UniProtKB - Q9BXJ9 (NAA15_HUMAN)
N-alpha-acetyltransferase 15, NatA auxiliary subunit
NAA15
Functioni
GO - Molecular functioni
- ribosome binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- N-terminal peptidyl-methionine acetylation Source: GO_Central
- N-terminal protein amino acid acetylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein stabilization Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Angiogenesis, Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000164134-MONOMER |
BRENDAi | 2.3.1.88, 2681 |
PathwayCommonsi | Q9BXJ9 |
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 15, NatA auxiliary subunitAlternative name(s): Gastric cancer antigen Ga19 N-terminal acetyltransferase NMDA receptor-regulated protein 1 Protein tubedown-1 Tbdn100 |
Gene namesi | Name:NAA15 Synonyms:GA19, NARG1, NATH, TBDN100 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164134.12 |
HGNCi | HGNC:30782, NAA15 |
MIMi | 608000, gene |
neXtProti | NX_Q9BXJ9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
- NatA complex Source: UniProtKB
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal dominant 50 (MRD50)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080534 | 52 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 815 | |
Natural variantiVAR_080535 | 112 | D → N in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs889543097Ensembl. | 1 | |
Natural variantiVAR_080536 | 290 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 577 | |
Natural variantiVAR_080537 | 450 | K → E in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1436993876Ensembl. | 1 | |
Natural variantiVAR_080538 | 475 | A → V in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202204424Ensembl. | 1 | |
Natural variantiVAR_080539 | 565 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 302 | |
Natural variantiVAR_080540 | 696 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 171 | |
Natural variantiVAR_080541 | 782 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 85 | |
Natural variantiVAR_080542 | 797 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 70 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 834 | Y → F or A: Reduced NatA complex stability and reduced catalytic activity. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Mental retardationOrganism-specific databases
DisGeNETi | 80155 |
MalaCardsi | NAA15 |
MIMi | 617787, phenotype |
OpenTargetsi | ENSG00000164134 |
PharmGKBi | PA165664293 |
Miscellaneous databases
Pharosi | Q9BXJ9, Tbio |
Polymorphism and mutation databases
BioMutai | NAA15 |
DMDMi | 57012969 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106294 | 1 – 866 | N-alpha-acetyltransferase 15, NatA auxiliary subunitAdd BLAST | 866 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 262 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 302 | PhosphoserineCombined sources | 1 | |
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 588 | PhosphoserineCombined sources | 1 | |
Modified residuei | 735 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 756 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 855 | PhosphoserineCombined sources | 1 | |
Modified residuei | 856 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BXJ9 |
jPOSTi | Q9BXJ9 |
MassIVEi | Q9BXJ9 |
MaxQBi | Q9BXJ9 |
PaxDbi | Q9BXJ9 |
PeptideAtlasi | Q9BXJ9 |
PRIDEi | Q9BXJ9 |
ProteomicsDBi | 79443 [Q9BXJ9-1] 79444 [Q9BXJ9-4] |
PTM databases
iPTMneti | Q9BXJ9 |
MetOSitei | Q9BXJ9 |
PhosphoSitePlusi | Q9BXJ9 |
SwissPalmi | Q9BXJ9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164134, Expressed in stomach and 239 other tissues |
ExpressionAtlasi | Q9BXJ9, baseline and differential |
Genevisiblei | Q9BXJ9, HS |
Organism-specific databases
HPAi | ENSG00000164134, Low tissue specificity |
Interactioni
Subunit structurei
Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15 (PubMed:15496142, PubMed:16638120).
Interacts with XRCC6, NAA50 and XRCC5 (PubMed:12145306, PubMed:29754825, PubMed:16507339). Associates with HYPK when in a complex with NAA10 (PubMed:20154145, PubMed:29754825). Interaction with HYPK reduces the capacity to interact with NAA50 (PubMed:29754825).
