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Protein

Krueppel-like factor 16

Gene

KLF16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9BXK1

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 16
Alternative name(s):
Basic transcription element-binding protein 4
Short name:
BTE-binding protein 4
Novel Sp1-like zinc finger transcription factor 2
Transcription factor BTEB4
Transcription factor NSLP2
Gene namesi
Name:KLF16
Synonyms:BTEB4, NSLP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129911.8
HGNCiHGNC:16857 KLF16
MIMi606139 gene
neXtProtiNX_Q9BXK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83855
OpenTargetsiENSG00000129911
PharmGKBiPA30135

Polymorphism and mutation databases

BioMutaiKLF16
DMDMi17366682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471581 – 252Krueppel-like factor 16Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineCombined sources1
Modified residuei152PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXK1
MaxQBiQ9BXK1
PaxDbiQ9BXK1
PeptideAtlasiQ9BXK1
PRIDEiQ9BXK1
ProteomicsDBi79445

PTM databases

iPTMnetiQ9BXK1
PhosphoSitePlusiQ9BXK1

Expressioni

Gene expression databases

BgeeiENSG00000129911 Expressed in 157 organ(s), highest expression level in putamen
CleanExiHS_KLF16
ExpressionAtlasiQ9BXK1 baseline and differential
GenevisibleiQ9BXK1 HS

Organism-specific databases

HPAiHPA052481

Interactioni

Protein-protein interaction databases

BioGridi123771, 27 interactors
ELMiQ9BXK1
IntActiQ9BXK1, 22 interactors
MINTiQ9BXK1
STRINGi9606.ENSP00000250916

Structurei

3D structure databases

ProteinModelPortaliQ9BXK1
SMRiQ9BXK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 130Ala/Pro-richAdd BLAST128
Compositional biasi99 – 112Ser-richAdd BLAST14
Compositional biasi210 – 249Pro/Ser-richAdd BLAST40

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 150C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri157 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ9BXK1
KOiK09208
OMAiPMSAYSE
OrthoDBiEOG091G1BN0
PhylomeDBiQ9BXK1
TreeFamiTF351003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9BXK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAVACVDY FAADVLMAIS SGAVVHRGRP GPEGAGPAAG LDVRAARREA
60 70 80 90 100
ASPGTPGPPP PPPAASGPGP GAAAAPHLLA ASILADLRGG PGAAPGGASP
110 120 130 140 150
ASSSSAASSP SSGRAPGAAP SAAAKSHRCP FPDCAKAYYK SSHLKSHLRT
160 170 180 190 200
HTGERPFACD WQGCDKKFAR SDELARHHRT HTGEKRFSCP LCSKRFTRSD
210 220 230 240 250
HLAKHARRHP GFHPDLLRRP GARSTSPSDS LPCSLAGSPA PSPAPSPAPA

GL
Length:252
Mass (Da):25,431
Last modified:June 1, 2001 - v1
Checksum:i9A0CB4B1A585A118
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWX5A0A087WWX5_HUMAN
Krueppel-like factor 16
KLF16
115Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327440 mRNA Translation: AAK15698.1
CCDSiCCDS12075.1
RefSeqiNP_114124.1, NM_031918.3
UniGeneiHs.136280

Genome annotation databases

EnsembliENST00000250916; ENSP00000250916; ENSG00000129911
ENST00000541015; ENSP00000439973; ENSG00000129911
ENST00000617223; ENSP00000483701; ENSG00000129911
GeneIDi83855
KEGGihsa:83855
UCSCiuc002luc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327440 mRNA Translation: AAK15698.1
CCDSiCCDS12075.1
RefSeqiNP_114124.1, NM_031918.3
UniGeneiHs.136280

3D structure databases

ProteinModelPortaliQ9BXK1
SMRiQ9BXK1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123771, 27 interactors
ELMiQ9BXK1
IntActiQ9BXK1, 22 interactors
MINTiQ9BXK1
STRINGi9606.ENSP00000250916

PTM databases

iPTMnetiQ9BXK1
PhosphoSitePlusiQ9BXK1

Polymorphism and mutation databases

BioMutaiKLF16
DMDMi17366682

Proteomic databases

EPDiQ9BXK1
MaxQBiQ9BXK1
PaxDbiQ9BXK1
PeptideAtlasiQ9BXK1
PRIDEiQ9BXK1
ProteomicsDBi79445

Protocols and materials databases

DNASUi83855
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250916; ENSP00000250916; ENSG00000129911
ENST00000541015; ENSP00000439973; ENSG00000129911
ENST00000617223; ENSP00000483701; ENSG00000129911
GeneIDi83855
KEGGihsa:83855
UCSCiuc002luc.4 human

Organism-specific databases

CTDi83855
DisGeNETi83855
EuPathDBiHostDB:ENSG00000129911.8
GeneCardsiKLF16
HGNCiHGNC:16857 KLF16
HPAiHPA052481
MIMi606139 gene
neXtProtiNX_Q9BXK1
OpenTargetsiENSG00000129911
PharmGKBiPA30135
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000233575
HOVERGENiHBG050746
InParanoidiQ9BXK1
KOiK09208
OMAiPMSAYSE
OrthoDBiEOG091G1BN0
PhylomeDBiQ9BXK1
TreeFamiTF351003

Enzyme and pathway databases

SIGNORiQ9BXK1

Miscellaneous databases

GenomeRNAii83855
PROiPR:Q9BXK1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129911 Expressed in 157 organ(s), highest expression level in putamen
CleanExiHS_KLF16
ExpressionAtlasiQ9BXK1 baseline and differential
GenevisibleiQ9BXK1 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF16_HUMAN
AccessioniPrimary (citable) accession number: Q9BXK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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