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Protein

Cytosolic 5'-nucleotidase 1A

Gene

NT5C1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.1 Publication

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactori

Activity regulationi

Activated by ADP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS04074-MONOMER
BRENDAi3.1.3.5 2681
ReactomeiR-HSA-73621 Pyrimidine catabolism
R-HSA-74259 Purine catabolism
SABIO-RKiQ9BXI3

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic 5'-nucleotidase 1A (EC:3.1.3.5)
Short name:
cN1A
Alternative name(s):
Cytosolic 5'-nucleotidase IA
Short name:
cN-I
Short name:
cN-IA
Gene namesi
Name:NT5C1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116981.3
HGNCiHGNC:17819 NT5C1A
MIMi610525 gene
neXtProtiNX_Q9BXI3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84618
OpenTargetsiENSG00000116981
PharmGKBiPA31799

Polymorphism and mutation databases

BioMutaiNT5C1A
DMDMi47116736

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447951 – 368Cytosolic 5'-nucleotidase 1AAdd BLAST368

Proteomic databases

PaxDbiQ9BXI3
PeptideAtlasiQ9BXI3
PRIDEiQ9BXI3
ProteomicsDBi79426

PTM databases

DEPODiQ9BXI3
iPTMnetiQ9BXI3
PhosphoSitePlusiQ9BXI3

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000116981 Expressed in 67 organ(s), highest expression level in muscle of leg
CleanExiHS_NT5C1A
GenevisibleiQ9BXI3 HS

Organism-specific databases

HPAiHPA050283
HPA054158

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
WDYHV1Q96HA84EBI-10441581,EBI-741158

Protein-protein interaction databases

BioGridi124149, 3 interactors
IntActiQ9BXI3, 2 interactors
STRINGi9606.ENSP00000235628

Structurei

3D structure databases

ProteinModelPortaliQ9BXI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 5'-nucleotidase type 3 family.Curated

Phylogenomic databases

eggNOGiENOG410IE01 Eukaryota
ENOG410XPRD LUCA
GeneTreeiENSGT00390000017767
HOGENOMiHOG000243802
HOVERGENiHBG101325
KOiK01081
OMAiQLDHENE
OrthoDBiEOG091G0EZE
PhylomeDBiQ9BXI3
TreeFamiTF329831

Family and domain databases

InterProiView protein in InterPro
IPR010394 5-nucleotidase
PANTHERiPTHR31367 PTHR31367, 1 hit
PfamiView protein in Pfam
PF06189 5-nucleotidase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXI3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGQPREPQ EPREPGPGAE TAAAPVWEEA KIFYDNLAPK KKPKSPKPQN
60 70 80 90 100
AVTIAVSSRA LFRMDEEQQI YTEQGVEEYV RYQLEHENEP FSPGPAFPFV
110 120 130 140 150
KALEAVNRRL RELYPDSEDV FDIVLMTNNH AQVGVRLINS INHYDLFIER
160 170 180 190 200
FCMTGGNSPI CYLKAYHTNL YLSADAEKVR EAIDEGIAAA TIFSPSRDVV
210 220 230 240 250
VSQSQLRVAF DGDAVLFSDE SERIVKAHGL DRFFEHEKAH ENKPLAQGPL
260 270 280 290 300
KGFLEALGRL QKKFYSKGLR LECPIRTYLV TARSAASSGA RALKTLRSWG
310 320 330 340 350
LETDEALFLA GAPKGPLLEK IRPHIFFDDQ MFHVAGAQEM GTVAAHVPYG
360
VAQTPRRTAP AKQAPSAQ
Length:368
Mass (Da):41,021
Last modified:June 1, 2001 - v1
Checksum:i7FB3CCEED50BA50D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 11Missing in AAK30000 (Ref. 2) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331801 mRNA Translation: AAK01294.1
AY028778 mRNA Translation: AAK30000.1
AL035404 Genomic DNA No translation available.
BC103879 mRNA Translation: AAI03880.1
BC103880 mRNA Translation: AAI03881.1
CCDSiCCDS440.1
RefSeqiNP_115915.1, NM_032526.2
UniGeneiHs.307006

Genome annotation databases

EnsembliENST00000235628; ENSP00000235628; ENSG00000116981
GeneIDi84618
KEGGihsa:84618
UCSCiuc001cdq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331801 mRNA Translation: AAK01294.1
AY028778 mRNA Translation: AAK30000.1
AL035404 Genomic DNA No translation available.
BC103879 mRNA Translation: AAI03880.1
BC103880 mRNA Translation: AAI03881.1
CCDSiCCDS440.1
RefSeqiNP_115915.1, NM_032526.2
UniGeneiHs.307006

3D structure databases

ProteinModelPortaliQ9BXI3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124149, 3 interactors
IntActiQ9BXI3, 2 interactors
STRINGi9606.ENSP00000235628

PTM databases

DEPODiQ9BXI3
iPTMnetiQ9BXI3
PhosphoSitePlusiQ9BXI3

Polymorphism and mutation databases

BioMutaiNT5C1A
DMDMi47116736

Proteomic databases

PaxDbiQ9BXI3
PeptideAtlasiQ9BXI3
PRIDEiQ9BXI3
ProteomicsDBi79426

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235628; ENSP00000235628; ENSG00000116981
GeneIDi84618
KEGGihsa:84618
UCSCiuc001cdq.1 human

Organism-specific databases

CTDi84618
DisGeNETi84618
EuPathDBiHostDB:ENSG00000116981.3
GeneCardsiNT5C1A
HGNCiHGNC:17819 NT5C1A
HPAiHPA050283
HPA054158
MIMi610525 gene
neXtProtiNX_Q9BXI3
OpenTargetsiENSG00000116981
PharmGKBiPA31799
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE01 Eukaryota
ENOG410XPRD LUCA
GeneTreeiENSGT00390000017767
HOGENOMiHOG000243802
HOVERGENiHBG101325
KOiK01081
OMAiQLDHENE
OrthoDBiEOG091G0EZE
PhylomeDBiQ9BXI3
TreeFamiTF329831

Enzyme and pathway databases

BioCyciMetaCyc:HS04074-MONOMER
BRENDAi3.1.3.5 2681
ReactomeiR-HSA-73621 Pyrimidine catabolism
R-HSA-74259 Purine catabolism
SABIO-RKiQ9BXI3

Miscellaneous databases

GenomeRNAii84618
PROiPR:Q9BXI3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116981 Expressed in 67 organ(s), highest expression level in muscle of leg
CleanExiHS_NT5C1A
GenevisibleiQ9BXI3 HS

Family and domain databases

InterProiView protein in InterPro
IPR010394 5-nucleotidase
PANTHERiPTHR31367 PTHR31367, 1 hit
PfamiView protein in Pfam
PF06189 5-nucleotidase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5NT1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BXI3
Secondary accession number(s): Q3SYB9, Q5TG98, Q9BWT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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