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Entry version 147 (10 Apr 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Hydroxycarboxylic acid receptor 1

Gene

HCAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.4 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 1
Alternative name(s):
G-protein coupled receptor 104
G-protein coupled receptor 81
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCAR1
Synonyms:GPR104, GPR81, HCA1
ORF Names:FKSG80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196917.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4532 HCAR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606923 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXC0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 49CytoplasmicSequence analysis7
Transmembranei50 – 70Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini71 – 89ExtracellularSequence analysisAdd BLAST19
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 130CytoplasmicSequence analysisAdd BLAST20
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 182ExtracellularSequence analysisAdd BLAST31
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 220CytoplasmicSequence analysisAdd BLAST17
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 261ExtracellularSequence analysisAdd BLAST20
Transmembranei262 – 281Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini282 – 346CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi99R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi233Y → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi240R → A: Diminishes the response to L-lactate. 1 Publication1
Mutagenesisi267T → A: Diminishes the response to L-lactate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27198

Open Targets

More...
OpenTargetsi
ENSG00000196917

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28925

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075101

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
311

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HCAR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000695861 – 346Hydroxycarboxylic acid receptor 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi88 ↔ 165PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXC0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXC0

PeptideAtlas

More...
PeptideAtlasi
Q9BXC0

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXC0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79402

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196917 Expressed in 56 organ(s), highest expression level in thoracic mammary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXC0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118073, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BXC0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389255

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BXC0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BXC0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKI5 Eukaryota
ENOG4110VUM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182614

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051680

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXC0

KEGG Orthology (KO)

More...
KOi
K08401

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLEFFLP

Database of Orthologous Groups

More...
OrthoDBi
856254at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXC0

TreeFam database of animal gene trees

More...
TreeFami
TF330775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028016 HCAR1_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24231:SF29 PTHR24231:SF29, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BXC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNGSCCRIE GDTISQVMPP LLIVAFVLGA LGNGVALCGF CFHMKTWKPS
60 70 80 90 100
TVYLFNLAVA DFLLMICLPF RTDYYLRRRH WAFGDIPCRV GLFTLAMNRA
110 120 130 140 150
GSIVFLTVVA ADRYFKVVHP HHAVNTISTR VAAGIVCTLW ALVILGTVYL
160 170 180 190 200
LLENHLCVQE TAVSCESFIM ESANGWHDIM FQLEFFMPLG IILFCSFKIV
210 220 230 240 250
WSLRRRQQLA RQARMKKATR FIMVVAIVFI TCYLPSVSAR LYFLWTVPSS
260 270 280 290 300
ACDPSVHGAL HITLSFTYMN SMLDPLVYYF SSPSFPKFYN KLKICSLKPK
310 320 330 340
QPGHSKTQRP EEMPISNLGR RSCISVANSF QSQSDGQWDP HIVEWH
Length:346
Mass (Da):39,295
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0DB114EEB3A47A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38C → Y in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti113R → K in AAH66883 (PubMed:15489334).Curated1
Sequence conflicti187M → I in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti213A → T in AAH95506 (PubMed:15489334).Curated1
Sequence conflicti222I → T in AAH95506 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02515143H → Q1 PublicationCorresponds to variant dbSNP:rs35292336Ensembl.1
Natural variantiVAR_025152253D → E1 Publication1
Natural variantiVAR_061218253D → H. Corresponds to variant dbSNP:rs36124671Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF411110 Genomic DNA Translation: AAL26481.1
EU809458 mRNA Translation: ACJ03844.1
AF345568 mRNA Translation: AAK29071.1
AB065866 Genomic DNA Translation: BAC06084.1
AY507143 mRNA Translation: AAR92485.1
AK313955 mRNA Translation: BAG36671.1
AB083631 Genomic DNA Translation: BAB89344.1
DQ157221 Genomic DNA Translation: AAZ67915.1
AC026333 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98337.1
BC066881 mRNA Translation: AAH66881.1
BC066882 mRNA Translation: AAH66882.1
BC066883 mRNA Translation: AAH66883.1
BC067484 mRNA Translation: AAH67484.1
BC095506 mRNA Translation: AAH95506.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9236.1

NCBI Reference Sequences

More...
RefSeqi
NP_115943.1, NM_032554.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.610873
Hs.711001

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000432564; ENSP00000389255; ENSG00000196917

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27198

UCSC genome browser

More...
UCSCi
uc001ucz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411110 Genomic DNA Translation: AAL26481.1
EU809458 mRNA Translation: ACJ03844.1
AF345568 mRNA Translation: AAK29071.1
AB065866 Genomic DNA Translation: BAC06084.1
AY507143 mRNA Translation: AAR92485.1
AK313955 mRNA Translation: BAG36671.1
AB083631 Genomic DNA Translation: BAB89344.1
DQ157221 Genomic DNA Translation: AAZ67915.1
AC026333 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW98337.1
BC066881 mRNA Translation: AAH66881.1
BC066882 mRNA Translation: AAH66882.1
BC066883 mRNA Translation: AAH66883.1
BC067484 mRNA Translation: AAH67484.1
BC095506 mRNA Translation: AAH95506.1
CCDSiCCDS9236.1
RefSeqiNP_115943.1, NM_032554.3
UniGeneiHs.610873
Hs.711001

3D structure databases

ProteinModelPortaliQ9BXC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118073, 5 interactors
IntActiQ9BXC0, 1 interactor
STRINGi9606.ENSP00000389255

Chemistry databases

BindingDBiQ9BXC0
ChEMBLiCHEMBL1075101
GuidetoPHARMACOLOGYi311

Protein family/group databases

TCDBi9.A.14.13.4 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

PhosphoSitePlusiQ9BXC0

Polymorphism and mutation databases

BioMutaiHCAR1
DMDMi47117701

Proteomic databases

jPOSTiQ9BXC0
PaxDbiQ9BXC0
PeptideAtlasiQ9BXC0
PRIDEiQ9BXC0
ProteomicsDBi79402

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27198
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432564; ENSP00000389255; ENSG00000196917
GeneIDi27198
KEGGihsa:27198
UCSCiuc001ucz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27198
DisGeNETi27198
EuPathDBiHostDB:ENSG00000196917.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HCAR1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0026348
HGNCiHGNC:4532 HCAR1
MIMi606923 gene
neXtProtiNX_Q9BXC0
OpenTargetsiENSG00000196917
PharmGKBiPA28925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKI5 Eukaryota
ENOG4110VUM LUCA
GeneTreeiENSGT00950000182614
HOVERGENiHBG051680
InParanoidiQ9BXC0
KOiK08401
OMAiQLEFFLP
OrthoDBi856254at2759
PhylomeDBiQ9BXC0
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-3296197 Hydroxycarboxylic acid-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR81

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27198

Protein Ontology

More...
PROi
PR:Q9BXC0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196917 Expressed in 56 organ(s), highest expression level in thoracic mammary gland
GenevisibleiQ9BXC0 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR028016 HCAR1_rcpt
PANTHERiPTHR24231:SF29 PTHR24231:SF29, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCAR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXC0
Secondary accession number(s): B2R9X4
, Q3Y5J3, Q4VBN1, Q6NXU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: April 10, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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