NPL

Functionⁱ

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).By similarity

Catalytic activityⁱ

N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

Pathwayⁱ: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	143	Involved in proton transfer during cleavageBy similarity		1
Active siteⁱ	173	Schiff-base intermediate with substrateBy similarity		1

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
N-acetylneuraminate lyase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: UniProtKB-KW
N-acetylneuraminate catabolic process
Source: UniProtKB
Traceable author statementⁱ
- 22692205

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Carbohydrate metabolism
Ligand	Schiff base

Enzyme and pathway databases

BRENDAⁱ	4.1.3.3 2681
Reactomeⁱ	R-HSA-4085001 Sialic acid metabolism
UniPathwayⁱ	UPA00629

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-acetylneuraminate lyase (EC:4.1.3.3) Short name: NALase Alternative name(s): N-acetylneuraminate pyruvate-lyase N-acetylneuraminic acid aldolase Sialate lyase Sialate-pyruvate lyase Sialic acid aldolase Sialic acid lyase
Gene namesⁱ	Name:NPL Synonyms:C1orf13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135838.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16781 NPL
MIMⁱ	611412 gene
neXtProtⁱ	NX_Q9BXD5

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80896
Open Targets More...OpenTargetsⁱ	ENSG00000135838
PharmGKBⁱ	PA25602

Polymorphism and mutation databases

BioMutaⁱ	NPL
DMDMⁱ	74752428

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000273352	1 – 320	N-acetylneuraminate lyaseAdd BLAST		320

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BXD5
PaxDbⁱ	Q9BXD5
PeptideAtlas More...PeptideAtlasⁱ	Q9BXD5
PRIDEⁱ	Q9BXD5
ProteomicsDBⁱ	79405 79406 [Q9BXD5-2] 79407 [Q9BXD5-3] 79408 [Q9BXD5-4] 79409 [Q9BXD5-5]

PTM databases

iPTMnetⁱ	Q9BXD5
PhosphoSitePlusⁱ	Q9BXD5

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135838 Expressed in 190 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_NPL
ExpressionAtlasⁱ	Q9BXD5 baseline and differential
Genevisibleⁱ	Q9BXD5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028345

HPAⁱ

HPA028345

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-10287915,EBI-10287915
WDYHV1	Q96HA8	3	EBI-10287915,EBI-741158

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123344, 5 interactors
IntActⁱ	Q9BXD5, 1 interactor
STRINGⁱ	9606.ENSP00000258317

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BXD5
SMRⁱ	Q9BXD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	51 – 52	Substrate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the DapA family. NanA subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IGJ4 Eukaryota COG0329 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063604
HOGENOMⁱ	HOG000218206
HOVERGENⁱ	HBG082055
InParanoidⁱ	Q9BXD5
KEGG Orthology (KO) More...KOⁱ	K01639
OMAⁱ	SALNHQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AT4
PhylomeDBⁱ	Q9BXD5
TreeFamⁱ	TF353639

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00954 NAL, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR002220 DapA-like IPR005264 NanA
PANTHERⁱ	PTHR12128 PTHR12128, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00701 DHDPS, 1 hit
PIRSFⁱ	PIRSF001365 DHDPS, 1 hit
PRINTSⁱ	PR00146 DHPICSNTHASE
SMARTⁱ	View protein in SMART SM01130 DHDPS, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BXD5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG 
        60         70         80         90        100
TTGEGLSLSV SERRQVAEEW VTKGKDKLDQ VIIHVGALSL KESQELAQHA 
       110        120        130        140        150
AEIGADGIAV IAPFFLKPWT KDILINFLKE VAAAAPALPF YYYHIPALTG 
       160        170        180        190        200
VKIRAEELLD GILDKIPTFQ GLKFSDTDLL DFGQCVDQNR QQQFAFLFGV 
       210        220        230        240        250
DEQLLSALVM GATGAVGSTY NYLGKKTNQM LEAFEQKDFS LALNYQFCIQ 
       260        270        280        290        300
RFINFVVKLG FGVSQTKAIM TLVSGIPMGP PRLPLQKASR EFTDSAEAKL 
       310        320
KSLDFLSFTD LKDGNLEAGS

Length:320

Mass (Da):35,163

Last modified:June 1, 2001 - v1

Checksum:ⁱFC0EBA9B05FE9E62

GO

Isoform 2 (identifier: Q9BXD5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-77: MAFPKKKLQG...EEWVTKGKDK → MSRAPGILAS...LTVTRLWAER

