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UniProtKB - Q9BXJ9 (NAA15_HUMAN)

Entry version 181 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Gene

NAA15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000164134-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.88, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BXJ9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Alternative name(s):
Gastric cancer antigen Ga19
N-terminal acetyltransferase
NMDA receptor-regulated protein 1
Protein tubedown-1
Tbdn100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAA15
Synonyms:GA19, NARG1, NATH, TBDN100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000164134.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:30782, NAA15

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608000, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BXJ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 50 (MRD50)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08053452 – 866Missing in MRD50. 1 PublicationAdd BLAST815
Natural variantiVAR_080535112D → N in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs889543097Ensembl.1
Natural variantiVAR_080536290 – 866Missing in MRD50. 1 PublicationAdd BLAST577
Natural variantiVAR_080537450K → E in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1436993876Ensembl.1
Natural variantiVAR_080538475A → V in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202204424Ensembl.1
Natural variantiVAR_080539565 – 866Missing in MRD50. 1 PublicationAdd BLAST302
Natural variantiVAR_080540696 – 866Missing in MRD50. 1 PublicationAdd BLAST171
Natural variantiVAR_080541782 – 866Missing in MRD50. 1 PublicationAdd BLAST85
Natural variantiVAR_080542797 – 866Missing in MRD50. 1 PublicationAdd BLAST70

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi834Y → F or A: Reduced NatA complex stability and reduced catalytic activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		80155

MalaCards human disease database

More...MalaCardsi		NAA15
MIMi617787, phenotype

Open Targets

More...OpenTargetsi		ENSG00000164134

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165664293

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BXJ9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NAA15

Domain mapping of disease mutations (DMDM)

More...DMDMi		57012969

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062941 – 866N-alpha-acetyltransferase 15, NatA auxiliary subunitAdd BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262N6-acetyllysineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1
Modified residuei735N6-acetyllysineCombined sources1
Modified residuei756N6-acetyllysineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BXJ9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BXJ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BXJ9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BXJ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BXJ9

PeptideAtlas

More...PeptideAtlasi		Q9BXJ9

PRoteomics IDEntifications database

More...PRIDEi		Q9BXJ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79443 [Q9BXJ9-1]
79444 [Q9BXJ9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BXJ9

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9BXJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BXJ9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BXJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164134, Expressed in stomach and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BXJ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BXJ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164134, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15 (PubMed:15496142, PubMed:16638120).

Interacts with XRCC6, NAA50 and XRCC5 (PubMed:12145306, PubMed:29754825, PubMed:16507339). Associates with HYPK when in a complex with NAA10 (PubMed:20154145, PubMed:29754825). Interaction with HYPK reduces the capacity to interact with NAA50 (PubMed:29754825).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123146, 64 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9BXJ9

Protein interaction database and analysis system

More...IntActi		Q9BXJ9, 31 interactors

Molecular INTeraction database

More...MINTi		Q9BXJ9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296543

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BXJ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1866
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BXJ9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 79TPR 1Add BLAST34
Repeati80 – 113TPR 2Add BLAST34
Repeati148 – 184TPR 3Add BLAST37
Repeati224 – 257TPR 4Add BLAST34
Repeati374 – 407TPR 5Add BLAST34
Repeati409 – 441TPR 6Add BLAST33
Repeati485 – 518TPR 7Add BLAST34
Repeati672 – 705TPR 8Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni500 – 866Interaction with HYPK1 PublicationAdd BLAST367

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi612 – 629Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi629 – 632Poly-Asp4

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1156, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183174

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BXJ9

KEGG Orthology (KO)

More...KOi		K20792

Identification of Orthologs from Complete Genome Data

More...OMAi		WQEDQFD

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BXJ9

TreeFam database of animal gene trees

More...TreeFami		TF106301

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021183, NatA_aux_su
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12569, NARP1, 1 hit
PF13181, TPR_8, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 5 hits
PS50293, TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BXJ9-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA 
        60         70         80         90        100
MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI 
       110        120        130        140        150
KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS 
       160        170        180        190        200
WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL 
       210        220        230        240        250
REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL 
       260        270        280        290        300
QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF 
       310        320        330        340        350
LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE 
       360        370        380        390        400
TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA 
       410        420        430        440        450
IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK 
       460        470        480        490        500
YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK 
       510        520        530        540        550
FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD LLKLEDVLRQ 
       560        570        580        590        600
HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR 
       610        620        630        640        650
RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV 
       660        670        680        690        700
ETPLEEAIKF LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA 
       710        720        730        740        750
IDSSHPWLHE CMIRLFNTAV CESKDLSDTV RTVLKQEMNR LFGATNPKNF 
       760        770        780        790        800
NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ KRAIELATTL DESLTNRNLQ 
       810        820        830        840        850
TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP PGYEEDMKIT 
       860 
VNGDSSAEAE ELANEI
Length:866
Mass (Da):101,272
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B4BA23B99D99121
GO
Isoform 2 (identifier: Q9BXJ9-4) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     514-525: HFIEITDDQFDF → KSLMTSLTFIHTV
     526-866: Missing.