6 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 123146, 64 interactors |
CORUMi | Q9BXJ9 |
IntActi | Q9BXJ9, 31 interactors |
MINTi | Q9BXJ9 |
STRINGi | 9606.ENSP00000296543 |
Miscellaneous databases
RNActi | Q9BXJ9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BXJ9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 79 | TPR 1Add BLAST | 34 | |
Repeati | 80 – 113 | TPR 2Add BLAST | 34 | |
Repeati | 148 – 184 | TPR 3Add BLAST | 37 | |
Repeati | 224 – 257 | TPR 4Add BLAST | 34 | |
Repeati | 374 – 407 | TPR 5Add BLAST | 34 | |
Repeati | 409 – 441 | TPR 6Add BLAST | 33 | |
Repeati | 485 – 518 | TPR 7Add BLAST | 34 | |
Repeati | 672 – 705 | TPR 8Add BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 500 – 866 | Interaction with HYPK1 PublicationAdd BLAST | 367 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 612 – 629 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 629 – 632 | Poly-Asp | 4 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
InParanoidi | Q9BXJ9 |
OMAi | WQEDQFD |
PhylomeDBi | Q9BXJ9 |
TreeFami | TF106301 |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF13181, TPR_8, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA
60 70 80 90 100
MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI
110 120 130 140 150
KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS
160 170 180 190 200
WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL
210 220 230 240 250
REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL
260 270 280 290 300
QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF
310 320 330 340 350
LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE
360 370 380 390 400
TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA
410 420 430 440 450
IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK
460 470 480 490 500
YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK
510 520 530 540 550
FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD LLKLEDVLRQ
560 570 580 590 600
HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR
610 620 630 640 650
RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV
660 670 680 690 700
ETPLEEAIKF LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA
710 720 730 740 750
IDSSHPWLHE CMIRLFNTAV CESKDLSDTV RTVLKQEMNR LFGATNPKNF
760 770 780 790 800
NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ KRAIELATTL DESLTNRNLQ
810 820 830 840 850
TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP PGYEEDMKIT
860
VNGDSSAEAE ELANEI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J1W3 | A0A0B4J1W3_HUMAN | N-alpha-acetyltransferase 15, NatA ... | NAA15 | 865 | Annotation score: | ||
D6RAP7 | D6RAP7_HUMAN | N-alpha-acetyltransferase 15, NatA ... | NAA15 | 98 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 425 | K → R in AAM48746 (PubMed:12145306).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080534 | 52 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 815 | |
Natural variantiVAR_080535 | 112 | D → N in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs889543097Ensembl. | 1 | |
Natural variantiVAR_080536 | 290 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 577 | |
Natural variantiVAR_080537 | 450 | K → E in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1436993876Ensembl. | 1 | |
Natural variantiVAR_080538 | 475 | A → V in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202204424Ensembl. | 1 | |
Natural variantiVAR_080539 | 565 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 302 | |
Natural variantiVAR_080540 | 696 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 171 | |
Natural variantiVAR_080541 | 782 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 85 | |
