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Protein

Hydroxycarboxylic acid receptor 1

Gene

HCAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

TCDBi9.A.14.13.4 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 1
Alternative name(s):
G-protein coupled receptor 104
G-protein coupled receptor 81
Gene namesi
Name:HCAR1
Synonyms:GPR104, GPR81, HCA1
ORF Names:FKSG80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000196917.5
HGNCiHGNC:4532 HCAR1
MIMi606923 gene
neXtProtiNX_Q9BXC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 49CytoplasmicSequence analysis7
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 89ExtracellularSequence analysisAdd BLAST19
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 130CytoplasmicSequence analysisAdd BLAST20
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 182ExtracellularSequence analysisAdd BLAST31
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 220CytoplasmicSequence analysisAdd BLAST17
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 261ExtracellularSequence analysisAdd BLAST20
Transmembranei262 – 281Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini282 – 346CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi233Y → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi240R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi267T → A: Diminishes the response to L-lactate. 1 Publication1

Organism-specific databases

DisGeNETi27198
OpenTargetsiENSG00000196917
PharmGKBiPA28925

Chemistry databases

ChEMBLiCHEMBL1075101
GuidetoPHARMACOLOGYi311

Polymorphism and mutation databases

BioMutaiHCAR1
DMDMi47117701

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695861 – 346Hydroxycarboxylic acid receptor 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 165PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXC0
PeptideAtlasiQ9BXC0
PRIDEiQ9BXC0
ProteomicsDBi79402

PTM databases

PhosphoSitePlusiQ9BXC0

Expressioni

Tissue specificityi

Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.2 Publications

Gene expression databases

BgeeiENSG00000196917 Expressed in 56 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_GPR81
GenevisibleiQ9BXC0 HS

Interactioni

Protein-protein interaction databases

BioGridi118073, 5 interactors
IntActiQ9BXC0, 1 interactor
STRINGi9606.ENSP00000349478

Chemistry databases

BindingDBiQ9BXC0

Structurei

3D structure databases

ProteinModelPortaliQ9BXC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00510000046798
HOVERGENiHBG051680
InParanoidiQ9BXC0
KOiK08401
OMAiQLEFFLP
OrthoDBiEOG091G0AN6
PhylomeDBiQ9BXC0
TreeFamiTF330775

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028016 HCAR1_rcpt
PANTHERiPTHR24231:SF29 PTHR24231:SF29, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS
60 70 80 90 100
TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA
110 120 130 140 150
GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL
160 170 180 190 200
LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV
210 220 230 240 250
WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS
260 270 280 290 300
ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK
310 320 330 340
QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH
Length:346
Mass (Da):39,295
Last modified:June 1, 2001 - v1
Checksum:iE0DB114EEB3A47A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38C → Y in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti113R → K in AAH66883 (PubMed:15489334).Curated1
Sequence conflicti187M → I in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti213A → T in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti222I → T in AAH95506 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02515143H → Q1 PublicationCorresponds to variant dbSNP:rs35292336Ensembl.1
Natural variantiVAR_025152253D → E1 Publication1
Natural variantiVAR_061218253D → H. Corresponds to variant dbSNP:rs36124671Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411110 Genomic DNA Translation: AAL26481.1
EU809458 mRNA Translation: ACJ03844.1
AF345568 mRNA Translation: AAK29071.1
AB065866 Genomic DNA Translation: BAC06084.1
AY507143 mRNA Translation: AAR92485.1
AK313955 mRNA Translation: BAG36671.1
AB083631 Genomic DNA Translation: BAB89344.1
DQ157221 Genomic DNA Translation: AAZ67915.1
AC026333 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98337.1
BC066881 mRNA Translation: AAH66881.1
BC066882 mRNA Translation: AAH66882.1
BC066883 mRNA Translation: AAH66883.1
BC067484 mRNA Translation: AAH67484.1
BC095506 mRNA Translation: AAH95506.1
CCDSiCCDS9236.1
RefSeqiNP_115943.1, NM_032554.3
UniGeneiHs.610873
Hs.711001

Genome annotation databases

EnsembliENST00000432564; ENSP00000389255; ENSG00000196917
GeneIDi27198
KEGGihsa:27198
UCSCiuc001ucz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411110 Genomic DNA Translation: AAL26481.1
EU809458 mRNA Translation: ACJ03844.1
AF345568 mRNA Translation: AAK29071.1
AB065866 Genomic DNA Translation: BAC06084.1
AY507143 mRNA Translation: AAR92485.1
AK313955 mRNA Translation: BAG36671.1
AB083631 Genomic DNA Translation: BAB89344.1
DQ157221 Genomic DNA Translation: AAZ67915.1
AC026333 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98337.1
BC066881 mRNA Translation: AAH66881.1
BC066882 mRNA Translation: AAH66882.1
BC066883 mRNA Translation: AAH66883.1
BC067484 mRNA Translation: AAH67484.1
BC095506 mRNA Translation: AAH95506.1
CCDSiCCDS9236.1
RefSeqiNP_115943.1, NM_032554.3
UniGeneiHs.610873
Hs.711001

3D structure databases

ProteinModelPortaliQ9BXC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118073, 5 interactors
IntActiQ9BXC0, 1 interactor
STRINGi9606.ENSP00000349478

Chemistry databases

BindingDBiQ9BXC0
ChEMBLiCHEMBL1075101
GuidetoPHARMACOLOGYi311

Protein family/group databases

TCDBi9.A.14.13.4 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9BXC0

Polymorphism and mutation databases

BioMutaiHCAR1
DMDMi47117701

Proteomic databases

PaxDbiQ9BXC0
PeptideAtlasiQ9BXC0
PRIDEiQ9BXC0
ProteomicsDBi79402

Protocols and materials databases

DNASUi27198
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432564; ENSP00000389255; ENSG00000196917
GeneIDi27198
KEGGihsa:27198
UCSCiuc001ucz.4 human

Organism-specific databases

CTDi27198
DisGeNETi27198
EuPathDBiHostDB:ENSG00000196917.5
GeneCardsiHCAR1
H-InvDBiHIX0026348
HGNCiHGNC:4532 HCAR1
MIMi606923 gene
neXtProtiNX_Q9BXC0
OpenTargetsiENSG00000196917
PharmGKBiPA28925
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00510000046798
HOVERGENiHBG051680
InParanoidiQ9BXC0
KOiK08401
OMAiQLEFFLP
OrthoDBiEOG091G0AN6
PhylomeDBiQ9BXC0
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiGPR81
GenomeRNAii27198
PROiPR:Q9BXC0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196917 Expressed in 56 organ(s), highest expression level in thoracic mammary gland
CleanExiHS_GPR81
GenevisibleiQ9BXC0 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028016 HCAR1_rcpt
PANTHERiPTHR24231:SF29 PTHR24231:SF29, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHCAR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXC0
Secondary accession number(s): B2R9X4
, Q3Y5J3, Q4VBN1, Q6NXU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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