CARD14

Functionⁱ

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.4 Publications

Isoform 3: Not able to activate the inflammatory transcription factor NF-kappa-B and may fuction as a dominant negative regulator (PubMed:21302310, PubMed:26358359).2 Publications

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11278692

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of NF-kappaB-inducing kinase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 11278692
apoptotic process Source: UniProtKB-KW
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21302310
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21302310
- 27113748
positive regulation of protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11278692
tumor necrosis factor-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21302310

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caspase recruitment domain-containing protein 14 Alternative name(s): CARD-containing MAGUK protein 2 Short name: Carma 2
Gene namesⁱ	Name:CARD14 Synonyms:CARMA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141527.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16446 CARD14
MIMⁱ	607211 gene
neXtProtⁱ	NX_Q9BXL6

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Psoriasis 2 (PSORS2)5 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078583	69	R → W in PSORS2; reduces NF-kappa-B activation. 1 PublicationCorresponds to variant dbSNP:rs375624435Ensembl.	1
Natural variantⁱVAR_068225	138	E → A in PSORS2; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 4 PublicationsCorresponds to variant dbSNP:rs281875214EnsemblClinVar.	1
Natural variantⁱVAR_068226	142	E → G in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs281875213EnsemblClinVar.	1
Natural variantⁱVAR_068227	142	E → K in PSORS2; increases NF-kappaB transcription factor activity; enhances MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875212EnsemblClinVar.	1
Natural variantⁱVAR_068228	150	L → R in PSORS2; increases NF-kappaB transcription factor activity. 2 PublicationsCorresponds to variant dbSNP:rs146214639EnsemblClinVar.	1
Natural variantⁱVAR_078586	151	R → Q in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200731780Ensembl.	1
Natural variantⁱVAR_078587	151	R → W in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs777305616Ensembl.	1
Natural variantⁱVAR_078588	197	E → K in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200790561EnsemblClinVar.	1
Natural variantⁱVAR_078589	209	L → P in PSORS2; unknown pathological significance; no effect on NF-kappaB transcription factor activity. 1 Publication	1
Natural variantⁱVAR_078590	216	A → T in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs574982768Ensembl.	1
Natural variantⁱVAR_078595	420	T → A in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs762364495Ensembl.	1
Natural variantⁱVAR_078596	602	S → L in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs201285077EnsemblClinVar.	1
Natural variantⁱVAR_078597	639	A → G in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 Publication	1

Pityriasis rubra pilaris (PRP)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_078584	127	C → S in PRP. 1 Publication	1
Natural variantⁱVAR_078585	136	Q → L in PRP. 1 Publication	1
Natural variantⁱVAR_068819	138	Missing in PRP. 1 Publication	1
Natural variantⁱVAR_068820	156	L → P in PRP. 1 PublicationCorresponds to variant dbSNP:rs387907240EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79092
MalaCards human disease database More...MalaCardsⁱ	CARD14
MIMⁱ	173200 phenotype 602723 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000141527
Orphanetⁱ	2897 Pityriasis rubra pilaris
PharmGKBⁱ	PA134959119

Polymorphism and mutation databases

BioMutaⁱ	CARD14
DMDMⁱ	296434421

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144088	1 – 1004	Caspase recruitment domain-containing protein 14Add BLAST		1004

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	544	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXL6
PaxDbⁱ	Q9BXL6
PeptideAtlas More...PeptideAtlasⁱ	Q9BXL6
PRIDEⁱ	Q9BXL6
ProteomicsDBⁱ	79449

PTM databases

iPTMnetⁱ	Q9BXL6
PhosphoSitePlusⁱ	Q9BXL6

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000141527 Expressed in 126 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_CARD14
ExpressionAtlasⁱ	Q9BXL6 baseline and differential
Genevisibleⁱ	Q9BXL6 HS

Interactionⁱ

Subunit structureⁱ

Interacts (via CARD domain) with BCL10 (via CARD domain) (PubMed:21302310). Forms a complex with MALT1 and BCL10; resulting in the formation of a CBM (CARD14-BLC10-MALT1) complex (PubMed:27113748, PubMed:27071417). Interacts with TRAF2, TRAF3 and TRAF6 (PubMed:21302310).3 Publications

GO - Molecular functionⁱ

CARD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11278692

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122540, 9 interactors
IntActⁱ	Q9BXL6, 7 interactors
STRINGⁱ	9606.ENSP00000344549

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXL6
SMRⁱ	Q9BXL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	15 – 107	CARDPROSITE-ProRule annotationAdd BLAST	93
Domainⁱ	568 – 658	PDZPROSITE-ProRule annotationAdd BLAST	91
Domainⁱ	807 – 990	Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST	184

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	409 – 568	Maintains the protein in an inactive state1 PublicationAdd BLAST		160

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	128 – 409	Sequence analysisAdd BLAST		282

Domainⁱ

A linker region between the coiled-coil and PDZ region holds the protein in an inactive state (PubMed:27071417).1 Publication

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0708 Eukaryota COG0194 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063108
HOGENOMⁱ	HOG000049174
HOVERGENⁱ	HBG106927
InParanoidⁱ	Q9BXL6
KEGG Orthology (KO) More...KOⁱ	K20913
OMAⁱ	TQIVMVD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0T58
PhylomeDBⁱ	Q9BXL6
TreeFamⁱ	TF315606

Family and domain databases

InterProⁱ	View protein in InterPro IPR001315 CARD IPR011029 DEATH-like_dom_sf IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR027417 P-loop_NTPase IPR001478 PDZ IPR036034 PDZ_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit PF00625 Guanylate_kin, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF50156 SSF50156, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit PS50106 PDZ, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXL6-1) [UniParc]FASTA Add to basket

Also known as: CARD14fl1 Publication, CARMA2fl1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC 
        60         70         80         90        100
QLDEEEVLHS PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY 
       110        120        130        140        150
TLVTGLQPDV DFSNFSGLME TSKLTECLAG AIGSLQEELN QEKGQKEVLL 
       160        170        180        190        200
RRCQQLQEHL GLAETRAEGL HQLEADHSRM KREVSAHFHE VLRLKDEMLS 
       210        220        230        240        250
LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS SCELELQEQS 
       260        270        280        290        300
LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE 
       310        320        330        340        350
LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL 
       360        370        380        390        400
QAQVCELQKE RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR 
       410        420        430        440        450
TQLRQLQAEP PGVLKQEART REPCPREKQR LVRMHAICPR DDSDCSLVSS 
       460        470        480        490        500
TESQLLSDLS ATSSRELVDS FRSSSPAPPS QQSLYKRVAE DFGEEPWSFS 
       510        520        530        540        550
SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL QPVSPGRLDV 
       560        570        580        590        600
SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP 
       610        620        630        640        650
GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC 
       660        670        680        690        700
CLSVKVNTDG YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN 
       710        720        730        740        750
EVLHVTDTMF QGCGCWHAHR VNSYTMKDTA AHGTIPNYSR AQQQLIALIQ 
       760        770        780        790        800
DMTQQCTVTR KPSSGGPQKL VRIVSMDKAK ASPLRLSFDR GQLDPSRMEG 
       810        820        830        840        850
SSTCFWAESC LTLVPYTLVR PHRPARPRPV LLVPRAVGKI LSEKLCLLQG 
       860        870        880        890        900
FKKCLAEYLS QEEYEAWSQR GDIIQEGEVS GGRCWVTRHA VESLMEKNTH 
       910        920        930        940        950
ALLDVQLDSV CTLHRMDIFP IVIHVSVNEK MAKKLKKGLQ RLGTSEEQLL 
       960        970        980        990       1000
EAARQEEGDL DRAPCLYSSL APDGWSDLDG LLSCVRQAIA DEQKKVVWTE 

QSPR

Length:1,004

Mass (Da):113,270

Last modified:May 18, 2010 - v2

Checksum:ⁱ761CBAC219956076

GO

Isoform 2 (identifier: Q9BXL6-2) [UniParc]FASTA Add to basket

Also known as: Short, CARD14sh1 Publication, CARMA2sh1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
741-1004: Missing.

« Hide

        10         20         30         40         50
MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC 
        60         70         80         90        100
QLDEEEVLHS PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY 
       110        120        130        140        150
TLVTGLQPDV DFSNFSGLME TSKLTECLAG AIGSLQEELN QEKGQKEVLL 
       160        170        180        190        200
RRCQQLQEHL GLAETRAEGL HQLEADHSRM KREVSAHFHE VLRLKDEMLS 
       210        220        230        240        250
LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS SCELELQEQS 
       260        270        280        290        300
LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE 
       310        320        330        340        350
LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL 
       360        370        380        390        400
QAQVCELQKE RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR 
       410        420        430        440        450
TQLRQLQAEP PGVLKQEART REPCPREKQR LVRMHAICPR DDSDCSLVSS 
       460        470        480        490        500
TESQLLSDLS ATSSRELVDS FRSSSPAPPS QQSLYKRVAE DFGEEPWSFS 
       510        520        530        540        550
SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL QPVSPGRLDV 
       560        570        580        590        600
SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP 
       610        620        630        640        650
GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC 
       660        670        680        690        700
CLSVKVNTDG YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN 
       710        720        730        740
EVLHVTDTMF QGCGCWHAHR VNSYTMKDTA AHGTIPNYSR

Show »

Length:740

Mass (Da):83,679

Checksum:ⁱ90FCA1B1C2DB28D1

GO

Isoform 3 (identifier: Q9BXL6-3) [UniParc]FASTA Add to basket

Also known as: Cardless, CARD14cardless, CARMA2cl1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     619-671: DYEASEPLFK...KRLLQDLEAK → SRARPLLSPG...WADVKRSAHL
     672-1004: Missing.

« Hide

        10         20         30         40         50
MVSSCELELQ EQSLRTASDQ ESGDEELNRL KEENEKLRSL TFSLAEKDIL 
        60         70         80         90        100
EQSLDEARGS RQELVERIHS LRERAVAAER QREQYWEEKE QTLLQFQKSK 
       110        120        130        140        150
MACQLYREKV NALQAQVCEL QKERDQAYSA RDSAQREISQ SLVEKDSLRR 
       160        170        180        190        200
QVFELTDQVC ELRTQLRQLQ AEPPGVLKQE ARTREPCPRE KQRLVRMHAI 
       210        220        230        240        250
CPRDDSDCSL VSSTESQLLS DLSATSSREL VDSFRSSSPA PPSQQSLYKR 
       260        270        280        290        300
VAEDFGEEPW SFSSCLEIPE GDPGALPGAK AGDPHLDYEL LDTADLPQLE 
       310        320        330        340        350
SSLQPVSPGR LDVSESGVLM RRRPARRILS QVTMLAFQGD ALLEQISVIG 
       360        370        380        390        400
GNLTGIFIHR VTPGSAADQM ALRPGTQIVM VSRARPLLSP GLLMGTVAAG 
       410        420        430 
GVTQADFTSP RRCRSTLGWA SALSWADVKR SAHL

Show »

Length:434

Mass (Da):48,505

Checksum:ⁱD351699781B6D6EB

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L414	I3L414_HUMAN	Caspase recruitment domain family, ... Caspase recruitment domain family, member 14, isoform CRA_d (Caspase recruitment domain-containing protein 14)	CARD14 hCG_28572	493	Annotation score:
I3L3F1	I3L3F1_HUMAN	Caspase recruitment domain-containi... Caspase recruitment domain-containing protein 14	CARD14	475	Annotation score:
I3L1Z7	I3L1Z7_HUMAN	Caspase recruitment domain-containi... Caspase recruitment domain-containing protein 14	CARD14	70	Annotation score:
I3L4Q8	I3L4Q8_HUMAN	Caspase recruitment domain-containi... Caspase recruitment domain-containing protein 14	CARD14	43	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068222	38	R → C1 PublicationCorresponds to variant dbSNP:rs281875217EnsemblClinVar.	1
Natural variantⁱVAR_068223	62	R → Q2 PublicationsCorresponds to variant dbSNP:rs115582620EnsemblClinVar.	1
Natural variantⁱVAR_078583	69	R → W in PSORS2; reduces NF-kappa-B activation. 1 PublicationCorresponds to variant dbSNP:rs375624435Ensembl.	1
Natural variantⁱVAR_068224	117	G → S in PSORS2 and PRP; may result in altered splicing of exon 3; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 6 PublicationsCorresponds to variant dbSNP:rs281875215EnsemblClinVar.	1
Natural variantⁱVAR_078584	127	C → S in PRP. 1 Publication	1
Natural variantⁱVAR_078585	136	Q → L in PRP. 1 Publication	1
Natural variantⁱVAR_068225	138	E → A in PSORS2; increases NF-kappaB transcription factor activity; enhances CBCL10-MALT1-CARD14 complex formation; enhances MALT1 protease activity. 4 PublicationsCorresponds to variant dbSNP:rs281875214EnsemblClinVar.	1
Natural variantⁱVAR_068819	138	Missing in PRP. 1 Publication	1
Natural variantⁱVAR_068226	142	E → G in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs281875213EnsemblClinVar.	1
Natural variantⁱVAR_068227	142	E → K in PSORS2; increases NF-kappaB transcription factor activity; enhances MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875212EnsemblClinVar.	1
Natural variantⁱVAR_068228	150	L → R in PSORS2; increases NF-kappaB transcription factor activity. 2 PublicationsCorresponds to variant dbSNP:rs146214639EnsemblClinVar.	1
Natural variantⁱVAR_078586	151	R → Q in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200731780Ensembl.	1
Natural variantⁱVAR_078587	151	R → W in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs777305616Ensembl.	1
Natural variantⁱVAR_068820	156	L → P in PRP. 1 PublicationCorresponds to variant dbSNP:rs387907240EnsemblClinVar.	1
Natural variantⁱVAR_068229	171	H → N May be associated with susceptibility to psoriasis; does not change MALT1 protease activity. 2 PublicationsCorresponds to variant dbSNP:rs281875216EnsemblClinVar.	1
Natural variantⁱVAR_068230	176	D → H2 PublicationsCorresponds to variant dbSNP:rs144475004EnsemblClinVar.	1
Natural variantⁱVAR_068231	179	R → H1 PublicationCorresponds to variant dbSNP:rs199517469EnsemblClinVar.	1
Natural variantⁱVAR_068232	191	V → L1 PublicationCorresponds to variant dbSNP:rs281875218EnsemblClinVar.	1
Natural variantⁱVAR_078588	197	E → K in PSORS2; increases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200790561EnsemblClinVar.	1
Natural variantⁱVAR_068233	200	S → N2 PublicationsCorresponds to variant dbSNP:rs114688446EnsemblClinVar.	1
Natural variantⁱVAR_078589	209	L → P in PSORS2; unknown pathological significance; no effect on NF-kappaB transcription factor activity. 1 Publication	1
Natural variantⁱVAR_078590	216	A → T in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs574982768Ensembl.	1
Natural variantⁱVAR_078591	218	R → C Polymorphism; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs747854314Ensembl.	1
Natural variantⁱVAR_068234	285	D → G May be associated with susceptibility to psoriasis. 1 PublicationCorresponds to variant dbSNP:rs281875219EnsemblClinVar.	1
Natural variantⁱVAR_078592	338	M → V Polymorphism; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs200132496Ensembl.	1
Natural variantⁱVAR_078593	350	L → P1 Publication	1
Natural variantⁱVAR_078594	357	L → P1 Publication	1
Natural variantⁱVAR_078595	420	T → A in PSORS2; unknown pathological significance; decreases NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs762364495Ensembl.	1
Natural variantⁱVAR_024401	547	R → S. Corresponds to variant dbSNP:rs2066964EnsemblClinVar.	1
Natural variantⁱVAR_048608	585	V → I. Corresponds to variant dbSNP:rs34367357Ensembl.	1
Natural variantⁱVAR_068235	593	I → N1 PublicationCorresponds to variant dbSNP:rs281875220EnsemblClinVar.	1
Natural variantⁱVAR_078596	602	S → L in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 PublicationCorresponds to variant dbSNP:rs201285077EnsemblClinVar.	1
Natural variantⁱVAR_078597	639	A → G in PSORS2; unknown pathological significance; does not change NF-kappaB transcription factor activity. 1 Publication	1
Natural variantⁱVAR_068236	682	R → W1 PublicationCorresponds to variant dbSNP:rs117918077EnsemblClinVar.	1
Natural variantⁱVAR_068237	714	G → S1 PublicationCorresponds to variant dbSNP:rs151150961EnsemblClinVar.	1
Natural variantⁱVAR_059196	820	R → W2 PublicationsCorresponds to variant dbSNP:rs11652075EnsemblClinVar.	1
Natural variantⁱVAR_022043	883	R → H. Corresponds to variant dbSNP:rs2289541EnsemblClinVar.	1
Natural variantⁱVAR_061080	962	R → Q. Corresponds to variant dbSNP:rs34850974EnsemblClinVar.	1
Natural variantⁱVAR_068238	973	D → E1 PublicationCorresponds to variant dbSNP:rs144285237EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047400	1 – 237	Missing in isoform 3. 2 PublicationsAdd BLAST	237
Alternative sequenceⁱVSP_047401	619 – 671	DYEAS…DLEAK → SRARPLLSPGLLMGTVAAGG VTQADFTSPRRCRSTLGWAS ALSWADVKRSAHL in isoform 3. 2 PublicationsAdd BLAST	53
Alternative sequenceⁱVSP_047402	672 – 1004	Missing in isoform 3. 2 PublicationsAdd BLAST	333
Alternative sequenceⁱVSP_047403	741 – 1004	Missing in isoform 2. 2 PublicationsAdd BLAST	264

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF322642 mRNA Translation: AAG53403.1 AY032927 mRNA Translation: AAK54453.1 EU652409 mRNA Translation: ACF49506.1 AC087741 Genomic DNA No translation available. BC018142 mRNA Translation: AAH18142.1 BC001326 mRNA Translation: AAH01326.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11768.1 [Q9BXL6-1] CCDS58605.1 [Q9BXL6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001244899.1, NM_001257970.1 [Q9BXL6-2] NP_077015.2, NM_024110.4 [Q9BXL6-1] NP_438170.1, NM_052819.2 [Q9BXL6-3] XP_011523514.1, XM_011525212.1 XP_011523515.1, XM_011525213.1 [Q9BXL6-1] XP_011523517.1, XM_011525215.1 XP_011523518.1, XM_011525216.1 [Q9BXL6-1] XP_011523519.1, XM_011525217.1 [Q9BXL6-1] XP_011523520.1, XM_011525218.2 [Q9BXL6-1]
UniGeneⁱ	Hs.675480 Hs.696253 Hs.735899

Genome annotation databases

Ensemblⁱ	ENST00000344227; ENSP00000344549; ENSG00000141527 [Q9BXL6-1] ENST00000570421; ENSP00000461806; ENSG00000141527 [Q9BXL6-2] ENST00000573882; ENSP00000458715; ENSG00000141527 [Q9BXL6-1]
GeneIDⁱ	79092
KEGGⁱ	hsa:79092
UCSC genome browser More...UCSCⁱ	uc002jxw.3 human [Q9BXL6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL6	Isoform 2 of Caspase recruitment domain-containing protein 14		HUMAN		740	UniRef100_Q9BXL6
UPI000D0C73BC		HUMAN		936

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL6	Isoform 2 of Caspase recruitment domain-containing protein 14		HUMAN		740	UniRef90_Q9BXL6
Uncharacterized protein		PONAB		1034
Uncharacterized protein		RHIBE		1004
Uncharacterized protein		AOTNA		1004
Caspase recruitment domain family member 14		GORGO		1004
+37
Q9BXL6-3	Caspase recruitment domain-containing protein 14 (Fragment)		HUMAN		475	UniRef90_Q9BXL6-3
CARD14 isoform 11 (Fragment)		PONAB		474
CARD14 isoform 10 (Fragment)		PANTR		474
cDNA FLJ60652, highly similar to Caspase recruitment domain-containing protein 14		HUMAN		441

Protein	Similar proteins		Species	Score	Length	Source
Q9BXL6	Caspase recruitment domain-containing protein 14		MOUSE		999	UniRef50_Q9BXL6
Isoform 2 of Caspase recruitment domain-containing protein 14		HUMAN		740
Uncharacterized protein		PONAB		1034
Uncharacterized protein		CHLSB		1004
Uncharacterized protein		AOTNA		1004
+226
Q9BXL6-3	Caspase recruitment domain-containing protein 14 (Fragment)		HUMAN		475	UniRef50_Q9BXL6-3
CARD14 isoform 10 (Fragment)		PANTR		474
CARD14 isoform 11 (Fragment)		PONAB		474
LOW QUALITY PROTEIN: caspase recruitment domain family, member 14		LEPWE		510
Uncharacterized protein (Fragment)		MOUSE		506
+2

Cross-referencesⁱ

Web resourcesⁱ

Caspase recruitment domain family, member 14 (CARD14)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF322642 mRNA Translation: AAG53403.1 AY032927 mRNA Translation: AAK54453.1 EU652409 mRNA Translation: ACF49506.1 AC087741 Genomic DNA No translation available. BC018142 mRNA Translation: AAH18142.1 BC001326 mRNA Translation: AAH01326.1
CCDSⁱ	CCDS11768.1 [Q9BXL6-1] CCDS58605.1 [Q9BXL6-2]
RefSeqⁱ	NP_001244899.1, NM_001257970.1 [Q9BXL6-2] NP_077015.2, NM_024110.4 [Q9BXL6-1] NP_438170.1, NM_052819.2 [Q9BXL6-3] XP_011523514.1, XM_011525212.1 XP_011523515.1, XM_011525213.1 [Q9BXL6-1] XP_011523517.1, XM_011525215.1 XP_011523518.1, XM_011525216.1 [Q9BXL6-1] XP_011523519.1, XM_011525217.1 [Q9BXL6-1] XP_011523520.1, XM_011525218.2 [Q9BXL6-1]
UniGeneⁱ	Hs.675480 Hs.696253 Hs.735899

3D structure databases

ProteinModelPortalⁱ	Q9BXL6
SMRⁱ	Q9BXL6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122540, 9 interactors
IntActⁱ	Q9BXL6, 7 interactors
STRINGⁱ	9606.ENSP00000344549

PTM databases

iPTMnetⁱ	Q9BXL6
PhosphoSitePlusⁱ	Q9BXL6

Polymorphism and mutation databases

BioMutaⁱ	CARD14
DMDMⁱ	296434421

Proteomic databases

MaxQBⁱ	Q9BXL6
PaxDbⁱ	Q9BXL6
PeptideAtlasⁱ	Q9BXL6
PRIDEⁱ	Q9BXL6
ProteomicsDBⁱ	79449

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000344227; ENSP00000344549; ENSG00000141527 [Q9BXL6-1] ENST00000570421; ENSP00000461806; ENSG00000141527 [Q9BXL6-2] ENST00000573882; ENSP00000458715; ENSG00000141527 [Q9BXL6-1]
GeneIDⁱ	79092
KEGGⁱ	hsa:79092
UCSCⁱ	uc002jxw.3 human [Q9BXL6-1]

Organism-specific databases

CTDⁱ	79092
DisGeNETⁱ	79092
EuPathDBⁱ	HostDB:ENSG00000141527.16
GeneCardsⁱ	CARD14
H-InvDBⁱ	HIX0173685
HGNCⁱ	HGNC:16446 CARD14
MalaCardsⁱ	CARD14
MIMⁱ	173200 phenotype 602723 phenotype 607211 gene
neXtProtⁱ	NX_Q9BXL6
OpenTargetsⁱ	ENSG00000141527
Orphanetⁱ	2897 Pityriasis rubra pilaris
PharmGKBⁱ	PA134959119
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0708 Eukaryota COG0194 LUCA
GeneTreeⁱ	ENSGT00530000063108
HOGENOMⁱ	HOG000049174
HOVERGENⁱ	HBG106927
InParanoidⁱ	Q9BXL6
KOⁱ	K20913
OMAⁱ	TQIVMVD
OrthoDBⁱ	EOG091G0T58
PhylomeDBⁱ	Q9BXL6
TreeFamⁱ	TF315606

Miscellaneous databases

ChiTaRSⁱ	CARD14 human
GeneWikiⁱ	CARD14
GenomeRNAiⁱ	79092
Protein Ontology More...PROⁱ	PR:Q9BXL6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141527 Expressed in 126 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_CARD14
ExpressionAtlasⁱ	Q9BXL6 baseline and differential
Genevisibleⁱ	Q9BXL6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001315 CARD IPR011029 DEATH-like_dom_sf IPR008145 GK/Ca_channel_bsu IPR008144 Guanylate_kin-like_dom IPR027417 P-loop_NTPase IPR001478 PDZ IPR036034 PDZ_sf
Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit PF00625 Guanylate_kin, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF50156 SSF50156, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit PS50052 GUANYLATE_KINASE_2, 1 hit PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAR14_HUMAN
Accessionⁱ	Q9BXL6Primary (citable) accession number: Q9BXL6 Secondary accession number(s): B8QQJ3, Q9BVB5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q9BXL6 (CAR14_HUMAN)

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Caspase recruitment domain-containing protein 14

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Other locations

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Keywords - Domaini

Phylogenomic databases

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Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Miscellaneous databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