Show »
Length:526
Mass (Da):61,602
Checksum:i6C66BCE4B7377BB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1W3A0A0B4J1W3_HUMAN
N-alpha-acetyltransferase 15, NatA ...
NAA15
865Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAP7D6RAP7_HUMAN
N-alpha-acetyltransferase 15, NatA ...
NAA15
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39818 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti425K → R in AAM48746 (PubMed:12145306).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08053452 – 866Missing in MRD50. 1 PublicationAdd BLAST815
Natural variantiVAR_080535112D → N in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs889543097Ensembl.1
Natural variantiVAR_080536290 – 866Missing in MRD50. 1 PublicationAdd BLAST577
Natural variantiVAR_080537450K → E in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1436993876Ensembl.1
Natural variantiVAR_080538475A → V in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202204424Ensembl.1
Natural variantiVAR_080539565 – 866Missing in MRD50. 1 PublicationAdd BLAST302
Natural variantiVAR_080540696 – 866Missing in MRD50. 1 PublicationAdd BLAST171
Natural variantiVAR_080541782 – 866Missing in MRD50. 1 PublicationAdd BLAST85
Natural variantiVAR_080542797 – 866Missing in MRD50. 1 PublicationAdd BLAST70

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012560514 – 525HFIEI…DQFDF → KSLMTSLTFIHTV in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_012561526 – 866Missing in isoform 2. 1 PublicationAdd BLAST341

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY039242 mRNA Translation: AAK68661.1
AY112670 mRNA Translation: AAM48746.1
AJ314788 mRNA Translation: CAC43228.1
AF327722 mRNA Translation: AAK15707.1
AK023402 mRNA Translation: BAB14562.1
AC097376 Genomic DNA Translation: AAY40950.1
CH471056 Genomic DNA Translation: EAX05119.1
BC039818 mRNA Translation: AAH39818.1 Sequence problems.
BC093928 mRNA Translation: AAH93928.1
BC104806 mRNA Translation: AAI04807.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43270.1 [Q9BXJ9-1]

NCBI Reference Sequences

More...RefSeqi		NP_476516.1, NM_057175.4 [Q9BXJ9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80155

UCSC genome browser

More...UCSCi		uc003ihu.2, human [Q9BXJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039242 mRNA Translation: AAK68661.1
AY112670 mRNA Translation: AAM48746.1
AJ314788 mRNA Translation: CAC43228.1
AF327722 mRNA Translation: AAK15707.1
AK023402 mRNA Translation: BAB14562.1
AC097376 Genomic DNA Translation: AAY40950.1
CH471056 Genomic DNA Translation: EAX05119.1
BC039818 mRNA Translation: AAH39818.1 Sequence problems.
BC093928 mRNA Translation: AAH93928.1
BC104806 mRNA Translation: AAI04807.1
CCDSiCCDS43270.1 [Q9BXJ9-1]
RefSeqiNP_476516.1, NM_057175.4 [Q9BXJ9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6C95X-ray3.15A1-866[»]
6C9MX-ray2.80A/C1-866[»]
6PPLelectron microscopy3.02B1-866[»]
6PW9electron microscopy4.03B1-866[»]
SMRiQ9BXJ9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123146, 64 interactors
CORUMiQ9BXJ9
IntActiQ9BXJ9, 31 interactors
MINTiQ9BXJ9
STRINGi9606.ENSP00000296543

PTM databases

iPTMnetiQ9BXJ9
MetOSiteiQ9BXJ9
PhosphoSitePlusiQ9BXJ9
SwissPalmiQ9BXJ9

Polymorphism and mutation databases

BioMutaiNAA15
DMDMi57012969

Proteomic databases

EPDiQ9BXJ9
jPOSTiQ9BXJ9
MassIVEiQ9BXJ9
MaxQBiQ9BXJ9
PaxDbiQ9BXJ9
PeptideAtlasiQ9BXJ9
PRIDEiQ9BXJ9
ProteomicsDBi79443 [Q9BXJ9-1]
79444 [Q9BXJ9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7371, 218 antibodies

Genome annotation databases

EnsembliENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1]
GeneIDi80155
KEGGihsa:80155
UCSCiuc003ihu.2, human [Q9BXJ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80155
DisGeNETi80155
EuPathDBiHostDB:ENSG00000164134.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		NAA15
HGNCiHGNC:30782, NAA15
HPAiENSG00000164134, Low tissue specificity
MalaCardsiNAA15
MIMi608000, gene
617787, phenotype
neXtProtiNX_Q9BXJ9
OpenTargetsiENSG00000164134
PharmGKBiPA165664293

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1156, Eukaryota
GeneTreeiENSGT00950000183174
InParanoidiQ9BXJ9
KOiK20792
OMAiWQEDQFD
PhylomeDBiQ9BXJ9
TreeFamiTF106301

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000164134-MONOMER
BRENDAi2.3.1.88, 2681
PathwayCommonsiQ9BXJ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80155, 698 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NAA15, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NARG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80155
PharosiQ9BXJ9, Tbio

Protein Ontology

More...PROi		PR:Q9BXJ9
RNActiQ9BXJ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164134, Expressed in stomach and 239 other tissues
ExpressionAtlasiQ9BXJ9, baseline and differential
GenevisibleiQ9BXJ9, HS

Family and domain databases

InterProiView protein in InterPro
IPR021183, NatA_aux_su
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF12569, NARP1, 1 hit
PF13181, TPR_8, 1 hit
PIRSFiPIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 6 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 5 hits
PS50293, TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAA15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXJ9
Secondary accession number(s): D3DNY6
, Q52LG9, Q8IWH4, Q8NEV2, Q9H8P6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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