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Protein

Oxysterol-binding protein-related protein 11

Gene

OSBPL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193).2 Publications

GO - Molecular functioni

  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

GO - Biological processi

  • fat cell differentiation Source: BHF-UCL
  • positive regulation of sequestering of triglyceride Source: BHF-UCL

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 11
Short name:
ORP-11
Short name:
OSBP-related protein 11
Gene namesi
Name:OSBPL11
Synonyms:ORP11, OSBP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144909.7
HGNCiHGNC:16397 OSBPL11
MIMi606739 gene
neXtProtiNX_Q9BXB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114885
OpenTargetsiENSG00000144909
PharmGKBiPA32825

Polymorphism and mutation databases

BioMutaiOSBPL11
DMDMi20139127

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003811 – 747Oxysterol-binding protein-related protein 11Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei27PhosphothreonineCombined sources1
Modified residuei62PhosphotyrosineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei177PhosphoserineBy similarity1
Modified residuei181PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BXB4
MaxQBiQ9BXB4
PaxDbiQ9BXB4
PeptideAtlasiQ9BXB4
PRIDEiQ9BXB4
ProteomicsDBi79398

PTM databases

iPTMnetiQ9BXB4
PhosphoSitePlusiQ9BXB4

Expressioni

Tissue specificityi

Present at highest levels in ovary, testis, kidney, liver, stomach, brain, and adipose tissue. Strong expression (at protein level) in epithelial cells of kidney tubules, testicular tubules, caecum, and skin (PubMed:20599956). Present at low levels in subcutaneous and visceral adipose tissue (at protein level)(PubMed:23028956).2 Publications

Developmental stagei

During adipocyte differentiation, levels are elevated two-fold (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000144909 Expressed in 223 organ(s), highest expression level in biceps brachii
CleanExiHS_OSBPL11
ExpressionAtlasiQ9BXB4 baseline and differential
GenevisibleiQ9BXB4 HS

Organism-specific databases

HPAiHPA039144

Interactioni

Subunit structurei

Heterodimer with OSBPL9.1 Publication

Protein-protein interaction databases

BioGridi125386, 25 interactors
IntActiQ9BXB4, 7 interactors
STRINGi9606.ENSP00000296220

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BXB4
SMRiQ9BXB4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BXB4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 155PHPROSITE-ProRule annotationAdd BLAST98

Domaini

The PH domain binds phosphoinositides.1 Publication

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233871
HOVERGENiHBG053376
InParanoidiQ9BXB4
KOiK20465
OMAiFHCSWRM
OrthoDBiEOG091G0FV2
PhylomeDBiQ9BXB4
TreeFamiTF312807