« Hide

        10         20         30         40         50
MSRAPGILAS WRRAPSLSVQ KGSQTARHTC HPEVPLGNCF LPVYKASPLT 
        60         70         80         90        100
VTRLWAERLD QVIIHVGALS LKESQELAQH AAEIGADGIA VIAPFFLKPW 
       110        120        130        140        150
TKDILINFLK EVAAAAPALP FYYYHIPALT GVKIRAEELL DGILDKIPTF 
       160        170        180        190        200
QGLKFSDTDL LDFGQCVDQN RQQQFAFLFG VDEQLLSALV MGATGAVGST 
       210        220        230        240        250
YNYLGKKTNQ MLEAFEQKDF SLALNYQFCI QRFINFVVKL GFGVSQTKAI 
       260        270        280        290        300
MTLVSGIPMG PPRLPLQKAS REFTDSAEAK LKSLDFLSFT DLKDGNLEAG 

S

Show »

Length:301

Mass (Da):33,117

Checksum:ⁱD7168A22A2A7CD14

GO

Isoform 3 (identifier: Q9BXD5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
260-320: GFGVSQTKAI...LKDGNLEAGS → ENSKLKVSKNQRTLPLGTTNFPFLH

« Hide

        10         20         30         40         50
MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG 
        60         70         80         90        100
TTGEGLSLSV SERRQVAEEW VTKGKDKLDQ VIIHVGALSL KESQELAQHA 
       110        120        130        140        150
AEIGADGIAV IAPFFLKPWT KDILINFLKE VAAAAPALPF YYYHIPALTG 
       160        170        180        190        200
VKIRAEELLD GILDKIPTFQ GLKFSDTDLL DFGQCVDQNR QQQFAFLFGV 
       210        220        230        240        250
DEQLLSALVM GATGAVGSTY NYLGKKTNQM LEAFEQKDFS LALNYQFCIQ 
       260        270        280 
RFINFVVKLE NSKLKVSKNQ RTLPLGTTNF PFLH

Note: No experimental confirmation available.

Show »

Length:284

Mass (Da):31,562

Checksum:ⁱ949BD9DA5FA2DB5C

GO

Isoform 4 (identifier: Q9BXD5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
203-246: Missing.
260-320: GFGVSQTKAI...LKDGNLEAGS → ENSKLKVSKNQRTLPLGTTNFPFLH

« Hide

        10         20         30         40         50
MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG 
        60         70         80         90        100
TTGEGLSLSV SERRQVAEEW VTKGKDKLDQ VIIHVGALSL KESQELAQHA 
       110        120        130        140        150
AEIGADGIAV IAPFFLKPWT KDILINFLKE VAAAAPALPF YYYHIPALTG 
       160        170        180        190        200
VKIRAEELLD GILDKIPTFQ GLKFSDTDLL DFGQCVDQNR QQQFAFLFGV 
       210        220        230        240
DEFCIQRFIN FVVKLENSKL KVSKNQRTLP LGTTNFPFLH

Note: No experimental confirmation available.

Show »

Length:240

Mass (Da):26,765

Checksum:ⁱ2DAC394E4ACB1943

GO

Isoform 5 (identifier: Q9BXD5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
78-109: LDQVIIHVGALSLKESQELAQHAAEIGADGIA → SNHHKLGTIRTTQSRQSSFRRQLKAWHSGSHL
110-320: Missing.

« Hide

        10         20         30         40         50
MAFPKKKLQG LVAATITPMT ENGEINFSVI GQYVDYLVKE QGVKNIFVNG 
        60         70         80         90        100
TTGEGLSLSV SERRQVAEEW VTKGKDKSNH HKLGTIRTTQ SRQSSFRRQL 

KAWHSGSHL

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:109

Mass (Da):12,201

Checksum:ⁱ3FEC87DFA591B0E1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WZ70	A0A087WZ70_HUMAN		N-acetylneuraminate lyase N-acetylneuraminate lyase	NPL	230	Annotation score:

Sequence cautionⁱ

The sequence BC042003 differs from that shown. Reason: Frameshift at position 213.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	4	P → S in BC034966 (PubMed:15489334).Curated	1
Sequence conflictⁱ	98	Q → E in BC042003 (PubMed:15489334).Curated	1
Sequence conflictⁱ	212	A → E in BC042003 (PubMed:15489334).Curated	1
Sequence conflictⁱ	260	G → V in BAG36036 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_022518	1 – 77	MAFPK…KGKDK → MSRAPGILASWRRAPSLSVQ KGSQTARHTCHPEVPLGNCF LPVYKASPLTVTRLWAER in isoform 2. 1 PublicationAdd BLAST	77
Alternative sequenceⁱVSP_022519	78 – 109	LDQVI…ADGIA → SNHHKLGTIRTTQSRQSSFR RQLKAWHSGSHL in isoform 5. 1 PublicationAdd BLAST	32
Alternative sequenceⁱVSP_022520	110 – 320	Missing in isoform 5. 1 PublicationAdd BLAST	211
Alternative sequenceⁱVSP_022521	203 – 246	Missing in isoform 4. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_022522	260 – 320	GFGVS…LEAGS → ENSKLKVSKNQRTLPLGTTN FPFLH in isoform 3 and isoform 4. 1 PublicationAdd BLAST	61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF338436 mRNA Translation: AAK25795.1 AY336748 mRNA Translation: AAQ82432.1 AK313225 mRNA Translation: BAG36036.1 AL355999 Genomic DNA No translation available. AL513344 Genomic DNA No translation available. BC034966 mRNA No translation available. BC042003 mRNA No translation available. BC058003 mRNA Translation: AAH58003.1 BC125051 mRNA Translation: AAI25052.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1350.1 [Q9BXD5-1] CCDS55666.1 [Q9BXD5-4] CCDS55667.1 [Q9BXD5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001186979.1, NM_001200050.1 [Q9BXD5-2] NP_001186980.1, NM_001200051.1 [Q9BXD5-4] NP_001186985.1, NM_001200056.1 [Q9BXD5-3] NP_110396.1, NM_030769.2 [Q9BXD5-1]
UniGeneⁱ	Hs.496969 Hs.731792

Genome annotation databases

Ensemblⁱ	ENST00000258317; ENSP00000258317; ENSG00000135838 [Q9BXD5-1] ENST00000367552; ENSP00000356523; ENSG00000135838 [Q9BXD5-4] ENST00000367553; ENSP00000356524; ENSG00000135838 [Q9BXD5-1] ENST00000367554; ENSP00000356525; ENSG00000135838 [Q9BXD5-2] ENST00000367555; ENSP00000356526; ENSG00000135838 [Q9BXD5-4]
GeneIDⁱ	80896
KEGGⁱ	hsa:80896
UCSC genome browser More...UCSCⁱ	uc001gpo.2 human [Q9BXD5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BXD5-3	N-acetylneuraminate pyruvate lyase (Dihydrodipicolinate synthase)		PANTR		296	UniRef100_G2HFT8
Q9BXD5-4	N-acetylneuraminate pyruvate lyase (Fragment)		PANTR		241	UniRef100_Q9BXD5-4
UPI0000E1EE84		PANPA		252

Protein	Similar proteins		Species	Score	Length	Source
Q9BXD5	Uncharacterized protein		CHLSB		343	UniRef90_Q9BXD5
Uncharacterized protein		PANPA		331
Uncharacterized protein		PAPAN		285
Uncharacterized protein		CERAT		285
Uncharacterized protein		MACMU		285
+4
Q9BXD5-2	Uncharacterized protein		CALJA		301	UniRef90_Q9BXD5-2
Uncharacterized protein		NOMLE		301
N-acetylneuraminate pyruvate lyase		PANTR		301
N-acetylneuraminate pyruvate lyase		SAIBB		301
NPL isoform 2		PONAB		301
+20
Q9BXD5-3	Uncharacterized protein		PANPA		291	UniRef90_A0A2R9CKV6
N-acetylneuraminate pyruvate lyase (Dihydrodipicolinate synthase)		PANTR		296
Q9BXD5-4	N-acetylneuraminate pyruvate lyase (Fragment)		PANTR		241	UniRef90_Q9BXD5-4
NPL isoform 11		PONAB		240
Uncharacterized protein		NOMLE		240
Uncharacterized protein		FELCA		240
Uncharacterized protein		Cebus capucinus imitator		240
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9BXD5	N-acetylneuraminate lyase		RAT		320	UniRef50_Q9BXD5
N-acetylneuraminate lyase		MOUSE		320
Uncharacterized protein		CHLSB		343
Uncharacterized protein		PANPA		331
Uncharacterized protein		MACMU		285
+106
Q9BXD5-3	N-acetylneuraminate lyase		CHICK		308	UniRef50_Q5ZKD4
N-acetylneuraminate lyase		XENTR		305
N-acetylneuraminate lyase		NIPNI		308
N-acetylneuraminate lyase		CHAVO		308
N-acetylneuraminate pyruvate lyase (Dihydrodipicolinate synthase)		COLLI		308
+163
Q9BXD5-4	N-acetylneuraminate pyruvate lyase (Fragment)		PANTR		241	UniRef50_Q9BXD5-4
NPL isoform 11		PONAB		240
Uncharacterized protein		FELCA		240
Uncharacterized protein		Cebus capucinus imitator		240
Uncharacterized protein		NOMLE		240
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF338436 mRNA Translation: AAK25795.1 AY336748 mRNA Translation: AAQ82432.1 AK313225 mRNA Translation: BAG36036.1 AL355999 Genomic DNA No translation available. AL513344 Genomic DNA No translation available. BC034966 mRNA No translation available. BC042003 mRNA No translation available. BC058003 mRNA Translation: AAH58003.1 BC125051 mRNA Translation: AAI25052.1
CCDSⁱ	CCDS1350.1 [Q9BXD5-1] CCDS55666.1 [Q9BXD5-4] CCDS55667.1 [Q9BXD5-2]
RefSeqⁱ	NP_001186979.1, NM_001200050.1 [Q9BXD5-2] NP_001186980.1, NM_001200051.1 [Q9BXD5-4] NP_001186985.1, NM_001200056.1 [Q9BXD5-3] NP_110396.1, NM_030769.2 [Q9BXD5-1]
UniGeneⁱ	Hs.496969 Hs.731792

