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UniProtKB - Q9BXJ1 (C1QT1_HUMAN)
Protein
Complement C1q tumor necrosis factor-related protein 1
Gene
C1QTNF1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- collagen binding Source: UniProtKB
- identical protein binding Source: Ensembl
GO - Biological processi
- negative regulation of platelet activation Source: UniProtKB
- negative regulation of platelet aggregation Source: UniProtKB
- positive regulation of aldosterone secretion Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- regulation of glucose metabolic process Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9BXJ1 |
SignaLinki | Q9BXJ1 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C1q tumor necrosis factor-related protein 1Alternative name(s): G protein-coupled receptor-interacting protein Short name: GIP |
Gene namesi | Name:C1QTNF1 Synonyms:CTRP1 ORF Names:UNQ310/PRO353 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14324, C1QTNF1 |
MIMi | 610365, gene |
neXtProti | NX_Q9BXJ1 |
VEuPathDBi | HostDB:ENSG00000173918 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- collagen trimer Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 114897 |
OpenTargetsi | ENSG00000173918 |
PharmGKBi | PA25628 |
Miscellaneous databases
Pharosi | Q9BXJ1, Tbio |
Genetic variation databases
BioMutai | C1QTNF1 |
DMDMi | 20177862 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000003529 | 26 – 281 | Complement C1q tumor necrosis factor-related protein 1Add BLAST | 256 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9BXJ1 |
PaxDbi | Q9BXJ1 |
PeptideAtlasi | Q9BXJ1 |
PRIDEi | Q9BXJ1 |
ProteomicsDBi | 67870 79433 [Q9BXJ1-1] |
PTM databases
GlyGeni | Q9BXJ1, 1 site |
iPTMneti | Q9BXJ1 |
PhosphoSitePlusi | Q9BXJ1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173918, Expressed in left coronary artery and 195 other tissues |
ExpressionAtlasi | Q9BXJ1, baseline and differential |
Genevisiblei | Q9BXJ1, HS |
Organism-specific databases
HPAi | ENSG00000173918, Tissue enhanced (adipose tissue, heart muscle) |
Interactioni
Binary interactionsi
Q9BXJ1
With | #Exp. | IntAct |
---|---|---|
LNX1 [Q8TBB1] | 3 | EBI-750200,EBI-739832 |
PRPF31 [Q8WWY3] | 3 | EBI-750200,EBI-1567797 |
SGTA [O43765] | 4 | EBI-750200,EBI-347996 |
Isoform 2 [Q9BXJ1-2]
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 125388, 48 interactors |
IntActi | Q9BXJ1, 9 interactors |
STRINGi | 9606.ENSP00000340864 |
Miscellaneous databases
RNActi | Q9BXJ1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 140 | Collagen-likeAdd BLAST | 42 | |
Domaini | 141 – 281 | C1qPROSITE-ProRule annotationAdd BLAST | 141 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 34 – 68 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 100 – 138 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 62 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Collagen, SignalPhylogenomic databases
eggNOGi | ENOG502QT5D, Eukaryota |
GeneTreei | ENSGT00940000161333 |
InParanoidi | Q9BXJ1 |
OMAi | QCFRCCD |
OrthoDBi | 1136568at2759 |
PhylomeDBi | Q9BXJ1 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BXJ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSRGQGLLL AYCLLLAFAS GLVLSRVPHV QGEQQEWEGT EELPSPPDHA
60 70 80 90 100
ERAEEQHEKY RPSQDQGLPA SRCLRCCDPG TSMYPATAVP QINITILKGE
110 120 130 140 150
KGDRGDRGLQ GKYGKTGSAG ARGHTGPKGQ KGSMGAPGER CKSHYAAFSV
160 170 180 190 200
GRKKPMHSNH YYQTVIFDTE FVNLYDHFNM FTGKFYCYVP GLYFFSLNVH
210 220 230 240 250
TWNQKETYLH IMKNEEEVVI LFAQVGDRSI MQSQSLMLEL REQDQVWVRL
260 270 280
YKGERENAIF SEELDTYITF SGYLVKHATE P
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFP7 | A0A0C4DFP7_HUMAN | Complement C1q tumor necrosis facto... | C1QTNF1 | 199 | Annotation score: |
Sequence cautioni
The sequence AAG44303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC20425 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | L → P in CAC20425 (Ref. 1) Curated | 1 | |
Sequence conflicti | 22 | L → P in AAG44303 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068885 | 241 | R → Q1 PublicationCorresponds to variant dbSNP:rs35035542Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055570 | 1 | M → MMSATGPGRKM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ272138 mRNA Translation: CAC20425.1 Different initiation. AF232905 mRNA Translation: AAG44303.1 Different initiation. AF329840 mRNA Translation: AAK17964.1 AY358424 mRNA Translation: AAQ88790.1 AK055541 mRNA Translation: BAB70947.1 AK075175 mRNA Translation: BAC11451.1 AK172767 mRNA Translation: BAD18750.1 AC073624 Genomic DNA No translation available. BC021553 mRNA Translation: AAH21553.1 |
CCDSi | CCDS11761.1 [Q9BXJ1-1] |
RefSeqi | NP_112230.1, NM_030968.4 [Q9BXJ1-1] NP_699203.1, NM_153372.2 [Q9BXJ1-1] NP_940995.1, NM_198593.4 [Q9BXJ1-1] NP_940996.1, NM_198594.3 XP_006721729.1, XM_006721666.1 [Q9BXJ1-2] XP_016879615.1, XM_017024126.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ272138 mRNA Translation: CAC20425.1 Different initiation. AF232905 mRNA Translation: AAG44303.1 Different initiation. AF329840 mRNA Translation: AAK17964.1 AY358424 mRNA Translation: AAQ88790.1 AK055541 mRNA Translation: BAB70947.1 AK075175 mRNA Translation: BAC11451.1 AK172767 mRNA Translation: BAD18750.1 AC073624 Genomic DNA No translation available. BC021553 mRNA Translation: AAH21553.1 |
CCDSi | CCDS11761.1 [Q9BXJ1-1] |
RefSeqi | NP_112230.1, NM_030968.4 [Q9BXJ1-1] NP_699203.1, NM_153372.2 [Q9BXJ1-1] NP_940995.1, NM_198593.4 [Q9BXJ1-1] NP_940996.1, NM_198594.3 XP_006721729.1, XM_006721666.1 [Q9BXJ1-2] XP_016879615.1, XM_017024126.1 |
3D structure databases
AlphaFoldDBi | Q9BXJ1 |
SMRi | Q9BXJ1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125388, 48 interactors |
IntActi | Q9BXJ1, 9 interactors |
STRINGi | 9606.ENSP00000340864 |
PTM databases
GlyGeni | Q9BXJ1, 1 site |
iPTMneti | Q9BXJ1 |
PhosphoSitePlusi | Q9BXJ1 |
Genetic variation databases
BioMutai | C1QTNF1 |
DMDMi | 20177862 |
Proteomic databases
MassIVEi | Q9BXJ1 |
PaxDbi | Q9BXJ1 |
PeptideAtlasi | Q9BXJ1 |
PRIDEi | Q9BXJ1 |
ProteomicsDBi | 67870 79433 [Q9BXJ1-1] |
Protocols and materials databases
Antibodypediai | 19749, 283 antibodies from 34 providers |
DNASUi | 114897 |
Genome annotation databases
Organism-specific databases
CTDi | 114897 |
DisGeNETi | 114897 |
GeneCardsi | C1QTNF1 |
HGNCi | HGNC:14324, C1QTNF1 |
HPAi | ENSG00000173918, Tissue enhanced (adipose tissue, heart muscle) |
MIMi | 610365, gene |
neXtProti | NX_Q9BXJ1 |
OpenTargetsi | ENSG00000173918 |
PharmGKBi | PA25628 |
VEuPathDBi | HostDB:ENSG00000173918 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT5D, Eukaryota |
GeneTreei | ENSGT00940000161333 |
InParanoidi | Q9BXJ1 |
OMAi | QCFRCCD |
OrthoDBi | 1136568at2759 |
PhylomeDBi | Q9BXJ1 |
TreeFami | TF329591 |
Enzyme and pathway databases
PathwayCommonsi | Q9BXJ1 |
SignaLinki | Q9BXJ1 |
Miscellaneous databases
BioGRID-ORCSi | 114897, 14 hits in 1065 CRISPR screens |
ChiTaRSi | C1QTNF1, human |
GeneWikii | C1QTNF1 |
GenomeRNAii | 114897 |
Pharosi | Q9BXJ1, Tbio |
PROi | PR:Q9BXJ1 |
RNActi | Q9BXJ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173918, Expressed in left coronary artery and 195 other tissues |
ExpressionAtlasi | Q9BXJ1, baseline and differential |
Genevisiblei | Q9BXJ1, HS |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QT1_HUMAN | |
Accessioni | Q9BXJ1Primary (citable) accession number: Q9BXJ1 Secondary accession number(s): Q6ZMH6, Q96NF2, Q9GZR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot