We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9BXK5 (B2L13_HUMAN)
Protein
Bcl-2-like protein 13
Gene
BCL2L13
Organism
Homo sapiens (Human)
Status
Functioni
May promote the activation of caspase-3 and apoptosis.
GO - Molecular functioni
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- apoptotic process Source: UniProtKB
- regulation of apoptotic process Source: InterPro
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q9BXK5 |
SignaLinki | Q9BXK5 |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-like protein 13Short name: Bcl2-L-13 Alternative name(s): Bcl-rambo Protein Mil1 |
Gene namesi | Name:BCL2L13 Synonyms:MIL1 ORF Names:CD003 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17164, BCL2L13 |
neXtProti | NX_Q9BXK5 |
VEuPathDBi | HostDB:ENSG00000099968 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane Curated; Single-pass membrane protein Curated
Nucleus
- Nucleus Curated
Nucleus
- Nucleus Curated
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 460 – 480 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23786 |
OpenTargetsi | ENSG00000099968 |
PharmGKBi | PA134912159 |
Miscellaneous databases
Pharosi | Q9BXK5, Tbio |
Genetic variation databases
BioMutai | BCL2L13 |
DMDMi | 23396740 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143073 | 1 – 485 | Bcl-2-like protein 13Add BLAST | 485 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineCombined sources | 1 | |
Modified residuei | 259 | PhosphoserineCombined sources | 1 | |
Modified residuei | 261 | PhosphoserineCombined sources | 1 | |
Modified residuei | 303 | PhosphoserineCombined sources | 1 | |
Modified residuei | 326 | PhosphoserineCombined sources | 1 | |
Modified residuei | 371 | PhosphoserineBy similarity | 1 | |
Modified residuei | 375 | PhosphoserineBy similarity | 1 | |
Modified residuei | 410 | PhosphoserineCombined sources | 1 | |
Modified residuei | 420 | PhosphoserineCombined sources | 1 | |
Modified residuei | 426 | PhosphoserineCombined sources | 1 | |
Modified residuei | 429 | PhosphoserineCombined sources | 1 | |
Modified residuei | 444 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BXK5 |
jPOSTi | Q9BXK5 |
MassIVEi | Q9BXK5 |
MaxQBi | Q9BXK5 |
PaxDbi | Q9BXK5 |
PeptideAtlasi | Q9BXK5 |
PRIDEi | Q9BXK5 |
ProteomicsDBi | 3529 79446 [Q9BXK5-1] 79447 [Q9BXK5-2] |
PTM databases
GlyGeni | Q9BXK5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXK5 |
PhosphoSitePlusi | Q9BXK5 |
SwissPalmi | Q9BXK5 |
Expressioni
Tissue specificityi
Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.
Gene expression databases
Bgeei | ENSG00000099968, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | Q9BXK5, baseline and differential |
Genevisiblei | Q9BXK5, HS |
Organism-specific databases
HPAi | ENSG00000099968, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Monomer.
CuratedBinary interactionsi
Q9BXK5
Protein-protein interaction databases
BioGRIDi | 117285, 104 interactors |
DIPi | DIP-60895N |
IntActi | Q9BXK5, 93 interactors |
MINTi | Q9BXK5 |
STRINGi | 9606.ENSP00000480836 |
Miscellaneous databases
RNActi | Q9BXK5, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 246 – 256 | AAdd BLAST | 11 | |
Repeati | 261 – 271 | A; approximateAdd BLAST | 11 | |
Repeati | 425 – 441 | BAdd BLAST | 17 | |
Repeati | 443 – 459 | B; approximateAdd BLAST | 17 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 218 – 248 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 418 – 451 | DisorderedSequence analysisAdd BLAST | 34 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 14 – 30 | BH4Add BLAST | 17 | |
Motifi | 100 – 116 | BH3Add BLAST | 17 | |
Motifi | 147 – 157 | BH1Add BLAST | 11 | |
Motifi | 193 – 206 | BH2Add BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 224 – 248 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the Bcl-2 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R6AP, Eukaryota |
GeneTreei | ENSGT00390000015552 |
HOGENOMi | CLU_032647_2_0_1 |
InParanoidi | Q9BXK5 |
OMAi | RTGFDRH |
PhylomeDBi | Q9BXK5 |
TreeFami | TF330744 |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR042398, BCL2L13 |
PANTHERi | PTHR15758, PTHR15758, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketNote: Experimental confirmation may be lacking for some isoforms.
This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q9BXK5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSSTVPLG FHYETKYVVL SYLGLLSQEK LQEQHLSSPQ GVQLDIASQS
60 70 80 90 100
LDQEILLKVK TEIEEELKSL DKEISEAFTS TGFDRHTSPV FSPANPESSM
110 120 130 140 150
EDCLAHLGEK VSQELKEPLH KALQMLLSQP VTYQAFRECT LETTVHASGW
160 170 180 190 200
NKILVPLVLL RQMLLELTRR GQEPLSALLQ FGVTYLEDYS AEYIIQQGGW
210 220 230 240 250
GTVFSLESEE EEYPGITAED SNDIYILPSD NSGQVSPPES PTVTTSWQSE
260 270 280 290 300
SLPVSLSASQ SWHTESLPVS LGPESWQQIA MDPEEVKSLD SNGAGEKSEN
310 320 330 340 350
NSSNSDIVHV EKEEVPEGME EAAVASVVLP ARELQEALPE APAPLLPHIT
360 370 380 390 400
ATSLLGTREP DTEVITVEKS SPATSLFVEL DEEEVKAATT EPTEVEEVVP
410 420 430 440 450
ALEPTETLLS EKEINAREES LVEELSPASE KKPVPPSEGK SRLSPAGEMK
460 470 480
PMPLSEGKSI LLFGGAAAVA ILAVAIGVAL ALRKK
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WX97 | A0A087WX97_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 509 | Annotation score: | ||
A0A087WTL4 | A0A087WTL4_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 461 | Annotation score: | ||
E9PDD6 | E9PDD6_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 171 | Annotation score: | ||
A0A087WW80 | A0A087WW80_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 80 | Annotation score: | ||
A0A0A0MR90 | A0A0A0MR90_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 128 | Annotation score: | ||
F2Z2C3 | F2Z2C3_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 78 | Annotation score: | ||
F6VJB4 | F6VJB4_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 92 | Annotation score: | ||
H0Y3R5 | H0Y3R5_HUMAN | Bcl-2-like protein 13 | BCL2L13 | 38 | Annotation score: |
Sequence cautioni
The sequence AAF03602 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG09680 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | R → L in AAF03602 (Ref. 8) Curated | 1 | |
Sequence conflicti | 391 | E → Q in CAB61361 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059141 | 46 | I → RCombined sourcesCorresponds to variant dbSNP:rs2587070EnsemblClinVar. | 1 | |
Natural variantiVAR_059142 | 46 | I → T. Corresponds to variant dbSNP:rs2587070EnsemblClinVar. | 1 | |
Natural variantiVAR_024377 | 55 | I → V. Corresponds to variant dbSNP:rs16981016Ensembl. | 1 | |
Natural variantiVAR_024378 | 360 | P → S1 PublicationCorresponds to variant dbSNP:rs9306198Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046931 | 1 – 162 | Missing in isoform 3. 1 PublicationAdd BLAST | 162 | |
Alternative sequenceiVSP_000526 | 201 | G → V in isoform 1. 3 Publications | 1 | |
Alternative sequenceiVSP_000527 | 202 – 485 | Missing in isoform 1. 3 PublicationsAdd BLAST | 284 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000317582; ENSP00000318883; ENSG00000099968 ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2] ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4] ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2] ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4] |
GeneIDi | 23786 |
KEGGi | hsa:23786 |
MANE-Selecti | ENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2 |
UCSCi | uc002zmu.4, human [Q9BXK5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117285, 104 interactors |
DIPi | DIP-60895N |
IntActi | Q9BXK5, 93 interactors |
MINTi | Q9BXK5 |
STRINGi | 9606.ENSP00000480836 |
PTM databases
GlyGeni | Q9BXK5, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BXK5 |
PhosphoSitePlusi | Q9BXK5 |
SwissPalmi | Q9BXK5 |
Genetic variation databases
BioMutai | BCL2L13 |
DMDMi | 23396740 |
Proteomic databases
EPDi | Q9BXK5 |
jPOSTi | Q9BXK5 |
MassIVEi | Q9BXK5 |
MaxQBi | Q9BXK5 |
PaxDbi | Q9BXK5 |
PeptideAtlasi | Q9BXK5 |
PRIDEi | Q9BXK5 |
ProteomicsDBi | 3529 79446 [Q9BXK5-1] 79447 [Q9BXK5-2] |
Protocols and materials databases
Antibodypediai | 3673, 273 antibodies from 35 providers |
DNASUi | 23786 |
Genome annotation databases
Ensembli | ENST00000317582; ENSP00000318883; ENSG00000099968 ENST00000399782; ENSP00000382682; ENSG00000099968 [Q9BXK5-2] ENST00000418951; ENSP00000410019; ENSG00000099968 [Q9BXK5-4] ENST00000493680; ENSP00000434764; ENSG00000099968 [Q9BXK5-2] ENST00000543133; ENSP00000437667; ENSG00000099968 [Q9BXK5-4] |
GeneIDi | 23786 |
KEGGi | hsa:23786 |
MANE-Selecti | ENST00000317582.10; ENSP00000318883.5; NM_015367.4; NP_056182.2 |
UCSCi | uc002zmu.4, human [Q9BXK5-1] |
Organism-specific databases
CTDi | 23786 |
DisGeNETi | 23786 |
GeneCardsi | BCL2L13 |
HGNCi | HGNC:17164, BCL2L13 |
HPAi | ENSG00000099968, Tissue enhanced (skeletal) |
neXtProti | NX_Q9BXK5 |
OpenTargetsi | ENSG00000099968 |
PharmGKBi | PA134912159 |
VEuPathDBi | HostDB:ENSG00000099968 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R6AP, Eukaryota |
GeneTreei | ENSGT00390000015552 |
HOGENOMi | CLU_032647_2_0_1 |
InParanoidi | Q9BXK5 |
OMAi | RTGFDRH |
PhylomeDBi | Q9BXK5 |
TreeFami | TF330744 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXK5 |
SignaLinki | Q9BXK5 |
Miscellaneous databases
BioGRID-ORCSi | 23786, 11 hits in 1052 CRISPR screens |
ChiTaRSi | BCL2L13, human |
GeneWikii | BCL2L13 |
GenomeRNAii | 23786 |
Pharosi | Q9BXK5, Tbio |
PROi | PR:Q9BXK5 |
RNActi | Q9BXK5, protein |
Gene expression databases
Bgeei | ENSG00000099968, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | Q9BXK5, baseline and differential |
Genevisiblei | Q9BXK5, HS |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR036834, Bcl-2-like_sf IPR026298, Bcl-2_fam IPR002475, Bcl2-like IPR042398, BCL2L13 |
PANTHERi | PTHR15758, PTHR15758, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2L13_HUMAN | |
Accessioni | Q9BXK5Primary (citable) accession number: Q9BXK5 Secondary accession number(s): B3KPE7 Q9UKN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families