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6ARH	X-ray	1.60	A/B/C/D	1-320	[»]
ProteinModelPortalⁱ	Q9BXD5
SMRⁱ	Q9BXD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123344, 5 interactors
IntActⁱ	Q9BXD5, 1 interactor
STRINGⁱ	9606.ENSP00000258317

PTM databases

iPTMnetⁱ	Q9BXD5
PhosphoSitePlusⁱ	Q9BXD5

Polymorphism and mutation databases

BioMutaⁱ	NPL
DMDMⁱ	74752428

Proteomic databases

MaxQBⁱ	Q9BXD5
PaxDbⁱ	Q9BXD5
PeptideAtlasⁱ	Q9BXD5
PRIDEⁱ	Q9BXD5
ProteomicsDBⁱ	79405 79406 [Q9BXD5-2] 79407 [Q9BXD5-3] 79408 [Q9BXD5-4] 79409 [Q9BXD5-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000258317; ENSP00000258317; ENSG00000135838 [Q9BXD5-1] ENST00000367552; ENSP00000356523; ENSG00000135838 [Q9BXD5-4] ENST00000367553; ENSP00000356524; ENSG00000135838 [Q9BXD5-1] ENST00000367554; ENSP00000356525; ENSG00000135838 [Q9BXD5-2] ENST00000367555; ENSP00000356526; ENSG00000135838 [Q9BXD5-4]
GeneIDⁱ	80896
KEGGⁱ	hsa:80896
UCSCⁱ	uc001gpo.2 human [Q9BXD5-1]

Organism-specific databases

CTDⁱ	80896
DisGeNETⁱ	80896
EuPathDBⁱ	HostDB:ENSG00000135838.13
GeneCardsⁱ	NPL
HGNCⁱ	HGNC:16781 NPL
HPAⁱ	HPA028345
MIMⁱ	611412 gene
neXtProtⁱ	NX_Q9BXD5
OpenTargetsⁱ	ENSG00000135838
PharmGKBⁱ	PA25602
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGJ4 Eukaryota COG0329 LUCA
GeneTreeⁱ	ENSGT00530000063604
HOGENOMⁱ	HOG000218206
HOVERGENⁱ	HBG082055
InParanoidⁱ	Q9BXD5
KOⁱ	K01639
OMAⁱ	SALNHQF
OrthoDBⁱ	EOG091G0AT4
PhylomeDBⁱ	Q9BXD5
TreeFamⁱ	TF353639

Enzyme and pathway databases

UniPathwayⁱ	UPA00629
BRENDAⁱ	4.1.3.3 2681
Reactomeⁱ	R-HSA-4085001 Sialic acid metabolism

Miscellaneous databases

ChiTaRSⁱ	NPL human
GenomeRNAiⁱ	80896
Protein Ontology More...PROⁱ	PR:Q9BXD5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135838 Expressed in 190 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_NPL
ExpressionAtlasⁱ	Q9BXD5 baseline and differential
Genevisibleⁱ	Q9BXD5 HS

Family and domain databases

CDDⁱ	cd00954 NAL, 1 hit
Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR002220 DapA-like IPR005264 NanA
PANTHERⁱ	PTHR12128 PTHR12128, 1 hit
Pfamⁱ	View protein in Pfam PF00701 DHDPS, 1 hit
PIRSFⁱ	PIRSF001365 DHDPS, 1 hit
PRINTSⁱ	PR00146 DHPICSNTHASE
SMARTⁱ	View protein in SMART SM01130 DHDPS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPL_HUMAN
Accessionⁱ	Q9BXD5Primary (citable) accession number: Q9BXD5 Secondary accession number(s): B2R839 , Q4G0Q8, Q4G0Z2, Q64L88, Q6PEL0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
	Last sequence update:	June 1, 2001
	Last modified:	October 10, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9BXD5 (NPL_HUMAN)

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N-acetylneuraminate lyase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: N-acetylneuraminate degradation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: N-acetylneuraminate degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