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UniProtKB - Q9BXL7 (CAR11_HUMAN)

Entry version 183 (25 May 2022)
Sequence version 3 (26 Feb 2008)
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Protein

Caspase recruitment domain-containing protein 11

Gene

CARD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734).

Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195).

Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955).

Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).

Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308).

Stimulates the phosphorylation of BCL10 (PubMed:11356195).

Also activates the TORC1 signaling pathway (PubMed:28628108).

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Maintained in an autoinhibited state via homodimerization in which the CARD domain forms an extensive interaction with the adjacent linker and coiled-coil regions (PubMed:31296852). Activation downstream of T-cell receptor (TCR) by phosphorylation by PRKCB and PRKCQ triggers CARD11 homooligomerization and BCL10 recruitment, followed by activation of NF-kappa-B (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXL7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-202424, Downstream TCR signaling
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5607764, CLEC7A (Dectin-1) signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BXL7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9BXL7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 111 Publication
Alternative name(s):
CARD-containing MAGUK protein 11 Publication
Short name:
Carma 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD111 PublicationImported
Synonyms:CARMA11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16393, CARD11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607210, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXL7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198286

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

B-cell expansion with NFKB and T-cell anergy (BENTA)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069710123G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar.1
Natural variantiVAR_069711134E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar.1
Immunodeficiency 11 A (IMD11A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079158945 – 1154Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST210
Immunodeficiency 11B with atopic dermatitis (IMD11B)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928457E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_079285194L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_079286975R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28C → A: Abolished homodimerization. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		84433

MalaCards human disease database

More...MalaCardsi		CARD11
MIMi615206, phenotype
616452, phenotype
617638, phenotype

Open Targets

More...OpenTargetsi		ENSG00000198286

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		464336, BENTA disease
300324, Persistent polyclonal B-cell lymphocytosis
357237, Severe combined immunodeficiency due to CARD11 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26073

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXL7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CARD11

Domain mapping of disease mutations (DMDM)

More...DMDMi		172046231

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440861 – 1154Caspase recruitment domain-containing protein 11Add BLAST1154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28InterchainCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei448PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei559Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei644Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei652Phosphoserine; by PKC/PRKCB and PKC/PRKCQBy similarity1
Modified residuei886PhosphoserineCombined sources1
Modified residuei925PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXL7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXL7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXL7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BXL7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXL7

PeptideAtlas

More...PeptideAtlasi		Q9BXL7

PRoteomics IDEntifications database

More...PRIDEi		Q9BXL7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79450

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198286, Expressed in granulocyte and 177 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BXL7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXL7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198286, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (PubMed:24224005). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (PubMed:24074955).

Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:11278692, PubMed:11356195, PubMed:27777308, PubMed:24074955, PubMed:31296852).

Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108, PubMed:24074955).

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217).

Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (PubMed:17287217).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124073, 32 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BXL7

Database of interacting proteins

More...DIPi		DIP-41797N

Protein interaction database and analysis system

More...IntActi		Q9BXL7, 18 interactors

Molecular INTeraction database

More...MINTi		Q9BXL7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380150

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXL7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9BXL7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXL7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 110CARDPROSITE-ProRule annotationAdd BLAST93
Domaini667 – 755PDZAdd BLAST89
Domaini973 – 1140Guanylate kinase-likeAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 128Linker1 PublicationAdd BLAST18
Regioni450 – 666Inhibitory domain (ID)1 PublicationAdd BLAST217
Regioni460 – 626DisorderedSequence analysisAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili130 – 449Sequence analysisAdd BLAST320

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi462 – 477Polar residuesSequence analysisAdd BLAST16
Compositional biasi534 – 566Polar residuesSequence analysisAdd BLAST33
Compositional biasi572 – 591Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi611 – 626Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The linker region, also named autoinhibitory interface, is less inhibitory on its own than that of CARD9 (PubMed:31296852). The linker region together with the inhibitory domain (ID) are required to prevent constitutive activation and maintain CARD11 in an autoinhibitory state (PubMed:31296852). Disruption of the inhibitory domain (ID) region triggers polymerization and activation, leading to formation of BCL10-nucleating filaments (PubMed:31296852).1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0708, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158573

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009760_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXL7

Identification of Orthologs from Complete Genome Data

More...OMAi		MWSSVEE

Database of Orthologous Groups

More...OrthoDBi		115953at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXL7

TreeFam database of animal gene trees

More...TreeFami		TF351139

Family and domain databases

Conserved Domains Database

More...CDDi		cd08808, CARD_CARD11_CARMA1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.533.10, 1 hit
2.30.42.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001315, CARD
IPR033538, CARD11
IPR042141, CARD_CARD11
IPR011029, DEATH-like_dom_sf
IPR027417, P-loop_NTPase
IPR036034, PDZ_sf

The PANTHER Classification System

More...PANTHERi		PTHR14559:SF4, PTHR14559:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00619, CARD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BXL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGGGPEMDD YMETLKDEED ALWENVECNR HMLSRYINPA KLTPYLRQCK 
        60         70         80         90        100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP 
       110        120        130        140        150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QMKAKDLQRC 
       160        170        180        190        200
ELLARLRQLE DEKKQMTLTR VELLTFQERY YKMKEERDSY NDELVKVKDD 
       210        220        230        240        250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS 
       260        270        280        290        300
LKLKNDIENR PKKEQVLELE RENEMLKTKN QELQSIIQAG KRSLPDSDKA 
       310        320        330        340        350
ILDILEHDRK EALEDRQELV NRIYNLQEEA RQAEELRDKY LEEKEDLELK 
       360        370        380        390        400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK 
       410        420        430        440        450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DSNNLDQSLP 
       460        470        480        490        500
RNLPVTIISQ DFGDASPRTN GQEADDSSTS EESPEDSKYF LPYHPPQRRM 
       510        520        530        540        550
NLKGIQLQRA KSPISLKRTS DFQAKGHEEE GTDASPSSCG SLPITNSFTK 
       560        570        580        590        600
MQPPRSRSSI MSITAEPPGN DSIVRRYKED APHRSTVEED NDSGGFDALD 
       610        620        630        640        650
LDDDSHERYS FGPSSIHSSS SSHQSEGLDA YDLEQVNLMF RKFSLERPFR 
       660        670        680        690        700
PSVTSVGHVR GPGPSVQHTT LNGDSLTSQL TLLGGNARGS FVHSVKPGSL 
       710        720        730        740        750
AEKAGLREGH QLLLLEGCIR GERQSVPLDT CTKEEAHWTI QRCSGPVTLH 
       760        770        780        790        800
YKVNHEGYRK LVKDMEDGLI TSGDSFYIRL NLNISSQLDA CTMSLKCDDV 
       810        820        830        840        850
VHVRDTMYQD RHEWLCARVD PFTDHDLDMG TIPSYSRAQQ LLLVKLQRLM 
       860        870        880        890        900
HRGSREEVDG THHTLRALRN TLQPEEALST SDPRVSPRLS RASFLFGQLL 
       910        920        930        940        950
QFVSRSENKY KRMNSNERVR IISGSPLGSL ARSSLDATKL LTEKQEELDP 
       960        970        980        990       1000
ESELGKNLSL IPYSLVRAFY CERRRPVLFT PTVLAKTLVQ RLLNSGGAME 
      1010       1020       1030       1040       1050
FTICKSDIVT RDEFLRRQKT ETIIYSREKN PNAFECIAPA NIEAVAAKNK 
      1060       1070       1080       1090       1100
HCLLEAGIGC TRDLIKSNIY PIVLFIRVCE KNIKRFRKLL PRPETEEEFL 
      1110       1120       1130       1140       1150
RVCRLKEKEL EALPCLYATV EPDMWGSVEE LLRVVKDKIG EEQRKTIWVD 

EDQL
Length:1,154
Mass (Da):133,284
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F3512D903795D18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY05H7BY05_HUMAN
Caspase recruitment domain-containi...
CARD11
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QRC0E2QRC0_HUMAN
Caspase recruitment domain-containi...
CARD11
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG53402 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11720 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96893 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL23962 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti815L → P in AAG53402 (PubMed:11278692).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928457E → D in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_069710123G → S in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 1 PublicationCorresponds to variant dbSNP:rs387907352EnsemblClinVar.1
Natural variantiVAR_069711134E → G in BENTA; results in protein aggregation; constitutive activation of NF-kappa-B signaling. 2 PublicationsCorresponds to variant dbSNP:rs387907351EnsemblClinVar.1
Natural variantiVAR_079285194L → P in IMD11B; no effect on protein abundance; decreased interaction with BCL10; dominant negative effect on NF-kappa-B signaling; dominant negative effect on TORC1 signaling. 1 Publication1
Natural variantiVAR_028117670T → M. Corresponds to variant dbSNP:rs3735134Ensembl.1
Natural variantiVAR_028118694S → L. Corresponds to variant dbSNP:rs3735133EnsemblClinVar.1
Natural variantiVAR_079158945 – 1154Missing in IMD11A; results in defective NF-kappa-B activation. 1 PublicationAdd BLAST210
Natural variantiVAR_079286975R → W in IMD11B; no effect on protein abundance; dominant negative effect on NF-kappaB signaling; dominant negative effect on TORC1 signaling. 1 PublicationCorresponds to variant dbSNP:rs1064795307EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF322641 mRNA Translation: AAG53402.1 Different initiation.
AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems.
BC111719 mRNA Translation: AAI11720.2 Different initiation.
AF352576 mRNA Translation: AAL34460.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5336.2

