
LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR
660 670 680 690 700
PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL
710 720 730 740 750
AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH
760 770 780 790 800
YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV
810 820 830 840 850
VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM
860 870 880 890 900
HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL
910 920 930 940 950
QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP
960 970 980 990 1000
ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME
1010 1020 1030 1040 1050
FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK
1060 1070 1080 1090 1100
HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL
1110 1120 1130 1140 1150
RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD
EDQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BY05 | H7BY05_HUMAN | Caspase recruitment domain-containi... | CARD11 | 271 | Annotation score: | ||
E2QRC0 | E2QRC0_HUMAN | Caspase recruitment domain-containi... | CARD11 | 73 | Annotation score: |
Sequence cautioni
The sequence AAG53402 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11720 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96893 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL23962 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 815 | L → P in AAG53402 (PubMed:11278692).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079284 | 57 | E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_069710 | 123 | G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar. | 1 | |
Natural variantiVAR_069711 | 134 | E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar. | 1 | |
Natural variantiVAR_079285 | 194 | L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication | 1 | |
Natural variantiVAR_028117 | 670 | T → M. Corresponds to variant dbSNP:rs3735134Ensembl. | 1 | |
Natural variantiVAR_028118 | 694 | S → L. Corresponds to variant dbSNP:rs3735133EnsemblClinVar. | 1 | |
Natural variantiVAR_079158 | 945 – 1154 | Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST | 210 | |
Natural variantiVAR_079286 | 975 | R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322641 mRNA Translation: AAG53402.1 Different initiation. AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems. BC111719 mRNA Translation: AAI11720.2 Different initiation. AF352576 mRNA Translation: AAL34460.1 |
CCDSi | CCDS5336.2 |
RefSeqi | NP_001311210.1, NM_001324281.1 NP_115791.3, NM_032415.5 XP_011513888.1, XM_011515586.2 |
Genome annotation databases
Ensembli | ENST00000396946; ENSP00000380150; ENSG00000198286 |
GeneIDi | 84433 |
KEGGi | hsa:84433 |
UCSCi | uc003smv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF322641 mRNA Translation: AAG53402.1 Different initiation. AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems. CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems. BC111719 mRNA Translation: AAI11720.2 Different initiation. AF352576 mRNA Translation: AAL34460.1 |
CCDSi | CCDS5336.2 |
RefSeqi | NP_001311210.1, NM_001324281.1 NP_115791.3, NM_032415.5 XP_011513888.1, XM_011515586.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JUP | X-ray | 3.20 | A/B | 21-116 | [»] | |
4LWD | X-ray | 1.79 | A | 18-110 | [»] | |
SMRi | Q9BXL7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124073, 30 interactors |
CORUMi | Q9BXL7 |
DIPi | DIP-41797N |
IntActi | Q9BXL7, 16 interactors |
MINTi | Q9BXL7 |
STRINGi | 9606.ENSP00000380150 |
PTM databases
iPTMneti | Q9BXL7 |
PhosphoSitePlusi | Q9BXL7 |
Genetic variation databases
BioMutai | CARD11 |
DMDMi | 172046231 |
Proteomic databases
EPDi | Q9BXL7 |
jPOSTi | Q9BXL7 |
MassIVEi | Q9BXL7 |
MaxQBi | Q9BXL7 |
PaxDbi | Q9BXL7 |
PeptideAtlasi | Q9BXL7 |
PRIDEi | Q9BXL7 |
ProteomicsDBi | 79450 |
Protocols and materials databases
Antibodypediai | 11155, 314 antibodies |
Genome annotation databases
Ensembli | ENST00000396946; ENSP00000380150; ENSG00000198286 |
GeneIDi | 84433 |
KEGGi | hsa:84433 |
UCSCi | uc003smv.5, human |
Organism-specific databases
CTDi | 84433 |
DisGeNETi | 84433 |
GeneCardsi | CARD11 |
HGNCi | HGNC:16393, CARD11 |
HPAi | ENSG00000198286, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | CARD11 |
MIMi | 607210, gene 615206, phenotype 616452, phenotype 617638, phenotype |
neXtProti | NX_Q9BXL7 |
OpenTargetsi | ENSG00000198286 |
Orphaneti | 464336, BENTA disease 300324, Persistent polyclonal B-cell lymphocytosis 357237, Severe combined immunodeficiency due to CARD11 deficiency |
PharmGKBi | PA26073 |
VEuPathDBi | HostDB:ENSG00000198286.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0708, Eukaryota |
GeneTreei | ENSGT00940000158573 |
HOGENOMi | CLU_009760_1_0_1 |
InParanoidi | Q9BXL7 |
OMAi | MHRGSRD |
OrthoDBi | 115953at2759 |
PhylomeDBi | Q9BXL7 |
TreeFami | TF351139 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXL7 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-202424, Downstream TCR signaling R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5607764, CLEC7A (Dectin-1) signaling |
SignaLinki | Q9BXL7 |
SIGNORi | Q9BXL7 |
Miscellaneous databases
BioGRID-ORCSi | 84433, 17 hits in 996 CRISPR screens |
ChiTaRSi | CARD11, human |
GeneWikii | CARD11 |
GenomeRNAii | 84433 |
Pharosi | Q9BXL7, Tbio |
PROi | PR:Q9BXL7 |
RNActi | Q9BXL7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198286, Expressed in granulocyte and 176 other tissues |
ExpressionAtlasi | Q9BXL7, baseline and differential |
Genevisiblei | Q9BXL7, HS |
Family and domain databases
CDDi | cd08808, CARD_CARD11_CARMA1, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001315, CARD IPR033538, CARD11 IPR042141, CARD_CARD11 IPR011029, DEATH-like_dom_sf IPR027417, P-loop_NTPase IPR036034, PDZ_sf |
PANTHERi | PTHR14559:SF4, PTHR14559:SF4, 1 hit |
Pfami | View protein in Pfam PF00619, CARD, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50209, CARD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAR11_HUMAN | |
Accessioni | Q9BXL7Primary (citable) accession number: Q9BXL7 Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references