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGGEPVSTM KVSESEGKLE GQATAVTPNK NSSCGGGISS SSSSRGGSAK
60 70 80 90 100
GWQYSDHMEN VYGYLMKYTN LVTGWQYRFF VLNNEAGLLE YFVNEQSRNQ
110 120 130 140 150
KPRGTLQLAG AVISPSDEDS HTFTVNAASG EQYKLRATDA KERQHWVSRL
160 170 180 190 200
QICTQHHTEA IGKNNPPLKS RSFSLASSSN SPISQRRPSQ NAISFFNVGH
210 220 230 240 250
SKLQSLSKRT NLPPDHLVEV REMMSHAEGQ QRDLIRRIEC LPTSGHLSSL
260 270 280 290 300
DQDLLMLKAT SMATMNCLND CFHILQLQHA SHQKGSLPSG TTIEWLEPKI
310 320 330 340 350
SLSNHYKNGA DQPFATDQSK PVAVPEEQPV AESGLLAREP EEINADDEIE
360 370 380 390 400
DTCDHKEDDL GAVEEQRSVI LHLLSQLKLG MDLTRVVLPT FILEKRSLLE
410 420 430 440 450
MYADFMSHPD LFIAITNGAT AEDRMIRFVE YYLTSFHEGR KGAIAKKPYN
460 470 480 490 500
PIIGETFHCS WKMPKSEVAS SVFSSSSTQG VTNHAPLSGE SLTQVGSDCY
510 520 530 540 550
TVRFVAEQVS HHPPVSGFYA ECTERKMCVN AHVWTKSKFL GMSIGVTMVG
560 570 580 590 600
EGILSLLEHG EEYTFSLPCA YARSILTVPW VELGGKVSVN CAKTGYSASI
610 620 630 640 650
TFHTKPFYGG KLHRVTAEVK HNITNTVVCR VQGEWNSVLE FTYSNGETKY
660 670 680 690 700
VDLTKLAVTK KRVRPLEKQD PFESRRLWKN VTDSLRESEI DKATEHKHTL
710 720 730 740
EERQRTEERH RTETGTPWKT KYFIKEGDGW VYHKPLWKII PTTQPAE
Length:747
Mass (Da):83,643
Last modified:February 11, 2002 - v2
Checksum:iB443D3BDE8AE5FB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036100184S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746035150Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392454 mRNA Translation: AAL40667.1
AK292702 mRNA Translation: BAF85391.1
CH471052 Genomic DNA Translation: EAW79389.1
BC065213 mRNA Translation: AAH65213.1
AF346292 mRNA Translation: AAK31141.1
CCDSiCCDS3033.1
RefSeqiNP_073613.2, NM_022776.4
UniGeneiHs.477440

Genome annotation databases

EnsembliENST00000296220; ENSP00000296220; ENSG00000144909
GeneIDi114885
KEGGihsa:114885
UCSCiuc003eic.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392454 mRNA Translation: AAL40667.1
AK292702 mRNA Translation: BAF85391.1
CH471052 Genomic DNA Translation: EAW79389.1
BC065213 mRNA Translation: AAH65213.1
AF346292 mRNA Translation: AAK31141.1
CCDSiCCDS3033.1
RefSeqiNP_073613.2, NM_022776.4
UniGeneiHs.477440

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9XNMR-A59-165[»]
ProteinModelPortaliQ9BXB4
SMRiQ9BXB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125386, 25 interactors
IntActiQ9BXB4, 7 interactors
STRINGi9606.ENSP00000296220

PTM databases

iPTMnetiQ9BXB4
PhosphoSitePlusiQ9BXB4

Polymorphism and mutation databases

BioMutaiOSBPL11
DMDMi20139127

Proteomic databases

EPDiQ9BXB4
MaxQBiQ9BXB4
PaxDbiQ9BXB4
PeptideAtlasiQ9BXB4
PRIDEiQ9BXB4
ProteomicsDBi79398

Protocols and materials databases

DNASUi114885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296220; ENSP00000296220; ENSG00000144909
GeneIDi114885
KEGGihsa:114885
UCSCiuc003eic.4 human

Organism-specific databases

CTDi114885
DisGeNETi114885
EuPathDBiHostDB:ENSG00000144909.7
GeneCardsiOSBPL11
HGNCiHGNC:16397 OSBPL11
HPAiHPA039144
MIMi606739 gene
neXtProtiNX_Q9BXB4
OpenTargetsiENSG00000144909
PharmGKBiPA32825
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233871
HOVERGENiHBG053376
InParanoidiQ9BXB4
KOiK20465
OMAiFHCSWRM
OrthoDBiEOG091G0FV2
PhylomeDBiQ9BXB4
TreeFamiTF312807

Miscellaneous databases

ChiTaRSiOSBPL11 human
EvolutionaryTraceiQ9BXB4
GeneWikiiOSBPL11
GenomeRNAii114885
PROiPR:Q9BXB4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144909 Expressed in 223 organ(s), highest expression level in biceps brachii
CleanExiHS_OSBPL11
ExpressionAtlasiQ9BXB4 baseline and differential
GenevisibleiQ9BXB4 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSB11_HUMAN
AccessioniPrimary (citable) accession number: Q9BXB4
Secondary accession number(s): A8K9I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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