Natural variantiVAR_080542 | 797 – 866 | Missing in MRD50. 1 PublicationAdd BLAST | 70 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012560 | 514 – 525 | HFIEI…DQFDF → KSLMTSLTFIHTV in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_012561 | 526 – 866 | Missing in isoform 2. 1 PublicationAdd BLAST | 341 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY039242 mRNA Translation: AAK68661.1 AY112670 mRNA Translation: AAM48746.1 AJ314788 mRNA Translation: CAC43228.1 AF327722 mRNA Translation: AAK15707.1 AK023402 mRNA Translation: BAB14562.1 AC097376 Genomic DNA Translation: AAY40950.1 CH471056 Genomic DNA Translation: EAX05119.1 BC039818 mRNA Translation: AAH39818.1 Sequence problems. BC093928 mRNA Translation: AAH93928.1 BC104806 mRNA Translation: AAI04807.1 |
CCDSi | CCDS43270.1 [Q9BXJ9-1] |
RefSeqi | NP_476516.1, NM_057175.4 [Q9BXJ9-1] |
Genome annotation databases
Ensembli | ENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1] |
GeneIDi | 80155 |
KEGGi | hsa:80155 |
UCSCi | uc003ihu.2, human [Q9BXJ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY039242 mRNA Translation: AAK68661.1 AY112670 mRNA Translation: AAM48746.1 AJ314788 mRNA Translation: CAC43228.1 AF327722 mRNA Translation: AAK15707.1 AK023402 mRNA Translation: BAB14562.1 AC097376 Genomic DNA Translation: AAY40950.1 CH471056 Genomic DNA Translation: EAX05119.1 BC039818 mRNA Translation: AAH39818.1 Sequence problems. BC093928 mRNA Translation: AAH93928.1 BC104806 mRNA Translation: AAI04807.1 |
CCDSi | CCDS43270.1 [Q9BXJ9-1] |
RefSeqi | NP_476516.1, NM_057175.4 [Q9BXJ9-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C95 | X-ray | 3.15 | A | 1-866 | [»] | |
6C9M | X-ray | 2.80 | A/C | 1-866 | [»] | |
6PPL | electron microscopy | 3.02 | B | 1-866 | [»] | |
6PW9 | electron microscopy | 4.03 | B | 1-866 | [»] | |
SMRi | Q9BXJ9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123146, 64 interactors |
CORUMi | Q9BXJ9 |
IntActi | Q9BXJ9, 31 interactors |
MINTi | Q9BXJ9 |
STRINGi | 9606.ENSP00000296543 |
PTM databases
iPTMneti | Q9BXJ9 |
MetOSitei | Q9BXJ9 |
PhosphoSitePlusi | Q9BXJ9 |
SwissPalmi | Q9BXJ9 |
Polymorphism and mutation databases
BioMutai | NAA15 |
DMDMi | 57012969 |
Proteomic databases
EPDi | Q9BXJ9 |
jPOSTi | Q9BXJ9 |
MassIVEi | Q9BXJ9 |
MaxQBi | Q9BXJ9 |
PaxDbi | Q9BXJ9 |
PeptideAtlasi | Q9BXJ9 |
PRIDEi | Q9BXJ9 |
ProteomicsDBi | 79443 [Q9BXJ9-1] 79444 [Q9BXJ9-4] |
Protocols and materials databases
Antibodypediai | 7371, 218 antibodies |
Genome annotation databases
Ensembli | ENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1] |
GeneIDi | 80155 |
KEGGi | hsa:80155 |
UCSCi | uc003ihu.2, human [Q9BXJ9-1] |
Organism-specific databases
CTDi | 80155 |
DisGeNETi | 80155 |
EuPathDBi | HostDB:ENSG00000164134.12 |
GeneCardsi | NAA15 |
HGNCi | HGNC:30782, NAA15 |
HPAi | ENSG00000164134, Low tissue specificity |
MalaCardsi | NAA15 |
MIMi | 608000, gene 617787, phenotype |
neXtProti | NX_Q9BXJ9 |
OpenTargetsi | ENSG00000164134 |
PharmGKBi | PA165664293 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
InParanoidi | Q9BXJ9 |
OMAi | WQEDQFD |
PhylomeDBi | Q9BXJ9 |
TreeFami | TF106301 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000164134-MONOMER |
BRENDAi | 2.3.1.88, 2681 |
PathwayCommonsi | Q9BXJ9 |
Miscellaneous databases
BioGRID-ORCSi | 80155, 698 hits in 852 CRISPR screens |
ChiTaRSi | NAA15, human |
GeneWikii | NARG1 |
GenomeRNAii | 80155 |
Pharosi | Q9BXJ9, Tbio |
PROi | PR:Q9BXJ9 |
RNActi | Q9BXJ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164134, Expressed in stomach and 239 other tissues |
ExpressionAtlasi | Q9BXJ9, baseline and differential |
Genevisiblei | Q9BXJ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF13181, TPR_8, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA15_HUMAN | |
Accessioni | Q9BXJ9Primary (citable) accession number: Q9BXJ9 Secondary accession number(s): D3DNY6 Q9H8P6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations