UniProtKB - Q9BXI6 (TB10A_HUMAN)

BLAST

>sp|Q9BXI6|TB10A_HUMAN TBC1 domain family member 10A OS=Homo sapiens OX=9606 GN=TBC1D10A PE=1 SV=1
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGF
IVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRA
WQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLF
RVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQL
DGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGV
KIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQ
IEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG
SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSA
PQDLAPQVSAHHRSQESLTSQESEDTYL

Align

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 Jun 2001)
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Protein

TBC1 domain family member 10A

Gene

TBC1D10A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	156	Arginine fingerBy similarity		1
Siteⁱ	197	Glutamine fingerBy similarity		1

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
GTPase activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
PDZ domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11285285
Rab GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18387192
activation of GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of proteolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 18387192
retrograde transport, endosome to Golgi
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17562788

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation, Guanine-nucleotide releasing factor

Molecular function

GTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TBC1 domain family member 10A Alternative name(s): EBP50-PDX interactor of 64 kDa Short name: EPI64 protein Rab27A-GAP-alpha
Gene namesⁱ	Name:TBC1D10A Synonyms:EPI64, TBC1D10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099992.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23609 TBC1D10A
MIMⁱ	610020 gene
neXtProtⁱ	NX_Q9BXI6

Keywords - Cellular componentⁱ

Cell projection

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	157	D → A: Loss of activity. No effect on subcellular location. 1 Publication	1
Mutagenesisⁱ	160	R → K: Loss of activity. No effect on subcellular location. 1 Publication	1
Mutagenesisⁱ	508	L → LA: Loss of interaction with EBP50 and impaired subcellular localization. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000099992
PharmGKBⁱ	PA134888210

Polymorphism and mutation databases

BioMutaⁱ	TBC1D10A
DMDMⁱ	20454903

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208035	1 – 508	TBC1 domain family member 10AAdd BLAST		508

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	39	PhosphoserineBy similarity	1
Modified residueⁱ	40	PhosphoserineCombined sources	1
Modified residueⁱ	45	PhosphoserineBy similarity	1
Modified residueⁱ	407	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Exists in both phosphorylated and non-phosphorylated state.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BXI6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXI6
PaxDbⁱ	Q9BXI6
PeptideAtlas More...PeptideAtlasⁱ	Q9BXI6
PRIDEⁱ	Q9BXI6
ProteomicsDBⁱ	79427 79428 [Q9BXI6-2]

PTM databases

iPTMnetⁱ	Q9BXI6
PhosphoSitePlusⁱ	Q9BXI6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000099992 Expressed in 186 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_TBC1D10A
ExpressionAtlasⁱ	Q9BXI6 baseline and differential
Genevisibleⁱ	Q9BXI6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007725 HPA008142 HPA076041

HPAⁱ

HPA007725
HPA008142
HPA076041

Interactionⁱ

Subunit structureⁱ

Binds to the first PDZ domain of SLC9A3R1 and SLC9A3R2.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACD	Q96AP0	2	EBI-7815040,EBI-717666
TEX13A	Q9BXU3	5	EBI-7815040,EBI-10301068

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
PDZ domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11285285
Rab GTPase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123787, 19 interactors
IntActⁱ	Q9BXI6, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9BXI6
STRINGⁱ	9606.ENSP00000384996

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXI6
SMRⁱ	Q9BXI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	111 – 299	Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST		189

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	505 – 508	Binding to the PDZ domain of EBP50		4

Domainⁱ

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Phylogenomic databases

eggNOGⁱ	KOG2221 Eukaryota ENOG410XPSR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148983
HOGENOMⁱ	HOG000007561
HOVERGENⁱ	HBG070028
InParanoidⁱ	Q9BXI6
KEGG Orthology (KO) More...KOⁱ	K19944
OMAⁱ	QYETMER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07CB
PhylomeDBⁱ	Q9BXI6
TreeFamⁱ	TF313293

Family and domain databases

InterProⁱ	View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXI6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSNGENGP RAPAAGESLS GTRESLAQGP DAATTDELSS LGSDSEANGF 
        60         70         80         90        100
AERRIDKFGF IVGSQGAEGA LEEVPLEVLR QRESKWLDML NNWDKWMAKK 
       110        120        130        140        150
HKKIRLRCQK GIPPSLRGRA WQYLSGGKVK LQQNPGKFDE LDMSPGDPKW 
       160        170        180        190        200
LDVIERDLHR QFPFHEMFVS RGGHGQQDLF RVLKAYTLYR PEEGYCQAQA 
       210        220        230        240        250
PIAAVLLMHM PAEQAFWCLV QICEKYLPGY YSEKLEAIQL DGEILFSLLQ 
       260        270        280        290        300
KVSPVAHKHL SRQKIDPLLY MTEWFMCAFS RTLPWSSVLR VWDMFFCEGV 
       310        320        330        340        350
KIIFRVGLVL LKHALGSPEK VKACQGQYET IERLRSLSPK IMQEAFLVQE 
       360        370        380        390        400
VVELPVTERQ IEREHLIQLR RWQETRGELQ CRSPPRLHGA KAILDAEPGP 
       410        420        430        440        450
RPALQPSPSI RLPLDAPLPG SKAKPKPPKQ AQKEQRKQMK GRGQLEKPPA 
       460        470        480        490        500
PNQAMVVAAA GDACPPQHVP PKDSAPKDSA PQDLAPQVSA HHRSQESLTS 

QESEDTYL

Length:508

Mass (Da):57,118

Last modified:June 1, 2001 - v1

Checksum:ⁱ17BFAA85BE86DE84

Isoform 2 (identifier: Q9BXI6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
70-70: A → APCPLLHR

« Hide

        10         20         30         40         50
MAKSNGENGP RAPAAGESLS GTRESLAQGP DAATTDELSS LGSDSEANGF 
        60         70         80         90        100
AERRIDKFGF IVGSQGAEGA PCPLLHRLEE VPLEVLRQRE SKWLDMLNNW 
       110        120        130        140        150
DKWMAKKHKK IRLRCQKGIP PSLRGRAWQY LSGGKVKLQQ NPGKFDELDM 
       160        170        180        190        200
SPGDPKWLDV IERDLHRQFP FHEMFVSRGG HGQQDLFRVL KAYTLYRPEE 
       210        220        230        240        250
GYCQAQAPIA AVLLMHMPAE QAFWCLVQIC EKYLPGYYSE KLEAIQLDGE 
       260        270        280        290        300
ILFSLLQKVS PVAHKHLSRQ KIDPLLYMTE WFMCAFSRTL PWSSVLRVWD 
       310        320        330        340        350
MFFCEGVKII FRVGLVLLKH ALGSPEKVKA CQGQYETIER LRSLSPKIMQ 
       360        370        380        390        400
EAFLVQEVVE LPVTERQIER EHLIQLRRWQ ETRGELQCRS PPRLHGAKAI 
       410        420        430        440        450
LDAEPGPRPA LQPSPSIRLP LDAPLPGSKA KPKPPKQAQK EQRKQMKGRG 
       460        470        480        490        500
QLEKPPAPNQ AMVVAAAGDA CPPQHVPPKD SAPKDSAPQD LAPQVSAHHR 
       510 
SQESLTSQES EDTYL

Note: No experimental confirmation available.

Show »

Length:515

Mass (Da):57,935

Checksum:ⁱ5B94655DC0511B51

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MD46	B5MD46_HUMAN	TBC1 domain family member 10A TBC1 domain family member 10A (TBC1 domain family, member 10A, isoform CRA_e)	TBC1D10A hCG_41315	420	Annotation score:
F8W9Y7	F8W9Y7_HUMAN	TBC1 domain family member 10A TBC1 domain family member 10A	TBC1D10A	154	Annotation score:
F8WCD1	F8WCD1_HUMAN	TBC1 domain family member 10A TBC1 domain family member 10A	TBC1D10A	296	Annotation score:
F8WDN6	F8WDN6_HUMAN	TBC1 domain family member 10A TBC1 domain family member 10A	TBC1D10A	95	Annotation score:

Sequence cautionⁱ

The sequence AAC23434 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052541	411	R → H. Corresponds to variant dbSNP:rs4823086Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043119	70	A → APCPLLHR in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331038 mRNA Translation: AAK35048.1 AB449894 mRNA Translation: BAH16637.1 CT841514 mRNA Translation: CAJ86444.1 AK074656 mRNA Translation: BAC11117.1 AK127939 mRNA Translation: BAG54600.1 AC004997 Genomic DNA Translation: AAC23434.1 Sequence problems. CH471095 Genomic DNA Translation: EAW59874.1 CH471095 Genomic DNA Translation: EAW59876.1 BC136815 mRNA Translation: AAI36816.1 BC142940 mRNA Translation: AAI42941.1 BC150214 mRNA Translation: AAI50215.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13874.1 [Q9BXI6-1] CCDS56227.1 [Q9BXI6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191169.1, NM_001204240.1 [Q9BXI6-2] NP_114143.1, NM_031937.2 [Q9BXI6-1]
UniGeneⁱ	Hs.655273

Genome annotation databases

Ensemblⁱ	ENST00000215790; ENSP00000215790; ENSG00000099992 [Q9BXI6-1] ENST00000403477; ENSP00000384996; ENSG00000099992 [Q9BXI6-2]
GeneIDⁱ	83874
KEGGⁱ	hsa:83874
UCSC genome browser More...UCSCⁱ	uc003ahk.5 human [Q9BXI6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXI6	TBC1 domain family, member 10A		PANTR		508	UniRef100_Q9BXI6
Q9BXI6-2	TBC1 domain family member 10A		HUMAN		420	UniRef100_B5MD46
TBC1D10A isoform 4		PANTR		515
cDNA FLJ35912 fis, clone TESTI2010180, highly similar to TBC1 domain family member 10A		HUMAN		366
TBC1D10A isoform 5		PANTR		420

Protein	Similar proteins		Species	Score	Length	Source
Q9BXI6	TBC1 domain family, member 10A		PANTR		508	UniRef90_Q9BXI6
Uncharacterized protein		Cebus capucinus imitator		555
TBC1 domain family member 10A (Fragment)		NEOVI		113
Uncharacterized protein		PIG		545
Uncharacterized protein		SAIBB		522
+61

Protein	Similar proteins		Species	Score	Length	Source
Q9BXI6	TBC1 domain family member 10A		MOUSE		500	UniRef50_Q9BXI6
TBC1 domain family, member 10A		PANTR		508
Uncharacterized protein		Cebus capucinus imitator		555
TBC1 domain family member 10A (Fragment)		NEOVI		113
Uncharacterized protein		PIG		545
+206

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF331038 mRNA Translation: AAK35048.1 AB449894 mRNA Translation: BAH16637.1 CT841514 mRNA Translation: CAJ86444.1 AK074656 mRNA Translation: BAC11117.1 AK127939 mRNA Translation: BAG54600.1 AC004997 Genomic DNA Translation: AAC23434.1 Sequence problems. CH471095 Genomic DNA Translation: EAW59874.1 CH471095 Genomic DNA Translation: EAW59876.1 BC136815 mRNA Translation: AAI36816.1 BC142940 mRNA Translation: AAI42941.1 BC150214 mRNA Translation: AAI50215.1
CCDSⁱ	CCDS13874.1 [Q9BXI6-1] CCDS56227.1 [Q9BXI6-2]
RefSeqⁱ	NP_001191169.1, NM_001204240.1 [Q9BXI6-2] NP_114143.1, NM_031937.2 [Q9BXI6-1]
UniGeneⁱ	Hs.655273

3D structure databases

ProteinModelPortalⁱ	Q9BXI6
SMRⁱ	Q9BXI6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123787, 19 interactors
IntActⁱ	Q9BXI6, 5 interactors
MINTⁱ	Q9BXI6
STRINGⁱ	9606.ENSP00000384996

PTM databases

iPTMnetⁱ	Q9BXI6
PhosphoSitePlusⁱ	Q9BXI6

Polymorphism and mutation databases

BioMutaⁱ	TBC1D10A
DMDMⁱ	20454903

Proteomic databases

EPDⁱ	Q9BXI6
MaxQBⁱ	Q9BXI6
PaxDbⁱ	Q9BXI6
PeptideAtlasⁱ	Q9BXI6
PRIDEⁱ	Q9BXI6
ProteomicsDBⁱ	79427 79428 [Q9BXI6-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000215790; ENSP00000215790; ENSG00000099992 [Q9BXI6-1] ENST00000403477; ENSP00000384996; ENSG00000099992 [Q9BXI6-2]
GeneIDⁱ	83874
KEGGⁱ	hsa:83874
UCSCⁱ	uc003ahk.5 human [Q9BXI6-1]

Organism-specific databases

CTDⁱ	83874
EuPathDBⁱ	HostDB:ENSG00000099992.15
GeneCardsⁱ	TBC1D10A
HGNCⁱ	HGNC:23609 TBC1D10A
HPAⁱ	HPA007725 HPA008142 HPA076041
MIMⁱ	610020 gene
neXtProtⁱ	NX_Q9BXI6
OpenTargetsⁱ	ENSG00000099992
PharmGKBⁱ	PA134888210
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2221 Eukaryota ENOG410XPSR LUCA
GeneTreeⁱ	ENSGT00920000148983
HOGENOMⁱ	HOG000007561
HOVERGENⁱ	HBG070028
InParanoidⁱ	Q9BXI6
KOⁱ	K19944
OMAⁱ	QYETMER
OrthoDBⁱ	EOG091G07CB
PhylomeDBⁱ	Q9BXI6
TreeFamⁱ	TF313293

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8854214 TBC/RABGAPs

Reactomeⁱ

R-HSA-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSⁱ	TBC1D10A human
GeneWikiⁱ	TBC1D10A
GenomeRNAiⁱ	83874
Protein Ontology More...PROⁱ	PR:Q9BXI6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000099992 Expressed in 186 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_TBC1D10A
ExpressionAtlasⁱ	Q9BXI6 baseline and differential
Genevisibleⁱ	Q9BXI6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000195 Rab-GTPase-TBC_dom IPR035969 Rab-GTPase_TBC_sf
Pfamⁱ	View protein in Pfam PF00566 RabGAP-TBC, 1 hit
SMARTⁱ	View protein in SMART SM00164 TBC, 1 hit
SUPFAMⁱ	SSF47923 SSF47923, 2 hits
PROSITEⁱ	View protein in PROSITE PS50086 TBC_RABGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TB10A_HUMAN
Accessionⁱ	Q9BXI6Primary (citable) accession number: Q9BXI6 Secondary accession number(s): B3KXT8 , O76053, Q20WK7, Q543A2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9BXI6 (TB10A_HUMAN)

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TBC1 domain family member 10A

TBC1D10A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