BCL2L13

Functionⁱ

May promote the activation of caspase-3 and apoptosis.

GO - Molecular functionⁱ

cysteine-type endopeptidase activator activity involved in apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11262395

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11262395
apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 11262395

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Bcl-2-like protein 13 Short name: Bcl2-L-13 Alternative name(s): Bcl-rambo Protein Mil1
Gene namesⁱ	Name:BCL2L13 Synonyms:MIL1 ORF Names:CD003
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099968.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17164 BCL2L13
neXtProtⁱ	NX_Q9BXK5

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	460 – 480	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23786
Open Targets More...OpenTargetsⁱ	ENSG00000099968
PharmGKBⁱ	PA134912159

Polymorphism and mutation databases

DMDMⁱ	23396740

DMDMⁱ

23396740

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000143073	1 – 485	Bcl-2-like protein 13Add BLAST		485

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	38	PhosphoserineCombined sources	1
Modified residueⁱ	259	PhosphoserineCombined sources	1
Modified residueⁱ	261	PhosphoserineCombined sources	1
Modified residueⁱ	303	PhosphoserineCombined sources	1
Modified residueⁱ	326	PhosphoserineCombined sources	1
Modified residueⁱ	371	PhosphoserineBy similarity	1
Modified residueⁱ	375	PhosphoserineBy similarity	1
Modified residueⁱ	410	PhosphoserineCombined sources	1
Modified residueⁱ	420	PhosphoserineCombined sources	1
Modified residueⁱ	426	PhosphoserineCombined sources	1
Modified residueⁱ	429	PhosphoserineCombined sources	1
Modified residueⁱ	444	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BXK5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXK5
PaxDbⁱ	Q9BXK5
PeptideAtlas More...PeptideAtlasⁱ	Q9BXK5
PRIDEⁱ	Q9BXK5
ProteomicsDBⁱ	79446 79447 [Q9BXK5-2]

PTM databases

iPTMnetⁱ	Q9BXK5
PhosphoSitePlusⁱ	Q9BXK5
SwissPalmⁱ	Q9BXK5

Expressionⁱ

Tissue specificityⁱ

Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000099968 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_BCL2L13
ExpressionAtlasⁱ	Q9BXK5 baseline and differential
Genevisibleⁱ	Q9BXK5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002052 HPA030994 HPA050377

HPAⁱ

CAB002052
HPA030994
HPA050377

Interactionⁱ

Subunit structureⁱ

Monomer.Curated

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	B2R9H7	3	EBI-747430,EBI-10175711
BET1	Q53XK0	3	EBI-747430,EBI-10242927
GABARAPL2	P60520	4	EBI-747430,EBI-720116
NINJ2	Q9NZG7	3	EBI-747430,EBI-10317425
PLLP	Q9Y342	3	EBI-747430,EBI-3919291
PLN	P26678	5	EBI-747430,EBI-692836
PLP1	P60201	3	EBI-747430,EBI-8653150
PLP1	P60201-2	5	EBI-747430,EBI-12188331
sidF	Q5ZSD5	7	EBI-747430,EBI-15625247	From Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513).
TMEM128	Q5BJH2	3	EBI-747430,EBI-10243515
TMEM86B	Q8N661	5	EBI-747430,EBI-2548832
TMUB2	Q71RG4	3	EBI-747430,EBI-2820477
VAMP3	Q15836	3	EBI-747430,EBI-722343
VAMP4	O75379-2	3	EBI-747430,EBI-10187996

Protein-protein interaction databases

BioGridⁱ	117285, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-60895N
IntActⁱ	Q9BXK5, 78 interactors
Molecular INTeraction database More...MINTⁱ	Q9BXK5
STRINGⁱ	9606.ENSP00000318883

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXK5
SMRⁱ	Q9BXK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	246 – 256	AAdd BLAST	11
Repeatⁱ	261 – 271	A; approximateAdd BLAST	11
Repeatⁱ	425 – 441	BAdd BLAST	17
Repeatⁱ	443 – 459	B; approximateAdd BLAST	17

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	14 – 30	BH4Add BLAST	17
Motifⁱ	100 – 116	BH3Add BLAST	17
Motifⁱ	147 – 157	BH1Add BLAST	11
Motifⁱ	193 – 206	BH2Add BLAST	14

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	207 – 212	Poly-Glu		6
Compositional biasⁱ	311 – 424	Glu-richAdd BLAST		114

Sequence similaritiesⁱ

Belongs to the Bcl-2 family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IK4J Eukaryota ENOG410XT6A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015552
HOGENOMⁱ	HOG000059276
HOVERGENⁱ	HBG050648
InParanoidⁱ	Q9BXK5
KEGG Orthology (KO) More...KOⁱ	K15485
PhylomeDBⁱ	Q9BXK5
TreeFamⁱ	TF330744

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR002475 Bcl2-like IPR036834 Blc2-like_sf IPR026298 Blc2_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 2 (identifier: Q9BXK5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS 
        60         70         80         90        100
LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM 
       110        120        130        140        150
EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW 
       160        170        180        190        200
NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW 
       210        220        230        240        250
GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES PTVTTSWQSE 
       260        270        280        290        300
SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN 
       310        320        330        340        350
NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT 
       360        370        380        390        400
ATSLLGTREP DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP 
       410        420        430        440        450
ALEPTETLLS EKEINAREES LVEELSPASE KKPVPPSEGK SRLSPAGEMK 
       460        470        480 
PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL ALRKK

Length:485

Mass (Da):52,723

Last modified:June 1, 2001 - v1

Checksum:ⁱD9404665111B6CE0

GO

Isoform 1 (identifier: Q9BXK5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
201-201: G → V
202-485: Missing.

« Hide

        10         20         30         40         50
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS 
        60         70         80         90        100
LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM 
       110        120        130        140        150
EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW 
       160        170        180        190        200
NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW 

V

Show »

Length:201

Mass (Da):22,612

Checksum:ⁱC343D4873BCC2A91

GO

Isoform 3 (identifier: Q9BXK5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-162: Missing.

« Hide

        10         20         30         40         50
MLLELTRRGQ EPLSALLQFG VTYLEDYSAE YIIQQGGWGT VFSLESEEEE 
        60         70         80         90        100
YPGITAEDSN DIYILPSDNS GQVSPPESPT VTTSWQSESL PVSLSASQSW 
       110        120        130        140        150
HTESLPVSLG PESWQQIAMD PEEVKSLDSN GAGEKSENNS SNSDIVHVEK 
       160        170        180        190        200
EEVPEGMEEA AVASVVLPAR ELQEALPEAP APLLPHITAT SLLGTREPDT 
       210        220        230        240        250
EVITVEKSSP ATSLFVELDE EEVKAATTEP TEVEEVVPAL EPTETLLSEK 
       260        270        280        290        300
EINAREESLV EELSPASEKK PVPPSEGKSR LSPAGEMKPM PLSEGKSILL 
       310        320 
FGGAAAVAIL AVAIGVALAL RKK

Show »

Length:323

Mass (Da):34,601

Checksum:ⁱ77A9CADD907ED1F9

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WX97	A0A087WX97_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	509	Annotation score:
A0A087WTL4	A0A087WTL4_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	461	Annotation score:
E9PDD6	E9PDD6_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	171	Annotation score:
A0A087WW80	A0A087WW80_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	80	Annotation score:
A0A0A0MR90	A0A0A0MR90_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	128	Annotation score:
F2Z2C3	F2Z2C3_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	78	Annotation score:
F6VJB4	F6VJB4_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	92	Annotation score:
H0Y3R5	H0Y3R5_HUMAN	Bcl-2-like protein 13 Bcl-2-like protein 13	BCL2L13	38	Annotation score:

Sequence cautionⁱ

The sequence AAF03602 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAG09680 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	170	R → L in AAF03602 (Ref. 8) Curated		1
Sequence conflictⁱ	391	E → Q in CAB61361 (PubMed:17974005).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059141	46	I → RCombined sourcesCorresponds to variant dbSNP:rs2587070Ensembl.	1
Natural variantⁱVAR_059142	46	I → T. Corresponds to variant dbSNP:rs2587070Ensembl.	1
Natural variantⁱVAR_024377	55	I → V. Corresponds to variant dbSNP:rs16981016Ensembl.	1
Natural variantⁱVAR_024378	360	P → S1 PublicationCorresponds to variant dbSNP:rs9306198Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046931	1 – 162	Missing in isoform 3. 1 PublicationAdd BLAST	162
Alternative sequenceⁱVSP_000526	201	G → V in isoform 1. 3 Publications	1
Alternative sequenceⁱVSP_000527	202 – 485	Missing in isoform 1. 3 PublicationsAdd BLAST	284

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF325209 mRNA Translation: AAK27358.1 AF246665 mRNA Translation: AAK15150.1 AF183411 mRNA Translation: AAG09680.1 Frameshift. CR456521 mRNA Translation: CAG30407.1 AK056248 mRNA Translation: BAG51659.1 AC006285 Genomic DNA No translation available. BC007658 mRNA Translation: AAH07658.1 BC016037 mRNA Translation: AAH16037.1 AF146568 mRNA Translation: AAF03602.1 Different initiation. AL133029 mRNA Translation: CAB61361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13746.1 [Q9BXK5-1] CCDS59448.1 [Q9BXK5-4] CCDS86995.1 [Q9BXK5-2]
PIRⁱ	T42703
NCBI Reference Sequences More...RefSeqⁱ	NP_001257658.1, NM_001270729.1 [Q9BXK5-4] NP_001257659.1, NM_001270730.1 [Q9BXK5-4] NP_001257660.1, NM_001270731.1 [Q9BXK5-4] NP_056182.2, NM_015367.3 [Q9BXK5-1] XP_011544423.1, XM_011546121.2 [Q9BXK5-1] XP_016884217.1, XM_017028728.1 [Q9BXK5-4] XP_016884218.1, XM_017028729.1 [Q9BXK5-4] XP_016884219.1, XM_017028730.1 [Q9BXK5-4] XP_016884220.1, XM_017028731.1 [Q9BXK5-4] XP_016884221.1, XM_017028732.1 [Q9BXK5-4] XP_016884222.1, XM_017028733.1 [Q9BXK5-2]
UniGeneⁱ	Hs.631672

Genome annotation databases

Ensemblⁱ	ENST00000317582; ENSP00000318883; ENSG00000099968 [Q9BXK5-1] ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2] ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4] ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2] ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4]
GeneIDⁱ	23786
KEGGⁱ	hsa:23786
UCSC genome browser More...UCSCⁱ	uc002zmu.4 human [Q9BXK5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXK5	Bcl-2-like protein 13		MACMU		485	UniRef90_Q9BXK5
Uncharacterized protein		MACFA		485
Uncharacterized protein		MACNE		485
BCL2 like 13		PANTR		485
Uncharacterized protein		PANPA		485
+34
Q9BXK5-2	BCL2L13 isoform 13		PANTR		201	UniRef90_A0A2J8Q206
BCL2L13 isoform 12		PONAB		201
UPI000C87CBF8		PTEVA		234
UPI0007871C8D		ROUAE		210
UPI00071A01C8		EQUAS		201
+2
Q9BXK5-4	BCL2 like 13		PANTR		509	UniRef90_H2RE23
Uncharacterized protein		CERAT		509
Uncharacterized protein		MACFA		509
Uncharacterized protein		PANPA		509
Uncharacterized protein		MANLE		509
+29

Protein	Similar proteins		Species	Score	Length	Source
Q9BXK5	BCL2 like 13		PANTR		485	UniRef50_Q9BXK5
Uncharacterized protein		PANPA		485
Uncharacterized protein		CHLSB		485
Bcl-2-like protein 13		MACMU		485
Uncharacterized protein		CERAT		485
+217
Q9BXK5-2	BCL2L13 isoform 13		PANTR		201	UniRef50_A0A2J8Q206
BCL2L13 isoform 12		PONAB		201
UPI000C87CBF8		PTEVA		234
UPI0007871C8D		ROUAE		210
UPI00071A01C8		EQUAS		201
+12
Q9BXK5-4	BCL2 like 13		PANTR		509	UniRef50_H2RE23
Uncharacterized protein		MACMU		509
Uncharacterized protein		MACFA		323
Uncharacterized protein		MACNE		323
Bcl-2-like protein 13		HUMAN		509
+30

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF325209 mRNA Translation: AAK27358.1 AF246665 mRNA Translation: AAK15150.1 AF183411 mRNA Translation: AAG09680.1 Frameshift. CR456521 mRNA Translation: CAG30407.1 AK056248 mRNA Translation: BAG51659.1 AC006285 Genomic DNA No translation available. BC007658 mRNA Translation: AAH07658.1 BC016037 mRNA Translation: AAH16037.1 AF146568 mRNA Translation: AAF03602.1 Different initiation. AL133029 mRNA Translation: CAB61361.1
CCDSⁱ	CCDS13746.1 [Q9BXK5-1] CCDS59448.1 [Q9BXK5-4] CCDS86995.1 [Q9BXK5-2]
PIRⁱ	T42703
RefSeqⁱ	NP_001257658.1, NM_001270729.1 [Q9BXK5-4] NP_001257659.1, NM_001270730.1 [Q9BXK5-4] NP_001257660.1, NM_001270731.1 [Q9BXK5-4] NP_056182.2, NM_015367.3 [Q9BXK5-1] XP_011544423.1, XM_011546121.2 [Q9BXK5-1] XP_016884217.1, XM_017028728.1 [Q9BXK5-4] XP_016884218.1, XM_017028729.1 [Q9BXK5-4] XP_016884219.1, XM_017028730.1 [Q9BXK5-4] XP_016884220.1, XM_017028731.1 [Q9BXK5-4] XP_016884221.1, XM_017028732.1 [Q9BXK5-4] XP_016884222.1, XM_017028733.1 [Q9BXK5-2]
UniGeneⁱ	Hs.631672

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IPD	model	-	@	1-485	[»]
ProteinModelPortalⁱ	Q9BXK5
SMRⁱ	Q9BXK5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117285, 15 interactors
DIPⁱ	DIP-60895N
IntActⁱ	Q9BXK5, 78 interactors
MINTⁱ	Q9BXK5
STRINGⁱ	9606.ENSP00000318883

PTM databases

iPTMnetⁱ	Q9BXK5
PhosphoSitePlusⁱ	Q9BXK5
SwissPalmⁱ	Q9BXK5

Polymorphism and mutation databases

DMDMⁱ	23396740

DMDMⁱ

23396740

Proteomic databases

EPDⁱ	Q9BXK5
MaxQBⁱ	Q9BXK5
PaxDbⁱ	Q9BXK5
PeptideAtlasⁱ	Q9BXK5
PRIDEⁱ	Q9BXK5
ProteomicsDBⁱ	79446 79447 [Q9BXK5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23786
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000317582; ENSP00000318883; ENSG00000099968 [Q9BXK5-1] ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2] ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4] ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2] ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4]
GeneIDⁱ	23786
KEGGⁱ	hsa:23786
UCSCⁱ	uc002zmu.4 human [Q9BXK5-1]

Organism-specific databases

CTDⁱ	23786
DisGeNETⁱ	23786
EuPathDBⁱ	HostDB:ENSG00000099968.17
GeneCardsⁱ	BCL2L13
HGNCⁱ	HGNC:17164 BCL2L13
HPAⁱ	CAB002052 HPA030994 HPA050377
neXtProtⁱ	NX_Q9BXK5
OpenTargetsⁱ	ENSG00000099968
PharmGKBⁱ	PA134912159
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK4J Eukaryota ENOG410XT6A LUCA
GeneTreeⁱ	ENSGT00390000015552
HOGENOMⁱ	HOG000059276
HOVERGENⁱ	HBG050648
InParanoidⁱ	Q9BXK5
KOⁱ	K15485
PhylomeDBⁱ	Q9BXK5
TreeFamⁱ	TF330744

Miscellaneous databases

ChiTaRSⁱ	BCL2L13 human
GeneWikiⁱ	BCL2L13
GenomeRNAiⁱ	23786
Protein Ontology More...PROⁱ	PR:Q9BXK5

Gene expression databases

Bgeeⁱ	ENSG00000099968 Expressed in 228 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_BCL2L13
ExpressionAtlasⁱ	Q9BXK5 baseline and differential
Genevisibleⁱ	Q9BXK5 HS

Family and domain databases

Gene3Dⁱ	1.10.437.10, 1 hit
InterProⁱ	View protein in InterPro IPR002475 Bcl2-like IPR036834 Blc2-like_sf IPR026298 Blc2_fam
Pfamⁱ	View protein in Pfam PF00452 Bcl-2, 1 hit
SUPFAMⁱ	SSF56854 SSF56854, 1 hit
PROSITEⁱ	View protein in PROSITE PS50062 BCL2_FAMILY, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2L13_HUMAN
Accessionⁱ	Q9BXK5Primary (citable) accession number: Q9BXK5 Secondary accession number(s): B3KPE7 Q9UKN3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q9BXK5 (B2L13_HUMAN)

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Bcl-2-like protein 13

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