NCBI Reference Sequences

More...RefSeqi		NP_001311210.1, NM_001324281.1
NP_115791.3, NM_032415.5
XP_011513888.1, XM_011515586.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396946.9; ENSP00000380150.4; ENSG00000198286.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84433

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84433

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000396946.9; ENSP00000380150.4; NM_032415.7; NP_115791.3

UCSC genome browser

More...UCSCi		uc003smv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322641 mRNA Translation: AAG53402.1 Different initiation.
AC004906 Genomic DNA Translation: AAQ96893.1 Sequence problems.
CH236953 Genomic DNA Translation: EAL23962.1 Sequence problems.
BC111719 mRNA Translation: AAI11720.2 Different initiation.
AF352576 mRNA Translation: AAL34460.1
CCDSiCCDS5336.2
RefSeqiNP_001311210.1, NM_001324281.1
NP_115791.3, NM_032415.5
XP_011513888.1, XM_011515586.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JUPX-ray3.20A/B21-116[»]
4LWDX-ray1.79A18-110[»]
AlphaFoldDBiQ9BXL7
SMRiQ9BXL7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124073, 32 interactors
CORUMiQ9BXL7
DIPiDIP-41797N
IntActiQ9BXL7, 18 interactors
MINTiQ9BXL7
STRINGi9606.ENSP00000380150

PTM databases

iPTMnetiQ9BXL7
PhosphoSitePlusiQ9BXL7

Genetic variation databases

BioMutaiCARD11
DMDMi172046231

Proteomic databases

EPDiQ9BXL7
jPOSTiQ9BXL7
MassIVEiQ9BXL7
MaxQBiQ9BXL7
PaxDbiQ9BXL7
PeptideAtlasiQ9BXL7
PRIDEiQ9BXL7
ProteomicsDBi79450

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11155, 323 antibodies from 45 providers

The DNASU plasmid repository

More...DNASUi		84433

Genome annotation databases

EnsembliENST00000396946.9; ENSP00000380150.4; ENSG00000198286.10
GeneIDi84433
KEGGihsa:84433
MANE-SelectiENST00000396946.9; ENSP00000380150.4; NM_032415.7; NP_115791.3
UCSCiuc003smv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84433
DisGeNETi84433

GeneCards: human genes, protein and diseases

More...GeneCardsi		CARD11
HGNCiHGNC:16393, CARD11
HPAiENSG00000198286, Tissue enhanced (lymphoid)
MalaCardsiCARD11
MIMi607210, gene
615206, phenotype
616452, phenotype
617638, phenotype
neXtProtiNX_Q9BXL7
OpenTargetsiENSG00000198286
Orphaneti464336, BENTA disease
300324, Persistent polyclonal B-cell lymphocytosis
357237, Severe combined immunodeficiency due to CARD11 deficiency
PharmGKBiPA26073
VEuPathDBiHostDB:ENSG00000198286

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0708, Eukaryota
GeneTreeiENSGT00940000158573
HOGENOMiCLU_009760_1_0_1
InParanoidiQ9BXL7
OMAiMWSSVEE
OrthoDBi115953at2759
PhylomeDBiQ9BXL7
TreeFamiTF351139

Enzyme and pathway databases

PathwayCommonsiQ9BXL7
ReactomeiR-HSA-1169091, Activation of NF-kappaB in B cells
R-HSA-202424, Downstream TCR signaling
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5607764, CLEC7A (Dectin-1) signaling
SignaLinkiQ9BXL7
SIGNORiQ9BXL7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84433, 25 hits in 1083 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CARD11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CARD11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84433
PharosiQ9BXL7, Tbio

Protein Ontology

More...PROi		PR:Q9BXL7
RNActiQ9BXL7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198286, Expressed in granulocyte and 177 other tissues
ExpressionAtlasiQ9BXL7, baseline and differential
GenevisibleiQ9BXL7, HS

Family and domain databases

CDDicd08808, CARD_CARD11_CARMA1, 1 hit
Gene3Di1.10.533.10, 1 hit
2.30.42.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR033538, CARD11
IPR042141, CARD_CARD11
IPR011029, DEATH-like_dom_sf
IPR027417, P-loop_NTPase
IPR036034, PDZ_sf
PANTHERiPTHR14559:SF4, PTHR14559:SF4, 1 hit
PfamiView protein in Pfam
PF00619, CARD, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAR11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXL7
Secondary accession number(s): A4D1Z7, Q2NKN7, Q548H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: February 26, 2008
Last modified: May 25, 2022
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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