Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q9BXK5 (B2L13_HUMAN)

Entry version 185 (23 Feb 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Bcl-2-like protein 13

Gene

BCL2L13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May promote the activation of caspase-3 and apoptosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXK5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BXK5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCL2L13
Synonyms:MIL1
ORF Names:CD003
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17164, BCL2L13

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXK5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000099968

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei460 – 480HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23786

Open Targets

More...OpenTargetsi		ENSG00000099968

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134912159

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXK5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCL2L13

Domain mapping of disease mutations (DMDM)

More...DMDMi		23396740

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001430731 – 485Bcl-2-like protein 13Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXK5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXK5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BXK5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXK5

PeptideAtlas

More...PeptideAtlasi		Q9BXK5

PRoteomics IDEntifications database

More...PRIDEi		Q9BXK5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3529
79446 [Q9BXK5-1]
79447 [Q9BXK5-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BXK5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXK5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BXK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000099968, Expressed in secondary oocyte and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BXK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXK5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000099968, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BXK5
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-747430,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-747430,EBI-11522760
AIG1 - isoform 1 [Q9NVV5-2]3EBI-747430,EBI-11957045
APOD [P05090]3EBI-747430,EBI-715495
AQP1 [P29972]3EBI-747430,EBI-745213
BET1 [Q53XK0]3EBI-747430,EBI-10242927
C4orf3 - isoform 2 [Q8WVX3-2]5EBI-747430,EBI-12003442
CD53 [P19397]3EBI-747430,EBI-6657396
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-747430,EBI-12256978
CRB3 - isoform 2 [Q9BUF7-2]3EBI-747430,EBI-17233035
DEFB127 [Q9H1M4]3EBI-747430,EBI-10305240
ERG28 [Q9UKR5]3EBI-747430,EBI-711490
ERMP1 [Q7Z2K6]3EBI-747430,EBI-10976398
FAM210B [Q96KR6]3EBI-747430,EBI-18938272
FXYD3 - isoform 3 [Q14802-3]3EBI-747430,EBI-12175685
FZD7 [O75084]3EBI-747430,EBI-746917
GABARAPL2 [P60520]4EBI-747430,EBI-720116
GALNT2 [Q10471]3EBI-747430,EBI-10226985
GAST [P01350]3EBI-747430,EBI-3436637
HMOX2 [P30519]3EBI-747430,EBI-712096
JAGN1 [Q8N5M9]3EBI-747430,EBI-10266796
KIF1B - isoform 2 [O60333-2]3EBI-747430,EBI-10975473
LAT - isoform 2 [O43561-2]3EBI-747430,EBI-8070286
LPAR3 [Q9UBY5]3EBI-747430,EBI-12033434
MAL [P21145]5EBI-747430,EBI-3932027
NINJ2 [Q9NZG7]3EBI-747430,EBI-10317425
PLLP [Q9Y342]3EBI-747430,EBI-3919291
PLN [P26678]8EBI-747430,EBI-692836
PLP1 [P60201]3EBI-747430,EBI-8653150
PLP1 - isoform DM-20 [P60201-2]6EBI-747430,EBI-12188331
PLPP4 [Q5VZY2]3EBI-747430,EBI-10485931
SLC30A8 [Q8IWU4]3EBI-747430,EBI-10262251
SLC35A1 [P78382]3EBI-747430,EBI-12870360
SLC35G5 [Q96KT7]3EBI-747430,EBI-13598465
SMIM1 [B2RUZ4]3EBI-747430,EBI-12188413
SPOCK1 [Q08629]3EBI-747430,EBI-2682560
STX12 [Q86Y82]3EBI-747430,EBI-2691717
STX8 [Q9UNK0]3EBI-747430,EBI-727240
TM6SF2 [Q9BZW4]3EBI-747430,EBI-13082040
TMEM128 [Q5BJH2]3EBI-747430,EBI-10243515
TMEM14C [Q9P0S9]3EBI-747430,EBI-2339195
TMEM242 [Q9NWH2]3EBI-747430,EBI-10315004
TMEM254 [Q8TBM7]3EBI-747430,EBI-11956809
TMEM51 [Q9NW97]3EBI-747430,EBI-726044
TMEM72 [A0PK05]3EBI-747430,EBI-12878352
TMEM86A [Q8N2M4]3EBI-747430,EBI-12015604
TMEM86B [Q8N661]6EBI-747430,EBI-2548832
TMEM97 [Q5BJF2]3EBI-747430,EBI-12111910
TMUB2 [Q71RG4]3EBI-747430,EBI-2820477
TNF [P01375]3EBI-747430,EBI-359977
TNMD - isoform 2 [Q9H2S6-2]3EBI-747430,EBI-12003398
TUSC5 [A5PKU2]3EBI-747430,EBI-11988865
VAMP3 [Q15836]3EBI-747430,EBI-722343
VAMP4 - isoform 2 [O75379-2]3EBI-747430,EBI-10187996
WFS1 [O76024]3EBI-747430,EBI-720609
B2R9H73EBI-747430,EBI-10175711
sidF [Q5ZSD5] from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513).7EBI-747430,EBI-15625247

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117285, 104 interactors

Database of interacting proteins

More...DIPi		DIP-60895N

Protein interaction database and analysis system

More...IntActi		Q9BXK5, 93 interactors

Molecular INTeraction database

More...MINTi		Q9BXK5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXK5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati246 – 256AAdd BLAST11
Repeati261 – 271A; approximateAdd BLAST11
Repeati425 – 441BAdd BLAST17
Repeati443 – 459B; approximateAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 248DisorderedSequence analysisAdd BLAST31
Regioni418 – 451DisorderedSequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi14 – 30BH4Add BLAST17
Motifi100 – 116BH3Add BLAST17
Motifi147 – 157BH1Add BLAST11
Motifi193 – 206BH2Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 248Polar residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R6AP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015552

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032647_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXK5

Identification of Orthologs from Complete Genome Data

More...OMAi		RTGFDRH

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXK5

TreeFam database of animal gene trees

More...TreeFami		TF330744

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.437.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036834, Bcl-2-like_sf
IPR026298, Bcl-2_fam
IPR002475, Bcl2-like
IPR042398, BCL2L13

The PANTHER Classification System

More...PANTHERi		PTHR15758, PTHR15758, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00452, Bcl-2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56854, SSF56854, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50062, BCL2_FAMILY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q9BXK5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS 
        60         70         80         90        100
LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM 
       110        120        130        140        150
EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW 
       160        170        180        190        200
NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW 
       210        220        230        240        250
GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES PTVTTSWQSE 
       260        270        280        290        300
SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN 
       310        320        330        340        350
NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT 
       360        370        380        390        400
ATSLLGTREP DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP 
       410        420        430        440        450
ALEPTETLLS EKEINAREES LVEELSPASE KKPVPPSEGK SRLSPAGEMK 
       460        470        480 
PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL ALRKK
Length:485
Mass (Da):52,723
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9404665111B6CE0
GO
Isoform 1 (identifier: Q9BXK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: G → V
     202-485: Missing.

Show »
Length:201
Mass (Da):22,612
Checksum:iC343D4873BCC2A91
GO
Isoform 3 (identifier: Q9BXK5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:323
Mass (Da):34,601
Checksum:i77A9CADD907ED1F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX97A0A087WX97_HUMAN
Bcl-2-like protein 13
BCL2L13
509Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTL4A0A087WTL4_HUMAN
Bcl-2-like protein 13
BCL2L13
461Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDD6E9PDD6_HUMAN
Bcl-2-like protein 13
BCL2L13
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW80A0A087WW80_HUMAN
Bcl-2-like protein 13
BCL2L13
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR90A0A0A0MR90_HUMAN
Bcl-2-like protein 13
BCL2L13
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2C3F2Z2C3_HUMAN
Bcl-2-like protein 13
BCL2L13
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VJB4F6VJB4_HUMAN
Bcl-2-like protein 13
BCL2L13
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3R5H0Y3R5_HUMAN
Bcl-2-like protein 13
BCL2L13
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF03602 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG09680 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170R → L in AAF03602 (Ref. 8) Curated1
Sequence conflicti391E → Q in CAB61361 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05914146I → RCombined sourcesCorresponds to variant dbSNP:rs2587070EnsemblClinVar.1
Natural variantiVAR_05914246I → T. Corresponds to variant dbSNP:rs2587070EnsemblClinVar.1
Natural variantiVAR_02437755I → V. Corresponds to variant dbSNP:rs16981016Ensembl.1
Natural variantiVAR_024378360P → S1 PublicationCorresponds to variant dbSNP:rs9306198Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469311 – 162Missing in isoform 3. 1 PublicationAdd BLAST162
Alternative sequenceiVSP_000526201G → V in isoform 1. 3 Publications1
Alternative sequenceiVSP_000527202 – 485Missing in isoform 1. 3 PublicationsAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF325209 mRNA Translation: AAK27358.1
AF246665 mRNA Translation: AAK15150.1
AF183411 mRNA Translation: AAG09680.1 Frameshift.
CR456521 mRNA Translation: CAG30407.1
AK056248 mRNA Translation: BAG51659.1
AC006285 Genomic DNA No translation available.
BC007658 mRNA Translation: AAH07658.1
BC016037 mRNA Translation: AAH16037.1
AF146568 mRNA Translation: AAF03602.1 Different initiation.
AL133029 mRNA Translation: CAB61361.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13746.1 [Q9BXK5-1]
CCDS59448.1 [Q9BXK5-4]
CCDS86995.1 [Q9BXK5-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T42703

NCBI Reference Sequences

More...RefSeqi		NP_001257658.1, NM_001270729.1 [Q9BXK5-4]
NP_001257659.1, NM_001270730.1 [Q9BXK5-4]
NP_001257660.1, NM_001270731.1 [Q9BXK5-4]
NP_056182.2, NM_015367.3 [Q9BXK5-1]
XP_011544423.1, XM_011546121.2 [Q9BXK5-1]
XP_016884217.1, XM_017028728.1 [Q9BXK5-4]
XP_016884218.1, XM_017028729.1 [Q9BXK5-4]
XP_016884219.1, XM_017028730.1 [Q9BXK5-4]
XP_016884220.1, XM_017028731.1 [Q9BXK5-4]
XP_016884221.1, XM_017028732.1 [Q9BXK5-4]
XP_016884222.1, XM_017028733.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317582; ENSP00000318883; ENSG00000099968
ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2]
ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4]
ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2]
ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23786

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2

UCSC genome browser

More...UCSCi		uc002zmu.4, human [Q9BXK5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325209 mRNA Translation: AAK27358.1
AF246665 mRNA Translation: AAK15150.1
AF183411 mRNA Translation: AAG09680.1 Frameshift.
CR456521 mRNA Translation: CAG30407.1
AK056248 mRNA Translation: BAG51659.1
AC006285 Genomic DNA No translation available.
BC007658 mRNA Translation: AAH07658.1
BC016037 mRNA Translation: AAH16037.1
AF146568 mRNA Translation: AAF03602.1 Different initiation.
AL133029 mRNA Translation: CAB61361.1
CCDSiCCDS13746.1 [Q9BXK5-1]
CCDS59448.1 [Q9BXK5-4]
CCDS86995.1 [Q9BXK5-2]
PIRiT42703
RefSeqiNP_001257658.1, NM_001270729.1 [Q9BXK5-4]
NP_001257659.1, NM_001270730.1 [Q9BXK5-4]
NP_001257660.1, NM_001270731.1 [Q9BXK5-4]
NP_056182.2, NM_015367.3 [Q9BXK5-1]
XP_011544423.1, XM_011546121.2 [Q9BXK5-1]
XP_016884217.1, XM_017028728.1 [Q9BXK5-4]
XP_016884218.1, XM_017028729.1 [Q9BXK5-4]
XP_016884219.1, XM_017028730.1 [Q9BXK5-4]
XP_016884220.1, XM_017028731.1 [Q9BXK5-4]
XP_016884221.1, XM_017028732.1 [Q9BXK5-4]
XP_016884222.1, XM_017028733.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117285, 104 interactors
DIPiDIP-60895N
IntActiQ9BXK5, 93 interactors
MINTiQ9BXK5
STRINGi9606.ENSP00000480836

PTM databases

GlyGeniQ9BXK5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BXK5
PhosphoSitePlusiQ9BXK5
SwissPalmiQ9BXK5

Genetic variation databases

BioMutaiBCL2L13
DMDMi23396740

Proteomic databases

EPDiQ9BXK5
jPOSTiQ9BXK5
MassIVEiQ9BXK5
MaxQBiQ9BXK5
PaxDbiQ9BXK5
PeptideAtlasiQ9BXK5
PRIDEiQ9BXK5
ProteomicsDBi3529
79446 [Q9BXK5-1]
79447 [Q9BXK5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3673, 273 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		23786

Genome annotation databases

EnsembliENST00000317582; ENSP00000318883; ENSG00000099968
ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2]
ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4]
ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2]
ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4]
GeneIDi23786
KEGGihsa:23786
MANE-SelectiENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2
UCSCiuc002zmu.4, human [Q9BXK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23786
DisGeNETi23786

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCL2L13
HGNCiHGNC:17164, BCL2L13
HPAiENSG00000099968, Tissue enhanced (skeletal)
neXtProtiNX_Q9BXK5
OpenTargetsiENSG00000099968
PharmGKBiPA134912159
VEuPathDBiHostDB:ENSG00000099968

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R6AP, Eukaryota
GeneTreeiENSGT00390000015552
HOGENOMiCLU_032647_2_0_1
InParanoidiQ9BXK5
OMAiRTGFDRH
PhylomeDBiQ9BXK5
TreeFamiTF330744

Enzyme and pathway databases

PathwayCommonsiQ9BXK5
SignaLinkiQ9BXK5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23786, 11 hits in 1052 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCL2L13, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCL2L13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23786
PharosiQ9BXK5, Tbio

Protein Ontology

More...PROi		PR:Q9BXK5
RNActiQ9BXK5, protein

Gene expression databases

BgeeiENSG00000099968, Expressed in secondary oocyte and 241 other tissues
ExpressionAtlasiQ9BXK5, baseline and differential
GenevisibleiQ9BXK5, HS

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR036834, Bcl-2-like_sf
IPR026298, Bcl-2_fam
IPR002475, Bcl2-like
IPR042398, BCL2L13
PANTHERiPTHR15758, PTHR15758, 1 hit
PfamiView protein in Pfam
PF00452, Bcl-2, 1 hit
SUPFAMiSSF56854, SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062, BCL2_FAMILY, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2L13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXK5
Secondary accession number(s): B3KPE7
, Q96B37, Q96IB7, Q9BY01, Q9HC05, Q9UFE0, Q9UKN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again