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Protein

Mitochondrial ornithine transporter 2

Gene

SLC25A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-70635 Urea cycle

Protein family/group databases

TCDBi2.A.29.19.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 2
Alternative name(s):
Solute carrier family 25 member 2
Gene namesi
Name:SLC25A2
Synonyms:ORNT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120329.6
HGNCiHGNC:22921 SLC25A2
MIMi608157 gene
neXtProtiNX_Q9BXI2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83884
OpenTargetsiENSG00000120329
PharmGKBiPA134910073

Chemistry databases

DrugBankiDB00129 L-Ornithine

Polymorphism and mutation databases

BioMutaiSLC25A2
DMDMi209572728

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906521 – 301Mitochondrial ornithine transporter 2Add BLAST301

Proteomic databases

PaxDbiQ9BXI2
PeptideAtlasiQ9BXI2
PRIDEiQ9BXI2
ProteomicsDBi79425

PTM databases

iPTMnetiQ9BXI2
PhosphoSitePlusiQ9BXI2

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas and cultured fibroblasts.

Gene expression databases

BgeeiENSG00000120329
CleanExiHS_SLC25A2
GenevisibleiQ9BXI2 HS

Organism-specific databases

HPAiHPA042146

Interactioni

Protein-protein interaction databases

BioGridi123796, 2 interactors
IntActiQ9BXI2, 1 interactor
STRINGi9606.ENSP00000239451

Structurei

3D structure databases

ProteinModelPortaliQ9BXI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 91Solcar 1Add BLAST85
Repeati104 – 197Solcar 2Add BLAST94
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0763 Eukaryota
ENOG410XNVH LUCA
GeneTreeiENSGT00730000110966
HOGENOMiHOG000168307
HOVERGENiHBG062630
InParanoidiQ9BXI2
KOiK15101
OMAiQIAPKGM
OrthoDBiEOG091G0HVE
PhylomeDBiQ9BXI2
TreeFamiTF314880

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9BXI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGPGIQAA IDLTAGAAGG TACVLTGQPF DTIKVKMQTF PDLYKGLTDC
60 70 80 90 100
FLKTYAQVGL RGFYKGTGPA LMAYVAENSV LFMCYGFCQQ FVRKVAGMDK
110 120 130 140 150
QAKLSDLQTA AAGSFASAFA ALALCPTELV KCRLQTMYEM EMSGKIAKSH
160 170 180 190 200
NTIWSVVKGI LKKDGPLGFY HGLSSTLLQE VPGYFFFFGG YELSRSFFAS
210 220 230 240 250
GRSKDELGPV HLMLSGGVAG ICLWLVVFPV DCIKSRIQVL SMYGKQAGFI
260 270 280 290 300
GTLLSVVRNE GIVALYSGLK ATMIRAIPAN GALFVAYEYS RKMMMKQLEA

Y
Length:301
Mass (Da):32,580
Last modified:October 14, 2008 - v3
Checksum:iF22760BADE31DE21
GO

Polymorphismi

Variant Cys-159 has a reduced ornithine transport activity, while variant Gly-181 has an increased activity.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017248159G → C2 PublicationsCorresponds to variant dbSNP:rs10075302Ensembl.1
Natural variantiVAR_017249181V → G1 PublicationCorresponds to variant dbSNP:rs3749779Ensembl.1
Natural variantiVAR_017250226V → I. Corresponds to variant dbSNP:rs3749780Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332005 mRNA Translation: AAK26320.1
AF378119 mRNA Translation: AAM94902.1
AY208943 mRNA Translation: AAO31753.1
CH471062 Genomic DNA Translation: EAW61967.1
BC069458 mRNA Translation: AAH69458.1
BC100935 mRNA Translation: AAI00936.1
BC100936 mRNA Translation: AAI00937.1
BC100937 mRNA Translation: AAI00938.1
CCDSiCCDS4258.1
RefSeqiNP_114153.1, NM_031947.3
UniGeneiHs.97647

Genome annotation databases

EnsembliENST00000239451; ENSP00000239451; ENSG00000120329
GeneIDi83884
KEGGihsa:83884
UCSCiuc003ljf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiORNT2_HUMAN
AccessioniPrimary (citable) accession number: Q9BXI2
Secondary accession number(s): Q496C1, Q6XUI0, Q8NFZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: October 14, 2008
Last modified: July 18, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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