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Protein

Caspase recruitment domain-containing protein 11

Gene

CARD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.4 Publications

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • guanylate kinase activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BXL7

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BXL7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 11
Alternative name(s):
CARD-containing MAGUK protein 1
Short name:
Carma 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD11
Synonyms:CARMA11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198286.9

Human Gene Nomenclature Database

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HGNCi
HGNC:16393 CARD11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607210 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXL7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

B-cell expansion with NFKB and T-cell anergy (BENTA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy.
See also OMIM:616452
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069710123G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar.1
Natural variantiVAR_069711134E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar.1
Immunodeficiency 11 A (IMD11A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function.
See also OMIM:615206
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079158945 – 1154Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST210
Immunodeficiency 11B with atopic dermatitis (IMD11B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia.
See also OMIM:617638
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928457E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_079285194L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_079286975R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84433

MalaCards human disease database

More...
MalaCardsi
CARD11
MIMi615206 phenotype
616452 phenotype
617638 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198286

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
464336 BENTA disease
300324 Persistent polyclonal B-cell lymphocytosis
357237 Severe combined immunodeficiency due to CARD11 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26073

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARD11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046231

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440861 – 1154Caspase recruitment domain-containing protein 11Add BLAST1154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei559Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei644Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei652Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei886PhosphoserineCombined sources1
Modified residuei925PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXL7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXL7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BXL7

PeptideAtlas

More...
PeptideAtlasi
Q9BXL7

PRoteomics IDEntifications database

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PRIDEi
Q9BXL7

ProteomicsDB human proteome resource

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ProteomicsDBi
79450

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198286 Expressed in 159 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

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CleanExi
HS_CARD11

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BXL7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BXL7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052984

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail). Interacts with BCL10; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124073, 30 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9BXL7

Database of interacting proteins

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DIPi
DIP-41797N

Protein interaction database and analysis system

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IntActi
Q9BXL7, 16 interactors

Molecular INTeraction database

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MINTi
Q9BXL7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BXL7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BXL7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 110CARDPROSITE-ProRule annotationAdd BLAST93
Domaini667 – 755PDZAdd BLAST89
Domaini973 – 1140Guanylate kinase-likeAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili130 – 449Sequence analysisAdd BLAST320

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISRJ Eukaryota
ENOG41126VR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158573

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG099790

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BXL7

KEGG Orthology (KO)

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KOi
K07367

Identification of Orthologs from Complete Genome Data

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OMAi
PPKRRMN

Database of Orthologous Groups

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OrthoDBi
EOG091G0T58

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXL7

TreeFam database of animal gene trees

More...
TreeFami
TF351139

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001315 CARD
IPR033538 CARD11
IPR011029 DEATH-like_dom_sf
IPR027417 P-loop_NTPase
IPR036034 PDZ_sf

The PANTHER Classification System

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PANTHERi
PTHR14559:SF4 PTHR14559:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00619 CARD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BXL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK
60 70 80 90 100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP
110 120 130 140 150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC
160 170 180 190 200
ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD
210 220 230 240 250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS
260 270 280 290 300
LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA
310 320 330 340 350
ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK
360 370 380 390 400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK
410 420 430 440 450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP
460 470 480 490 500
RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM
510 520 530 540 550
NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK
560 570 580 590 600
MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD
610 620 630 640 650
LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR
660 670 680 690 700
PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL
710 720 730 740 750
AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH
760 770 780 790 800
YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV
810 820 830 840 850
VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM
860 870 880 890 900
HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL
910 920 930 940 950
QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP
960 970 980 990 1000
ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME
1010 1020 1030 1040 1050
FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK
1060 1070 1080 1090 1100
HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL
1110 1120 1130 1140 1150
RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD

EDQL
Length:1,154
Mass (Da):133,284
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F3512D903795D18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2QRC0E2QRC0_HUMAN
Caspase recruitment domain-containi...
CARD11
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY05H7BY05_HUMAN
Caspase recruitment domain-containi...
CARD11
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG53402 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11720 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96893 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL23962 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti815L → P in AAG53402 (PubMed:11278692).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928457E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_069710123G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar.1
Natural variantiVAR_069711134E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappaB signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar.1
Natural variantiVAR_079285194L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_028117670T → M. Corresponds to variant dbSNP:rs3735134Ensembl.1
Natural variantiVAR_028118694S → L. Corresponds to variant dbSNP:rs3735133Ensembl.1
Natural variantiVAR_079158945 – 1154Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST210
Natural variantiVAR_079286975R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF322641 mRNA Translation: AAG53402.1 Different initiation.
AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems.
BC111719 mRNA Translation: AAI11720.2 Different initiation.
AF352576 mRNA Translation: AAL34460.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5336.2

NCBI Reference Sequences

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RefSeqi
NP_001311210.1, NM_001324281.1
NP_115791.3, NM_032415.5
XP_011513888.1, XM_011515586.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.648101

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396946; ENSP00000380150; ENSG00000198286

Database of genes from NCBI RefSeq genomes

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GeneIDi
84433

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84433

UCSC genome browser

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UCSCi
uc003smv.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322641 mRNA Translation: AAG53402.1 Different initiation.
AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems.
BC111719 mRNA Translation: AAI11720.2 Different initiation.
AF352576 mRNA Translation: AAL34460.1
CCDSiCCDS5336.2
RefSeqiNP_001311210.1, NM_001324281.1
NP_115791.3, NM_032415.5
XP_011513888.1, XM_011515586.2
UniGeneiHs.648101

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JUPX-ray3.20A/B21-116[»]
4LWDX-ray1.79A18-110[»]
ProteinModelPortaliQ9BXL7
SMRiQ9BXL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124073, 30 interactors
CORUMiQ9BXL7
DIPiDIP-41797N
IntActiQ9BXL7, 16 interactors
MINTiQ9BXL7
STRINGi9606.ENSP00000380150

PTM databases

iPTMnetiQ9BXL7
PhosphoSitePlusiQ9BXL7

Polymorphism and mutation databases

BioMutaiCARD11
DMDMi172046231

Proteomic databases

EPDiQ9BXL7
MaxQBiQ9BXL7
PaxDbiQ9BXL7
PeptideAtlasiQ9BXL7
PRIDEiQ9BXL7
ProteomicsDBi79450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396946; ENSP00000380150; ENSG00000198286
GeneIDi84433
KEGGihsa:84433
UCSCiuc003smv.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84433
DisGeNETi84433
EuPathDBiHostDB:ENSG00000198286.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CARD11

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0033921
HGNCiHGNC:16393 CARD11
HPAiHPA052984
MalaCardsiCARD11
MIMi607210 gene
615206 phenotype
616452 phenotype
617638 phenotype
neXtProtiNX_Q9BXL7
OpenTargetsiENSG00000198286
Orphaneti464336 BENTA disease
300324 Persistent polyclonal B-cell lymphocytosis
357237 Severe combined immunodeficiency due to CARD11 deficiency
PharmGKBiPA26073

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISRJ Eukaryota
ENOG41126VR LUCA
GeneTreeiENSGT00940000158573
HOVERGENiHBG099790
InParanoidiQ9BXL7
KOiK07367
OMAiPPKRRMN
OrthoDBiEOG091G0T58
PhylomeDBiQ9BXL7
TreeFamiTF351139

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
SignaLinkiQ9BXL7
SIGNORiQ9BXL7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CARD11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CARD11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84433

Protein Ontology

More...
PROi
PR:Q9BXL7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198286 Expressed in 159 organ(s), highest expression level in leukocyte
CleanExiHS_CARD11
ExpressionAtlasiQ9BXL7 baseline and differential
GenevisibleiQ9BXL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR033538 CARD11
IPR011029 DEATH-like_dom_sf
IPR027417 P-loop_NTPase
IPR036034 PDZ_sf
PANTHERiPTHR14559:SF4 PTHR14559:SF4, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAR11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXL7
Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: February 26, 2008
Last modified: December 5, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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