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Entry version 140 (11 Dec 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Complement C1q tumor necrosis factor-related protein 4

Gene

C1QTNF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).By similarity2 Publications

Caution

There are conflicting results in its involvement in the inflammatory network. It was first described to be a pro-inflammatory cytokine by inducing the activation of NF-kappa-B signaling pathway and up-regulates IL6 production in liver carcinoma cells (PubMed:21658842). While it seems to have the opposite effect in macrophages (PubMed:27086950).2 Publications
Involvement in food intake and energy was only observed when the protein was externally administered in the brain, but not when this protein was overexpressed in vivo.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 4
Alternative name(s):
C1q/TNF-related protein 41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C1QTNF4
Synonyms:CTRP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000172247.3

Human Gene Nomenclature Database

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HGNCi
HGNC:14346 C1QTNF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614911 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXJ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

NIAGADS Genomics Database

More...
NIAGADSi
ENSG00000172247

Open Targets

More...
OpenTargetsi
ENSG00000172247

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25631

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXJ3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1QTNF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241274

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000353317 – 329Complement C1q tumor necrosis factor-related protein 4Add BLAST313

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BXJ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXJ3

PeptideAtlas

More...
PeptideAtlasi
Q9BXJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79435

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at low levels (PubMed:21658842). Highest levels in adipocyte tissue and brain (PubMed:24366864).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IL6.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172247 Expressed in 111 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXJ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXJ3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041032

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer. Forms trimers, hexamers and high molecular weight oligomers (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125391, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9BXJ3, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302274

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXJ3 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 162C1q 1PROSITE-ProRule annotationAdd BLAST138
Domaini172 – 317C1q 2PROSITE-ProRule annotationAdd BLAST146

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAJ Eukaryota
ENOG4111IFJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000072708

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXJ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYSHQHD

Database of Orthologous Groups

More...
OrthoDBi
872445at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXJ3

TreeFam database of animal gene trees

More...
TreeFami
TF329591

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.40, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00386 C1q, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00007 COMPLEMNTC1Q

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00110 C1Q, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50871 C1Q, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BXJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLLLGLLG PAACWALGPT PGPGSSELRS AFSAARTTPL EGTSEMAVTF
60 70 80 90 100
DKVYVNIGGD FDVATGQFRC RVPGAYFFSF TAGKAPHKSL SVMLVRNRDE
110 120 130 140 150
VQALAFDEQR RPGARRAASQ SAMLQLDYGD TVWLRLHGAP QYALGAPGAT
160 170 180 190 200
FSGYLVYADA DADAPARGPP APPEPRSAFS AARTRSLVGS DAGPGPRHQP
210 220 230 240 250
LAFDTEFVNI GGDFDAAAGV FRCRLPGAYF FSFTLGKLPR KTLSVKLMKN
260 270 280 290 300
RDEVQAMIYD DGASRRREMQ SQSVMLALRR GDAVWLLSHD HDGYGAYSNH
310 320
GKYITFSGFL VYPDLAPAAP PGLGASELL
Length:329
Mass (Da):35,256
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16064DA8182A6732
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPZ5E9PPZ5_HUMAN
Complement C1q tumor necrosis facto...
C1QTNF4
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141Q → H in AAK17962 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081086198H → Q Found in a patient with systemic lupus erythematosus; unknown pathological significance; inhibits TNF-mediated NF-kB activation. 1 Publication1
Natural variantiVAR_081087301G → D Found in a patient with autosomal recessive retinitis pigmentosa; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1418830230Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF329838 mRNA Translation: AAK17962.1
BC035628 mRNA Translation: AAH35628.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7942.1

NCBI Reference Sequences

More...
RefSeqi
NP_114115.2, NM_031909.2
XP_016872654.1, XM_017017165.1
XP_016872655.1, XM_017017166.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302514; ENSP00000302274; ENSG00000172247
ENST00000642567; ENSP00000496508; ENSG00000284838

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114900

UCSC genome browser

More...
UCSCi
uc001ngc.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329838 mRNA Translation: AAK17962.1
BC035628 mRNA Translation: AAH35628.1
CCDSiCCDS7942.1
RefSeqiNP_114115.2, NM_031909.2
XP_016872654.1, XM_017017165.1
XP_016872655.1, XM_017017166.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125391, 1 interactor
IntActiQ9BXJ3, 4 interactors
STRINGi9606.ENSP00000302274

PTM databases

iPTMnetiQ9BXJ3
PhosphoSitePlusiQ9BXJ3

Polymorphism and mutation databases

BioMutaiC1QTNF4
DMDMi116241274

Proteomic databases

EPDiQ9BXJ3
jPOSTiQ9BXJ3
MassIVEiQ9BXJ3
PaxDbiQ9BXJ3
PeptideAtlasiQ9BXJ3
PRIDEiQ9BXJ3
ProteomicsDBi79435

Genome annotation databases

EnsembliENST00000302514; ENSP00000302274; ENSG00000172247
ENST00000642567; ENSP00000496508; ENSG00000284838
GeneIDi114900
KEGGihsa:114900
UCSCiuc001ngc.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114900
EuPathDBiHostDB:ENSG00000172247.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C1QTNF4
HGNCiHGNC:14346 C1QTNF4
HPAiHPA041032
MIMi614911 gene
neXtProtiNX_Q9BXJ3
NIAGADSiENSG00000172247
OpenTargetsiENSG00000172247
PharmGKBiPA25631

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFAJ Eukaryota
ENOG4111IFJ LUCA
GeneTreeiENSGT00940000161832
HOGENOMiHOG000072708
InParanoidiQ9BXJ3
OMAiLYSHQHD
OrthoDBi872445at2759
PhylomeDBiQ9BXJ3
TreeFamiTF329591

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114900
PharosiQ9BXJ3 Tbio

Protein Ontology

More...
PROi
PR:Q9BXJ3
RNActiQ9BXJ3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172247 Expressed in 111 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9BXJ3 baseline and differential
GenevisibleiQ9BXJ3 HS

Family and domain databases

Gene3Di2.60.120.40, 2 hits
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 2 hits
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 2 hits
SUPFAMiSSF49842 SSF49842, 2 hits
PROSITEiView protein in PROSITE
PS50871 C1Q, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC1QT4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXJ3
Secondary accession number(s): Q8IV25
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 17, 2006
Last modified: December 11, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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