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Protein

Rab11 family-interacting protein 5

Gene

RAB11FIP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.2 Publications

Miscellaneous

Antibodies against RIP11 are found in sera from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS). It is also found in the sera from mothers of children with neonatal lupus erythematosus (NLE).

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 5
Short name:
Rab11-FIP5
Alternative name(s):
Gamma-SNAP-associated factor 1
Short name:
Gaf-1
Phosphoprotein pp75
Rab11-interacting protein Rip11
Gene namesi
Name:RAB11FIP5
Synonyms:GAF1, KIAA0857, RIP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135631.15
HGNCiHGNC:24845 RAB11FIP5
MIMi605536 gene
neXtProtiNX_Q9BXF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi26056
OpenTargetsiENSG00000135631
PharmGKBiPA134971129

Polymorphism and mutation databases

BioMutaiRAB11FIP5
DMDMi34223002

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973071 – 653Rab11 family-interacting protein 5Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphoserineCombined sources1
Modified residuei283PhosphoserineBy similarity1
Modified residuei286PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei494PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei547PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXF6
MaxQBiQ9BXF6
PaxDbiQ9BXF6
PeptideAtlasiQ9BXF6
PRIDEiQ9BXF6
ProteomicsDBi79420

PTM databases

iPTMnetiQ9BXF6
PhosphoSitePlusiQ9BXF6

Expressioni

Tissue specificityi

Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000135631 Expressed in 227 organ(s), highest expression level in testis
CleanExiHS_RAB11FIP5
ExpressionAtlasiQ9BXF6 baseline and differential
GenevisibleiQ9BXF6 HS

Organism-specific databases

HPAiHPA036406
HPA036407

Interactioni

Subunit structurei

Forms a heterooligomeric complex with RAB11FIP4. Binds NAPG and TROVE2. Binds RAB11A that has been activated by GTP binding.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117518, 33 interactors
IntActiQ9BXF6, 22 interactors
MINTiQ9BXF6
STRINGi9606.ENSP00000258098

Structurei

3D structure databases

ProteinModelPortaliQ9BXF6
SMRiQ9BXF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 128C2PROSITE-ProRule annotationAdd BLAST123
Domaini586 – 648FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Domaini

Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg2+ rather than Ca2+.

Phylogenomic databases

eggNOGiENOG410IJ70 Eukaryota
ENOG410XQK9 LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG079127
InParanoidiQ9BXF6
KOiK12484
OrthoDBiEOG091G09IV
PhylomeDBiQ9BXF6
TreeFamiTF326172

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BXF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVRGAEPA AGPSRWLPTH VQVTVLRARG LRGKSSGAGS TSDAYTVIQV
60 70 80 90 100
GREKYSTSVV EKTHGCPEWR EECSFELPPG ALDGLLRAQE ADAGPAPWAA
110 120 130 140 150
SSAAACELVL TTMHRSLIGV DKFLGQATVA LDEVFGAGRA QHTQWYKLHS
160 170 180 190 200
KPGKKEKERG EIEVTIQFTR NNLSASMFDL SMKDKPRSPF SKIRDKMKGK
210 220 230 240 250
KKYDLESASA ILPSSAIEDP DLGSLGKMGK AKGFFLRNKL RKSSLTQSNT
260 270 280 290 300
SLGSDSTLSS ASGSLAYQGP GAELLTRSPS RSSWLSTEGG RDSAQSPKLF
310 320 330 340 350
THKRTYSDEA NQMRVAPPRA LLDLQGHLDA ASRSSLCVNG SHIYNEEPQG
360 370 380 390 400
PVRHRSSISG SLPSSGSLQA VSSRFSEEGP RSTDDTWPRG SRSNSSSEAV
410 420 430 440 450
LGQEELSAQA KVLAPGASHP GEEEGARLPE GKPVQVATPI VASSEAVAEK
460 470 480 490 500
EGARKEERKP RMGLFHHHHQ GLSRSELGRR SSLGEKGGPI LGASPHHSSS
510 520 530 540 550
GEEKAKSSWF GLREAKDPTQ KPSPHPVKPL SAAPVEGSPD RKQSRSSLSI
560 570 580 590 600
ALSSGLEKLK TVTSGSIQPV TQAPQAGQMV DTKRLKDSAV LDQSAKYYHL
610 620 630 640 650
THDELISLLL QRERELSQRD EHVQELESYI DRLLVRIMET SPTLLQIPPG

PPK
Length:653
Mass (Da):70,415
Last modified:June 1, 2001 - v1
Checksum:i716725537AA9D86E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTL5A0A1B0GTL5_HUMAN
Rab11 family-interacting protein 5
RAB11FIP5
1,324Annotation score:

Sequence cautioni

The sequence BAA74880 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176Missing in AAH35013 (PubMed:15489334).Curated1
Sequence conflicti503E → G in AAH35013 (PubMed:15489334).Curated1
Sequence conflicti599H → N in AAH35013 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334812 mRNA Translation: AAK20892.1
AB020664 mRNA Translation: BAA74880.1 Different initiation.
BC035013 mRNA Translation: AAH35013.1
AF153085 mRNA Translation: AAF34356.1
CCDSiCCDS1923.1
PIRiT17312
RefSeqiNP_056285.1, NM_015470.2
UniGeneiHs.24557

Genome annotation databases

EnsembliENST00000258098; ENSP00000258098; ENSG00000135631
GeneIDi26056
KEGGihsa:26056
UCSCiuc002siu.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334812 mRNA Translation: AAK20892.1
AB020664 mRNA Translation: BAA74880.1 Different initiation.
BC035013 mRNA Translation: AAH35013.1
AF153085 mRNA Translation: AAF34356.1
CCDSiCCDS1923.1
PIRiT17312
RefSeqiNP_056285.1, NM_015470.2
UniGeneiHs.24557

3D structure databases

ProteinModelPortaliQ9BXF6
SMRiQ9BXF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117518, 33 interactors
IntActiQ9BXF6, 22 interactors
MINTiQ9BXF6
STRINGi9606.ENSP00000258098

PTM databases

iPTMnetiQ9BXF6
PhosphoSitePlusiQ9BXF6

Polymorphism and mutation databases

BioMutaiRAB11FIP5
DMDMi34223002

Proteomic databases

EPDiQ9BXF6
MaxQBiQ9BXF6
PaxDbiQ9BXF6
PeptideAtlasiQ9BXF6
PRIDEiQ9BXF6
ProteomicsDBi79420

Protocols and materials databases

DNASUi26056
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258098; ENSP00000258098; ENSG00000135631
GeneIDi26056
KEGGihsa:26056
UCSCiuc002siu.4 human

Organism-specific databases

CTDi26056
DisGeNETi26056
EuPathDBiHostDB:ENSG00000135631.15
GeneCardsiRAB11FIP5
HGNCiHGNC:24845 RAB11FIP5
HPAiHPA036406
HPA036407
MIMi605536 gene
neXtProtiNX_Q9BXF6
OpenTargetsiENSG00000135631
PharmGKBiPA134971129
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ70 Eukaryota
ENOG410XQK9 LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG079127
InParanoidiQ9BXF6
KOiK12484
OrthoDBiEOG091G09IV
PhylomeDBiQ9BXF6
TreeFamiTF326172

Miscellaneous databases

ChiTaRSiRAB11FIP5 human
GeneWikiiRAB11FIP5
GenomeRNAii26056
PROiPR:Q9BXF6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135631 Expressed in 227 organ(s), highest expression level in testis
CleanExiHS_RAB11FIP5
ExpressionAtlasiQ9BXF6 baseline and differential
GenevisibleiQ9BXF6 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFIP5_HUMAN
AccessioniPrimary (citable) accession number: Q9BXF6
Secondary accession number(s): O94939, Q9P0M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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