UniProtKB - Q9BXJ9 (NAA15_HUMAN)

BLAST

>sp|Q9BXJ9|NAA15_HUMAN N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLG
KKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDL
SLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQT
SPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRL
EDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNF
LSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFN
PNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKH
AGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLN
EMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVD
LLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQR
RAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKF
LTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAV
CESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQ
KRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMP
PGYEEDMKITVNGDSSAEAEELANEI

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History
Entry version 165 (10 Oct 2018)
Sequence version 1 (01 Jun 2001)
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Protein

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Gene

NAA15

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.3 Publications

GO - Molecular functionⁱ

ribosome binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19480662
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
cell differentiation Source: UniProtKB-KW
negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19480662
N-terminal peptidyl-methionine acetylation Source: GO_Central
N-terminal protein amino acid acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 15496142
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12145306
protein stabilization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19480662
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Angiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000164134-MONOMER
BRENDAⁱ	2.3.1.88 2681

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-alpha-acetyltransferase 15, NatA auxiliary subunit Alternative name(s): Gastric cancer antigen Ga19 N-terminal acetyltransferase NMDA receptor-regulated protein 1 Protein tubedown-1 Tbdn100
Gene namesⁱ	Name:NAA15 Synonyms:GA19, NARG1, NATH, TBDN100
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164134.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30782 NAA15
MIMⁱ	608000 gene
neXtProtⁱ	NX_Q9BXJ9

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, autosomal dominant 50 (MRD50)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80155
MalaCards human disease database More...MalaCardsⁱ	NAA15
MIMⁱ	617787 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164134
PharmGKBⁱ	PA165664293

Polymorphism and mutation databases

BioMutaⁱ	NAA15
DMDMⁱ	57012969

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000106294	1 – 866	N-alpha-acetyltransferase 15, NatA auxiliary subunitAdd BLAST		866

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	262	N6-acetyllysineCombined sources	1
Modified residueⁱ	302	PhosphoserineCombined sources	1
Modified residueⁱ	537	PhosphoserineCombined sources	1
Modified residueⁱ	588	PhosphoserineCombined sources	1
Modified residueⁱ	735	N6-acetyllysineCombined sources	1
Modified residueⁱ	756	N6-acetyllysineCombined sources	1
Modified residueⁱ	855	PhosphoserineCombined sources	1
Modified residueⁱ	856	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BXJ9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXJ9
PaxDbⁱ	Q9BXJ9
PeptideAtlas More...PeptideAtlasⁱ	Q9BXJ9
PRIDEⁱ	Q9BXJ9
ProteomicsDBⁱ	79443 79444 [Q9BXJ9-4]

PTM databases

iPTMnetⁱ	Q9BXJ9
PhosphoSitePlusⁱ	Q9BXJ9
SwissPalmⁱ	Q9BXJ9

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000164134 Expressed in 228 organ(s), highest expression level in stomach
CleanExⁱ	HS_NARG1
ExpressionAtlasⁱ	Q9BXJ9 baseline and differential
Genevisibleⁱ	Q9BXJ9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023589 HPA050661

HPAⁱ

HPA023589
HPA050661

Interactionⁱ

Subunit structureⁱ

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NAA50	Q9GZZ1	2	EBI-1042540,EBI-1052523

With

Entry

#Exp.

IntAct

Notes

NAA50

Q9GZZ1

EBI-1042540,EBI-1052523

Protein-protein interaction databases

BioGridⁱ	123146, 58 interactors
CORUMⁱ	Q9BXJ9
IntActⁱ	Q9BXJ9, 18 interactors
STRINGⁱ	9606.ENSP00000296543

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 22	Combined sources	15
Helixⁱ	26 – 38	Combined sources	13
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	46 – 58	Combined sources	13
Helixⁱ	62 – 75	Combined sources	14
Helixⁱ	80 – 92	Combined sources	13
Helixⁱ	96 – 109	Combined sources	14
Helixⁱ	114 – 126	Combined sources	13
Helixⁱ	130 – 143	Combined sources	14
Beta strandⁱ	145 – 147	Combined sources	3
Helixⁱ	148 – 161	Combined sources	14
Helixⁱ	164 – 180	Combined sources	17
Helixⁱ	186 – 202	Combined sources	17
Helixⁱ	206 – 216	Combined sources	11
Helixⁱ	217 – 219	Combined sources	3
Helixⁱ	223 – 236	Combined sources	14
Helixⁱ	240 – 253	Combined sources	14
Helixⁱ	258 – 268	Combined sources	11
Helixⁱ	273 – 286	Combined sources	14
Helixⁱ	292 – 295	Combined sources	4
Helixⁱ	297 – 300	Combined sources	4
Helixⁱ	304 – 320	Combined sources	17
Helixⁱ	325 – 329	Combined sources	5
Helixⁱ	330 – 334	Combined sources	5
Helixⁱ	336 – 355	Combined sources	20
Beta strandⁱ	356 – 360	Combined sources	5
Beta strandⁱ	361 – 363	Combined sources	3
Helixⁱ	370 – 386	Combined sources	17
Helixⁱ	390 – 403	Combined sources	14
Helixⁱ	408 – 420	Combined sources	13
Helixⁱ	424 – 437	Combined sources	14
Beta strandⁱ	438 – 440	Combined sources	3
Helixⁱ	442 – 454	Combined sources	13
Helixⁱ	458 – 465	Combined sources	8
Turnⁱ	466 – 468	Combined sources	3
Beta strandⁱ	471 – 473	Combined sources	3
Helixⁱ	475 – 481	Combined sources	7
Helixⁱ	485 – 497	Combined sources	13
Helixⁱ	501 – 520	Combined sources	20
Helixⁱ	521 – 524	Combined sources	4
Helixⁱ	525 – 532	Combined sources	8
Helixⁱ	535 – 546	Combined sources	12
Helixⁱ	547 – 550	Combined sources	4
Helixⁱ	552 – 570	Combined sources	19
Helixⁱ	644 – 648	Combined sources	5
Helixⁱ	653 – 667	Combined sources	15
Helixⁱ	672 – 684	Combined sources	13
Helixⁱ	688 – 701	Combined sources	14
Helixⁱ	706 – 721	Combined sources	16
Helixⁱ	728 – 740	Combined sources	13
Helixⁱ	747 – 757	Combined sources	11
Turnⁱ	758 – 760	Combined sources	3
Helixⁱ	762 – 775	Combined sources	14
Helixⁱ	777 – 779	Combined sources	3
Helixⁱ	780 – 787	Combined sources	8
Helixⁱ	799 – 810	Combined sources	12
Beta strandⁱ	812 – 814	Combined sources	3
Helixⁱ	818 – 829	Combined sources	12
Helixⁱ	836 – 838	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BXJ9
SMRⁱ	Q9BXJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	46 – 79	TPR 1Add BLAST	34
Repeatⁱ	80 – 113	TPR 2Add BLAST	34
Repeatⁱ	148 – 184	TPR 3Add BLAST	37
Repeatⁱ	224 – 257	TPR 4Add BLAST	34
Repeatⁱ	374 – 407	TPR 5Add BLAST	34
Repeatⁱ	409 – 441	TPR 6Add BLAST	33
Repeatⁱ	485 – 518	TPR 7Add BLAST	34
Repeatⁱ	672 – 705	TPR 8Add BLAST	34

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	500 – 866	Interaction with HYPK1 PublicationAdd BLAST		367

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	612 – 629	Bipartite nuclear localization signalSequence analysisAdd BLAST		18

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	629 – 632	Poly-Asp		4

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

eggNOGⁱ	KOG1156 Eukaryota ENOG410XR7D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007676
HOGENOMⁱ	HOG000191711
HOVERGENⁱ	HBG052576
InParanoidⁱ	Q9BXJ9
KEGG Orthology (KO) More...KOⁱ	K20792
OMAⁱ	WQEDQFD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04NY
PhylomeDBⁱ	Q9BXJ9
TreeFamⁱ	TF106301

Family and domain databases

InterProⁱ	View protein in InterPro IPR021183 NatA_aux_su IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12569 NARP1, 1 hit PF13181 TPR_8, 1 hit
PIRSFⁱ	PIRSF000422 N-terminal-AcTrfase-A_aux_su, 1 hit
SMARTⁱ	View protein in SMART SM00028 TPR, 6 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 5 hits PS50293 TPR_REGION, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXJ9-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA 
        60         70         80         90        100
MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI 
       110        120        130        140        150
KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS 
       160        170        180        190        200
WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL 
       210        220        230        240        250
REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL 
       260        270        280        290        300
QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF 
       310        320        330        340        350
LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE 
       360        370        380        390        400
TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA 
       410        420        430        440        450
IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK 
       460        470        480        490        500
YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK 
       510        520        530        540        550
FGEALKKCHE IERHFIEITD DQFDFHTYCM RKITLRSYVD LLKLEDVLRQ 
       560        570        580        590        600
HPFYFKAARI AIEIYLKLHD NPLTDENKEH EADTANMSDK ELKKLRNKQR 
       610        620        630        640        650
RAQKKAQIEE EKKNAEKEKQ QRNQKKKKDD DDEEIGGPKE ELIPEKLAKV 
       660        670        680        690        700
ETPLEEAIKF LTPLKNLVKN KIETHLFAFE IYFRKEKFLL MLQSVKRAFA 
       710        720        730        740        750
IDSSHPWLHE CMIRLFNTAV CESKDLSDTV RTVLKQEMNR LFGATNPKNF 
       760        770        780        790        800
NETFLKRNSD SLPHRLSAAK MVYYLDPSSQ KRAIELATTL DESLTNRNLQ 
       810        820        830        840        850
TCMEVLEALY DGSLGDCKEA AEIYRANCHK LFPYALAFMP PGYEEDMKIT 
       860 
VNGDSSAEAE ELANEI

Length:866

Mass (Da):101,272

Last modified:June 1, 2001 - v1

Checksum:ⁱ6B4BA23B99D99121

Isoform 2 (identifier: Q9BXJ9-4) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
514-525: HFIEITDDQFDF → KSLMTSLTFIHTV
526-866: Missing.

« Hide

        10         20         30         40         50
MPAVSLPPKE NALFKRILRC YEHKQYRNGL KFCKQILSNP KFAEHGETLA 
        60         70         80         90        100
MKGLTLNCLG KKEEAYELVR RGLRNDLKSH VCWHVYGLLQ RSDKKYDEAI 
       110        120        130        140        150
KCYRNALKWD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPAQRAS 
       160        170        180        190        200
WIGYAIAYHL LEDYEMAAKI LEEFRKTQQT SPDKVDYEYS ELLLYQNQVL 
       210        220        230        240        250
REAGLYREAL EHLCTYEKQI CDKLAVEETK GELLLQLCRL EDAADVYRGL 
       260        270        280        290        300
QERNPENWAY YKGLEKALKP ANMLERLKIY EEAWTKYPRG LVPRRLPLNF 
       310        320        330        340        350
LSGEKFKECL DKFLRMNFSK GCPPVFNTLR SLYKDKEKVA IIEELVVGYE 
       360        370        380        390        400
TSLKSCRLFN PNDDGKEEPP TTLLWVQYYL AQHYDKIGQP SIALEYINTA 
       410        420        430        440        450
IESTPTLIEL FLVKAKIYKH AGNIKEAARW MDEAQALDTA DRFINSKCAK 
       460        470        480        490        500
YMLKANLIKE AEEMCSKFTR EGTSAVENLN EMQCMWFQTE CAQAYKAMNK 
       510        520 
FGEALKKCHE IERKSLMTSL TFIHTV

Show »

Length:526

Mass (Da):61,602

Checksum:ⁱ6C66BCE4B7377BB6

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0B4J1W3	A0A0B4J1W3_HUMAN	N-alpha-acetyltransferase 15, NatA ... N-alpha-acetyltransferase 15, NatA auxiliary subunit	NAA15	865	Annotation score:
D6RAP7	D6RAP7_HUMAN	N-alpha-acetyltransferase 15, NatA ... N-alpha-acetyltransferase 15, NatA auxiliary subunit	NAA15	98	Annotation score:

Sequence cautionⁱ

The sequence AAH39818 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	425	K → R in AAM48746 (PubMed:12145306).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080534	52 – 866	Missing in MRD50. 1 PublicationAdd BLAST	815
Natural variantⁱVAR_080535	112	D → N in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs889543097Ensembl.	1
Natural variantⁱVAR_080536	290 – 866	Missing in MRD50. 1 PublicationAdd BLAST	577
Natural variantⁱVAR_080537	450	K → E in MRD50; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_080538	475	A → V in MRD50; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202204424Ensembl.	1
Natural variantⁱVAR_080539	565 – 866	Missing in MRD50. 1 PublicationAdd BLAST	302
Natural variantⁱVAR_080540	696 – 866	Missing in MRD50. 1 PublicationAdd BLAST	171
Natural variantⁱVAR_080541	782 – 866	Missing in MRD50. 1 PublicationAdd BLAST	85
Natural variantⁱVAR_080542	797 – 866	Missing in MRD50. 1 PublicationAdd BLAST	70

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012560	514 – 525	HFIEI…DQFDF → KSLMTSLTFIHTV in isoform 2. 1 PublicationAdd BLAST		12
Alternative sequenceⁱVSP_012561	526 – 866	Missing in isoform 2. 1 PublicationAdd BLAST		341

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY039242 mRNA Translation: AAK68661.1 AY112670 mRNA Translation: AAM48746.1 AJ314788 mRNA Translation: CAC43228.1 AF327722 mRNA Translation: AAK15707.1 AK023402 mRNA Translation: BAB14562.1 AC097376 Genomic DNA Translation: AAY40950.1 CH471056 Genomic DNA Translation: EAX05119.1 BC039818 mRNA Translation: AAH39818.1 Sequence problems. BC093928 mRNA Translation: AAH93928.1 BC104806 mRNA Translation: AAI04807.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43270.1 [Q9BXJ9-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_476516.1, NM_057175.4 [Q9BXJ9-1]
UniGeneⁱ	Hs.745047

Genome annotation databases

Ensemblⁱ	ENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1]
GeneIDⁱ	80155
KEGGⁱ	hsa:80155
UCSC genome browser More...UCSCⁱ	uc003ihu.2 human [Q9BXJ9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit (Fragment)		MACMU		617	UniRef100_Q9BXJ9

Protein	Similar proteins		Species	Score	Length	Source
Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit		PONAB		866	UniRef90_Q9BXJ9
N-alpha-acetyltransferase 15, NatA auxiliary subunit		MOUSE		865
N-alpha-acetyltransferase 15, NatA auxiliary subunit (Fragment)		MACMU		617
N-alpha-acetyltransferase 15, NatA auxiliary subunit		MYOBR		882
Uncharacterized protein		MYOLU		848
+287
Q9BXJ9-4	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X2		ODORO		526	UniRef90_Q9BXJ9-4
N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X3		ERIEU		526
N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X2		LIPVE		526
UPI0002BCE182		ORCOR		526
UPI0003F06B2E		ELEED		526
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9BXJ9	N-alpha-acetyltransferase 15, NatA auxiliary subunit		PONAB		866	UniRef50_Q9BXJ9
N-alpha-acetyltransferase 15, NatA auxiliary subunit		MOUSE		865
N-alpha-acetyltransferase 15, NatA auxiliary subunit (Fragment)		MACMU		617
N-alpha-acetyltransferase 15, NatA auxiliary subunit		MYOBR		882
Uncharacterized protein		MYOLU		848
+288
Q9BXJ9-4	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X2		ODORO		526	UniRef50_Q9BXJ9-4
N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X3		ERIEU		526
N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform X2		LIPVE		526
NMDA receptor-regulated protein 1		ZOONE		591
Anaphase-promoting complex subunit 3 protein		Oryctes borbonicus		603
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY039242 mRNA Translation: AAK68661.1 AY112670 mRNA Translation: AAM48746.1 AJ314788 mRNA Translation: CAC43228.1 AF327722 mRNA Translation: AAK15707.1 AK023402 mRNA Translation: BAB14562.1 AC097376 Genomic DNA Translation: AAY40950.1 CH471056 Genomic DNA Translation: EAX05119.1 BC039818 mRNA Translation: AAH39818.1 Sequence problems. BC093928 mRNA Translation: AAH93928.1 BC104806 mRNA Translation: AAI04807.1
CCDSⁱ	CCDS43270.1 [Q9BXJ9-1]
RefSeqⁱ	NP_476516.1, NM_057175.4 [Q9BXJ9-1]
UniGeneⁱ	Hs.745047

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6C95	X-ray	3.15	A	1-866	[»]
	6C9M	X-ray	2.80	A/C	1-866	[»]
ProteinModelPortalⁱ	Q9BXJ9
SMRⁱ	Q9BXJ9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123146, 58 interactors
CORUMⁱ	Q9BXJ9
IntActⁱ	Q9BXJ9, 18 interactors
STRINGⁱ	9606.ENSP00000296543

PTM databases

iPTMnetⁱ	Q9BXJ9
PhosphoSitePlusⁱ	Q9BXJ9
SwissPalmⁱ	Q9BXJ9

Polymorphism and mutation databases

BioMutaⁱ	NAA15
DMDMⁱ	57012969

Proteomic databases

EPDⁱ	Q9BXJ9
MaxQBⁱ	Q9BXJ9
PaxDbⁱ	Q9BXJ9
PeptideAtlasⁱ	Q9BXJ9
PRIDEⁱ	Q9BXJ9
ProteomicsDBⁱ	79443 79444 [Q9BXJ9-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296543; ENSP00000296543; ENSG00000164134 [Q9BXJ9-1]
GeneIDⁱ	80155
KEGGⁱ	hsa:80155
UCSCⁱ	uc003ihu.2 human [Q9BXJ9-1]

Organism-specific databases

CTDⁱ	80155
DisGeNETⁱ	80155
EuPathDBⁱ	HostDB:ENSG00000164134.12
GeneCardsⁱ	NAA15
HGNCⁱ	HGNC:30782 NAA15
HPAⁱ	HPA023589 HPA050661
MalaCardsⁱ	NAA15
MIMⁱ	608000 gene 617787 phenotype
neXtProtⁱ	NX_Q9BXJ9
OpenTargetsⁱ	ENSG00000164134
PharmGKBⁱ	PA165664293
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1156 Eukaryota ENOG410XR7D LUCA
GeneTreeⁱ	ENSGT00390000007676
HOGENOMⁱ	HOG000191711
HOVERGENⁱ	HBG052576
InParanoidⁱ	Q9BXJ9
KOⁱ	K20792
OMAⁱ	WQEDQFD
OrthoDBⁱ	EOG091G04NY
PhylomeDBⁱ	Q9BXJ9
TreeFamⁱ	TF106301

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000164134-MONOMER
BRENDAⁱ	2.3.1.88 2681

Miscellaneous databases

ChiTaRSⁱ	NAA15 human
GeneWikiⁱ	NARG1
GenomeRNAiⁱ	80155
Protein Ontology More...PROⁱ	PR:Q9BXJ9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164134 Expressed in 228 organ(s), highest expression level in stomach
CleanExⁱ	HS_NARG1
ExpressionAtlasⁱ	Q9BXJ9 baseline and differential
Genevisibleⁱ	Q9BXJ9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR021183 NatA_aux_su IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR019734 TPR_repeat
Pfamⁱ	View protein in Pfam PF12569 NARP1, 1 hit PF13181 TPR_8, 1 hit
PIRSFⁱ	PIRSF000422 N-terminal-AcTrfase-A_aux_su, 1 hit
SMARTⁱ	View protein in SMART SM00028 TPR, 6 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 5 hits PS50293 TPR_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAA15_HUMAN
Accessionⁱ	Q9BXJ9Primary (citable) accession number: Q9BXJ9 Secondary accession number(s): D3DNY6 , Q52LG9, Q8IWH4, Q8NEV2, Q9H8P6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9BXJ9 (NAA15_HUMAN)

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N-alpha-acetyltransferase 15, NatA auxiliary subunit

NAA15

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

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Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